--- Log opened Sun Jan 27 00:00:32 2019
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01:08 < nmz787> .title https://www.pnas.org/content/114/28/7246
01:08 < yoleaux> Photoacoustic trace detection of gases at the parts-per-quadrillion level with a moving optical grating | PNAS
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09:33 < kanzure> "Can CRISPR-based gene drive be confined in the wild? A question for molecular and population biology" https://www.biorxiv.org/content/10.1101/173914v1
09:34 < kanzure> "... threshold-dependent drives, homing-based drive and remediation systems, and temporally self-limiting systems such as daisy-chain drives"
09:35 < kanzure> "Super-Mendelian inheritance mediated by CRISPR–Cas9 in the female mouse germline" https://www.nature.com/articles/s41586-019-0875-2
09:36 < kanzure> "Here we use an active genetic element that encodes a guide RNA, which is embedded in the mouse tyrosinase (Tyr) gene, to evaluate whether targeted gene conversion can occur when CRISPR–Cas9 is active in the early embryo or in the developing germline. Although Cas9 efficiently induces double-stranded DNA breaks in the early embryo and male germline, these breaks are not corrected by ...
09:36 < kanzure> ...homology-directed repair. By contrast, Cas9 expression limited to the female germline induces double-stranded breaks that are corrected by homology-directed repair, which copies the active genetic element from the donor to the receiver chromosome and increases its rate of inheritance in the next generation. These results demonstrate the feasibility of CRISPR–Cas9-mediated systems that bias ...
09:36 < kanzure> ...inheritance of desired alleles in mice and that have the potential to transform the use of rodent models in basic and biomedical research.
09:37 < kanzure> "
09:38 < kanzure> what is going on there? male germline simply doesn't repair the breaks and they are exploiting this fact?
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09:51 < kanzure> "Copy number variation in small nucleolar RNAs regulates personality behavior" https://www.biorxiv.org/node/143078.abstract
10:01 < kanzure> comparative anthropogeny database (human vs monkey/gorilla comparisons) https://carta.anthropogeny.org/moca/domains
10:03 < kanzure> https://carta.anthropogeny.org/moca/domains/genetics.wi
10:03 < kanzure> https://carta.anthropogeny.org/moca/domains/genetics
10:03 < kanzure> .wik human accelerated region
10:03 < yoleaux> "Human accelerated regions (HARs), first described in August 2006, are a set of 49 segments of the human genome that are conserved throughout vertebrate evolution but are strikingly different in humans." — https://en.wikipedia.org/wiki/Human_accelerated_region
10:04 < kanzure> "They are named according to their degree of difference between humans and chimpanzees (HAR1 showing the largest degree of human-chimpanzee differences)"
10:14 < kanzure> .wik long non-coding RNA
10:14 < yoleaux> "Long non-coding RNAs (long ncRNAs, lncRNA) are defined as transcripts longer than 200 nucleotides that are not translated into protein." — https://en.wikipedia.org/wiki/Long_non-coding_RNA
10:22 < kanzure> strong adhd gwas results on page 3 table 1 https://pure.mpg.de/rest/items/item_3014643/component/file_3014883/content
10:41 < kanzure> a few thousand intelligence gwas results https://www.ebi.ac.uk/gwas/efotraits/EFO_0004337 http://diyhpl.us/~bryan/papers2/neuro/gwas-associations-intelligence.2019-01-27.tsv
10:56 < kanzure> ftp://ftp.ebi.ac.uk/pub/databases/gwas/timeseries/current/GWAS_Catalog_annotated_diagram.pdf
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11:20 < kanzure> https://carta.anthropogeny.org/moca/domains/neuroscience
11:28 < kanzure> .wik DUF1220
11:28 < yoleaux> "" — https://en.wikipedia.org/wiki/DUF1220
11:30 < kanzure> "DUF1220 is a protein domain that shows a striking human lineage-specific (HLS) increase in copy number and may be involved in human brain evolution.[1] The copy number of DUF1220 domains increases generally as a function of a species's evolutionary proximity to humans. The increase in the number of copies that are present in connection with DUF1220 also seem to have a direct correlation with ...
11:30 < kanzure> ...several phenotypes of the brain including the increase in brain size as seen through evolution.[4] DUF1220 copy number is the highest in humans (~289, with some person-to-person variations)[5] and shows the largest HLS increase in copy number (an additional 160 copies) of any protein coding region in the human genome. DUF1220 copy number is reduced in African great apes (estimated 125 copies ...
11:30 < kanzure> ...in chimpanzees), further reduced in orangutan (92) and Old World monkeys (35), single- or low-copy in non-primate mammals and absent in non-mammals.[5]"
11:31 < kanzure> "The gene showing a human-specific increase in DUF1220 copy number was first identified as the result of a genome-wide array CGH study of lineage-specific copy number differences between human and great ape species.[9] The study found 134 genes that showed human lineage-specific increases in copy number."
11:45 < kanzure> "Lineage-specific gene duplication and loss in human and great ape evolution" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC449870/
11:58 < kanzure> i mean.... yeah let's try synaptic overgrowth. that seems easy enough.
12:05 < nmz787> .title https://www.spiedigitallibrary.org/conference-proceedings-of-spie/0368/0000/Interference-Film-Microscopy-For-Metal-Phase-Identification/10.1117/12.934334.short
12:05 < yoleaux> Interference Film Microscopy For Metal Phase Identification
12:06 < nmz787> "Constituents in metal alloys and rocks may be seen as different colours using interference film microscopy. The thin films which produce the interfeference colours may be deposited either by vacuum evaporation or reactive sputtering ."
12:06 < nmz787> "Calculated interference colour for film on glass(Films on metals are similar)"
12:07 < nmz787> fig 2 is where it's at
12:07 < nmz787> basically just a color-space plot relating thin film color to approx thickness
12:08 < nmz787> .title https://www.sciencedirect.com/science/article/pii/S0079663808706115
12:08 < yoleaux> ScienceDirect
12:08 < nmz787> "VI Interference Color"
12:10 < nmz787> fig 1(a) "CIE-chromaticity diagram and interference color"
12:11 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=45ce4794 Bryan Bishop: personality genetics, intelligence, memory, etc. >> 
12:15 < nmz787> how the heck to unwrap the rest of those wonky plots is beyond me...
12:15 < nmz787> a good hack for babies would be to limit their fingernail growth
12:16 < nmz787> seems like such a waste of energy, and cutting them is a serious effort
12:16 < nmz787> (they squirm around, and you don't want to cut them the wrong way)
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13:26 < juri_> I moved to berlin, if anyone cares. ;)
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15:23 < nmz787> juri_: good luck trying to do any diybio, let us know how it goes if so
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18:17 < kanzure> .g spindle transfer mitochondrial replacement therapy kyiv
18:18 < yoleaux> https://de.wikipedia.org/wiki/Mitochondrial_Replacement_Therapy
18:18 < kanzure> inhaled mRNA delivery to lung tissue https://onlinelibrary.wiley.com/doi/full/10.1002/adma.201805116
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--- Log closed Mon Jan 28 00:00:33 2019