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05:33 < kanzure> .tw https://twitter.com/GWASCatalog/status/1009732397758337024
05:33 < yoleaux> Check our latest release!! We added more than 800 genetic assoc linked to #intelligence #cardiovascular disease or major #depression!! We also include two #summarystats for #eye diseases and for clostridium infection in multiple myeloma. More in http://www.ebi.ac.uk/gwas https://pbs.twimg.com/media/DgNBPnAXcAAE2BX.jpg (@GWASCatalog)
05:34 < kanzure> "Robust genome editing with short single-stranded and long, partially single-stranded DNA donors in C. elegans" https://www.biorxiv.org/content/early/2018/06/20/352260
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05:35 < kanzure> "A theoretical analysis of single molecule protein sequencing via weak binding spectra" https://www.biorxiv.org/content/early/2018/06/20/352310
05:36 < kanzure> .tw https://twitter.com/btnaughton/status/1009446472742391808
05:36 < yoleaux> There's now a formidable batch of new DNA synthesis companies. At least four enzymatic: @AnsaBio, @molassemblies, @nuclera and @DNAScript plus many other techs... Fantastic up-to-date list here: http://www.calinplesa.com/dna-synthesis-companies/ https://twitter.com/NathanHillson/status/1008742556346142720 (@btnaughton)
05:37 < kanzure> .tw https://twitter.com/eboyden3/status/1009481796529065986
05:37 < yoleaux> Next gen DNA sequencing has revolutionized biology. But what if you could sequence individual proteins? Here we propose, and mathematically evaluate, a concept of how to do that. https://www.biorxiv.org/content/early/2018/06/20/352310 (@eboyden3)
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05:42 < kanzure> https://www.allencell.org/visual-guide-to-human-cells.html
05:42 < kanzure> ^ coolest thing you will see all day
05:45 < kanzure> "A modular dCas9-SunTag DNMT3A epigenome editing system overcomes pervasive off-target activity of direct fusion dCas9-DNMT3A constructs" http://m.genome.cshlp.org/content/early/2018/06/15/gr.233049.117
05:46 < kanzure> .tw https://twitter.com/NewYorkBotanics/status/1008907965947146240
05:46 < yoleaux> We turned red fluorescent protein into a thread via enzymatic crosslinking! #tangiblescience #biomaterials #fiberdesign https://pbs.twimg.com/media/DgBccNXX0AAvokf.jpg (@NewYorkBotanics)
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05:48 < kanzure> https://blog.addgene.org/a-practical-approach-to-choosing-the-brightest-fluorescent-protein
05:49 < kanzure> "Direct preparation of Cas9 ribonucleoprotein from E. coli for PCR-free seamless DNA assembly" https://www.biorxiv.org/content/early/2018/06/07/328468
05:50 < kanzure> .tw https://twitter.com/ichaydon/status/995365042747990016
05:50 < yoleaux> New gene circuits let scientists turn branching on or off in plants 🌿. What might these programmable plants mean for the future of farming? My latest: https://synbiobeta.com/are-programmable-plants-the-future-of-farming/ #synbio #CRISPR https://pbs.twimg.com/media/DdA_OTsVAAAh6Kc.jpg (@ichaydon)
05:52 < kanzure> "Random sequences rapidly evolve into de novo promoters" https://www.biorxiv.org/content/early/2017/08/07/111880
05:53 < kanzure> so.. nearly anything can be a promoter?
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06:56 < kanzure> https://iimarckus.org/spaceworld/
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07:22 < kanzure> http://gromnitsky.users.sourceforge.net/lit/an-oral-history-of-unix/book.pdf
08:03 < kanzure> buran abandoned equipment https://goo.gl/VNMRTw (google maps link)
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08:09 < kanzure> sneaky sneaky https://www.youtube.com/watch?v=-q7ZVXOU3kM
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10:27 < jrayhawk> that's pretty cool
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10:38 < nmz787> I've come across that before... probably around the time I watched 'long way around' (the motorcycle documentary thing)
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12:54 < kanzure> iiiiiiiiiiiiiiiii
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13:31 < JayDugger> Scream or fingerslip?
13:33 < kanzure> what is the transliteration of the lucy lawless battlecry?
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13:34 < JayDugger> Hum. I think it was a running gag in Dilbert at the time, so I defer to Scott Adams.
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13:36 < JayDugger> Wikipedia claims "Alalaes," but then gives a fishy-smelling etymology, "Her cry was an alternate pronunciation for "Alale" (or "Alala"), who in Greek mythology was the female personification of the war cry"
13:37 < JayDugger> See also http://www.theoi.com/Daimon/Alala.html
13:37 < JayDugger> So, in Greek, Αλαλη Αλαλα, or in Latin Alala.
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14:01 < TMA> do we have the contemporary latin transcription? it could have been Halala.
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14:44 < kanzure> music! https://www.youtube.com/watch?v=CKKCO7T6QJc
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15:42 < archels> kanzure: https://www.youtube.com/watch?v=gN61HqVaufc
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17:53 < ebowden_> An SLA printer that not only is somehow fast, but actually uses decently strong, somehow not absurdly expensive resins. Though I bet the printer is absurdly expensive.
17:53 < ebowden_> https://www.youtube.com/watch?v=O2thSsQrZUM
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17:55 < ebowden_> https://www.sculpteo.com/media/imagecontent/tds_ce_220_v2.0.pdf
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20:08 < kanzure> archels: too noisy/crackly for me
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20:46 < kanzure> "ray kurzweil is a pessimist" - george church      https://www.youtube.com/watch?v=Q_zzFRjeGRI&t=2m
20:59 < kanzure> what is the current state of blood substitutes
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21:21 < fenn> "Fluosol-DA remains the only oxygen therapeutic ever fully approved by the FDA. As of 2017 no haemoglobin-based product had been approved."
21:21 < fenn> it's basically the liquid perfluorocarbon coolant in supercomputers
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21:23 < kanzure> hmm alright, let's get some
21:23 < kanzure> can anyone actually get any?
21:23 < kanzure> or is this one of those things that "exists" but doesn't really?
21:23 < nmz787> 'as-seen in movies'
21:24 < fenn> you need to emulsify it in saline etc
21:24 < fenn> for most blood-loss situations saline solution works well enough
21:25 < fenn> john schloendorn was working on making artifical red blood cells from progenitor stem cells. i forget the exact cellular lineage
21:26 < kanzure> did you keep any?
21:27 < fenn> uh, first of all it was mouse blood, and there was like a tiny speck of it
21:32 < fenn> "blood is made from the hematopoietic stem cells removed from umbilical cord between the mother and fetus of humans after birth... Each cord can produce approximately 20 units of blood or three blood transfusions. The blood is being produced for the Defense Advanced Research Projects Agency by Arteriocyte. The Food and Drug Administration has examined and approved the safety of this blood"
21:32 < fenn> human trials in 2013
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21:36 < fenn> no mention of it on their website
21:38 < fenn> perhaps it was their commercial products division "compass biomedical"
21:43 < fenn> no mention on their website either
21:43 < kanzure> perfect. well done, society.
21:44 < fenn> you'd think it would be in their press releases from around the same time
21:48 < kanzure> .tw https://twitter.com/kanzure/status/1010006683593134080
21:48 < yoleaux> "Ray Kurzweil is a pessimist" - George Church (@geochurch) https://www.youtube.com/watch?v=Q_zzFRjeGRI&t=2m (@kanzure)
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--- Log closed Fri Jun 22 00:00:53 2018