--- Log opened Tue Nov 27 00:00:35 2018 00:24 -!- midnightmagic [~midnightm@unaffiliated/midnightmagic] has quit [Ping timeout: 260 seconds] 00:33 -!- midnightmagic [~midnightm@unaffiliated/midnightmagic] has joined ##hplusroadmap 00:37 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Read error: Connection reset by peer] 00:37 -!- ebowden_ [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap 01:09 -!- Urchin [~urchin@unaffiliated/urchin] has joined ##hplusroadmap 01:49 < jrayhawk> Okay, the web newuser form works, now. 01:55 < jrayhawk> now for the question of why that gnusha commit announcement failed to generate an ikiwiki link 01:56 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=e343473a Bryan Bishop: transcript: dana carroll >> http://diyhpl.us/diyhpluswiki/transcripts/human-genome-editing-summit/2018-hong-kong/genes-genomes-genetic-variation/ 01:56 < jrayhawk> uhhhhh 01:56 < jrayhawk> huh 01:56 -!- Gurkenglas [~Gurkengla@unaffiliated/gurkenglas] has joined ##hplusroadmap 01:57 < jrayhawk> literally the same inputs 02:01 < jrayhawk> well, if someone notices that fail again, please send me the stderr of the push 02:02 < kanzure> there has bwwn similar fail in the past 02:02 < kanzure> not a big deal 02:02 < jrayhawk> i do not like mysteries in my scripts 02:03 < kanzure> yes i bought an optical microscope. it isn't particularly special. 02:08 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=75981cbd Joe Rayhawk: Revert "update instructions for contributing" >> http://diyhpl.us/diyhpluswiki/index/ 02:20 -!- Gurkenglas [~Gurkengla@unaffiliated/gurkenglas] has quit [Ping timeout: 268 seconds] 02:26 -!- l_wl [~l_wl@pool-173-66-183-216.washdc.fios.verizon.net] has quit [Ping timeout: 250 seconds] 02:28 -!- Phil [uid148871@gateway/web/irccloud.com/x-lmhjerawpffdfafe] has quit [Quit: Connection closed for inactivity] 03:21 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Ping timeout: 268 seconds] 03:24 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 03:36 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Quit: leaving] 03:39 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 04:01 -!- sektor [~sektor@95.87.234.241] has joined ##hplusroadmap 04:30 < kanzure> .tw https://twitter.com/CRISPRhistory/status/1067366056426184705 04:30 < yoleaux> Podcast The Inside: „CRISPR Babies in China: Across the Rubicon“ with guest @antonioregalado http://insitome.libsyn.com/crispr-babies-in-china-across-the-rubicon #crisprbabies #crispr (@CRISPRhistory) 04:33 -!- Gurkenglas [~Gurkengla@unaffiliated/gurkenglas] has joined ##hplusroadmap 04:38 < jrayhawk> https://twitter.com/AndyBiotech/status/1067041987621203968 04:41 < kanzure> "#HeJiankui & whoever dare to edit human gene are enemy of whole mankind." 04:41 < kanzure> it's really interesting to see how rabid all the biologists are about this 04:41 < kanzure> i think they are going to try to push for an arrest to be made 04:48 < kanzure> .tw 04:48 < yoleaux> #CRISPR gene-edited baby story update from Chinese media He Jiankui's University "unaware of the research project" and will immediately launch an investigation. Shenzhen HarMoniCare Hospital denied any involvement in the project IRB approval questioned, signature likely forged https://pbs.twimg.com/media/Ds7jQfWW0AEYEuX.jpg (@AndyBiotech) 05:03 < archels> lols. heads must roll 05:04 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 268 seconds] 05:04 < archels> progress will continue (mostly) unabated 05:18 -!- Gurkenglas [~Gurkengla@unaffiliated/gurkenglas] has quit [Ping timeout: 268 seconds] 05:23 -!- TMA [tma@twin.jikos.cz] has joined ##hplusroadmap 05:43 < kanzure> .tw https://twitter.com/rhumbline_media/status/1067178572878536704 05:43 < yoleaux> Our #documentary team will be filming for next 3 days with Dr. #HeJiankui the #chinese #scientist who edited the first #geneticallymodified #babies Please post questions for us to ask https://www.technologyreview.com/s/612458/exclusive-chinese-scientists-are-creating-crispr-babies/ #geneeditingchina #crisprbabies #designerbabies #codeofthewild (@rhumbline_media) 05:48 < kanzure> oh they interviewed me 05:58 -!