--- Log opened Tue Jun 19 00:00:50 2018 00:03 -!- MultiColoredHat [~MultiColo@83.166.215.94] has quit [Quit: Leaving] 00:04 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 260 seconds] 00:58 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 01:33 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 245 seconds] 01:43 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 01:54 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 02:12 -!- l_wl [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has quit [Remote host closed the connection] 02:13 -!- l_wl [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has joined ##hplusroadmap 02:13 -!- jqtrde [~jqtrde@142-254-106-160.dsl.dynamic.fusionbroadband.com] has quit [Ping timeout: 248 seconds] 02:15 -!- jqtrde [~jqtrde@142-254-106-160.dsl.dynamic.fusionbroadband.com] has joined ##hplusroadmap 02:18 -!- l_wl [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has quit [Ping timeout: 264 seconds] 02:23 -!- l_wl [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has joined ##hplusroadmap 02:28 -!- l_wl [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has quit [Ping timeout: 240 seconds] 02:29 -!- l_wl [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has joined ##hplusroadmap 02:33 -!- l_wl [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has quit [Ping timeout: 255 seconds] 02:50 -!- jtimon [~quassel@40.28.134.37.dynamic.jazztel.es] has joined ##hplusroadmap 03:06 < kanzure> https://www.statnews.com/2018/06/18/synthesizing-dna-faster/ 03:07 < kanzure> .tw https://twitter.com/NatureBiotech/status/1008760407366995969 03:07 < yoleaux> De novo DNA synthesis using polymerase-nucleotide conjugates https://go.nature.com/2JMiZOh https://pbs.twimg.com/media/Df_VfjkV4AAdm6d.jpg (@NatureBiotech) 03:09 < kanzure> https://www.forbes.com/sites/techonomy/2011/11/14/for-synthetic-biologists-the-lab-is-the-place-to-procreate/amp/ 03:09 < kanzure> .tw https://twitter.com/patrickc/status/1008395516294545408 03:09 < yoleaux> Funding Breakthrough Research: Promises and Challenges of the “ARPA Model”: http://mitsloan.mit.edu/shared/ods/documents/?DocumentID=4615 https://pbs.twimg.com/media/Df6KPcbVMAECV7-.jpg (@patrickc) 03:11 < kanzure> .tw https://twitter.com/jamesheathers/status/1008356139606700033 03:11 < yoleaux> Anyway, how GV didn't get fleeced was simple: they did ordinary everyday due diligence. Basically, after not being able to figure out the tech, they got Kevvo from down the hall and went "Oi Kevvo, go and give blood". Kev goes down the road to Walgreens Theranos testing center. (@jamesheathers, in reply to tw:1008356138021212162) 04:35 -!- vurtz [~vurtz@2a02:c7d:ba9:9b00:3d91:4b8f:f25:1c69] has joined ##hplusroadmap 04:49 -!- bluebear_ [~dluhos@80.95.97.194] has joined ##hplusroadmap 04:49 -!- hehelleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 04:53 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 276 seconds] 05:10 < kanzure> securimage seems easy enough to solve.. (phpcaptcha?) 05:12 -!- jqtrde [~jqtrde@142-254-106-160.dsl.dynamic.fusionbroadband.com] has quit [Ping timeout: 264 seconds] 05:39 -!- l_wl [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has joined ##hplusroadmap 05:43 -!- l_wl [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has quit [Ping timeout: 245 seconds] 05:54 -!- l_wl [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has joined ##hplusroadmap 06:22 -!- ebowden [~ebowden@128.250.0.198] has quit [Ping timeout: 276 seconds] 06:22 -!