--- Log opened Thu Jun 06 00:00:33 2019 00:04 < kanzure> hmph 00:11 -!- preview [~quassel@2407:7000:8423:b75:5983:c203:baaa:a2a0] has joined ##hplusroadmap 00:20 < kanzure> "@transcriptic & @3scan merge into Strateos, 10x robotic-driven automation of pharma labs', ~$20M new funding" 00:20 < kanzure> "Ultrafast immunostaining of organ-scale tissues for scalable proteomic phenotyping" https://www.biorxiv.org/content/10.1101/660373v1 00:22 < kanzure> .tw https://twitter.com/SimonHanslmayr/status/1135496615526096896 00:22 < yoleaux> Why would you put an OPM (opticay pumped magnetometer) in your mouth? Because it picks up hippocampal theta. Beautiful work by Tim Tierney and colleagues from @UCL_ICN at #HippTaormina https://pbs.twimg.com/media/D8IYJXRXoAA_SFk.jpg (@SimonHanslmayr) 00:23 -!- purpleshift [purpleshif@gateway/vpn/mullvad/purpleshift] has joined ##hplusroadmap 00:23 < kanzure> "An engineered Cas-transposon system for programmable and precise DNA transpositions" https://www.biorxiv.org/content/10.1101/654996v1 https://twitter.com/harriswangnyc/status/1135651416666587137 00:24 < kanzure> "Gap junctions in the C. elegans nervous system regulate ageing and lifespan" https://www.biorxiv.org/content/10.1101/657817v1 https://twitter.com/biorxivpreprint/status/1135276211909926913 00:24 < kanzure> .tw https://twitter.com/MIT/status/1135200667197411329 00:24 < yoleaux> Dozens of FDA-approved drugs warn of immune-related side effects on their labels; many others never make it onto shelves for the same reason. MIT-rooted startup @SelectaBio aims to help by using nanoparticles to induce immune tolerance. http://mitsha.re/SaxB50utH1y https://pbs.twimg.com/media/D8EK_Z7WsAArUng.jpg (@MIT) 00:24 < kanzure> .tw https://twitter.com/matthewherper/status/1134465034342584320 00:24 < yoleaux> Fantastic opinion piece. "I have spinal muscular atrophy. Critics of the $2 million new gene therapy are missing the point." https://www.statnews.com/2019/05/31/spinal-muscular-atrophy-zolgensma-price-critics/ (@matthewherper) 00:25 < kanzure> .tw https://twitter.com/matthewherper/status/1134465034342584320 00:25 < yoleaux> Fantastic opinion piece. "I have spinal muscular atrophy. Critics of the $2 million new gene therapy are missing the point." https://www.statnews.com/2019/05/31/spinal-muscular-atrophy-zolgensma-price-critics/ (@matthewherper) 00:26 < kanzure> "We should not put a price tag on life, though. “$2.1 million is too much to spend for that baby’s survival” isn’t the kind of “value assessment” we should ever accept as a society." 00:26 < kanzure> uhh. 00:28 < kanzure> "AI-GAs: AI-generating algorithms, an alternate paradigm for producing general artificial intelligence" https://arxiv.org/abs/1905.10985 00:28 < kanzure> .tw https://twitter.com/jeffclune/status/1133403355739328514 00:28 < yoleaux> AI-GAs: AI-generating algorithms, an alternate paradigm for producing general artificial intelligence https://arxiv.org/abs/1905.10985 Historically, hand-designed pipelines are ultimately outperformed by entirely learned ones. Will that will be true of creating general AI itself? 