--- Log opened Thu Feb 07 00:00:42 2019
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02:42 < pompolic> https://www.pnas.org/content/early/2019/01/25/1816766116 maybe relevant here
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04:02 < archels> .title
04:02 < yoleaux> Stimulus complexity shapes response correlations in primary visual cortex | PNAS
04:28 < archels> this is some of the most boring neuroscience out there
04:41 < nsh> heh
04:41 < nsh> relevant to my interests :)
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11:51 < mrdata-> https://www.reuters.com/article/us-science-mirror/mirror-test-hints-at-surprising-cognitive-abilities-in-fish-idUSKCN1PW2FZ
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16:47 < kanzure> .title http://dev.biologists.org/content/146/3/dev175778
16:47 < yoleaux> CRISPR babies: a view from the centre of the storm | Development
16:48 < kanzure> http://dev.biologists.org/content/develop/146/3/dev175778/F2.large.jpg
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19:14 < kanzure> .tw https://twitter.com/kanzure/status/1093709583489617921
19:14 < yoleaux> So what exactly is the optimal number of so-called "bioethicists" in the world (@kanzure)
19:20 < kanzure> .tw https://twitter.com/JTRobinsonLab/status/1092854773462847491
19:20 < yoleaux> New data for the debate about #magnetogenetics out today in @BiophysJ. TLDR: transfected cells indeed show a selective (but weak) response to magnetic fields, and we have a *possible* explanation for why. https://authors.elsevier.com/a/1YWSa1SPSrwPU (1/n) https://pbs.twimg.com/media/DyqUOKpV4AAEn24.jpg (@JTRobinsonLab)
19:21 < kanzure> http://ml-neuronbrowser.janelia.org/
19:21 < kanzure> "Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids" https://www.biorxiv.org/content/10.1101/538421v1
19:22 < kanzure> "Reconstruction of 1,000 projection neurons reveals new cell types and organization of long-range connectivity in the mouse brain" https://www.biorxiv.org/content/10.1101/537233v1
19:23 < kanzure> "Freeze-frame imaging of synaptic activity using SynTagMA" https://www.biorxiv.org/content/10.1101/538041v1
19:23 < kanzure> "Information within the brain travels from neuron to neuron across synapses. At any given moment, only a few synapses within billions will be active and are thought to transmit key information about the environment, a behavior being executed or memory being recalled. Here we present SynTagMA, which marks active synapses within a ~2 s time window. Upon violet illumination, the genetically ...
19:23 < kanzure> ...expressed tag converts from green to red fluorescence if bound to calcium. Targeted to presynaptic terminals, preSynTagMA allows discrimination between active and silent axons. Targeted to excitatory postsynapses, postSynTagMA creates a snapshot of synapses active just before photoconversion. To analyze large datasets, we developed an analysis program that automatically identifies and tracks ...
19:23 < kanzure> ...the fluorescence of thousands of individual synapses in tissue. Together, these tools provide a high throughput method for repeatedly mapping active synapses in vitro and in vivo."
19:25 < kanzure> "Developmental barcoding of whole mouse via homing CRISPR" http://science.sciencemag.org/content/361/6405/eaat9804
19:25 < kanzure> "Molecular recording of mammalian embryogenesis" https://www.biorxiv.org/content/10.1101/384925v1
19:26 < kanzure> .tw https://twitter.com/smd4/status/1089677140230955008
19:26 < yoleaux> The basic idea is you add to every cell a writable memory module that can be used to record molecular events over time (e.g., differentiation, stress, neuronal potentials, cell-cell contacts, etc). The memory is can be read out at the single-cell level via DNA sequencing. (@smd4, in reply to tw:1089676825180045312)
19:26 < kanzure> .tw https://twitter.com/smd4/status/1089684408922066944
19:26 < yoleaux> p.s. — the sci-fi part comes when going to the doctor means taking a customized pill that triggers relevant tissues to dump cellular "stack traces" targeted to your salivary glands. Spit in a tube, sequence, and in a few hours, we know precisely what cells are ailing you and why. (@smd4, in reply to tw:1089678445326389248)
19:28 < kanzure> .tw https://twitter.com/kashthefuturist/status/1089238262625890304
19:28 < yoleaux> A nanobot finding a sperm cell, delivering it to an egg and inseminating it https://video.twimg.com/ext_tw_video/1089238153154547712/pu/vid/322x180/7DXL7v6OkZVx2cKs.mp4?tag=6 (@kashthefuturist)
19:29 < kanzure> "Targeted Cleavage and Polyadenylation of RNA by CRISPR-Cas13" https://www.biorxiv.org/content/10.1101/531111v1
19:30 < kanzure> "Cell type composition and circuit organization of neocortical radial clones" https://www.biorxiv.org/content/10.1101/526681v1
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23:59 < nsh> heh
--- Log closed Fri Feb 08 00:00:14 2019