- cerulean_syzygy [~cerulean_@5072B3C6.static.ziggozakelijk.nl] has quit [Ping timeout: 268 seconds] 06:12 < kanzure> tuesday 1030p EST is when he speaks 06:21 < archels> there's a kanzuromentary? link plz 06:25 < kanzure> not published yet 06:30 < fenn> looks fairly positive in tone https://youtu.be/0054UDJ_7I8 06:30 < fenn> .title 06:30 < yoleaux> A Revolution is Coming - YouTube 06:30 < fenn> "code of the wild" 06:31 < fenn> really sad to see how quickly all of china starts passing the buck and joining in the condemnation fury 06:33 < fenn> and all the language being used is as if a crime had been committed 06:35 < fenn> "the FDA’s approval is only necessary for medical treatments that are used on actual human beings. Simple laboratory research on embryos that will never be implanted isn’t covered — and there’s no law directly preventing gene-editing them." 06:36 < fenn> so all of this stuff about it being illegal to do in the US is simply that the FDA has jurisdiction because a modified human is "a drug" - although they probably haven't actually made any official statements to that effect because of how dumb it sounds 06:36 < kanzure> i think the biologists are working up a frenzy and they are worried about creating negative precedents for their field 06:37 < kanzure> but by calling for the arrest of this man, they are digging their own grave 06:37 < fenn> classic prisoner's dilemma 06:40 < kanzure> .tw https://twitter.com/aaas/status/1067425740839419904 06:40 < yoleaux> It is irresponsible to undertake human gene-editing clinical trials without sufficient pre-clinical scientific evidence and inclusive public dialogue on the risks and societal implications of gene-editing human embryos. Our statement: http://bit.ly/2BARDF7 #GeneEditSummit (@aaas) 06:41 < kanzure> american association for the *advancement* of science.... riiight. 06:41 < kanzure> https://www.aaas.org/sites/default/files/2018-11/AAAS%20Statement%20on%20Recent%20Media%20Reports%20of%20Human%20Gene-Editing.pdf?utm_source=64&utm_medium=social&utm_campaign=AAAS-(@aaas)&utm_term=gbyehuda&utm_content=AAAS 06:43 -!- ebowden_ [~ebowden@unaffiliated/ebowden] has quit [Read error: Connection reset by peer] 06:43 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap 06:44 < kanzure> this level of virtue signalling is so toxic 06:53 < fenn> i wonder why He's site is in english only 06:53 < fenn> strange to have only badly translated versions of ethics approvals etc 06:53 < kanzure> we should send him a nice love letter 06:54 < fenn> i'm sure he is busy with conference stuff and filtering hate mail from 9 million bioethicists 06:55 < fenn> but sure knock yourself out 06:56 < kanzure> i mean i am seeing literally no support for him other than us 06:56 < fenn> i'm shocked, shocked i say 06:57 < fenn> this is legit steve territory 06:57 < kanzure> hm? 06:57 < fenn> "i'm afraid of a hypothetical future in which a coalition is motivated to move against me" 06:58 < fenn> except in this case it's not much of a hypothetical, there is evidence that if you stick your neck out you'll get your neck cut 06:59 < fenn> it's not that nobody wants to support him, but the short term individual reward for doing so is miniscule compared to the consequences 06:59 -!