--- Log opened Fri Feb 22 00:00:56 2019 01:11 -!- ebowden_ [~ebowden@unaffiliated/ebowden] has quit [Remote host closed the connection] 01:40 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap 02:01 -!- ebowden_ [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap 02:05 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Ping timeout: 255 seconds] 02:15 -!- dustinm [~dustinm@68.ip-149-56-14.net] has quit [Quit: Leaving] 02:17 -!- dustinm [~dustinm@68.ip-149-56-14.net] has joined ##hplusroadmap 02:17 -!- dustinm [~dustinm@68.ip-149-56-14.net] has quit [Remote host closed the connection] 02:20 -!- dustinm [~dustinm@68.ip-149-56-14.net] has joined ##hplusroadmap 02:54 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 246 seconds] 03:30 -!- paradox195 [~pratik@2405:204:90a7:ded5:f09a:f5f:11da:e2ef] has joined ##hplusroadmap 03:31 -!- paradox195 [~pratik@2405:204:90a7:ded5:f09a:f5f:11da:e2ef] has quit [Quit: Leaving] 04:03 < fenn> http://www.thiswaifudoesnotexist.net/ 04:05 < fenn> the deep danbooru demo is pretty good 04:06 < fenn> http://kanotype.iptime.org:8003/deepdanbooru/ it gets confused if there's not a girl in the image 04:13 -!- Urchin [~urchin@unaffiliated/urchin] has quit [Remote host closed the connection] 04:29 -!- Gurkenglas [~Gurkengla@unaffiliated/gurkenglas] has joined ##hplusroadmap 04:37 < fenn> oh you have to scroll up to see the video 04:39 -!- CryptoDavid [uid14990@gateway/web/irccloud.com/x-zbrangkxhygskjha] has joined ##hplusroadmap 04:40 < fenn> lets see if i can type this right 04:41 < fenn> gwern's stylegan anime face generator at work: https://twitter.com/halcy/status/1098221818480082951 05:13 -!- Jay_Dugger [~jwdugger@47.185.249.138] has joined ##hplusroadmap 05:16 -!- Jay_Dugger [~jwdugger@47.185.249.138] has quit [Client Quit] 05:18 -!- NikopolSohru [~Nikopol_@93.190.137.173] has joined ##hplusroadmap 06:26 < kanzure> https://blog.stephenwolfram.com/2019/02/seeking-the-productive-life-some-details-of-my-personal-infrastructure/ 06:29 < kanzure> "I thought I’d have to build something myself, but actually one can just buy “walking desks”." alright 06:35 < kanzure> .tw https://twitter.com/kanzure/status/1098954097460477952 06:35 < yoleaux> There are many and far more interesting cognitive enhancements getting queued up in the pipeline. This is just the beginning. https://twitter.com/antonioregalado/status/1098614764446593024 (@kanzure) 06:42 < kanzure> what was that quote about the difference between john von neumann and average human was around estimated 100 mutations? 06:44 < kanzure> "My current estimate is that 100-200 common mutations (affecting only a small subset of the thousands of loci that influence intelligence) are what separate an ordinary person from a von Neumann. There's plenty of additive variance to be exploited, and many desirable human phenotypes that have never been realized." 06:44 < kanzure> from http://infoproc.blogspot.com/2012/03/only-he-was-fully-awake.html 06:46 < kanzure> .tw https://twitter.com/IanFelipeSays/status/1098955911589052416 06:46 < yoleaux> @kanzure @antonioregalado How are you measuring phenotypes for people who harbor thos mutations? (@IanFelipeSays, in reply to tw:1098955333928738822) 06:53 < kanzure> "Genetic enhancement of learning and memory in mice" http://www.bioteach.ubc.ca/TeachingResources/Genetics/DoogieMouseNature.pdf 06:53 < kanzure> via overexpression of NMDA receptor 2B (NR2B) 06:55 -!- Urchin [~urchin@unaffiliated/urchin] has joined ##hplusroadmap 06:59 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 06:59 -!- ebowden_ [~ebowden@unaffiliated/ebowden] has quit [Remote host closed the connection] 06:59 < kanzure> "irreducible complexity of phenotypic expression" i mean... just focus on the reliably repeatable phenotypes instead of the unrepeatable phenotypes. does it matter if it's irreducibly complex? 