--- Log opened Sat Jun 23 00:00:54 2018 00:14 < archels> l_wl: some Bluetooth in-ear headphone hacking ahead? 00:25 -!- l_wl [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has quit [Quit: gone for now but not for good] 00:42 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 00:42 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Client Quit] 00:42 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 00:50 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Read error: Connection reset by peer] 00:58 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 01:06 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Read error: Connection reset by peer] 01:09 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 01:22 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Ping timeout: 256 seconds] 01:41 -!- redlegion [~x@gateway/tor-sasl/redlegion] has quit [Remote host closed the connection] 01:41 -!- redlegion [~x@gateway/tor-sasl/redlegion] has joined ##hplusroadmap 01:54 -!- jtimon [~quassel@40.28.134.37.dynamic.jazztel.es] has quit [Ping timeout: 256 seconds] 02:26 < archels> "One man's stumbling block is another man's competency test." 02:31 < archels> (re making IRC more accessible for "the average user") 02:50 -!- ShaKata [~ShaKata@bzq-79-181-127-80.red.bezeqint.net] has joined ##hplusroadmap 03:26 -!- Gurkenglas [~Gurkengla@unaffiliated/gurkenglas] has joined ##hplusroadmap 03:29 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 264 seconds] 03:37 < kanzure> you could do a TET-inducible (or some other rainbow of inducibility) for targeting your genetic circuits i think. such that you can take some combination of inducible promoter triggers to retarget the expression of some pre-implanted genetic circuits. 03:38 < kanzure> (multiplexing...) 03:40 < kanzure> you would pre-set a hierarchy by which you target and select different cell lines, and only the final cell lines that you have targeted will have increased expression of whatever selection you had made 03:40 < kanzure> assuming each thing was already in every cell's genome in your body already etc 03:41 < kanzure> and then you would have a long list of different things to upregulate or downregulate for every cell available as a toolkit by default 03:48 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 04:42 -!- Gurkenglas [~Gurkengla@unaffiliated/gurkenglas] has quit [Remote host closed the connection] 04:42 -!- Gurkenglas [~Gurkengla@unaffiliated/gurkenglas] has joined ##hplusroadmap 04:50 -!- hehelleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 04:53 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 240 seconds] 04:55 -!- strages [uid11297@gateway/web/irccloud.com/x-nvyhtkprymlphymc] has quit [Quit: Connection closed for inactivity] 05:13 < kanzure> during in utero development, you could probably do programmed cell death and apoptosis for cells that were not activated or reached by any of the chemicals activating those circuits, to get around the problem of cells that were not accessed by hte chemistry or optogenetics in time 05:30 -!- Kacia [~kacia@95.87.234.241] has quit [Ping timeout: 240 seconds] 05:30 -!- Kacia [~kacia@95.87.234.241] has joined ##hplusroadmap 05:41 < kanzure> .wik limb development 05:41 < yoleaux> "Limb development in vertebrates is an area of active research in both developmental and evolutionary biology, with much of the latter work focused on the transition from fin to limb." — https://en.wikipedia.org/wiki/Limb_development 05:44 -!- drewbot [~cinch@54.205.131.214] has quit [Remote host closed the connection] 05:47 < kanzure> .wik embryo drawing 05:47 < yoleaux> "Embryo drawing is the illustration of embryos in their developmental sequence. In plants and animals, an embryo develops from a zygote, the single cell that results when an egg and sperm fuse during fertilization." — https://en.wikipedia.org/wiki/Embryo_drawing 05:49 -!- Kacia [~kacia@95.87.234.241] has quit [Remote host closed the connection] 05:49 -!- Kacia [~kacia@95.87.234.241] has joined ##hplusroadmap 05:50 -!- ebowden_ [~ebowden@124.183.192.230] has quit [Ping timeout: 255 seconds] 05:53 < kanzure> "... People heterozygous for the Aniridia gene lack the irises of their eyes ((Ton and his colleagues 1991)" 05:54 -!