- ebowden [~ebowden@128.250.0.198] has joined ##hplusroadmap 06:29 < l_wl> Anyone use PayPal by Braintree before? I'm somehow being scammed by being sent money. Like they tried to send me 13k USD, then 5.2k $ then 18k, then 18k again.... I don't get it 06:31 -!- ebowden [~ebowden@128.250.0.198] has quit [Ping timeout: 260 seconds] 06:31 -!- ebowden [~ebowden@128.250.0.198] has joined ##hplusroadmap 06:41 -!- ebowden [~ebowden@128.250.0.198] has quit [Ping timeout: 245 seconds] 06:42 -!- ebowden [~ebowden@128.250.0.198] has joined ##hplusroadmap 06:44 -!- jqtrde [~jqtrde@142-254-106-160.dsl.dynamic.fusionbroadband.com] has joined ##hplusroadmap 06:47 -!- Urchin [~urchin@unaffiliated/urchin] has joined ##hplusroadmap 06:51 -!- ebowden_ [~ebowden@e-nat-mobility-0-127.uniaccess.unimelb.edu.au] has joined ##hplusroadmap 06:54 -!- ebowden [~ebowden@128.250.0.198] has quit [Ping timeout: 240 seconds] 06:57 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Ping timeout: 264 seconds] 07:14 -!- l_wl [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has quit [Ping timeout: 240 seconds] 07:31 -!- vurtz [~vurtz@2a02:c7d:ba9:9b00:3d91:4b8f:f25:1c69] has quit [Ping timeout: 255 seconds] 07:42 -!- Urchin [~urchin@unaffiliated/urchin] has quit [Ping timeout: 265 seconds] 07:51 < kanzure> M. C. Davey, D. J. C. Mackay, Reliable communication over channels with insertions, deletions, and substitutions. IEEE Trans. Inf. Theory. 47​, 687–698 (2001). 07:51 -!- l_wl_ [~l_wl@96-88-198-77-static.hfc.comcastbusiness.net] has joined ##hplusroadmap 07:51 < kanzure> M. Mitzenmacher, A survey of results for deletion channels and related synchronization channels. Probab. Surv. 6​, 1–33 (2009). 07:52 < l_wl_> Was idsconected 07:52 < l_wl_> Is that in response to me being a victim of scamming attempts where they send me money 07:53 < kanzure> no 07:53 -!- lewl [~lewl@96-88-198-77-static.hfc.comcastbusiness.net] has joined ##hplusroadmap 08:22 < kanzure> fenn: should do backup/archive of http://tmp2.wikia.com/wiki/Main_Page before it vanishes 08:28 -!- lewl_ [~lewl@96-88-198-77-static.hfc.comcastbusiness.net] has joined ##hplusroadmap 08:28 -!- lewl [~lewl@96-88-198-77-static.hfc.comcastbusiness.net] has quit [Read error: Connection reset by peer] 08:29 -!- lewl_ [~lewl@96-88-198-77-static.hfc.comcastbusiness.net] has quit [Client Quit] 08:29 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has quit [Ping timeout: 240 seconds] 08:30 -!- johndoloresPARKE [81617c19@gateway/web/freenode/ip.129.97.124.25] has joined ##hplusroadmap 08:31 -!- johndoloresPARKE [81617c19@gateway/web/freenode/ip.129.97.124.25] has quit [Client Quit] 08:31 -!- l_wl_ [~l_wl@96-88-198-77-static.hfc.comcastbusiness.net] has quit [Ping timeout: 256 seconds] 08:32 -!- l_wl_ [~l_wl@96-88-198-77-static.hfc.comcastbusiness.net] has joined ##hplusroadmap 08:42 -!- Urchin [~urchin@46.188.148.151] has joined ##hplusroadmap 08:52 -!- yashgaroth [~yashgarot@2606:6000:c308:f700:f818:c5e1:50cb:7010] has joined ##hplusroadmap 09:00 -!- karkomah [~0x@a94-132-223-187.cpe.netcabo.pt] has joined ##hplusroadmap 09:01 -!- Gurkenglas [~Gurkengla@unaffiliated/gurkenglas] has joined ##hplusroadmap 09:13 -!- vurtz [~vurtz@90.194.209.116] has joined ##hplusroadmap 09:22 -!- hehelleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 248 seconds] 10:14 -!- bluebear_ [~dluhos@80.95.97.194] has quit [Quit: Leaving.] 10:19 -!- Gurkenglas [~Gurkengla@unaffiliated/gurkenglas] has quit [Ping timeout: 276 seconds] 10:22 -!