--- Log opened Sat Nov 17 00:00:23 2018 00:58 -!- sektor [~sektor@95.87.234.241] has joined ##hplusroadmap 01:01 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap 01:44 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 240 seconds] 01:54 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Ping timeout: 252 seconds] 01:59 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 02:39 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 03:28 -!- NikopolSohru [~Nikopol_@185.217.171.49] has quit [Read error: Connection reset by peer] 03:29 -!- NikopolSohru [~Nikopol_@185.217.171.49] has joined ##hplusroadmap 03:58 -!- NikopolSohru [~Nikopol_@185.217.171.49] has quit [Read error: Connection reset by peer] 03:59 -!- NikopolSohru [~Nikopol_@185.217.171.49] has joined ##hplusroadmap 04:05 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 245 seconds] 04:25 -!- TC [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 04:27 -!- Gurkenglas [~Gurkengla@unaffiliated/gurkenglas] has quit [Ping timeout: 252 seconds] 04:28 -!- hehelleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 240 seconds] 05:12 -!- Urchin [~urchin@unaffiliated/urchin] has quit [Remote host closed the connection] 05:13 -!- Gurkenglas [~Gurkengla@unaffiliated/gurkenglas] has joined ##hplusroadmap 05:26 -!- uniera [uniera@gateway/vpn/privateinternetaccess/uniera] has joined ##hplusroadmap 06:14 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Ping timeout: 246 seconds] 06:27 -!- Gurkenglas [~Gurkengla@unaffiliated/gurkenglas] has quit [Ping timeout: 244 seconds] 06:31 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap 06:37 -!- TC [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 268 seconds] 06:41 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Ping timeout: 268 seconds] 06:58 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 07:08 -!- nullniverse [~nullniver@unaffiliated/nullniverse] has joined ##hplusroadmap 07:12 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap --- Log closed Sat Nov 17 07:35:01 2018 --- Log opened Sat Nov 17 07:35:01 2018 07:40 -!- Gurkenglas [~Gurkengla@unaffiliated/gurkenglas] has joined ##hplusroadmap 07:49 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Ping timeout: 268 seconds] 07:57 < kanzure> "su/sudo from root to another user allows TTY hijacking and arbitrary code execution" https://ruderich.org/simon/notes/su-sudo-from-root-tty-hijacking 08:00 < kanzure> what exactly is the efficiency of gene therapy via liposomes? i thought you still have the same accessible-cells-only delivery problems as with viral nanoparticle delivery method. 08:03 < kanzure> i guess in theory you could argue that somehow all cells are getting fed with foods so therefore it should be possible to diffuse other small molecules to all targets.... but dna is a lot bigger than what sustains these cells in protected niches. 08:09 < mrdata__> if youre going from root to another user this isnt considered privilege escalation 08:09 < mrdata__> and isnt a vulnerability because root can always do anything it wants 08:10 < mrdata__> thats just how the OS works 08:11 < mrdata__> but thats why no one should ever be allowed to log in as root 08:11 < mrdata__> admin should only log in as regular user, then do privilege escalation 08:12 < mrdata__> which is logged 08:17 -!- spaceangel [~spaceange@ip-86-49-16-65.net.upcbroadband.cz] has joined ##hplusroadmap 08:19 < kanzure> does lentivirus (like HIV) get into protected stem cell niches over a sufficiently long period of time? 08:22 < uniera> How long is *sufficiently long* kanzure 08:23 < kanzure> i don't care, just trying to find evidence that this problem has been solved in nature already 08:24 < uniera> The problem being? 08:25 < kanzure> it was stated above. 08:26 < kanzure> and, also, fenn directly referenced a liposomal gene therapy method the other day. 08:46 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Ping timeout: 252 seconds] 08:51 < kanzure> oisin senolytics slides (about their liposome method) https://static1.squarespace.com/static/58f6968115d5dbcc64eb277e/t/5b498b981ae6cf6f42e484b6/1531546526008/Oisin+Slide+Deck+2018.07.11c+%28ICSA2018%293.pdf 08:55 -!- yashgaroth [~yashgarot@2606:6000:c308:f700:eda9:48f0:cf13:c0a8] has joined ##hplusroadmap 09:01 -!- nullniverse [~nullniver@unaffiliated/nullniverse] has quit [Quit: Undertaking stack overflow prevention] 09:34 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 09:40 < justanotheruser> is the topic a joke, wrt fbi? 09:43 -!- spaceangel [~spaceange@ip-86-49-16-65.net.upcbroadband.cz] has quit [Remote host closed the connection] 10:11 < kanzure> justanotheruser: no, they were deeply concerned about do-it-yourself biohacking stuff 10:16 -!