07:00 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap 07:01 -!- ebowden_ [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap 07:04 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Ping timeout: 255 seconds] 07:09 < kanzure> "List of transgenic and knockout mice: behavioral profiles" http://sci-hub.tw/https://link.springer.com/article/10.1007/s003350010051 07:10 < kanzure> "Genes and signaling pathways involved in memory enhancement in mutant mice" https://molecularbrain.biomedcentral.com/articles/10.1186/1756-6606-7-43 07:11 < kanzure> table 1 is useful 07:13 < kanzure> also fun things in "Adverse effects of mutations that enhance memory" 07:15 < kanzure> https://blogs.plos.org/synbio/2019/02/22/crispr-human-babies-too-soon-not-never/ 07:24 -!- NikopolSohru [~Nikopol_@93.190.137.173] has quit [Ping timeout: 268 seconds] 07:25 < kanzure> wasn't there a paper about looking at recently-modified regions of human genome based on phylogenetic ancestral data, something something 'accelerated evolution regions'? 07:58 < kanzure> https://www.congress.gov/bill/116th-congress/house-bill/265/text 07:58 < kanzure> "None of the funds made available by this Act may be used to notify a sponsor or otherwise acknowledge receipt of a submission for an exemption for investigational use of a drug or biological product under section 505(i) of the Federal Food, Drug, and Cosmetic Act (21 U.S.C. 355(i)) or section 351(a)(3) of the Public Health Service Act (42 U.S.C. 262(a)(3)) in research in which a human embryo ... 07:59 < kanzure> ...is intentionally created or modified to include a heritable genetic modification. Any such submission shall be deemed to have not been received by the Secretary, and the exemption may not go into effect." 08:05 -!- yashgaroth [~yashgarot@2606:6000:c308:f700:f885:1266:18c5:3637] has joined ##hplusroadmap 08:06 < kanzure> .tw https://twitter.com/antonioregalado/status/1098958291701563392 08:06 < yoleaux> A defense “self-experimentation.” It is co-authored by Brian Hanley (who did gene therapy on himself) and…surprise…@geochurch of Harvard. (THREAD with some examples) https://www.liebertpub.com/doi/pdf/10.1089/rej.2018.2059 (@antonioregalado) 08:06 < kanzure> "Review of self-experimentation" https://www.liebertpub.com/doi/abs/10.1089/rej.2018.2059?journalCode=rej 08:07 < kanzure> "When the self-experimenter is a true investigator, there is no other party to be protected from unethical behavior." 08:07 < kanzure> okay but now they are going to no true scotsman "true investigator" 08:16 -!- Gurkenglas [~Gurkengla@unaffiliated/gurkenglas] has quit [Ping timeout: 255 seconds] 08:31 < kanzure> take a recently deceased human brain, microtome slice it, then do cell cultures for every slice and region, e.g. maybe 32000 separate cell/tissue cultures, even if you don't have the wiring you should be able to get at least relative recordings of mRNA expression levels etc. 08:59 < kanzure> .title https://blog.0patch.com/2019/02/no-source-code-for-14-year-old.html 08:59 < yoleaux> 0patch Blog: No Source Code For a 14-Year Old Vulnerable DLL? No Problem. (CVE-2018-20250) 09:17 -!- CryptoDavid [uid14990@gateway/web/irccloud.com/x-zbrangkxhygskjha] has quit [Quit: Connection closed for inactivity] 09:44 < fenn> .title http://ganbreeder.app 09:44 < yoleaux> Ganbreeder 09:44 < fenn> bah 09:48 < fenn> mashing mutant neural networks together for fun and ... fun 09:58 < kanzure> .title https://news.ycombinator.com/item?id=19225268 09:58 < yoleaux> A Heavily-Commented Linux Kernel Source Code [pdf] | Hacker News 10:17 -!- NikopolSohru [~Nikopol_@89.238.185.108] has joined ##hplusroadmap 10:27 -!- NikopolS [~Nikopol_@89.238.185.108] has joined ##hplusroadmap 10:27 -!- NikopolSohru [~Nikopol_@89.238.185.108] has quit [Ping timeout: 246 seconds] 10:29 -!- NikSohru [~Nikopol_@89.238.185.108] has joined ##hplusroadmap 10:32 -!