- karkomah [~0x@a94-132-223-187.cpe.netcabo.pt] has quit [Read error: Connection reset by peer] 10:22 -!- karkomah [~0x@a94-132-223-187.cpe.netcabo.pt] has joined ##hplusroadmap 10:25 -!- Gurkenglas [~Gurkengla@unaffiliated/gurkenglas] has joined ##hplusroadmap 10:48 -!- jqtrde [~jqtrde@142-254-106-160.dsl.dynamic.fusionbroadband.com] has quit [Ping timeout: 265 seconds] 11:24 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 11:29 -!- jqtrde [~jqtrde@173.195.78.226] has joined ##hplusroadmap 11:56 -!- vurtz [~vurtz@90.194.209.116] has quit [Ping timeout: 264 seconds] 12:48 -!- ebowden_ [~ebowden@e-nat-mobility-0-127.uniaccess.unimelb.edu.au] has quit [Ping timeout: 264 seconds] 13:02 -!- ebowden [~ebowden@e-nat-mobility-0-127.uniaccess.unimelb.edu.au] has joined ##hplusroadmap 13:15 -!- ebowden [~ebowden@e-nat-mobility-0-127.uniaccess.unimelb.edu.au] has quit [Ping timeout: 240 seconds] 13:17 -!- ebowden [~ebowden@1.152.107.214] has joined ##hplusroadmap 13:30 -!- JayDugger [~jwdugger@47.185.249.138] has quit [Remote host closed the connection] 13:42 -!- vurtz [~vurtz@2a02:c7d:ba9:9b00:3d91:4b8f:f25:1c69] has joined ##hplusroadmap 13:45 -!- jtimon [~quassel@40.28.134.37.dynamic.jazztel.es] has quit [Ping timeout: 245 seconds] 13:53 -!- atrus6 [~atrus6@72.240.75.37] has joined ##hplusroadmap 13:58 -!- Gurkenglas [~Gurkengla@unaffiliated/gurkenglas] has quit [Ping timeout: 256 seconds] 14:35 -!- Urchin [~urchin@46.188.148.151] has quit [Remote host closed the connection] 14:54 -!- karkomah [~0x@a94-132-223-187.cpe.netcabo.pt] has quit [Quit: Going offline, see ya! (www.adiirc.com)] 14:58 -!- atrus6 [~atrus6@72.240.75.37] has quit [Quit: Leaving] 15:06 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 15:18 -!- jtimon [~quassel@40.28.134.37.dynamic.jazztel.es] has joined ##hplusroadmap 15:40 < kanzure> .tw https://twitter.com/antonioregalado/status/1009121848204853250 15:40 < yoleaux> Two big weeks for "enzymatic" DNA synthesis - potentially the tech that will make the cost of building genomes fall as fast as reading them has. https://www.linkedin.com/pulse/enzymatic-dna-synthesis-coming-jiahao-huang/?published=t (@antonioregalado) 15:42 < kanzure> .tw https://twitter.com/Addgene/status/1009194655081271296 15:42 < yoleaux> Use ultrasound for imaging with acoustic reporter genes from the Shapiro Lab @Caltech https://hubs.ly/H0cHTBr0 (@Addgene) 15:44 < kanzure> .tw https://twitter.com/biorxivpreprint/status/1009192261341544448 15:44 < yoleaux> Microbial adaptation to venom is common in snakes and spiders http://biorxiv.org/cgi/content/short/348433v1 #bioRxiv (@biorxivpreprint) 15:44 < kanzure> "... the genome sequence data of venom-specific isolates feature an additional 45 genes, at least 11 of which improve membrane integrity" 15:47 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Ping timeout: 264 seconds] 15:48 < kanzure> "Pivoting of microtubules driven by minus end directed motors leads to their alignment to form an interpolar bundle" https://www.biorxiv.org/content/early/2018/06/15/347831 15:49 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 15:49 < kanzure> "Cell boundary confinement sets the size and position of the E. coli chromosome" https://www.biorxiv.org/content/early/2018/06/15/348052 16:00 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Ping timeout: 260 seconds] 16:02 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 16:06 -!