--- Log opened Wed Jan 02 00:00:09 2019 01:05 -!- Urchin [~urchin@unaffiliated/urchin] has quit [Remote host closed the connection] 01:32 -!- TC [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 01:35 -!- hehelleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 246 seconds] 04:08 -!- Gurkenglas [~Gurkengla@unaffiliated/gurkenglas] has quit [Ping timeout: 250 seconds] 04:16 -!- Pompolic_ [~A@unaffiliated/pompolic] has joined ##hplusroadmap 04:18 -!- pompolic [~A@unaffiliated/pompolic] has quit [Ping timeout: 250 seconds] 06:04 -!- pribib [~pribib@unaffiliated/pribib] has joined ##hplusroadmap 06:06 < pribib> what bodily fluids can a person easily extract from themselves using needles and syringes other than blood? 06:07 < pribib> in this case easily being comparable to the difficuly of extraction of blood 06:38 < nsh> .title https://opentextbc.ca/anatomyandphysiology/chapter/26-1-body-fluids-and-fluid-compartments/ 06:38 < yoleaux> 26.1 Body Fluids and Fluid Compartments – Anatomy and Physiology 06:39 < nsh> probably the various lymphatic fluids are easiest to extract after blood 06:39 < nsh> well, maybe earwax is easier than blood idk depends how you define easy 06:41 < nsh> seems like in plembotomy, which i think nominally is the field of practice here, they're called "nonblood specimens" 06:41 < nsh> so there are probably some guidelines and best practices for these 06:57 < pribib> thanks 07:14 -!- sachy [~sachy@91.146.121.5] has joined ##hplusroadmap 07:23 -!- Pompolic_ is now known as pompolic 07:42 -!- uniera [uniera@gateway/vpn/privateinternetaccess/uniera] has joined ##hplusroadmap 08:18 -!- yashgaroth [~yashgarot@2606:6000:c308:f700:58e2:11ef:e020:72c] has joined ##hplusroadmap 08:22 -!- strages [uid11297@gateway/web/irccloud.com/x-jfprytftlbunypqr] has joined ##hplusroadmap 08:26 < kanzure> "The androgen receptor gene: A major modifier of speed of neuronal transmission and intelligence?" https://www.sciencedirect.com/science/article/pii/S030698770600658X?via%3Dihub 08:47 < kanzure> "Home range overlap as a driver of intelligence in primates" https://onlinelibrary.wiley.com/doi/full/10.1002/ajp.22357 08:58 < kanzure> "When larger brains do not have more neurons: increased numbers of cells are compensated by decreased average cell size across mouse individuals" https://www.frontiersin.org/articles/10.3389/fnana.2015.00064/full 09:01 -!- Gurkenglas [~Gurkengla@unaffiliated/gurkenglas] has joined ##hplusroadmap 09:06 < kanzure> "Dopamine D1 receptor density in the mPFC responds to cognitive demands and receptor turnover contributes to general cognitive ability in mice" https://www.nature.com/articles/s41598-018-22668-0 09:06 < kanzure> ".. In both humans and mice, performance on tests of intelligence or general cognitive ability (GCA) is related to dopamine D1 receptor-mediated activity in the prelimbic cortex, and levels of DRD1 mRNA predict the GCA of mice. Here we assessed the turnover rate of D1 receptors as well as the expression level of the D1 chaperone protein (DRiP78) in the medial PPC (mPFC) of mice to determine ... 09:06 < kanzure> ...whether rate of receptor turnover was associated with variations in the GCA of genetically heterogeneous mice. ... Additionally, the density of D1 receptors was observed to increase within 60 min (or less) in response to intense demands on working memory, suggesting that a pool of immature receptors was available to accommodate high cognitive loads. These results provide evidence that ... 09:06 < kanzure> ...innate general cognitive abilities are related to D1 receptor turnover rates in the prefrontal cortex, and that an intracellular pool of immature D1 receptors are available to accommodate cognitive demands." 