1/6 https://pbs.twimg.com/media/D7qN_PQUwAA5ETE.jpg (@jeffclune) 00:28 < kanzure> .tw https://twitter.com/HumanBrainProj/status/1131926782876291073 00:28 < yoleaux> The Scientific Case for Brain Simulations - Neuron 22/5/2019 https://www.cell.com/neuron/fulltext/S0896-6273(19)30290-9 Gaute T. Einevoll, Alain Destexhe, Markus Diesmann, Sonja Grün, Viktor Jirsa, Marc de Kamps, Michele Miglior, Torbjørn V. Ness, Hans E. Plesser and Felix Schürmann https://doi.org/10.1016/j.neuron.2019.03.027 /4 https://pbs.twimg.com/media/D7VpDNxXYAU-5HF.png (@HumanBrainProj, in reply to tw:1131925678339891201) 00:28 < kanzure> .tw https://twitter.com/NatureBiotech/status/1132916141066772480 00:28 < yoleaux> A single-cell atlas of macrophages in the mouse brain https://go.nature.com/2wmBxM7 #NBThighlight (@NatureBiotech) 00:29 < kanzure> "Multiplex secretome engineering enhances recombinant protein production and purity" https://www.biorxiv.org/content/10.1101/647214v1 00:30 < kanzure> .tw https://twitter.com/ekelsic/status/1132410982423302144 00:30 < yoleaux> Excited to share this perspective I wrote together with George Church, 4 years in the making! Summarizes our view on applying machine learning to AAV capsid engineering: new technologies will enable more effective gene therapies for curing genetic disease. https://insights.bio/cell-and-gene-therapy-insights/journal/articles/challenges-and-opportunities-of-machine-guided-capsid-engineering-for-gene-therapy/ (@ekelsic) 00:36 < fenn> holy textwall batman 00:36 < kanzure> i'm not batman just sleep deprived 00:37 < fenn> does 3scan and transcriptic merger even make sense? 00:37 < kanzure> well, from an outside perspective, it did sort of seem like both were dead in the water 00:38 < kanzure> 3scan presumably had a lot of clinical pharma work for tissue or organ analysis 00:38 < kanzure> and transcriptic would probably prefer to focus on pharma customers.. dunno. 00:39 < fenn> everyone complains about the availability of health care, but you're not allowed to complain about the price of health care? 00:44 < fenn> "Zolgensma has been developed by Genethon, a French lab financed by donations and public funding." 00:44 < fenn> lol 00:53 < kanzure> i should send a message to max "congrats on being acquired by 3scan" and one to todd "congrats on being acquired by transcriptic" 00:53 < fenn> then put them in a jello pool and have them wrestle 00:54 < kanzure> that wasn't quite what i had in mind 00:54 < fenn> whoever wins gets majority share 00:59 < kanzure> ready for 5 hours of typing? 01:01 < fenn> "The strong implication is that a state would be justified in banning — or, at least, harshly regulating — birth control in order to combat eugenics." 01:01 < fenn> [popcorn.gif] 01:01 < kanzure> we need a culture war that actually matters 01:03 < kanzure> utreexo https://eprint.iacr.org/2019/611.pdf 01:15 < kanzure> https://fidoalliance.org/ 01:47 -!- adamsky [~adamsky3@178235181168.unknown.vectranet.pl] has joined ##hplusroadmap 02:08 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=4eeecfc8 Bryan Bishop: more utreexo >> http://diyhpl.us/diyhpluswiki/transcripts/bitcoin-core-dev-tech/2019-06-06-utreexo/ 02:12 -!- preview [~quassel@2407:7000:8423:b75:5983:c203:baaa:a2a0] has quit [Ping timeout: 248 seconds] 02:28 -!- spaceangel [~spaceange@ip-62-24-76-6.net.upcbroadband.cz] has joined ##hplusroadmap 02:38 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=420fbae4 Bryan Bishop: tweeter link >> http://diyhpl.us/diyhpluswiki/transcripts/bitcoin-core-dev-tech/2019-06-06-utreexo/ 02:38 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=026b7ac2 Bryan Bishop: transcript: group therapy for bitcoin core maintainers >> http://diyhpl.us/diyhpluswiki/transcripts/bitcoin-core-dev-tech/2019-06-06-maintainers/ 02:40 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=1b557944 Bryan Bishop: tweeter link >> 03:34 -!- purpleshift [purpleshif@gateway/vpn/mullvad/purpleshift] has quit [Quit: .] 