- cerulean_syzygy [~cerulean_@client-145-120-36-118.surfnet.eduroam.rug.nl] has joined ##hplusroadmap 07:01 < fenn> you'd need to circulate a letter of interest, and get support from a large group of scientists etc before anyone is even willing to attach their name, sort of like kickstarter but with credibility and normativity 07:01 < fenn> but you personally don't have the academic clout to get it started 07:02 < fenn> it's a terrible chicken and egg situation 07:02 < fenn> all we have is chicken shit 07:04 < fenn> if anything were to happen, it would be a lukewarm sentiment from the genome editing conference, but i don't expect even that 07:04 < fenn> so go ahead and rage on twitter and hope history looks on you fondly 07:05 < kanzure> shouldn't the transhumanist "public relations is important!!!" organizations be saying positive things in support? where the fuck are they? 07:05 < kanzure> or are they also cowards 07:05 < fenn> co-opted by awful people like alex pearlman 07:06 < kanzure> okay, what about gp-write 07:06 < kanzure> .. hah don't answer that. 07:09 < fenn> yes maybe you'd have better luck getting organizations and institutions to attach their name to a sort of joint statement of organizations, and that way nobody has to personally stick their necks out 07:12 -!- cerulean_syzygy [~cerulean_@client-145-120-36-118.surfnet.eduroam.rug.nl] has quit [Quit: WeeChat 2.3-rc1] 07:12 -!- cerulean_syzygy [~cerulean_@client-145-120-36-118.surfnet.eduroam.rug.nl] has joined ##hplusroadmap 07:13 < kanzure> it'd have to be a pretty mild statement like... "We support the development of genomic technologies, and while facts are still emerging about the particular situation, it may not be prudent to throw out the twins with the bath water" or something. 07:14 < kanzure> https://bitcoin.stackexchange.com/questions/81115/if-someone-wanted-to-pretend-to-be-satoshi-by-posting-a-fake-signature-to-defrau 07:14 -!- Gurkenglas [~Gurkengla@unaffiliated/gurkenglas] has joined ##hplusroadmap 07:17 < kanzure> http://web.archive.org/web/20180123225724/http://www.mwdeem.rice.edu/mwdeem/ mwdeem@rice.edu 713-348-5852 07:27 * fenn goes back to watching blacksmithing videos 07:33 < kanzure> http://www.nationalacademies.org/gene-editing/2nd_summit/first_day/index.htm 07:35 < kanzure> .tw https://twitter.com/pembertonfilms/status/1067412968046964736 07:35 < yoleaux> @kanzure It was a question raised in the context of the current national regulations - many countries require a scientist to get a licence to tweak the genome but not an individual. (@pembertonfilms, in reply to tw:1067394365679706112) 07:39 < fenn> it might be good to just remind the twitter outrage machine that 50% of americans would want genetic engineering for their baby: https://www.genome.gov/27569226/what-do-people-think-about-genome-editing/ 07:44 -!- Phil [uid148871@gateway/web/irccloud.com/x-qjdemeagxehetbtg] has joined ##hplusroadmap 07:45 -!- strages [uid11297@gateway/web/irccloud.com/x-xglhhdzjnvfuosue] has joined ##hplusroadmap 07:54 < kanzure> thanks 07:54 < kanzure> .tw https://twitter.com/kanzure/status/1067446318925262855 07:54 < yoleaux> While everyone is busy virtue signalling about human embryo editing, keep in mind that there's already enthusiastic broad support in the U.S. at least, https://www.genome.gov/27569226/what-do-people-think-about-genome-editing/ #GeneEditSummit @rhumbline_media @antonioregalado (@kanzure) 07:54 < kanzure> however, i don't think the outrage is from twitter, it's from the biologists and bioethicists 07:55 < fenn> .title https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491050/ 07:55 < yoleaux> The moral imperative to continue gene editing research on human embryos 07:56 < fenn> "There is already a moratorium on unsafe research and we don’t need a further moratorium on unsafe gene editing research." 07:58 -!