--- Log opened Thu Mar 28 00:00:29 2019
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05:35 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=a341015a Bryan Bishop: add more about pain insensitivity >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
05:36 < kanzure> "Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity" https://bjanaesthesia.org/article/S0007-0912(19)30138-2/fulltext
05:37 < kanzure> "Detecting nanoscale distribution of protein pairs by proximity-dependent super-resolution microscopy" https://www.biorxiv.org/content/10.1101/591081v1
05:43 < kanzure> .tw https://twitter.com/antonioregalado/status/1106573073329856512
05:44 < kanzure> yoleaux!
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05:45 < nsh> .t https://twitter.com/antonioregalado/status/1106573073329856512
05:45 < EmmyNoether> Wow! Badass. 13,200 crispr base edits in a single cell! On the way to “recoded” human cells. From Oscar Castanon and @corysmith1618 of Church lab. https://www.biorxiv.org/content/10.1101/574020v1 (@antonioregalado)
05:45 < nsh> \o/
05:48 < kanzure> "DNA nanostructures coordinate gene silencing in mature plants" https://www.pnas.org/content/early/2019/03/22/1818290116
05:48 < kanzure> "Unified rational protein engineering with sequence-only deep representation learning" https://www.biorxiv.org/content/10.1101/589333v1
05:48 < kanzure> "Recovery of trait heritability from whole genome sequence data" https://www.biorxiv.org/content/10.1101/588020v1
05:49 < kanzure> "Direct visualization of single nuclear pore complex proteins using genetically-encoded probes for DNA-PAINT" https://www.biorxiv.org/content/10.1101/579961v2
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05:50 < kanzure> "A critique of pure learning: What artificial neural networks can learn from animal brains" https://www.biorxiv.org/content/10.1101/582643v1
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05:50 < kanzure> subsynaptic organization of synapses https://www.sciencedirect.com/science/article/pii/S2211124719302499
05:51 < kanzure> "Ultrasound imaging of gene expression in mammalian cells" https://www.biorxiv.org/content/10.1101/580647v1
05:51 < kanzure> ".. we introduce the first mammalian acoustic reporter genes. Starting with an eleven-gene polycistronic gene cluster derived from bacteria, we engineered a eukaryotic genetic program whose introduction into mammalian cells results in the expression of a unique class of intracellular air-filled protein nanostructures called gas vesicles. The scattering of ultrasound by these nanostructures ...
05:51 < kanzure> ...allows mammalian cells to be visualized at volumetric densities below 0.5%, enables the monitoring of dynamic circuit-driven gene expression, and permits high-resolution imaging of gene expression in living animals."
05:53 < kanzure> optogenetic modulation of memory systems reconsolidation during anesthesia or sleep https://www.pnas.org/content/early/2019/03/14/1818432116
05:54 < kanzure> or here https://elifesciences.org/articles/42786
05:55 < kanzure> gotlieb complaining that US clinical trials are not using electronic consent forms https://endpts.com/scott-gottlieb-to-biopharma-you-wanted-us-to-help-modernize-rd-now-go-out-and-do-it/
05:55 < kanzure> er, gottlieb rather
05:55 < kanzure> "Enabling large-scale genome editing by reducing DNA nicking" https://www.biorxiv.org/content/10.1101/574020v1
05:57 < kanzure> "The sewing machine for minimally invasive neural recording" https://www.biorxiv.org/content/10.1101/578542v1
05:58 < kanzure> "Ultrapotent chemogenetics for research and potential clinical applications" http://science.sciencemag.org/content/early/2019/03/13/science.aav5282
05:59 < kanzure> "PESCA: A scalable platform for the development of cell-type-specific viral drivers" https://www.biorxiv.org/content/10.1101/570895v1
06:00 < kanzure> (better cell-specific enhancers and targeting)
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11:33 < kanzure> "An amygdalar neural ensemble that encodes the unpleasantness of pain" http://science.sciencemag.org/content/363/6424/276
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13:08 < kanzure> .wik https://en.wikipedia.org/wiki/Auto-brewery_syndrome
13:08 < yoleaux> "Auto-brewery syndrome, also known as gut fermentation syndrome, is a rare medical condition in which intoxicating quantities of ethanol are produced through endogenous fermentation within the digestive system. One gastrointestinal organism, Saccharomyces cerevisiae, a type of yeast, has been identified as a pathogen for this condition." — https://en.wikipedia.org/w/index.php?search=https://en.wikipedia.org/wiki/Auto-brewery_syndrome&
13:08 < yoleaux> title=Special%3ASearch&ns0=1
13:08 < kanzure> hmmmmm
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14:11 < archels_> kanzure: woah, the methods in that amygdala paper are also really impressive
14:12 < archels_> (in addition to the main result, that is)
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14:26 < nmz787> juul: I never ended up getting that far, but this is what I was planning to coat the CCD in https://shop.kremerpigments.com/en/dyes-und-vegetable-color-paints/fluorescent-colors/7015/fluorescent-violet?number=94730_
14:26 < nmz787> juul: specs here https://shop.kremerpigments.com/media/pdf/94730e.pdf
14:27 < juul> nmz787: thanks!
14:33 < juul> i'll have to get some and test it down to 200 nm
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19:06 < kanzure> hmph
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20:42 < fenn> debunking "boskop man" http://johnhawks.net/weblog/reviews/brain/paleo/return-amazing-boskops-lynch-granger-2009.html
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20:55 < fenn> gee i dunno this is a pretty big fragment http://greaterancestors.com/wp-content/uploads/2018/08/boskop8.jpeg
20:56 < fenn> it's hard to argue that such a person didn't exist with a fragment that large
20:56 < fenn> even if they are mixing together bones from different populations
20:57 < fenn> woah that air-filled nanostructures thing is cool
20:58 < fenn> .wik denisovian
20:58 < yoleaux> "" — https://en.wikipedia.org/wiki/Denisovian
21:01 < fenn> "asian neanderthals" diverging 650,000 years ago
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--- Log closed Fri Mar 29 00:00:29 2019