- spaceangel [~spaceange@ip-86-49-16-65.net.upcbroadband.cz] has joined ##hplusroadmap 10:20 -!- spaceangel [~spaceange@ip-86-49-16-65.net.upcbroadband.cz] has quit [Remote host closed the connection] 10:25 -!- spaceangel [~spaceange@ip-86-49-16-65.net.upcbroadband.cz] has joined ##hplusroadmap 10:30 -!- spaceangel [~spaceange@ip-86-49-16-65.net.upcbroadband.cz] has quit [Ping timeout: 240 seconds] 10:35 -!- spaceangel [~spaceange@ip-86-49-16-65.net.upcbroadband.cz] has joined ##hplusroadmap 10:40 -!- spaceangel [~spaceange@ip-86-49-16-65.net.upcbroadband.cz] has quit [Remote host closed the connection] 10:44 -!- spaceangel [~spaceange@ip-86-49-16-65.net.upcbroadband.cz] has joined ##hplusroadmap 11:21 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 268 seconds] 11:22 -!- Phil [uid148871@gateway/web/irccloud.com/x-rrkjyuoxcsoqhcjd] has joined ##hplusroadmap 11:28 -!- Urchin[emacs] [~user@unaffiliated/urchin] has quit [Ping timeout: 272 seconds] 11:42 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 11:45 -!- sektor [~sektor@95.87.234.241] has quit [Ping timeout: 268 seconds] 12:06 -!- sektor [~sektor@95.87.234.241] has joined ##hplusroadmap 12:33 -!- Jay_Dugger [~jwdugger@47.185.249.138] has joined ##hplusroadmap 13:20 -!- sektor [~sektor@95.87.234.241] has quit [Ping timeout: 246 seconds] 14:08 -!- Jay_Dugger [~jwdugger@47.185.249.138] has quit [Quit: Leaving] 15:12 -!- Phil [uid148871@gateway/web/irccloud.com/x-rrkjyuoxcsoqhcjd] has quit [Quit: Connection closed for inactivity] 15:24 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap 15:26 < kanzure> some of my thoughts on the state of academic privacy https://news.ycombinator.com/edit?id=18477933 15:40 -!- preview [~quassel@2407:7000:8423:b00::4] has joined ##hplusroadmap 15:45 -!- mu__ [~mu__@xd520f256.cust.hiper.dk] has joined ##hplusroadmap 15:46 < kanzure> mu__: be greeted. 15:52 < mu__> hi 15:52 < mu__> thank you for your post 15:54 < kanzure> you're very welcome. 15:58 < mu__> I've been aware of the potential issues with data inserted in pdfs. But your write-up really gave it new perspective for me. 15:59 < kanzure> yeah i don't think anyone really thinks about these issues 16:00 < kanzure> they are too focused on the authors and not on the readers 16:07 < mu__> It's definitely on my radar now. Pdfparanoia looks great btw, I'll check it out. Might recommend it on to phd students I teach literature search. 16:09 -!- uniera [uniera@gateway/vpn/privateinternetaccess/uniera] has quit [Remote host closed the connection] 16:10 < mu__> I mirror your worry that the scihub collection could be lost. But as I wrote in my post, haven't I dared touch the torrents due to my position. 16:11 < kanzure> well, you could always go get a seedbox in anothe jurisdiction, pay with bitcoin, etc... but yeah it's a hassle to do things right. 16:11 < kanzure> *another 16:12 < kanzure> i am not a lawyer, but my understanding is that the law particularly cares about distribution not possession in this context 16:13 < mu__> Tell that to Elsevier :) 16:18 < kanzure> mu__: teach them about tor 16:36 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Ping timeout: 240 seconds] 16:38 -!- NikopolS [~Nikopol_@185.217.171.49] has joined ##hplusroadmap 16:40 -!- NikopolSohru [~Nikopol_@185.217.171.49] has quit [Ping timeout: 252 seconds] 16:43 -!- Urchin[emacs] [~user@unaffiliated/urchin] has joined ##hplusroadmap 17:04 < jrayhawk> https://www.eff.org/cases/capitol-v-thomas "making available" is perhaps a more relevant threshold 17:19 -!- mu__ [~mu__@xd520f256.cust.hiper.dk] has quit [Remote host closed the connection] 17:22 -!- sachy [~sachy@91.146.121.5] has quit [Quit: Leaving.] 17:40 < kanzure> even in the absence of fda regulation and clinical trials, i think drug development costs will continue to go up because of basic dollar economic reasons but also investment opportunity cost and why invest in something that is cheap when others can easily compete (competition is bad for investors) 17:47 -!- shpx [~shpx@unaffiliated/shpx] has joined ##hplusroadmap 17:47 < kanzure> shpx: be greeted. 