--- Log opened Wed May 23 00:00:25 2018
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05:29 < kanzure> ginkgo bioworks again https://www.cnbc.com/2018/05/22/bill-gates-is-betting-on-this-synthetic-biology-start-up.html
05:30 < kanzure> "Iterative algorithm-guided design of massive strain libraries, applied to itaconic acid production in yeast" https://www.sciencedirect.com/science/article/pii/S1096717618301186
05:31 < kanzure> .title https://www.nature.com/collections/dhppvlvxxb
05:31 < yoleaux> Yeast 2.0
05:31 < kanzure> .tw https://twitter.com/rosscloney/status/998945672496861185
05:31 < yoleaux> I am v e r y excited to announce the latest @NatureComms collection and the first #syntheticbiology collection: From @SynGenome, SCRaMbLE – 7 papers about the power of #synbio for yeast engineering using synthetic chromosomes https://go.nature.com/2KJNnF2 (@rosscloney)
05:32 < kanzure> .tw https://twitter.com/MentorPlanet/status/991274641728704512
05:32 < yoleaux> Jennifer Doudna is developing an at-home CRISPR diagnostics kit #womeninscience #womenleaders #WomeninBusiness .@mammothbiosci https://futurism.com/mammoth-biosciences-crispr-diagnostics/amp/ (@MentorPlanet)
05:33 < kanzure> https://nbmecommunity.nature.com/users/109579-benjamin-blount/posts/33177-messing-up-the-synthetic-yeast-genome-in-a-good-way
05:35 < kanzure> .title https://www.nature.com/articles/d41586-018-05149-2
05:35 < yoleaux> Blood, sweat and tears in biotech — the Theranos story
05:44 < kanzure> .title https://www.youtube.com/watch?v=AfrU2wHQnrs
05:44 < yoleaux> Blake Richards - Deep learning with segregated dendrites - YouTube
05:44 < kanzure> "Neural interactome: Interactive simulation of a neuronal system" https://www.biorxiv.org/content/early/2017/11/26/209155
05:45 < kanzure> .tw https://twitter.com/KordingLab/status/998585706485297153
05:45 < yoleaux> Louis Scheffer of @HHMIJanelia promises us a whole simulated Drosophila within 5-10 years. If they fail I get beer, if they succeed I buy beer. I am pretty confident. Why do people believe the path from connectomics to simulation is short? (@KordingLab)
05:46 < kanzure> https://neurdiness.wordpress.com/2018/05/17/deep-convolutional-neural-networks-as-models-of-the-visual-system-qa/
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06:26 < fenn> .wik itaconic acid
06:26 < yoleaux> "Itaconic acid, or methylidenesuccinic acid, is an organic compound. This dicarboxylic acid is a white solid that is soluble in water, ethanol, and acetone. Historically, itaconic acid was obtained by the distillation of citric acid, but currently it is produced by fermentation." — https://en.wikipedia.org/wiki/Itaconic_acid
06:27 < fenn> "Itaconic acid is primarily used as a co-monomer in the production of acrylonitrile butadiene styrene and acrylate latexes with applications in the paper and architectural coating industry"
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07:48 < kanzure> .title https://www.youtube.com/playlist?list=PLZAQ3kBXUjJlcAbxUcNOcMjexOcckaLS7
07:48 < yoleaux> TransVision 2017 - YouTube
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08:14 < kanzure> fenn: why are robots/androids still so lame? is it actuators? lack of good batteries?
08:15 < fenn> half-assed biomimicry
08:15 < fenn> we adopt biological shapes and then apply high precision trajectory planning, gears and other rigid actuators
08:16 < fenn> a fully biomimetic control system would not have many of the problems inherent in modern robots
08:16 < archels> related https://youtu.be/jJYsOsoBIZU
08:16 < archels> .title
08:16 < yoleaux> Toyota T-HR3 Humanoid Robot - YouTube
08:16 < kanzure> my assumption was that we can't pack enough actuators to get human-like motion
08:16 < archels> apparently a human is a pretty fine controller, so why shouldn't an algorithm be able to do the job?
08:16 < kanzure> (and then we have actual motor control problems of course, but i consider that separate)
08:17 < fenn> rigid actuators are hard to pack into a small volume
08:17 < fenn> anyway i think the problems are more to do with learning, observing, and planning
08:17 < kanzure> is packing the problem or am i fooling myself?
08:18 < kanzure> archel's remote operation video looks kinda right to me.. i guess actuation is working.
08:18 < fenn> no, there are lots of applications for robots that aren't being filled, most of them don't require large numbers of degrees of freedom
08:18 < fenn> ugh just look at that thing try to wave
08:19 < fenn> fail
08:19 < archels> it's a little jittery around the edges, but the general idea's there
08:19 < archels> it's not a hardware-limited problem
08:20 < kanzure> for motion maybe, but i thought heavy lifts are limited for a lot of these?