- JayDugger [~jwdugger@47.185.249.138] has joined ##hplusroadmap 16:06 -!- CandleGlow [~CandleGlo@unaffiliated/candleglow] has joined ##hplusroadmap 16:10 -!- ebowden_ [~ebowden@128.250.0.206] has joined ##hplusroadmap 16:13 -!- ebowden [~ebowden@1.152.107.214] has quit [Ping timeout: 260 seconds] 16:21 < kanzure> .wik bromodomain 16:21 < yoleaux> "A bromodomain is an approximately 110 amino acid protein domain that recognizes acetylated lysine residues, such as those on the N-terminal tails of histones." — https://en.wikipedia.org/wiki/Bromodomain 16:22 < kanzure> "Bromodomains, as the "readers" of lysine acetylation, are responsible in transducing the signal carried by acetylated lysine residues and translating it into various normal or abnormal phenotypes.[2] Their affinity is higher for regions where multiple acetylation sites exist in proximity. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. The ... 16:22 < kanzure> ...domain itself adopts an all-α protein fold, a bundle of four alpha helices each separated by loop regions of variable lengths that form a hydrophobic pocket that recognizes the acetyl lysine.[1][3]" 16:23 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Ping timeout: 256 seconds] 16:30 -!- l_wl_ [~l_wl@96-88-198-77-static.hfc.comcastbusiness.net] has quit [Quit: gone for now but not for good] 16:31 -!- lewl [~lewl@96-88-198-77-static.hfc.comcastbusiness.net] has joined ##hplusroadmap 16:33 < kanzure> bromodomain signal transduction stuff https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042883/ 16:50 < kanzure> "Multiple phases of chondrocyte enlargement underlie differences in skeletal proportions" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606657/ 16:51 < kanzure> "The largest contribution to the lengthening of a skeletal element, and to the differential elongation of elements, comes from a dramatic increase in the volume of hypertrophic chondrocytes in the growth plate as they undergo terminal differentiation[1-7]. Despite this recognized importance, the mechanisms of chondrocyte volume enlargement have remained a mystery[8-11]. Here we use ... 16:51 < kanzure> ...quantitative phase microscopy[12] to show that chondrocytes undergo three distinct phases of volume increase, including a phase of massive cell swelling in which the cellular dry mass is significantly diluted. In light of the tight fluid regulatory mechanisms known to control volume in many cell types[13], this stands as a remarkable mechanism for increasing cell size and regulating growth ... 16:51 < kanzure> ...rate. It is, however, the duration of the final phase of volume enlargement by proportional dry mass increase at low density that varies most between rapidly and slowly elongating growth plates. Moreover, we find that this third phase is locally regulated through an Insulin-like Growth Factor-dependent mechanism. This study provides a framework for understanding how skeletal size is regulated ... 16:51 < kanzure> ...and for exploring how cells sense, modify, and establish a volume set point." 16:53 < kanzure> okay... well let's just upregulate that. 17:00 < kanzure> "A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation" http://dev.biologists.org/content/142/5/817.full 17:00 < kanzure> .wik runx2 17:00 < yoleaux> "Runt-related transcription factor 2 (RUNX2) also known as core-binding factor subunit alpha-1 (CBF-alpha-1) is a protein that in humans is encoded by the RUNX2 gene. RUNX2 is a key transcription factor associated with osteoblast differentiation." — https://en.wikipedia.org/wiki/Runx2 17:00 < kanzure> wait it's even called runt-related transcription factor... 