04:10 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=17e6d46e Bryan Bishop: transcript: great consensus cleanup >> http://diyhpl.us/diyhpluswiki/transcripts/bitcoin-core-dev-tech/2019-06-06-great-consensus-cleanup/ 04:11 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=ff76e3df Bryan Bishop: tweeter link >> http://diyhpl.us/diyhpluswiki/transcripts/bitcoin-core-dev-tech/2019-06-06-great-consensus-cleanup/ 05:49 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id= 06:03 < fenn> .title http://elifesciences.org/articles/31157 06:03 < yoleaux> Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age | eLife 06:03 < fenn> 30 years of mole rats 06:06 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=b869f79f Bryan Bishop: more words >> http://diyhpl.us/diyhpluswiki/transcripts/bitcoin-core-dev-tech/2019-06-06-taproot/ 06:11 -!- hrofu_ is now known as hrofu 06:12 -!- transhumanist [~transhuma@2601:196:8800:6719:dd87:3a92:31c:e70e] has joined ##hplusroadmap 06:46 -!- hrofu is now known as hrofu_ 06:47 -!- hrofu_ is now known as hrofu 07:10 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=c70339f5 Bryan Bishop: transcript: NOINPUT and CHECKSIGFROMSTACK and SECURETHEBAG >> http://diyhpl.us/diyhpluswiki/transcripts/bitcoin-core-dev-tech/2019-06-06-noinput-etc/ 08:11 -!- adamsky [~adamsky3@178235181168.unknown.vectranet.pl] has quit [Remote host closed the connection] 08:56 -!- yashgaroth [~ffffffff@2606:6000:ca81:3100:1cf:ab28:cb2d:43c8] has joined ##hplusroadmap 10:05 -!- preview [~quassel@2407:7000:8423:b75:5983:c203:baaa:a2a0] has joined ##hplusroadmap 10:33 -!- strages [uid11297@gateway/web/irccloud.com/x-wqnsrkiyqlfccwcn] has joined ##hplusroadmap 10:35 -!- NikopolSohru [~NikopolSo@195.181.173.201] has joined ##hplusroadmap 10:35 -!- NikopolSohru [~NikopolSo@195.181.173.201] has quit [Changing host] 10:35 -!- NikopolSohru [~NikopolSo@unaffiliated/nikopolsohru] has joined ##hplusroadmap 11:50 -!- hrofu is now known as hrofu_ 11:53 -!- hrofu [~hrofu@unaffiliated/hrofu] has joined ##hplusroadmap 11:54 -!- hrofu_ [hrofu@gateway/vpn/mullvad/hrofu] has quit [Ping timeout: 248 seconds] 12:07 -!- transhumanist [~transhuma@2601:196:8800:6719:dd87:3a92:31c:e70e] has quit [Quit: Leaving] 12:27 < kanzure> hmph 12:30 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=a47e5217 Bryan Bishop: tweeter link >> http://diyhpl.us/diyhpluswiki/transcripts/bitcoin-core-dev-tech/2019-06-06-noinput-etc/ 12:30 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=2ff5b411 Bryan Bishop: fix typo about digestion control (i was hungry) >> http://diyhpl.us/diyhpluswiki/transcripts/bitcoin-core-dev-tech/2019-06-06-noinput-etc/ 12:32 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=bd810583 Bryan Bishop: add tweeter link about post-quantum security sentiments >> http://diyhpl.us/diyhpluswiki/transcripts/bitcoin-core-dev-tech/2019-06-06-taproot/ 12:38 -!- NikopolSohru [~NikopolSo@unaffiliated/nikopolsohru] has quit 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[~sachy@78.108.102.220] has quit [Quit: Leaving.] 19:13 < fenn> https://planetary.s3.amazonaws.com/assets/images/universe/20130115_radio_broadcasts.jpg 19:30 < hrofu_> we're truly insignificant 20:03 -!- strages [uid11297@gateway/web/irccloud.com/x-wqnsrkiyqlfccwcn] has quit [Quit: Connection closed for inactivity] 20:17 -!- hrofu_ is now known as hrofu 21:23 -!- yashgaroth [~ffffffff@2606:6000:ca81:3100:1cf:ab28:cb2d:43c8] has quit [Read error: Connection reset by peer] 22:25 -!- darsie [~kvirc@84-114-73-160.cable.dynamic.surfer.at] has joined ##hplusroadmap 23:45 -!- preview [~quassel@2407:7000:8423:b75:5983:c203:baaa:a2a0] has joined ##hplusroadmap --- Log closed Fri Jun 07 00:00:34 2019