08:21 < fenn> due to the need for high precision trajectories, payload limits are de-rated
08:21 < fenn> the actual torque from motors can be quite high
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08:28 < fenn> unfortunately full body teleoperation also requires a high performance exoskeleton on the human end
08:28 < fenn> but you can relax the weight limits there because it's stationary
08:29 < fenn> human in the loop control systems are hard
08:30 < fenn> especially once you start adding latency and messing around with inertia and gravity
08:30 < fenn> the THR-3 performs much more smoothly in robot mode
08:31 < fenn> T-HR3? wah
08:31 < fenn> it still uses that awful static balance algorithm
08:35 < fenn> you can do better with a completely unpowered mechanism
08:35 < fenn> .title http://youtu.be/-zsldBFnC3I
08:35 < yoleaux> Passive Kneed Walker, by Martijn Wisse - YouTube
08:38 < fenn> the shadow dexterous hand is what i believe to be the correct way to build humanoid robots (with current materials science)
08:39 < fenn> ray baughman has been inventing lots of new schemes for high power to weight ratio electroactive and thermoactive polymer actuators
08:40 < fenn> i don't really like thermoactive materials because they're hugely inefficient by design, but it allows you to play with a lot of different material physics
08:40 < fenn> electroactive carbon fiber actuators use voltages that are much too high to be practical, but the power to weight ratio is phenomenal
08:41 < fenn> some sort of auxetic nanostructure based on electrostatics is probably the way forward
08:41 < fenn> in other news, i finally learned what a dielectric is
08:42 < fenn> you can shield electric fields with dielectrics, so this might alleviate some concerns about using high voltages in robot actuators
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08:53 < fenn> .title http://youtu.be/Qmuf_6h7Kl8
08:53 < yoleaux> 3D / 4D printing inflatable structures - YouTube
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09:38 < kanzure> .tw https://twitter.com/neurowitz/status/999101178519617536
09:38 < yoleaux> Woo hoo! The IARPA Molecular Information Storage (MIST) program solicitation has been released: https://www.fbo.gov/notices/69b2f8da0c65d53319e5137bcb9a6e23 (@neurowitz)
09:38 < kanzure> .title https://www.fbo.gov/index?s=opportunity&mode=form&tab=core&id=69b2f8da0c65d53319e5137bcb9a6e23
09:38 < yoleaux> Molecular Information Storage (MIST) Program FINAL BAA RELEASE - Federal Business Opportunities: Opportunities
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11:59 < justanotheruser> maaku: could you elaborate on this? Shouldn't people be freaking out more about this? https://twitter.com/MarkFriedenbach/status/998661686318981120
12:06 < kanzure> merge mining itself shouldn't be particularly dangerous, although being able to talk with and get 85% of the hashrate to agree about a private proposal is alarming
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12:10 < justanotheruser> yep
12:18 < kanzure> https://www.wsj.com/articles/blockchain-talent-wars-escalate-hindering-product-development-1527006462
12:18 < kanzure> text https://pastebin.com/Fj876kZ9
12:19 < kanzure> .tw https://twitter.com/WSJ/status/998986894099845120
12:19 < yoleaux> Fresh graduates: $120,000 plus; 3-5 years of experience: $500,000. The going rate for developers at crypto startups https://on.wsj.com/2IFZoit (@WSJ)
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13:20 < maaku> what kanzure said
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18:07 < kanzure> .tw https://twitter.com/aantonop/status/926973857537421317
18:07 < yoleaux> I thought it was impossible to transribe @roasbeef live. I was wrong. @kanzure's hands should be banned as a fully automatic weapon https://twitter.com/petertoddbtc/status/926942016990208000 (@aantonop)
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19:18 < CaptHindsight> i think everyone should submit the same proposal to IARPA for MIST
19:19 < kanzure> hm?
19:19 < CaptHindsight> how will they respond to 10 or more submissions with the same approach?
19:19 < kanzure> they seem to be interested in funding multiple implementers
19:19 < kanzure> anyway, i'm not interested in applying solo
19:20 < CaptHindsight> would their heads explode?
19:20 < kanzure> don't think so-- they seem interested in hedging their bets
19:21 < CaptHindsight> some of the big guberment contractor think tanks are looking for DNA storage experts
19:21 < CaptHindsight> probably to say they have some "experts" on staff
19:22 < kanzure> did you read my transcript? http://diyhpl.us/wiki/transcripts/2018-02-21-iarpa-mist/
19:23 < jrayhawk> Did you ever wind up getting a Gemini PDA?
19:23 < CaptHindsight> yes
19:24 < kanzure> jrayhawk: batch delays https://www.indiegogo.com/projects/gemini-pda-android-linux-keyboard-mobile-device--2#/updates/all
19:24 < CaptHindsight> https://www.monster.com/jobs/search/?q=molecular-storage-memory&jobid=042d259b-4346-4728-8192-1b874c0dd46e
19:25 < CaptHindsight> 3 years of experience with established tools for polymer synthesis, chemical or enzymatic DNA synthesis, nanopore or mass spec sequencing
19:25 < jrayhawk> Ah, bummer.
19:26 < kanzure> well i shouldn't say delays. they seem to be on schedule. just a large backlog of orders.
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19:27 < CaptHindsight> there were a few other listings, can't find them now
19:27 < CaptHindsight> Booz Allen was another
19:27 < kanzure> there was an attendee list with the government contractors interested in the BAA
19:28 < CaptHindsight> you know they will get some chunks of the funding
19:30 < CaptHindsight> CIJ oligo cannon
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21:09 < ebowden> https://www.ccn.com/bitcoin-gold-hit-by-double-spend-attack-exchanges-lose-millions/
21:14 < kanzure> they didn't wait a sufficient number of confirmations
21:14 < kanzure> and also, bitcoin gold isn't bitcoin (it's a fork of bitcoin)
21:17 < ebowden> Any idea why they would be so lax with confirmations?
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23:31 < nmz787> so this is pretty good at freeing up chrome from the clutches of tab-rot https://chrome.google.com/webstore/detail/tabcopy/micdllihgoppmejpecmkilggmaagfdmb?hl=en-US
23:32 < nmz787> .title
23:32 < yoleaux> TabCopy - Chrome Web Store
23:32 < nmz787> it can export as HTML table, or custom, which I also made into an HTML table, but with clickable links
23:32 < nmz787> export meaning copy to the clipboard
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--- Log closed Thu May 24 00:00:26 2018