17:02 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 17:10 < kanzure> "Skeletal overgrowth in transgenic mice that overexpress brain natriuretic peptide" http://www.pnas.org/content/95/5/2337.short 17:22 < kanzure> "ADAM12‐S stimulates bone growth in transgenic mice by modulating chondrocyte proliferation and maturation" https://onlinelibrary.wiley.com/doi/full/10.1359/jbmr.060502 17:22 < kanzure> "ADAM12‐S transgenic mice exhibit increased longitudinal bone growth. The increased bone length is progressive and age dependent, with a maximum increase of 17% seen in the femur from 6‐month‐old transgenic mice. The effect is gene dose dependent, being more pronounced in mice expressing higher levels of the transgene than in a lower‐expressing line. Histological analysis revealed no ... 17:22 < kanzure> ...alterations in the growth plate organization, but mean growth plate width was increased." 17:23 < kanzure> okie dokey 17:23 < kanzure> welp. 17:35 < kanzure> "Identification of novel genes significantly affecting growth in catfish through GWAS analysis" https://link.springer.com/article/10.1007/s00438-017-1406-1 17:36 -!- CandleGlow [~CandleGlo@unaffiliated/candleglow] has quit [Quit: ...and all my responses they stay the same.] 17:56 -!- ebowden_ [~ebowden@128.250.0.206] has quit [Remote host closed the connection] 17:57 -!- ebowden [~ebowden@128.250.0.206] has joined ##hplusroadmap 18:01 -!- ebowden [~ebowden@128.250.0.206] has quit [Ping timeout: 240 seconds] 18:13 -!- ebowden [~ebowden@128.250.0.206] has joined ##hplusroadmap 18:13 -!- ebowden [~ebowden@128.250.0.206] has quit [Remote host closed the connection] 18:41 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=3228c1ac Bryan Bishop: gene targets and overexpression for height >> http://diyhpl.us/diyhpluswiki/genetic-modifications/ 18:42 -!- jqtrde [~jqtrde@173.195.78.226] has quit [Ping timeout: 240 seconds] 18:44 < kanzure> "Comparison of ADAM and ADAMTS protein families in human, frog, fly and worm genomes" https://www.researchgate.net/profile/Hemalatha_Ramulu/publication/269585387_Comparison_of_ADAM_and_ADAMTS_protein_families_in_human_frog_fly_and_worm_genomes/links/5763e8b608aedbc345e8f1d5.pdf 18:49 -!- lewl_ [~lewl@96-88-198-77-static.hfc.comcastbusiness.net] has joined ##hplusroadmap 18:49 -!- lewl [~lewl@96-88-198-77-static.hfc.comcastbusiness.net] has quit [Read error: Connection reset by peer] 18:53 -!- lewl_ [~lewl@96-88-198-77-static.hfc.comcastbusiness.net] has quit [Remote host closed the connection] 18:54 -!- lewl [~lewl@96-88-198-77-static.hfc.comcastbusiness.net] has joined ##hplusroadmap 19:09 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=eb18ca4c Bryan Bishop: leptin overexpression >> http://diyhpl.us/diyhpluswiki/genetic-modifications/ 19:11 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=8759c11e Bryan Bishop: NR2B overexpression in mice >> http://diyhpl.us/diyhpluswiki/genetic-modifications/ 19:20 -!