--- Log opened Tue Dec 25 00:00:01 2018
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15:15 < kanzure> http://libgen.io/scimag/index.php?s=&journalid=2624&v=39&i=4
15:19 < kanzure> "The dyslexia candidate locus on 2p12 is associated with general cognitive ability and white matter structure" https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0050321
15:22 < kanzure> "A sequence variant associating with educational attainment also affects childhood cognition" https://www.nature.com/articles/srep36189
15:30 < kanzure> "A dopamine receptor genetic variant enhances perceptual speed in cognitive healthy subjects" https://www.sciencedirect.com/science/article/pii/S2352873717300215
15:31 < kanzure> "Our results identified a variant in the promoter region of the dopamine receptor D4 gene strongly associated with performance on speed of processing."
15:32 < kanzure> "DRD4 promoter variant rs3758653 ... To our knowledge, this is the first report implicating the same DRD4 polymorphism in cognitively European healthy individuals with a sample size >1000. In a smaller sample (n = ∼500 healthy Chinese adults), a correlation between this SNP and the speed of processing of the Tower of Hanoi task was reported [71]. Regarding the functional implications of the ...
15:32 < kanzure> ...gene's promoter variants, it has been shown that the DRD4 gene's polymorphisms lead to the difference in how well the receptors bind with dopamine and similar compounds [72], and therefore it has been assumed this basic difference leads to the differences observed in the phenotypes."
15:35 < kanzure> making a receptor that binds dopamine 1000x better is kind of trivial. biologists are very good at solving that kind of problem.........
15:45 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=a77a351b Bryan Bishop: more genetics related to intelligence >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
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15:53 < kanzure> http://web.archive.org/web/20150122215647/http://iqdb.cbi.pku.edu.cn/
15:54 < kanzure> http://web.archive.org/web/20131202000216/http://iqdb.cbi.pku.edu.cn:80/gene_list.txt
15:54 < kanzure> http://web.archive.org/web/20131201235716/http://iqdb.cbi.pku.edu.cn:80/core_dataset.txt
15:57 < kanzure> http://web.archive.org/web/20131202000347/http://iqdb.cbi.pku.edu.cn:80/snp.html
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16:01 < kanzure> "A predicted molecular model for development of human intelligence" https://link.springer.com/article/10.1134/S1819712418030091
16:01 < kanzure> "Herein, we selected a total of 181 intelligence- related genes (IRGs), selected from genome-wide association studies and literatures, to incorporate these genes in related signaling pathways, aiming to understand the underlying biological mechanisms. Disregarding the tissue types, computational pathway analyses demonstrated that IRGs were mostly enriched in the Wnt signaling pathway. ...
16:01 < kanzure> ...Nevertheless, pathway enrichment of brain-specific IRGs, highlighted the role of G-protein- and dopamine-mediated signaling pathways."
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16:10 < kanzure> "DAB1. An adaptor protein that is an obligate effector of the Reelin signaling pathway, and is essential for laminar organization of multiple neuron types of the cerebral cortex [61]. Increased activation of DAB1 by Reelin signaling pathway is correlated with increased dendritic spine density and enhanced performance in associative and spatial learning and memory [62]."
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16:18 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=289d9029 Bryan Bishop: more intelligence stuff >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
16:24 < kanzure> "Identification of novel loci associated with infant cognitive ability" https://www.nature.com/articles/s41380-018-0205-3
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--- Log closed Wed Dec 26 00:00:02 2018