--- Log opened Thu Dec 13 00:00:50 2018
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01:40 < fenn> Toxoplasma gondii
01:46 < fenn> https://www.agexinc.com/technology/
01:48 < fenn> injecting immortalized cells could be dangerous
01:50 < fenn> even if you are careful and keep the immortalizing genes separate, there's a tiny chance the cell could pick up the telomerase gene from the culture medium
01:50 < fenn> then it's just a matter of time until your cancer becomes a problem
01:51 < fenn> better than dying of old age though
01:55 < fenn> i guess they can screen out cell lines that still have telomerase activity after clonal expansion
02:29 < fenn> anyone tried magnesium threonate?
02:41 < archels> yeah, I used it for a few years, it's great
02:41 < archels> switched to glycinate now due to supply issues
02:41 < fenn> what supply issues?
02:41 < fenn> iirc it was always expensive
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02:44 < archels> local shops' stock combined with my laziness
02:44 < archels> ordering supplements in the EU from the USA is a bit of a drag, because customs is likely to hit you with a massive VAT bill post-hoc
02:44 < fenn> did you notice that it took some time to kick in? like 20 days
02:45 < archels> no, not at all
02:45 < fenn> would you say it does the same thing as magnesium glycinate?
02:46 < archels> shrug
02:46 < archels> I haven't tested the latter very much yet
02:46 < archels> but I guess they should be comparable, I selected these Mg variants based on bioavailability
02:47 < archels> the reports are good
02:47 < fenn> i'm more interested in your personal experience
02:48 < archels> I tried taking them a few times during the day, but it didn't do good things to my performance. so I only take them in evenings now
02:48 < archels> I used to get a little bit of a mellowy effect from the threonate, but just at the border of the liminal
02:48 < archels> oops, at the border of the liminal is a pleonasm
02:49 < fenn> i get the gist
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02:50 < fenn> do you have any stories about improved memory or cognition?
02:50 < archels> no, just restful sleep and no major post-amphetamine hangovers ^_^
02:50 < archels> I also drink coffee daily so I probably should be taking more Mg
02:51 < fenn> any negative effects or withdrawal?
02:51 < archels> no, like I said I just wouldn't take them in the morning or during the day due to potential drowsiness
02:52 < fenn> ok thanks for participating :D
02:52 < archels> no problem. and godspeed
02:53 < fenn> i've noticed magnesium induced drowsiness can be countered by co-supplementing with calcium or milk, however whole milk also contains saturated fat which can reduce the bioavailability
02:53 < fenn> i'm not sure if the saturated fat affects amino acid chelates
02:53 < archels> supplementing calcium requires great care to do good instead of harm
02:53 < fenn> (or threose chelates)
02:54 < fenn> yeah i don't take calcium supplements
02:54 < archels> you should only supplement Ca together with... what was it, vitamin K?
02:54 < fenn> right
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05:19 < jrayhawk> Retinoids, vitamin D, and menatetrenone.
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09:45 < nmz787> archels: and vitamin K2 at that, though I don't know if that's a relatively uncommon form or what
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14:07 < kanzure> gene-hacker-clon: howdy.
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14:12 < kanzure> https://www.statnews.com/wp-content/uploads/2018/12/He-manuscript-on-PCSK9-in-embryos_p1.pdf
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18:26 < jrayhawk> .title https://www.bmj.com/content/363/bmj.k5094 advances in troll epistemology
18:26 < yoleaux> jrayhawk: Sorry, that command (.title) crashed.
18:26 < jrayhawk> .title https://www.bmj.com/content/363/bmj.k5094
18:26 < yoleaux> Parachute use to prevent death and major trauma when jumping from aircraft: randomized controlled trial | The BMJ
18:27 < superkuh> Heh.
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--- Log closed Fri Dec 14 00:00:51 2018