- jqtrde [~jqtrde@142-254-106-160.dsl.dynamic.fusionbroadband.com] has joined ##hplusroadmap 19:20 < kanzure> "Efficient generation of transgenic mice by lentivirus-mediated modification of spermatozoa" was referenced in https://motherboard.vice.com/en_us/article/4x3yg9/introducing-designer-babies-sperm-edition 19:21 < kanzure> https://www.technologyreview.com/s/519856/should-you-worry-about-23andme-patenting-designer-babies/ 19:22 < kanzure> oh brother "On Wednesday, the Center for Genetics and Society called on 23andMe to abstain from offering any product based on this patent and to use its patent to prevent others from doing so." 19:23 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=68ea4d7e Bryan Bishop: NR2A overexpression >> http://diyhpl.us/diyhpluswiki/genetic-modifications/ 19:26 -!- lewl [~lewl@96-88-198-77-static.hfc.comcastbusiness.net] has quit [] 19:55 -!- jqtrde [~jqtrde@142-254-106-160.dsl.dynamic.fusionbroadband.com] has quit [Ping timeout: 248 seconds] 20:01 -!- jqtrde [~jqtrde@142-254-106-160.dsl.dynamic.fusionbroadband.com] has joined ##hplusroadmap 20:17 < Douhet> kanzure, Center for Genetics and Society can get wrecked :( 20:26 < kanzure> "Lad, 18, finally has seven-inch human tail removed after spending his life being worshipped as a monkey god in India" 20:26 < kanzure> hmm. 20:40 -!- potatope [sid139423@gateway/web/irccloud.com/x-codabbvautiojytd] has quit [Ping timeout: 276 seconds] 20:42 -!- Solgriffin [sid282649@gateway/web/irccloud.com/x-kvviqsxhkdkdicsg] has quit [Ping timeout: 265 seconds] 20:42 -!- potatope [sid139423@gateway/web/irccloud.com/x-oegafkfkiivdajci] has joined ##hplusroadmap 20:45 -!- Solgriffin [sid282649@gateway/web/irccloud.com/x-edyjqljloycbxwqa] has joined ##hplusroadmap 20:47 -!- strages [uid11297@gateway/web/irccloud.com/x-uiibzwkdrqbeqvqi] has quit [Ping timeout: 256 seconds] 20:47 -!- EnabrinTain [sid11525@gateway/web/irccloud.com/x-tqsmslaonrmhdaad] has quit [Ping timeout: 256 seconds] 20:48 -!- nickjohnson [sid789@gateway/web/irccloud.com/x-krvmqdryresaywum] has quit [Ping timeout: 255 seconds] 20:50 -!- s0ph1a [sid246387@gateway/web/irccloud.com/x-tkxbunwsywxlfuuc] has quit [Ping timeout: 276 seconds] 20:50 -!- potatope [sid139423@gateway/web/irccloud.com/x-oegafkfkiivdajci] has quit [Ping timeout: 260 seconds] 20:50 -!- Solgriffin [sid282649@gateway/web/irccloud.com/x-edyjqljloycbxwqa] has quit [Ping timeout: 260 seconds] 20:50 -!- Joshchamp [sid159459@gateway/web/irccloud.com/x-qhogartmmsgldpfs] has quit [Ping timeout: 255 seconds] 20:51 -!- cloudcell [sid266768@gateway/web/irccloud.com/x-gdwxgxrthflrbrzt] has quit [Ping timeout: 255 seconds] 20:52 -!- l_wl [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has joined ##hplusroadmap 20:53 -!- Kacia [~kacia@95.87.234.241] has joined ##hplusroadmap 20:54 < kanzure> "One developmental control gene known to promote limb skeletal elongation is Prx1, also called MHox or Prrx1 (Martin et al. 1995). Prx1 is a paired-related homeobox gene expressed in somites, craniofacial mesenchyme, and limb mesoderm during mouse development (Cserjesi et al. 1992; Martin et al. 1995). Prx1-null mutants die at birth with severe craniofacial defects and significantly shortened ... 20:54 < kanzure> ...limbs (Martin et al. 1995). Early events of limb development are normal in Prx1-null mutants as the limb skeleton forms and is patterned correctly. However the long bones of the limbs are significantly shortened, showing that this transcription factor is an essential regulator of long bone elongation during limb development. Given that the forelimb long bones are strikingly elongated during ... 20:54 < kanzure> ...bat development (Fig. 1C; Cretekos et al. 2005; Sears et al. 2006), and mouse Prx1-null mutants show a specific defect in the elongation of these elements (Martin et al. 1995), we hypothesized that differences in Prx1 activity between mouse and bat may contribute to the morphological differences that develop in the forelimbs of these two divergent mammals." 