09:11 < kanzure> "Individual differences in the proneness to have flow experiences are linked to dopamine D2-receptor availability in the dorsal striatum" https://www.sciencedirect.com/science/article/pii/S1053811912010762 09:13 < kanzure> DRD2 C957T is "flow proneness" 09:15 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=18ea78ad Bryan Bishop: flow proneness >> http://diyhpl.us/diyhpluswiki/genetic-modifications/ 09:22 < kanzure> "Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory" https://www.nature.com/articles/nn1846 11:06 -!- Urchin [~urchin@unaffiliated/urchin] has joined ##hplusroadmap 11:52 -!- uniera [uniera@gateway/vpn/privateinternetaccess/uniera] has quit [Remote host closed the connection] 11:52 -!- uniera [uniera@gateway/vpn/privateinternetaccess/uniera] has joined ##hplusroadmap 12:06 -!- Urchin [~urchin@unaffiliated/urchin] has quit [Read error: Connection reset by peer] 12:07 -!- Urchin [~urchin@unaffiliated/urchin] has joined ##hplusroadmap 12:07 -!- Gurkenglas [~Gurkengla@unaffiliated/gurkenglas] has quit [Ping timeout: 244 seconds] 13:09 -!- cluelessperson [~cluelessp@unaffiliated/cluelessperson] has quit [Ping timeout: 252 seconds] 13:56 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-kyhdlqptyeyzhrbz] has joined ##hplusroadmap 14:12 -!- pribib [~pribib@unaffiliated/pribib] has quit [Quit: WeeChat 2.3-dev] 14:13 -!- pribib [~pribib@unaffiliated/pribib] has joined ##hplusroadmap 14:20 -!- sachy [~sachy@91.146.121.5] has quit [Quit: Leaving.] 16:00 -!- AgenttiX [agenttix@lakka.kapsi.fi] has quit [Ping timeout: 250 seconds] 16:16 < fenn> pribib: saliva, semen, sweat 16:23 -!- AgenttiX [agenttix@lakka.kapsi.fi] has joined ##hplusroadmap 17:05 < pribib> fenn do you have a link? 17:40 < fenn> oh you want to use needles 17:47 < pribib> looking for info on this 17:49 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Ping timeout: 240 seconds] 17:50 < kanzure> maybe my disdane for "oh it's just dopamine receptors" is misplaced 17:50 < kanzure> (what with everyone hyping up serotonin/dopamine axis for literally all ailments ever) 17:51 < uniera> What do you mean kanzure 17:51 < yoleaux> 12 Dec 2018 01:17Z uniera: you must be new to IRC, because that's a stupid question >>>>> "23:27:53 Wow how the f did you know I was here yoleaux" 17:51 < uniera> Alright I already understand how you work yoleaux, good job 17:52 < uniera> Can you expand on the serotonin / dopamine axis hyping theory kanzure 17:52 < uniera> Not sure I got that 17:54 < kanzure> everyone blames dopamine for everything 17:55 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 17:59 -!- cluelessperson_ [~cluelessp@2604:4080:1326:83c5:604f:2ff:fe8e:c545] has joined ##hplusroadmap 18:06 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Ping timeout: 245 seconds] 18:21 -!- Gurkenglas [~Gurkengla@unaffiliated/gurkenglas] has joined ##hplusroadmap 18:25 -!- strages [uid11297@gateway/web/irccloud.com/x-jfprytftlbunypqr] has quit [Quit: Connection closed for inactivity] 19:02 -!- uniera [uniera@gateway/vpn/privateinternetaccess/uniera] has quit [Quit: Leaving...] 19:41 -!- cluelessperson_ [~cluelessp@2604:4080:1326:83c5:604f:2ff:fe8e:c545] has quit [Quit: Laters] 19:41 -!- cluelessperson_ [~cluelessp@unaffiliated/cluelessperson] has joined ##hplusroadmap 19:43 -!- cluelessperson_ [~cluelessp@unaffiliated/cluelessperson] has quit [Client Quit] 19:44 -!- cluelessperson [~cluelessp@unaffiliated/cluelessperson] has joined ##hplusroadmap 20:55 -!- CheckDavid [uid14990@gateway/web/irccloud.com/x-kyhdlqptyeyzhrbz] has quit [Quit: Connection closed for inactivity] 21:14 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 21:16 -!- TC [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 250 seconds] 21:35 -!- yashgaroth [~yashgarot@2606:6000:c308:f700:58e2:11ef:e020:72c] has quit [Quit: Leaving] 22:25 < adlai> "dopamine doesn't agonize neurons, neurons agonize neurons." 23:26 -!- Gurkenglas [~Gurkengla@unaffiliated/gurkenglas] has quit [Ping timeout: 250 seconds] --- Log closed Thu Jan 03 00:00:10 2019