- CandleGlow [~CandleGlo@unaffiliated/candleglow] has joined ##hplusroadmap 05:56 < kanzure> .title https://www.gwern.net/Embryo-editing 05:56 < yoleaux> Embryo editing for intelligence - Gwern.net 06:00 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=5985fe70 Bryan Bishop: human height >> http://diyhpl.us/diyhpluswiki/genetic-modifications/ 06:08 < kanzure> ".. Demonstrated by limb transplants in salamanders, limb size is genetically determined .. " http://www.mun.ca/biology/desmid/brian/BIOL3530/DEVO_13/ch13f05.jpg 06:16 < kanzure> "Repeated removal of developing limb buds permanently reduces appendage size in the highly-regenerative axolotl" http://europepmc.org/articles/PMC5707178/ 06:19 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 06:20 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Read error: Connection reset by peer] 06:49 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Read error: Connection reset by peer] 06:52 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 07:12 -!- ShaKata [~ShaKata@bzq-79-181-127-80.red.bezeqint.net] has quit [Quit: Leaving] 07:55 -!- emeraldgreen [~user@70.ip-145-239-90.eu] has joined ##hplusroadmap 08:13 -!- jtimon [~quassel@40.28.134.37.dynamic.jazztel.es] has joined ##hplusroadmap 08:49 -!- Kacia [~kacia@95.87.234.241] has quit [Ping timeout: 260 seconds] 08:51 -!- emeraldgreen [~user@70.ip-145-239-90.eu] has quit [Quit: Leaving.] 08:53 -!- Kacia [~kacia@95.87.234.241] has joined ##hplusroadmap 09:25 -!- yashgaroth [~yashgarot@2606:6000:c308:f700:4d37:904e:84cd:4600] has joined ##hplusroadmap 10:57 -!- strages [uid11297@gateway/web/irccloud.com/x-vcqpvgqdxllegcyi] has joined ##hplusroadmap 11:14 -!- redlegion [~x@gateway/tor-sasl/redlegion] has quit [Remote host closed the connection] 11:14 -!- redlegion [~x@gateway/tor-sasl/redlegion] has joined ##hplusroadmap 11:25 -!- ebowden [~ebowden@2001:8003:1014:2500:6d89:820:7386:39fd] has joined ##hplusroadmap 11:41 -!- Kacia [~kacia@95.87.234.241] has quit [Ping timeout: 264 seconds] 12:00 -!- l_wl [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has joined ##hplusroadmap 12:00 -!- Kacia [~kacia@95.87.234.241] has joined ##hplusroadmap 12:10 -!- ebowden [~ebowden@2001:8003:1014:2500:6d89:820:7386:39fd] has quit [Remote host closed the connection] 12:10 -!- ebowden_ [~ebowden@124.183.192.230] has joined ##hplusroadmap 12:16 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 264 seconds] 13:11 -!- l_wl [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has quit [Quit: gone for now but not for good] 13:28 -!- l_wl [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has joined ##hplusroadmap 13:53 -!- l_wl [~l_wl@pool-173-66-205-23.washdc.fios.verizon.net] has quit [Quit: gone for now but not for good] 13:57 -!- Kacia [~kacia@95.87.234.241] has quit [Ping timeout: 240 seconds] 14:20 < kanzure> hmph 14:23 -!- Kacia [~kacia@95.87.234.241] has joined ##hplusroadmap 15:03 -!- emeraldgreen [~user@70.ip-145-239-90.eu] has joined ##hplusroadmap 15:04 < kanzure> alan watts complains about gene editing https://www.youtube.com/watch?v=cn1NoxeGigI 15:10 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 15:48 -!- sachy [~sachy@78.108.102.220] has joined ##hplusroadmap 15:55 < Douhet> kanzure, why's he unhappy this time? 16:04 -!- lewl [~lewl@205.153.92.177] has joined ##hplusroadmap 16:11 < kanzure> well i would imagine it's partly because he's dead, people can be funny like that 16:13 -!- lewl_ [~lewl@ip-173-120-198-235.kscymo.spcsdns.net] has joined ##hplusroadmap 16:14 < kanzure> .title https://www.youtube.com/watch?v=RVU62CQTXFI 16:14 < yoleaux> Ted Nelson struggles with uncomprehending radio interviewer, 1979 - YouTube 16:17 -!- lewl [~lewl@205.153.92.177] has quit [Ping timeout: 268 seconds] 16:26 -!- lewl [~lewl@205.153.92.177] has joined ##hplusroadmap 16:29 -!- lewl [~lewl@205.153.92.177] has quit [Remote host closed the connection] 16:30 -!- lewl_ [~lewl@ip-173-120-198-235.kscymo.spcsdns.net] has quit [Ping timeout: 260 seconds] 16:41 < jrayhawk> http://www.stephanguyenet.com/nutrition-science-initiative-nusi-in-retrospect/ 16:46 < Douhet> http://www.delano.com/blog/?p=70 cross-post. Thoughts? Is use of black pepper to improve bioavailability of turmeric more harm than benefit? 