- custom_ [~custom_@70-36-235-234.dsl.static.fusionbroadband.com] has quit [Ping timeout: 268 seconds] 07:58 < kanzure> haha someone replied, "So Nuremberg is also virtue signalling to you?" 08:00 < kanzure> .tw https://twitter.com/kanzure/status/1067448079664771072 08:00 < yoleaux> @sudogene @rhumbline_media @antonioregalado There's actually nothing in the Nuremberg code that would prohibit human embryo editing. See https://news.ycombinator.com/item?id=18531314 (@kanzure, in reply to tw:1067447096465346561) 08:14 < fenn> well, technically, "9. The human subjects must be free to immediately quit the experiment at any point" 08:15 < fenn> but i think people are forgetting that this was written in the context of mengele's concentration camp torture to death vivisections 08:18 < kanzure> yeah easy to forget as much 08:27 -!- sachy [~sachy@91.146.121.5] has joined ##hplusroadmap 08:40 < fenn> https://www.japantimes.co.jp/news/2018/11/27/national/science-health/japanese-u-s-researchers-say-allergy-shots-pregnancy-protect-infants/ 08:40 < fenn> you don't see people screaming about nuremburg code violations for allergy shots 08:43 -!- uniera [uniera@gateway/vpn/privateinternetaccess/uniera] has joined ##hplusroadmap 08:43 < kanzure> https://jonrappoport.wordpress.com/2018/11/27/flashback-creating-genetically-altered-human/ 08:43 < kanzure> "BBC Online (May 4, 2001): “Scientists have confirmed that the first genetically altered humans have been born and are healthy.”" 08:44 < fenn> "one can only imagine" uh huh 08:50 < kanzure> "A machine-checked formalization of sigma-protocols" https://hal.inria.fr/inria-00552886 08:52 < fenn> ok here is the actual article jon rappoport is referring to www.nature.com/articles/35096722 and the 2001 "genetically altered humans born" thing was referring to mitochondrial donation 08:52 < fenn> also, don't waste your time on conspiracy nut blogs like that 08:53 < kanzure> he started following me on twitter. didn't check him out. 08:54 < kanzure> thanks though 08:54 < fenn> he makes it sound as if human-rabbit hybrids were created, and disentangling all the crap is annoying 10:18 -!- uniera_ [uniera@gateway/vpn/privateinternetaccess/uniera] has joined ##hplusroadmap 10:18 -!- uniera [uniera@gateway/vpn/privateinternetaccess/uniera] has quit [Read error: Connection reset by peer] 10:35 -!- uniera_ [uniera@gateway/vpn/privateinternetaccess/uniera] has quit [Remote host closed the connection] 10:52 -!- Urchin [~urchin@unaffiliated/urchin] has quit [Remote host closed the connection] 10:54 -!- entity8421[Ru-Li [entity8421@gateway/shell/matrix.org/x-qofqkibwbjqbzirn] has quit [Remote host closed the connection] 10:54 -!- kershaw[m] [kershawmat@gateway/shell/matrix.org/x-sdkboigdioididlc] has quit [Remote host closed the connection] 10:54 -!- kun0[m] [kun0matrix@gateway/shell/matrix.org/x-qexdggespupzscfr] has quit [Read error: Connection reset by peer] 10:54 -!- MarkOtaris [mark-otari@wikimedia/Mark-Otaris] has quit [Read error: Connection reset by peer] 11:06 -!- Phil [uid148871@gateway/web/irccloud.com/x-qjdemeagxehetbtg] has quit [Quit: Connection closed for inactivity] 11:12 -!- entity8421[Ru-Li [entity8421@gateway/shell/matrix.org/x-jajlkairrhzwjrqk] has joined ##hplusroadmap 11:27 -!- kershaw[m] [kershawmat@gateway/shell/matrix.org/x-wwulkkhmzsfvxpjd] has joined ##hplusroadmap 11:27 -!- kun0[m] [kun0matrix@gateway/shell/matrix.org/x-pqdgbvxvtwzkclmm] has joined ##hplusroadmap 11:27 -!- MarkOtaris [mark-otari@wikimedia/Mark-Otaris] has joined ##hplusroadmap 11:56 -!- entity8421[Ru-Li [entity8421@gateway/shell/matrix.org/x-jajlkairrhzwjrqk] has quit [Read error: Connection reset by peer] 11:56 -!- kun0[m] [kun0matrix@gateway/shell/matrix.org/x-pqdgbvxvtwzkclmm] has quit [Read error: Connection reset by peer] 11:56 -!- MarkOtaris [mark-otari@wikimedia/Mark-Otaris] has quit [Remote host closed the connection] 11:56 -!- kershaw[m] [kershawmat@gateway/shell/matrix.org/x-wwulkkhmzsfvxpjd] has quit [Remote host closed the connection] 12:03 -!- entity8421[Ru-Li [entity8421@gateway/shell/matrix.org/x-vmcirwccifyraxbs] has joined ##hplusroadmap 12:18 -!- kershaw[m] [kershawmat@gateway/shell/matrix.org/x-wrfwwmzwoovbkqib] has joined ##hplusroadmap 12:18 -!- MarkOtaris [mark-otari@wikimedia/Mark-Otaris] has joined ##hplusroadmap 12:18 -!