20:56 < kanzure> "The bat Prx1 limb enhancer increases forelimb length in mice during development" http://genesdev.cshlp.org/content/22/2/141.full 21:13 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 21:16 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 240 seconds] 22:05 -!- jtimon [~quassel@40.28.134.37.dynamic.jazztel.es] has quit [Ping timeout: 268 seconds] 22:16 -!- yashgaroth [~yashgarot@2606:6000:c308:f700:f818:c5e1:50cb:7010] has quit [Quit: Leaving] 22:22 -!- nickjohnson [sid789@gateway/web/irccloud.com/x-epqdlvcriaazpujc] has joined ##hplusroadmap 22:23 -!- s0ph1a [sid246387@gateway/web/irccloud.com/x-ohsuiufjkgtyljcr] has joined ##hplusroadmap 22:23 -!- EnabrinTain [sid11525@gateway/web/irccloud.com/x-fqjfhptosrbdpiub] has joined ##hplusroadmap 22:23 -!- vurtz [~vurtz@2a02:c7d:ba9:9b00:3d91:4b8f:f25:1c69] has quit [Ping timeout: 255 seconds] 22:24 -!- Solgriffin [sid282649@gateway/web/irccloud.com/x-ndgwnnnktcsouqkr] has joined ##hplusroadmap 22:26 -!- Joshchamp [sid159459@gateway/web/irccloud.com/x-abxwuqgkshplwpag] has joined ##hplusroadmap 22:29 -!- ebowden [~ebowden@2001:8003:1014:2500:19ae:bccd:490c:12f] has joined ##hplusroadmap 22:31 -!- strages [uid11297@gateway/web/irccloud.com/x-rantzbfolmlyxfff] has joined ##hplusroadmap 22:36 -!- cloudcell [sid266768@gateway/web/irccloud.com/x-raumfnuxtviavfjt] has joined ##hplusroadmap 22:53 -!- poppingtonic [~brian@unaffiliated/poppingtonic] has joined ##hplusroadmap 22:55 -!- Solgriffin [sid282649@gateway/web/irccloud.com/x-ndgwnnnktcsouqkr] has quit [Ping timeout: 276 seconds] 22:56 -!- Joshchamp [sid159459@gateway/web/irccloud.com/x-abxwuqgkshplwpag] has quit [Ping timeout: 256 seconds] 22:57 -!- nickjohnson [sid789@gateway/web/irccloud.com/x-epqdlvcriaazpujc] has quit [Ping timeout: 256 seconds] 22:57 -!- cloudcell [sid266768@gateway/web/irccloud.com/x-raumfnuxtviavfjt] has quit [Ping timeout: 276 seconds] 22:57 -!- s0ph1a [sid246387@gateway/web/irccloud.com/x-ohsuiufjkgtyljcr] has quit [Ping timeout: 256 seconds] 22:57 -!- EnabrinTain [sid11525@gateway/web/irccloud.com/x-fqjfhptosrbdpiub] has quit [Ping timeout: 256 seconds] 22:58 -!- strages [uid11297@gateway/web/irccloud.com/x-rantzbfolmlyxfff] has quit [Ping timeout: 265 seconds] 23:09 < l_wl> Evan Burfield 23:16 -!- jqtrde [~jqtrde@142-254-106-160.dsl.dynamic.fusionbroadband.com] has quit [Ping timeout: 256 seconds] 23:17 -!- potatope [sid139423@gateway/web/irccloud.com/x-qchxgcvplqrymrok] has joined ##hplusroadmap 23:20 -!- Joshchamp [sid159459@gateway/web/irccloud.com/x-wvmmppjxrphpazdy] has joined ##hplusroadmap 23:22 -!- nickjohnson [sid789@gateway/web/irccloud.com/x-ctckenrbalwtdnhp] has joined ##hplusroadmap 23:22 -!- cloudcell [sid266768@gateway/web/irccloud.com/x-flemhpvdikbolkmr] has joined ##hplusroadmap 23:24 -!- yoleaux [~yoleaux@xn--ht-1ia18f.nonceword.org] has quit [Ping timeout: 268 seconds] 23:24 -!- Solgriffin [sid282649@gateway/web/irccloud.com/x-kojqpiefkxyuhtla] has joined ##hplusroadmap 23:25 -!- strages [uid11297@gateway/web/irccloud.com/x-eqtflgdghdrfuxtu] has joined ##hplusroadmap 23:26 -!- s0ph1a [sid246387@gateway/web/irccloud.com/x-ckcsuwepkoxlrdid] has joined ##hplusroadmap 23:27 -!- EnabrinTain [sid11525@gateway/web/irccloud.com/x-hnsitlxhbyxgyvtr] has joined ##hplusroadmap --- Log closed Wed Jun 20 00:00:51 2018