--- Log opened Thu Nov 29 00:00:37 2018
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01:09 < archels> kanzure: yeah, but where do you draw the line? If you're reScience, do you ask people to include the neural network simulator with the Python script that replicates your figures? What about numpy? Some obscure Python library that is or is not on pypi? The OS?
01:09 < archels> the fact is that replicable science is really hard, especially when you're simulating chaotic dynamical systems that might be influenced even by the machine floating point precision
01:14 < archels> kanzure: what's your sane, level-headed view of the #HeBabies?
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01:19 < archels> "I also thank my university, although they were unaware of these studies conducted."
01:28 < archels> "[...] unless and until [...] there is universal societal consensus" yeah so what you're basically saying is *never*
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05:45 < archels> .title https://bbp.epfl.ch/nexus/cell-atlas/?v=v2&std=1
05:45 < yoleaux> CellAtlas
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07:04 < kanzure> "language in a rider in the Consolidated Appropriation Act of 2016, which has now been repeated in subsequent years, “none of the funds made available… [to the FDA] may be used to review or approve an application for an exemption for investigational use of a drug or biological product… in which a human embryo is intentionally created or modified to include a heritable genetic ...
07:04 < kanzure> ...modification .”"
07:04 < kanzure> interesting, what if you make the germline intentionally infertile at the same time? suddenly the FDA is able to say yes/no?
07:05 < kanzure> archels: i think he's work is good and interesting and should be encouraged
07:05 < kanzure> "In other words, one cannot make use of the “investigational use” exception of the Food Drug and Cosmetic Act for gene editing embryos, and any researchers who attempt to do so without explicit permission from the FDA would be acting in violation of the statute."
07:06 < kanzure> http://blog.petrieflom.law.harvard.edu/2018/11/29/how-scott-gottlieb-is-wrong-on-the-gene-edited-baby-debacle/
07:07 < kanzure> .title http://www8.nationalacademies.org/onpinews/newsitem.aspx?RecordID=11282018b
07:08 < yoleaux> Statement from the Organizing Committee on Reported Human Embryo Genome Editing
07:08 < kanzure> https://www.sciencemag.org/news/2018/11/organizers-gene-editing-meeting-blast-chinese-study-call-pathway-human-trials
07:10 < kanzure> .tw https://twitter.com/PlamenAkaliyski/status/1068131409817030656
07:10 < yoleaux> Despite the public outrage, most people in China are supportive of gene editing for various life threatening conditions, including for extending life span and preventing HIV #GeneEditSummit https://pbs.twimg.com/media/DtLD2DKUUAAKlQz.jpg (@PlamenAkaliyski)
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07:42 < kanzure> "On Thursday, China's science ministry said it had "demanded that the relevant organisation suspend the scientific activities of relevant personnel".
07:43 < uniera> China's a mess kanzure
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08:34 < mrdata__> huh
08:34 < mrdata__> "off with their heads, whomever those are i guess"
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09:45 < fenn> how is it possible that the twins are mosaic? wouldn't you expect an organism derived from a single cell to have one genotype?
09:46 < fenn> is CRISPR really slow or something? like maybe it hadn't had any effect until after the cell started dividing
09:53 < fenn> there needs to be a generic sounding lobbying organization like ICTA whose answer to everything is "yes" instead of "no", just so we can start getting some balanced soundbites in news articles
09:54 < fenn> journalists don't have anyone to quote for the pro side of any argument, but there's many ready sources of scaremongering quotes
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10:49 < kanzure> fenn: cas9 is fast but double strand break repair is slow
10:50 < kanzure> anyway this is why my technique isn't crispr.... we have something better that doesn't have such high rates of mosaicism.