- kun0[m] [kun0matrix@gateway/shell/matrix.org/x-uanhhctxcowfborj] has joined ##hplusroadmap 12:29 < kanzure> .title http://newsroom.ucla.edu/releases/UCLA-Report-Recommends-Open-Exploration-617 12:29 < yoleaux> UCLA Report Recommends Open Exploration, Ongoing Appraisal of Continued Development of Human Germline Engineering | UCLA 12:29 < kanzure> (1998) 12:31 < kanzure> .tw https://twitter.com/cecilejanssens/status/1067508670056071172 12:31 < yoleaux> @draparente @antonioregalado @carlzimmer @pknoepfler Earlier this year, He's website still mentioned his vision for gene editing: "industrialization has caused great environmental change" so "by correcting the disease genes, gaining protective alleles, we human can better live in the fast changing environment." #GeneEditSummit https://pbs.twimg.com/media/DtCMDgAXgAEHd04.jpg (@cecilejanssens, in reply to tw:1067500990373318657) 13:02 < kanzure> grindhouse has posted a "bioethics bingo" https://pbs.twimg.com/media/DtCRaUFVYAAzodO.jpg 13:03 -!- sektor [~sektor@95.87.234.241] has quit [Ping timeout: 250 seconds] 13:10 < kanzure> i wonder if we should just write an op ed somewhere 13:29 < kanzure> .tw https://twitter.com/kanzure/status/1067529938071371776 13:29 < yoleaux> I am in favor of human embryo editing, and against the baby drama. It's up to parents. #GeneEditSummit #crisprbabies (@kanzure) 13:31 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Ping timeout: 246 seconds] 13:40 -!- srk [sorki@fedora/sorki] has quit [Ping timeout: 268 seconds] 13:42 -!- srk [sorki@base48.cz] has joined ##hplusroadmap 13:42 -!- srk [sorki@base48.cz] has quit [Changing host] 13:42 -!- srk [sorki@fedora/sorki] has joined ##hplusroadmap 13:57 < kanzure> .tw https://twitter.com/anderssandberg/status/1067537149506002944 13:57 < yoleaux> @kanzure From a bioethics standpoint I think @juliansavulescu got it right: (if the gene editing happened) it was unethical because the *method* isn't safe enough yet to merit use in humans for the small intended benefit. Had the benefit been huge or the method proven safe, then fine. (@anderssandberg, in reply to tw:1067530331597737987) 13:57 < kanzure> omg even anders 13:57 < kanzure> .tw https://twitter.com/kanzure/status/1067537880430665728 13:57 < yoleaux> @anderssandberg @juliansavulescu You can't prove an embryo is safe. You might be able to show that something is unsafe or unreliable, though. (@kanzure, in reply to tw:1067537149506002944) 13:58 < fenn> i'd like these people complaining about safety to describe exactly what they want to have happened instead 13:59 < kanzure> committees. meetings. approvals from the entire human race. 13:59 < fenn> is that supposed to make it safer? 14:00 < fenn> do we really want to require a billion dollars of investment before doing literally anything to humans? 14:01 < fenn> surely it costs less than that to set up your own country and just fucking do it 14:01 < fenn> and then once you've proven that it's safe, everyone else can take advantage of your hard work 14:01 < fenn> and also you're a terrorist 14:07 < kanzure> no mr. bond, i expect it to cost.... $100 billion dollars. 14:08 < fenn> "embryo farming" is a tough bingo square to get 14:09 < kanzure> maybe i'll ask them how to get that square or if they just made it up 14:10 < fenn> i'm surprised i've never seen "frankenbaby" anywhere 14:11 < kanzure> don't give them any ideas damn it 14:11 -!- l_wl [~l_wl@pool-173-66-183-216.washdc.fios.verizon.net] has joined ##hplusroadmap 14:11 < fenn> it's all halloween costumes 14:14 < l_wl> Isn't halloween in February? 