--- Log opened Mon Feb 11 00:00:46 2019
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08:11 < kanzure> "Absence of stressful conditions accelerates dexterous skill acquisition in surgery" https://www.nature.com/articles/s41598-019-38727-z https://www.reddit.com/r/science/comments/apfyod/the_best_way_to_train_surgeons_may_be_to_remove/
08:16 < kanzure> .tw https://twitter.com/HankGreelyLSJU/status/1093769564385509376
08:16 < yoleaux> @antonioregalado Why pull in Quake and He? Not in the story (wh/is from December). And IP He might have gotten in his 1 yr in the Quake lab - if any - wouldn’t have been significant in CRISPR’ing babies. This seems almost clickbait from you - I think I’m disappointed. (@HankGreelyLSJU, in reply to tw:1093642721393364992)
08:17 < kanzure> .tw https://twitter.com/antonioregalado/status/1093895728907407360
08:17 < yoleaux> @ChrisLaPuma @HankGreelyLSJU (6/n) The argument CRISPR babies has nothing to do with sequencing is obviously wrong. Pretty much the whole game was the ability to sequence the DNA in single cells of the embryo biopsy. (@antonioregalado, in reply to tw:1093895187313627136)
08:18 < kanzure> .tw https://twitter.com/HankGreelyLSJU/status/1094053136145117184
08:18 < yoleaux> @antonioregalado @ChrisLaPuma Not clear to me. I don't know what He did (no one does) but he wouldn't need tricky single cell sequencing to look for CCR5 changes. He might for a braod scan for off target, though even there he could wait for blastocyst stage and take 5-10 cells (pretty standard for day 5 PGD) (@HankGreelyLSJU, in reply to tw:1093895728907407360)
08:19 < kanzure> .tw https://twitter.com/alchemytoday/status/1093904585574547456
08:19 < yoleaux> @antonioregalado @ChrisLaPuma @HankGreelyLSJU Quake gave an interview denying anything to do with direct genomics in November - https://www.nytimes.com/2018/11/26/health/gene-editing-babies-china.html (@alchemytoday, in reply to tw:1093896550202384384)
08:19 < kanzure> quake is mentioned here tho https://www.prweb.com/releases/2015/10/prweb13044436.htm
08:19 < kanzure> .title
08:19 < yoleaux> China’s Direct Genomics introduces the first single molecule genome sequencer for the clinic
08:19 < nsh> heh
08:19 < nsh> single molecule sequencing is pretty impressive
08:20 < nsh> although is it full take or SNPs?
08:21 < kanzure> .tw https://twitter.com/WonkaWasRight/status/1093626343122763777
08:21 < yoleaux> @antonioregalado PCSK9 + that rare APP Gene defect that has reduced alzeimers risk + myostatin null= muscular, low cardio risk, low AD risk= PLZ give me some (@WonkaWasRight, in reply to tw:1093626004302635009)
08:21 < kanzure> nsh: my understanding is that it's whole genome sequencing not just SNP panel testing
08:21 < nsh> very cool
08:21 < kanzure> nsh: SNP assays would have to be developed for all the places where you accidentally deleted, which doesn't make sense. more sense to do whole sequencing.
08:22 < nsh> oh sure, it just seems hard to achieve in terms of having to trace the whole molecule comprehensively
08:22 < kanzure> .tw https://twitter.com/WonkaWasRight/status/1093621867687096320
08:22 < yoleaux> @antonioregalado @emilylmullin My repeated 2 cents: IVF with PGD would be SOOOOOO much cheaper and is far more reliable and realistic than a thousand cures for a thousand diff rare diseases (@WonkaWasRight, in reply to tw:1093569861970743298)
08:22 < nsh> but i haven't kept up with the tech
08:22 < nmz787> also there's probably not enough DNA to physically cover all SNP sites, unless the SNP sites were arranged in some way that basically reflected their position in a sequence
08:22 < nsh> i suppose it's harder to do selective sequencing with a single molecule
08:22 < kanzure> "Male development of chromosomally female mice transgenic for Sry" https://www.ncbi.nlm.nih.gov/pubmed/2030730
08:23 < kanzure> nmz787: that's not fair. you'd use PCR or something.
08:23 < nmz787> then it wouldn't be single molecule
08:23 < kanzure> hmm
08:23 < nsh> right, i was wondering if it's just a single DNA molecule being sequenced serially
08:23 < nmz787> SNP analysis isn't considered sequencing from what I remember
08:23 < nsh> because i guess cleaving and sequencing doesn't wokr with only a single molecule
08:23 < kanzure> i believe single molecule techniques start with a single molecule but don't necessarily end with a single molecule
08:23 < nsh> because you have no overlaps to use for patching together
08:23 < nmz787> it's a hybridization assay
08:24 < kanzure> also, single molecule doesn't make sense anyway because we all know there's multiple dna strands floating around
08:24 < kanzure> nmz787: correct
08:27 < nmz787> well, I guess those tweets say "single cell"
08:27 < nmz787> which doesn't rule out PCR
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10:16 < kanzure> .title https://www.youtube.com/playlist?list=PLxiUDysqkJ9xTGggKpeHwdANjPnM4Fxv3
10:16 < yoleaux> Stanford Blockchain Conference 2019 - YouTube
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10:37 < kanzure> .title https://news.ycombinator.com/item?id=19136734
10:37 < yoleaux> Launch HN: Aura Vision (YC W19) – Google Analytics for Physical Stores | Hacker News
10:41 < fenn> no thanks
10:42 < kanzure> citizen you are obligated to take your mandatory dose of surveillance
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12:29 < kanzure> https://bitcoindev.network/bitcoin-script-101/
12:29 < kanzure> https://bitcoindev.network/exploiting-cve-2018-20587/
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13:40 < kanzure> https://marcan.st/2017/12/debugging-an-evil-go-runtime-bug/
13:41 < kanzure> https://arwen.io/whitepaper.pdf
13:54 < kanzure> i don't see anything new here https://ipscell.com/2019/02/counterpoints-to-lovell-badge-daleys-crispr-baby-rationales/
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15:46 < yashgaroth> at least it saves me having to type out my own version of his counterarguments to the 'curing disease' excuse, since they're accurate. I like how in Antonio's 'annotations' there's a line about "freedom to choose?" for deaf parents who want deaf children...you can ensure your children are disabled if you feel like it, but enhancement bad
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16:59 < kanzure> .title https://www.nature.com/articles/d41586-018-07600-w
16:59 < yoleaux> UN treaty agrees to limit gene drives but rejects a moratorium
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--- Log closed Tue Feb 12 00:00:47 2019