17:48 < shpx> howdy 17:48 < shpx> I saw your scihub comment 17:48 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap 17:49 < kanzure> i'd like to get a complete copy of that soon. 17:49 < shpx> sounds kind of paranoid, but I'm wondering if we can set up some sort of scihub pdf auditing project 17:49 < kanzure> i think publishers might agree to do that because it's sort of a liability issue (what happens if someone inserts dangerous instructions or parameters into a chemistry paper or whatever and someone gets killed) 17:49 < shpx> kanzure: here's a complete copy of your comment https://news.ycombinator.com/item?id=18477933 17:49 < kanzure> copy of scihub :) 17:50 < shpx> no you just need a place for people to upload pdfs they downloaded from scihub 17:50 < shpx> so you can diff them and analyze them for watermarks 17:50 < shpx> are you mirroring scihub? don't they release a torrent or something? 17:51 < kanzure> unfortunately there is very little bandwidth from the seeders 17:52 < kanzure> if you try to use the torrents then please let me know 17:54 < kanzure> i think the DOI databases should have hashes of all the files, but they don't (AFAIK) 17:55 < shpx> huh 17:59 < shpx> what do you mean "should", in your opinion? 17:59 < kanzure> i'm just being judgemental 18:09 -!- Gurkenglas [~Gurkengla@unaffiliated/gurkenglas] has quit [Ping timeout: 244 seconds] 18:22 < kanzure> about high price lab equipment http://slatestarcodex.com/2017/02/09/considerations-on-cost-disease/#comment-465352 (something about people being deluded into demanding a high price, and also maybe liability-reduction by having made the choice to spend big) 18:30 < kanzure> "consulting fees replacing bribes" http://slatestarcodex.com/2017/02/09/considerations-on-cost-disease/#comment-465387 18:32 < kanzure> "Moreover, if it is all aboveboard, an explicit set of hoops to jump through, then you know what the price is and can plan ahead. My understanding of Jim’s point is not that 10 people with vetos means 10x the bribe, but unlimited bribes. If there is one boss, he asks for a percent of your profit, low enough not to kill the golden goose. If there are 10 veto points sizing you up demanding ... 18:32 < kanzure> ...bribes, it is a prisoners’ dilemma between them and they ask for too much and you don’t build. Whereas NIH has explicit guidelines. The cost requires more money in planning a lab, preventing some labs, but it is a predictable cost so richer labs still happen." 18:43 -!- shpx [~shpx@unaffiliated/shpx] has quit [Quit: Textual IRC Client: www.textualapp.com] 19:42 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 21:04 -!- ExeciN [~nicexe@bnc.stormbit.net] has quit [Ping timeout: 268 seconds] 21:09 -!- shpx [~shpx@unaffiliated/shpx] has joined ##hplusroadmap 21:16 -!- hehelleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 21:20 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 260 seconds] 21:28 -!- ExeciN [~nicexe@bnc.stormbit.net] has joined ##hplusroadmap 21:33 < Jenda`> mrdata__: but the problem with su/sudo is that root does "su - unprivileged_user" (for example to investigate some issue the user is having with his account) and then that user can escalate to root 21:35 -!- spaceangel [~spaceange@ip-86-49-16-65.net.upcbroadband.cz] has quit [Remote host closed the connection] 21:40 -!- preview [~quassel@2407:7000:8423:b00::4] has quit [Ping timeout: 252 seconds] 21:42 < mrdata__> Jenda`, oh that isnt good 21:43 < mrdata__> that should not work at all 21:46 < kanzure> "The number of drugs that have gotten FDA approval at a billion+ cost only to be later rescinded is pretty massive as well... so it's not like the current system is fool-proof." 21:47 < kanzure> "Note that I'm not arguing for complete deregulation of drug manufacturing. Testing for product integrity through factory audits and the like is the original—and still core—purpose of bodies like the FDA and its EU equivalent(s). You want to know that your "ibuprofen, 20mg" indeed contains 20mg of ibuprofen in each pill, and nothing else. But that's cheap! That doesn't cost a hundred ... 21:47 < kanzure> ...million dollars to do. Proving product integrity is something that any food processing plant manages on the regular, not to mention manufacturers of generic/non-patented drugs. If we stop with the need to prove—with overwhelming statistical power—the safety-and-efficacy..." 21:48 -!- shpx [~shpx@unaffiliated/shpx] has quit [Ping timeout: 240 seconds] 21:49 < mrdata__> kanzure, for new drugs there is a lot more to prove 21:49 < mrdata__> efficacy and adverse effects have to be found 21:50 < mrdata__> and companies have fudged this before 22:18 -!- preview [~quassel@2407:7000:8423:b00::4] has joined ##hplusroadmap 22:30 -!- yashgaroth_ [~yashgarot@2606:6000:c308:f700:eda9:48f0:cf13:c0a8] has joined ##hplusroadmap 22:33 -!- yashgaroth [~yashgarot@2606:6000:c308:f700:eda9:48f0:cf13:c0a8] has quit [Ping timeout: 276 seconds] 23:19 -!- yashgaroth_ [~yashgarot@2606:6000:c308:f700:eda9:48f0:cf13:c0a8] has quit [Quit: Leaving] --- Log closed Sun Nov 18 00:00:24 2018