14:14 < fenn> man i need to come up with a pithy name for this incident, because writing "human gene editing drama" over and over in my journal is going to get tiring 14:41 < kanzure> "baby drama" 14:45 < kanzure> .tw https://twitter.com/anderssandberg/status/1067543823486779397 14:45 < yoleaux> @kanzure @juliansavulescu Nothing in medicine is perfectly safe. Safety is relative: a safe enough OTC painkiller better have far less side-effects than a chemotherapy. For human germline CRISPR like to see good monkey trials (Niu was a start; Kang&Liang need addressing) to really bound off-target risk. (@anderssandberg, in reply to tw:1067539080110620672) 14:45 < kanzure> .tw https://twitter.com/kanzure/status/1067549467363213313 14:45 < yoleaux> @anderssandberg @juliansavulescu Off-target risk can be mitigated by sequencing (multiple samples from different cell populations) before implantation. Furthermore, there's no actual reason to use CRISPR here, there are many gene editing tools: http://diyhpl.us/wiki/gene-editing/ (@kanzure, in reply to tw:1067543823486779397) 14:52 -!- cerulean_syzygy [~cerulean_@client-145-120-36-118.surfnet.eduroam.rug.nl] has quit [Ping timeout: 268 seconds] 15:11 -!- sachy [~sachy@91.146.121.5] has quit [Quit: Leaving.] 15:41 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 15:41 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 15:45 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 240 seconds] 16:07 < kanzure> julian savulescu liked anders' tweets but not mine, ha 16:29 -!- cerulean_syzygy [~cerulean_@5072B3C6.static.ziggozakelijk.nl] has joined ##hplusroadmap 17:50 -!- andytoshi [~apoelstra@unaffiliated/andytoshi] has quit [Ping timeout: 245 seconds] 18:31 -!- Gurkenglas [~Gurkengla@unaffiliated/gurkenglas] has quit [Ping timeout: 268 seconds] 18:33 -!- strages [uid11297@gateway/web/irccloud.com/x-xglhhdzjnvfuosue] has quit [Quit: Connection closed for inactivity] 19:07 < kanzure> .tw https://twitter.com/dbikard/status/1067604107391725569 19:07 < yoleaux> High fidelity Cas9 variant probably safer than life (lower off-target mutation rate than background spontaneous mutations) #GeneEditSummit (@dbikard, in reply to tw:1067602611740655617) 19:09 < kanzure> .tw https://twitter.com/antonioregalado/status/1067585399046979585 19:09 < yoleaux> holy cow Harvard Medical School dean George Daley is making the case, big time, and eloquently, FOR editing embryos, at #geneeditsummit he is says technically we are *ready* for RESPONSIBLE clinic use. (@antonioregalado) 19:13 < kanzure> .tw https://twitter.com/antonioregalado/status/1067416672062095360 19:13 < yoleaux> NEW: Chinese Academy of Sciences (ie state organ) statement. Promises public investigation of CRISPR baby but, very interesting, no clear statement it was illegal. https://pbs.twimg.com/media/DtA5zcGWsAAhNYf.jpg (@antonioregalado) 19:54 -!- andytoshi [~apoelstra@unaffiliated/andytoshi] has joined ##hplusroadmap 20:21 < kanzure> .tw https://twitter.com/jonrappoport/status/1067631385937145856 20:21 < yoleaux> 10) #GeneEditSummit sidebar: Page 235 of "A Crack in Creation" (by Doudna, Sternberg) notes that, putting aside germline cell gene editing, "...the [40 year old] practice of in vitro fertilization [IVF]... never underwent formal clinical trials or FDA review." / [~4mil babies]. (@jonrappoport, in reply to tw:1067625303865024512) 20:23 < kanzure> .tw https://twitter.com/anderssandberg/status/1067588981108498433 20:23 < yoleaux> @kanzure @juliansavulescu So was sequencing used here? And is it really effective when doing germline modifications? I suspect no to both questions, although I think sequencing ought to be done in any case for any embryo. What gene editing tool would you say minimizes off-target in humans? (@anderssandberg, in reply to tw:1067549467363213313) 21:09 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=1cab88d0 Bryan Bishop: transcript: jiankui he >> http://diyhpl.us/diyhpluswiki/transcripts/human-genome-editing-summit/2018-hong-kong/jiankui-he-human-genome-editing/ 21:09 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=9d7e587b Bryan Bishop: Merge remote-tracking branch 'origin/master' >> http://diyhpl.us/diyhpluswiki/ 21:10 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=ed312af2 Bryan Bishop: twitter link >> http://diyhpl.us/diyhpluswiki/transcripts/human-genome-editing-summit/2018-hong-kong/jiankui-he-human-genome-editing/ 21:12 < ebowden> What about a high fidelity cas15 variant? 