16:52 < kanzure> .tw https://twitter.com/KevinH_PhD/status/1008713794481262593 16:52 < yoleaux> kanzure: Sorry: that command is a web-service, but its response was too long. 17:01 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 245 seconds] 17:05 -!- karkomah [~0x@a94-132-223-187.cpe.netcabo.pt] has joined ##hplusroadmap 17:07 -!- elCachorro [~elCachorr@208-104-162-62.rh4.cm.dyn.comporium.net] has joined ##hplusroadmap 17:07 < kanzure> elCachorro: greetings 17:08 -!- elCachorro [~elCachorr@208-104-162-62.rh4.cm.dyn.comporium.net] has left ##hplusroadmap [] 17:20 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 17:36 < fenn> jrayhawk: what's the tl;dr on those NuSI articles? i don't see anything wrong in Hall's timeline 17:40 < kanzure> nmz787: i didn't really get anything out of drmeister 17:44 < fenn> oh it's a bug in how twitter shows multiple pictures (or rather, doesn't show them) on a non-js browser 17:45 < jrayhawk> are there supposed to be more than three images? 17:48 < fenn> there are three images. i was only seeing one 17:57 -!- Gurkenglas [~Gurkengla@unaffiliated/gurkenglas] has quit [Ping timeout: 260 seconds] 17:58 -!- karkomah [~0x@a94-132-223-187.cpe.netcabo.pt] has quit [Remote host closed the connection] 18:13 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 18:14 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Client Quit] 18:15 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 18:16 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Client Quit] 18:16 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 18:24 < fenn> "Sign in to GitHub to continue to Gist" looks like microsoft isn't wasting any time 18:26 -!- ebowden_ [~ebowden@124.183.192.230] has quit [Ping timeout: 265 seconds] 19:24 < kanzure> https://www.scpr.org/programs/airtalk/2018/06/21/63237/diy-biohackers-aim-to-democratize-science-but-what/ 19:25 < kanzure> "Sparse bursts optimize information transmission in a multiplexed neural code" http://www.pnas.org/content/pnas/early/2018/06/21/1720995115.full.pdf 19:26 < kanzure> .tw https://twitter.com/harriswangnyc/status/1010205927079858176 19:26 < yoleaux> Judge question: where will you get Woolly mammoth cells [to grow and make fur in the lab]. Team answer: George Church’s lab. Wonder what else is in these magical freezers these days! @geochurch #BCD2018 https://twitter.com/harriswangnyc/status/1010157286592077824 (@harriswangnyc) 19:35 -!- vurtz [~vurtz@2a02:c7d:ba9:9b00:3d91:4b8f:f25:1c69] has joined ##hplusroadmap 19:39 < kanzure> http://aleph.se/andart2/space/seti/dissolving-the-fermi-paradox/ 19:43 < kanzure> "Isn’t this armchair astrobiology? Yes. We are after all from the philosophy department." 19:55 -!- ebowden [~ebowden@124.183.192.230] has joined ##hplusroadmap 20:11 -!- strages [uid11297@gateway/web/irccloud.com/x-vcqpvgqdxllegcyi] has quit [Quit: Connection closed for inactivity] 20:16 < kanzure> .tw https://twitter.com/Daniel_Plante/status/1010714653893132288 20:16 < yoleaux> @kanzure @Hermetec Just my own notes. Did the math based on available data and it worked out. The only unknown (even to this date) is the vacuum crush resistance of the stiffest aerogel formulation when coated with 2 microns each of PTFE, PET and polypropylene. (@Daniel_Plante, in reply to tw:1010512288300838917) 20:24 < fenn> probably wants an actual gas barrier in there, like aluminum film or sputtered alumina or PVDC 20:41 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Read error: Connection reset by peer] 20:43 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 21:04 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Ping timeout: 240 seconds] 21:51 -!- jtimon [~quassel@40.28.134.37.dynamic.jazztel.es] has quit [Ping timeout: 240 seconds] 22:28 -!- yashgaroth [~yashgarot@2606:6000:c308:f700:4d37:904e:84cd:4600] has quit [Quit: Leaving] 22:29 -!- vurtz [~vurtz@2a02:c7d:ba9:9b00:3d91:4b8f:f25:1c69] has quit [Ping timeout: 256 seconds] 22:59 -!- emeraldgreen [~user@70.ip-145-239-90.eu] has quit [Quit: Leaving.] --- Log closed Sun Jun 24 00:00:55 2018