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11:02 < kanzure> https://biohackinfo.com/news-biohackers-offer-crispr-construct-china-gene-edited-babies/
11:04 < kanzure> http://transcendence.systems/
11:04 < kanzure> https://docs.google.com/document/d/1v-iypqu6ueWJVn6CbkDcnolbxwLEK7VfWlkBqlXqqq4/edit
11:05 < kanzure> http://sustc-genome.org.cn/ is offline
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11:38 < kanzure> https://www.nytimes.com/2018/11/29/science/gene-editing-babies-china.html
11:39 < kanzure> .title https://www.reddit.com/r/korea/comments/a1e3js/11_arrested_trying_to_hand_over_samsungs_latest/
11:39 < yoleaux> reddit: the front page of the internet
11:39 < kanzure> blah
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13:00 < kanzure> josiah says george owns a small part of his company
13:02 < kanzure> .title https://www.youtube.com/channel/UCn_Elifynj3LrubPKHXecwQ
13:02 < yoleaux> The He Lab - YouTube
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14:07 < kanzure> http://www.acmg.net/PDFLibrary/Genome-Editing-Clinical-Genetics.pdf
14:07 < kanzure> .tw https://twitter.com/TheACMG/status/1068264085953888256
14:07 < yoleaux> (1/2) The ACMG would like to reaffirm and remind our members and others about our 2017 statement “Genome editing in clinical genetics: points to consider – a statement of the American College of Medical Genetics and Genomics” #CRISPRbabies https://goo.gl/Njo6fU (@TheACMG)
14:11 < kanzure> https://www.bloomberg.com/opinion/articles/2018-11-27/crispr-fears-designer-baby-outrage-won-t-last-as-ethics-evolve
14:11 < kanzure> "As an editorial in Nature Medicine pointed out last summer, all acts of sexual reproduction carry a background probability of spontaneous mutation — that’s why evolution is possible. If the rate of off-target effects is lower than that of natural mutation, scientists and regulators may come to consider it to be tolerable."
14:13 < kanzure> "At one point there were 1.8 million viewers watching the live stream of He Jiankui's presentation"
14:22 < kanzure> .tw https://twitter.com/PaulMeeh/status/1068224221329809409
14:22 < yoleaux> @biohackinfo You should magnetic bead sort the CD34+ cells out and transfect them instead. That way, if they home back to the bone marrow, you have a person with a cache of CD 4 T cells that will never make CCR5. (@PaulMeeh, in reply to tw:1068215556237488128)
14:54 < kanzure> "Last week, a great chunk of missing euchromatic DNA was published that was not seen under the HGP and ref seq"
14:55 < kanzure> "Encryption and steganography of synthetic gene circuits" https://www.nature.com/articles/s41467-018-07144-7
14:55 < kanzure> "Here, we introduce strategies to hide the design of synthetic gene circuits, making it more difficult for an unauthorized third party to determine circuit structure and function. We present two different approaches: the first uses encryption by overlapping uni-directional recombinase sites to scramble circuit topology and the second uses steganography by adding genes and interconnections to ...
14:56 < kanzure> ...obscure circuit topology. We also discuss a third approach: to use synthetic genetic codes to mask the function of synthetic circuits."
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17:56 < kanzure> https://blogs.plos.org/synbio/2018/11/30/opinion-the-first-crispred-babies-are-here-whats-next/
17:56 < kanzure> "What we now need to do in order to redeem CRISPR technology is start a single long-term, wide-ranging project to treat one genetic disorder using germline editing. This project should be structured like the Human Genome Project (or the more recent Synthetic Yeast project), be funded solely through public funding, and be as consultative as possible."
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18:25 < fenn> "What we do know is that this experiment clearly flouts ethical standards"
18:26 < fenn> i've also read that He methodically went down the ethics checklist and did every step that was asked
18:26 < fenn> just repeat whatever you want until it becomes truthy
18:37 < fenn> pronunciation of He i guess https://upload.wikimedia.org/wikipedia/commons/7/78/Zh-h%C3%A9.ogg
18:41 < fenn> He wrote a paper on CRISPR in 2010, thats quite a bit earlier than most people involved in this: http://arxiv.org/abs/1008.2714
18:41 < fenn> .title
18:41 < yoleaux> [1008.2714] Heterogeneous diversity of spacers within CRISPR
18:52 < fenn> "a restrictive list of permitted alleles and traits"
18:53 < fenn> welcome to the new dark ages
18:53 < fenn> where do you think they'll burn He at the stake?
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23:04 < fenn> .title http://www.makeitfrom.com
23:04 < yoleaux> MakeItFrom.com: Material Properties Database
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--- Log closed Fri Nov 30 00:00:38 2018