--- Log opened Mon Dec 10 00:00:48 2018
07:53 < kanzure> .tw https://twitter.com/GenomeNathan/status/1071831112245223424
07:53 < yoleaux> @HankGreelyLSJU @antonioregalado @gwern @juliaoftoronto @pknoepfler @carlzimmer What if someone edits an (i)PSC, then differentiates it to gamete? (@GenomeNathan, in reply to tw:1071655460501999616)
09:20 < kanzure> https://theconversation.com/those-designer-babies-everyone-is-freaking-out-about-its-not-likely-to-happen-103079
09:43 < kanzure> uhhh
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09:52 < kanzure> fixed logs
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09:53 < kanzure> hmph
09:53 < kanzure> maybe not
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09:54 < kanzure> well the other logs are working but not this one
09:54 < kanzure> http://gnusha.org/logs/2018-12-10.log
09:54 < kanzure> http://gnusha.org/bitcoin-wizards/2018-12-10.log
10:00 < kanzure> https://medium.com/@jcliff/behind-mimblewimble-cd9da78a00e9
10:01 < kanzure> https://blockstream.com/2018/12/06/esplora-source-announcement/
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12:05 < nmz787> http://pure.tudelft.nl/ws/files/41674647/Thesis_SJHeerema.pdf
12:05 < nmz787> "DNA sensing with nanopores in graphene nanoribbons"
12:05 < nmz787> that woman had something to do with this https://bluemics.nl/
12:05 < nmz787> "A startup company Bluemics launched. We develop a single-molecule protein sequencer."
12:07 < nmz787> of course there's a stupid paywall on this article https://www.genomeweb.com/proteomics-protein-research/single-molecule-proteomics-approach-could-enable-improved-sensitivity
12:07 < nmz787> cached version is readable https://webcache.googleusercontent.com/search?q=cache:O8D7Y695bOQJ:https://www.genomeweb.com/proteomics-protein-research/single-molecule-proteomics-approach-could-enable-improved-sensitivity+&cd=9&hl=en&ct=clnk&gl=us#.XA7Hc5xKiUk
12:09 < nmz787> "His approach uses the ClpXP protease, which denatures and degrades target proteins. By monitoring this process using FRET, Joo and his colleagues are able to detect the removal of labeled amino acids much like Marcotte's group, though Joo's approach is focused on full-length proteins rather than peptides. He launched a company, Bluemics, in August, to commercialize the method."
12:10 < nmz787> https://projectreporter.nih.gov/project_info_description.cfm?aid=9620552&icde=0
12:10 < nmz787> "According to the grant, the method uses DNA-tagged peptides on beads combined with an "Edmanase" enzyme capable of gently degrading peptides one amino acid at a time. Upon removal, the DNA tags can be sequenced using conventional NGS, allowing for read-out of the tagged peptide sequences."
12:10 < nmz787> .wik edmanase
12:10 < yoleaux> nmz787: Sorry, I couldn't find article.
12:11 < nmz787> "engineered Edmanase (the deliverable of this proposal)"
12:12 < nmz787> I don't know any of them https://www.encodia.com/team.html
12:12 < nmz787> https://www.nature.com/articles/nbt.4278
12:12 < nmz787> .title
12:12 < yoleaux> Highly parallel single-molecule identification of proteins in zeptomole-scale mixtures | Nature Biotechnology
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20:14 < l_wl> is there any news about the readings of mars' internal temperature and structure
20:49 < fenn> they won't deploy the sensors until around march
20:49 < fenn> i have no idea why it will take so long
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23:07 < kanzure> hmph
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