- NikopolS [~Nikopol_@89.238.185.108] has quit [Ping timeout: 255 seconds] 10:46 -!- NikSohru is now known as NikopolSohru 10:47 < kanzure> https://www.kxan.com/news/local/austin/you-can-get-microchipped-at-austin-s-body-hacking-conference/1801167609 10:56 -!- sachy [~sachy@91.146.121.5] has joined ##hplusroadmap 11:06 -!- NikopolS [~Nikopol_@89.238.185.108] has joined ##hplusroadmap 11:08 -!- NikopolS [~Nikopol_@89.238.185.108] has quit [Read error: Connection reset by peer] 11:08 -!- NikopolS [~Nikopol_@89.238.185.108] has joined ##hplusroadmap 11:08 -!- NikopolSohru [~Nikopol_@89.238.185.108] has quit [Ping timeout: 240 seconds] 11:34 -!- Gurkenglas [~Gurkengla@unaffiliated/gurkenglas] has joined ##hplusroadmap 11:54 -!- NikopolS is now known as NikopolSohru 12:17 -!- Gurkenglas [~Gurkengla@unaffiliated/gurkenglas] has quit [Ping timeout: 246 seconds] 12:22 -!- NikopolSohru [~Nikopol_@89.238.185.108] has quit [Remote host closed the connection] 12:24 -!- NikopolSohru [~Nikopol_@89.238.185.108] has joined ##hplusroadmap 12:24 -!- NikopolSohru [~Nikopol_@89.238.185.108] has quit [Remote host closed the connection] 12:26 -!- NikopolSohru [~Nikopol_@89.238.185.108] has joined ##hplusroadmap 12:27 < nmz787> reading the 0patch URL, I thought it was something about not allowing kids to have source code 12:28 -!- NikopolSohru [~Nikopol_@89.238.185.108] has quit [Remote host closed the connection] 12:28 -!- NikopolSohru [~Nikopol_@89.238.185.108] has joined ##hplusroadmap 12:30 -!- NikopolSohru [~Nikopol_@89.238.185.108] has quit [Read error: Connection reset by peer] 12:30 < superkuh> There are apparently 70+ people running around in my town with some sort of rfid chips in their hand. A business promotes the tech for vending machines and encourages it's employees to get chipped. It's weird. 12:31 < superkuh> It's either near-field of some type of low (ie, 13.5 MHz ISM) because I couldn't detect it from the parking lot with a broadband directional antenna. 12:33 -!- NikopolSohru [~Nikopol_@89.238.185.108] has joined ##hplusroadmap 12:39 -!- Gurkenglas [~Gurkengla@unaffiliated/gurkenglas] has joined ##hplusroadmap 12:45 -!- NikopolS [~Nikopol_@89.238.185.108] has joined ##hplusroadmap 12:47 -!- NikopolSohru [~Nikopol_@89.238.185.108] has quit [Ping timeout: 246 seconds] 12:49 -!- NikopolSohru [~Nikopol_@89.238.185.108] has joined ##hplusroadmap 12:51 -!- NikopolS [~Nikopol_@89.238.185.108] has quit [Ping timeout: 245 seconds] 12:52 -!- NikopolSohru [~Nikopol_@89.238.185.108] has quit [Remote host closed the connection] 12:52 -!- NikopolS [~Nikopol_@89.238.185.108] has joined ##hplusroadmap 13:03 -!- NikSohru [~Nikopol_@89.238.185.108] has joined ##hplusroadmap 13:04 -!- NikSohru [~Nikopol_@89.238.185.108] has quit [Remote host closed the connection] 13:06 -!- NikopolS [~Nikopol_@89.238.185.108] has quit [Ping timeout: 255 seconds] 15:01 < kanzure> .tw https://twitter.com/ZvxyWu/status/1098410124417261568 15:01 < yoleaux> Directed Evolution (DE) is an optimization algorithm for proteins, so Machine Learning (ML) should help! We show on a large fitness landscape that DE+ML improves proteins better than DE alone and provide an example application. https://arxiv.org/abs/1902.07231 @francesarnold @sbjennykan (@ZvxyWu) 15:02 < kanzure> "Machine-learning assisted directed protein evolution with combinatorial libraries" https://arxiv.org/abs/1902.07231 15:05 < kanzure> "Epigenetic landscape and AAV targeting of human neocortical cell classes" https://www.biorxiv.org/content/10.1101/555318v1 15:11 < kanzure> .tw https://twitter.com/assertpub_/status/1097878849055088640 15:11 < yoleaux> "Comment on 'The aestivation hypothesis for resolving Fermi's paradox'" is the #1 paper on Arxiv today in popular physics. Congrats @robinhanson. See it at -> http://assert.pub/arxiv/physics/physics.pop-ph and http://assert.pub/papers/1902.06730. Please retweet. (@assertpub_) 16:06 < nsh> .title https://phys.org/news/2019-02-navy-patent-room-temperature-superconductor.html 16:06 < yoleaux> nsh: Sorry, that doesn't appear to be an HTML page. 16:06 < nsh> shup 16:07 < nsh> .tw https://twitter.com/mjk1093/status/1097881293222805504 16:07 < yoleaux> @assertpub_ @robinhanson This one never made sense to me. If you're waiting for the universe to cool down so that you can do more efficient computing, you're still going to want to go around right now and wipe out all potential competitors. (@mjk1093, in reply to tw:1097878849055088640) 16:08 < nsh> the sheer audacity with which people who know presumably probably practically nothing go about telling hypothetically extremely advanced cultures how they should be planning their civilisations is very sweet and uplifting 16:08 < nsh> but also very dull and overdone 16:08 < nsh> people should fix their own problems before solving the problems of whole species they invented in their imaginations 16:11 < kanzure> that's the same kind of low-quality argument observed in space discussions- "we shouldn't go to mars because " 16:26 < nsh> we should go to mars :) 16:27 < nsh> in fact, having a sensible collective set of species goals might help us with our domestic strife 16:27 < nsh> the devil makes work for idle thumbs as they say 16:44 < nsh> NB: the comment is more interesting than the article [in terms of general intelligence, if not aliens] 16:45 < nsh> (in terms of aliens the problem is not the extent of vacuum between us and them, it's our relationship to the vacuum, but you wouldn't like it if i explained) 16:49 < nsh> actually forget it, the comment paper is also mainly bunkum 16:49 < nsh> people have very naive notions of computation, which is hard to justify in 2019 16:57 -!- l_wl [~l_wl@pool-108-45-141-95.washdc.fios.verizon.net] has quit [Read error: Connection reset by peer] 17:33 -!- Urchin [~urchin@unaffiliated/urchin] has quit [Remote host closed the connection] 17:54 -!- Jay_Dugger [~jwdugger@47.185.249.138] has joined ##hplusroadmap 17:55 -!- Jay_Dugger [~jwdugger@47.185.249.138] has quit [Client Quit] 18:15 < fenn> i didn't realize the navy could own patents 18:15 < fenn> aren't works of the US government supposed to be public domain? 18:17 < fenn> this is not the first room temperature superconductor i've heard of, but it sure sounds complicated 19:23 -!- Gurkenglas [~Gurkengla@unaffiliated/gurkenglas] has quit [Ping timeout: 246 seconds] 20:41 -!- helleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has joined ##hplusroadmap 20:45 -!- hehelleshin [~talinck@cpe-174-97-113-184.cinci.res.rr.com] has quit [Ping timeout: 268 seconds] 21:56 -!- yashgaroth [~yashgarot@2606:6000:c308:f700:f885:1266:18c5:3637] has quit [Quit: Leaving] 23:30 -!- sivoais_ [~zaki@199.19.225.239] has joined ##hplusroadmap 23:31 -!- dentist_ [~poetry@li354-248.members.linode.com] has joined ##hplusroadmap 23:40 -!- abetusk [~abe@68.175.142.87] has quit [Excess Flood] 23:40 -!- namespace [~user@li72-90.members.linode.com] has quit [Excess Flood] 23:40 -!- dentist [~poetry@178.79.185.248] has quit [Write error: Broken pipe] 23:40 -!- sivoais [~zaki@unaffiliated/sivoais] has quit [Write error: Broken pipe] 23:40 -!- HEx1 [~HEx@hexwab.plus.com] has quit [Excess Flood] 23:40 -!- sachy [~sachy@91.146.121.5] has quit [Excess Flood] 23:40 -!- namespace [user@2600:3c02::f03c:91ff:fe7b:227f] has joined ##hplusroadmap 23:40 -!- abetusk [~abe@68.175.142.87] has joined ##hplusroadmap 23:41 -!- abetusk is now known as Guest10360 23:41 -!- sachy [~sachy@91.146.121.5] has joined ##hplusroadmap 23:42 -!- pepesza [~pepesza@185.83.218.228] has quit [Ping timeout: 249 seconds] 23:45 -!- HEx1 [~HEx@hexwab.plus.com] has joined ##hplusroadmap 23:45 -!- pepesza [~pepesza@185.83.218.228] has joined ##hplusroadmap 23:51 -!- Guest10360 is now known as abetusk --- Log closed Sat Feb 23 00:00:57 2019