21:14 -!- Urchin [~urchin@unaffiliated/urchin] has joined ##hplusroadmap 21:17 -!- hehelleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 21:21 -!- TC [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 250 seconds] 21:26 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Remote host closed the connection] 21:31 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=8afefd0f Bryan Bishop: more questions >> http://diyhpl.us/diyhpluswiki/transcripts/human-genome-editing-summit/2018-hong-kong/jiankui-he-human-genome-editing/ 21:39 -!- t4nk [t4nk@gateway/shell/panicbnc/x-lslsrpodcpwwxnfu] has quit [Ping timeout: 252 seconds] 21:49 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=937028a5 Bryan Bishop: end of questions >> http://diyhpl.us/diyhpluswiki/transcripts/human-genome-editing-summit/2018-hong-kong/jiankui-he-human-genome-editing/ 21:53 -!- t4nk [t4nk@gateway/shell/panicbnc/x-sbtbhhhksmgupkvp] has joined ##hplusroadmap 21:53 -!- t4nk [t4nk@gateway/shell/panicbnc/x-sbtbhhhksmgupkvp] has quit [Changing host] 21:53 -!- t4nk [t4nk@unaffiliated/t4nk] has joined ##hplusroadmap 21:53 -!- t4nk [t4nk@unaffiliated/t4nk] has quit [Changing host] 21:53 -!- t4nk [t4nk@gateway/shell/panicbnc/x-sbtbhhhksmgupkvp] has joined ##hplusroadmap 21:58 < kanzure> slides https://drive.google.com/drive/folders/1T1zLTtHS2z_cgl29fN_7qJg7fLA4qlrd 22:11 < kanzure> https://v.youku.com/v_show/id_XMzkzNzM3NTM3Ng==.html?spm=a2hzp.8253876.0.0&f=51978056 22:11 < kanzure> http://www.sustc-genome.org.cn/source/pdf/Informed-consent-women-English.pdf 22:11 < kanzure> http://www.sustc-genome.org.cn/source/pdf/Second-informed-consent-English.pdf 22:12 < kanzure> from http://www.sustc-genome.org.cn/research.html 22:13 -!- custom_ [~custom_@70-36-235-234.dsl.static.fusionbroadband.com] has joined ##hplusroadmap 22:16 -!- Urchin [~urchin@unaffiliated/urchin] has quit [Ping timeout: 250 seconds] 22:17 -!- custom_ [~custom_@70-36-235-234.dsl.static.fusionbroadband.com] has quit [Client Quit] 22:18 < kanzure> all of the twitter users retweeting this transcript are really over-educated, lots of postdocs and professors 22:23 -!- custom_ [~custom_@70-36-235-234.dsl.static.fusionbroadband.com] has joined ##hplusroadmap 22:31 < kanzure> https://twitter.com/redbiolab https://twitter.com/AkshatRathi https://twitter.com/jennymadison https://twitter.com/Alexis_Verger who the hell is carl zimmer 22:31 < kanzure> custom_: be greeted 22:32 < kanzure> https://twitter.com/DJ_de_Koning who are these people; i have stumbled into a vein of biology people that use computers i think. 22:36 < kanzure> ".. He Jiankui is the shareholder of seven companies and the legal representative of six companies. He Jiankui is the legal representative of Shenzhen Hanhai Gene Biotechnology Co., Ltd., Shenzhen Hanhai Venture Capital Management Partnership (Limited Partnership), Shenzhen Yinhe Biotechnology Co., Ltd., Zhuhai Hanhai Chuangmeng Science and Technology Management Partnership (Limited ... 22:36 < kanzure> ...Partnership), Zhuhai Nanjundao Science and Technology Partnership. Enterprise (limited partnership), Shenzhen Yinhe Medical Laboratory, Shenzhen Hanhai Gene Biotechnology Co., Ltd." 22:36 < kanzure> why are some of those repeated 22:42 < kanzure> https://twitter.com/iAmphioxus https://twitter.com/MWesson01 https://twitter.com/simonbayly https://twitter.com/LabCarpenter they're all biologists.. 22:43 < kanzure> .. https://twitter.com/gratacapr .. it's pretty interesting how high signal this is. i've never had a specifically postdoc-only audience. --- Log closed Wed Nov 28 00:00:36 2018