--- Log opened Wed Jun 26 00:00:53 2019
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00:49 < archels_> what about Natasha Vita-More's work, didn't she do learning of behavioural response -> vitrify -> reanimate -> validation that response is still there?
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00:52 < archels_> .title https://www.liebertpub.com/doi/full/10.1089/rej.2014.1636
00:53 < archels_> yoleaux!
00:53 < yoleaux> archels_!
00:53 < archels_> .title
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02:22 < docl> kanzure: Hayworth recognizes Robert's work as neuroscience, and does not consider it cryonics.
02:23 < docl> Natasha's work does validate that memory can survive vitrification, but doesn't really extend to large mammals at present
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02:25 < docl> Although it does lend some indirect support to the claim that Hayworth makes, that ASC and glutaraldehyde fixation do preserve memory
02:27 < docl> .tw https://twitter.com/KennethHayworth/status/1143731615413264384
02:27 < yoleaux> @kendmil @KordingLab @jhewitt123 Again, you can shut down spiking with cold and the person survives with long-term memories https://www.sciencedirect.com/science/article/abs/pii/0013469489900333. If we were not discussing uploading but just long-term memory encoding at a conference you would not be bringing up these examples. (@KennethHayworth, in reply to tw:1143727837481971712)
02:28 < docl> .tw https://twitter.com/KennethHayworth/status/1143738631292641280
02:28 < yoleaux> @kendmil @RokoMijicUK High pressure freezing (HPF) is only possible on tiny pieces of tissue (<1mm) but is considered as close to the living biology as you can study. The paper compares glutaraldehyde fixation to HPF to quantify the artifacts in glutaraldehyde fixation. (@KennethHayworth, in reply to tw:1143737660328030208)
02:28 < docl> .tw https://twitter.com/KennethHayworth/status/1143739337718358017
02:28 < yoleaux> @kendmil @RokoMijicUK Aldehyde-Stabilized Cryopreservation begins with glutaraldehyde perfusion fixation so it has all of its artifacts. Follows with a slow perfusion of inert cryoprotectant to allow for long-term storage. Result is basically the same as glutaraldehyde alone but can last indefinitely (@KennethHayworth, in reply to tw:1143738631292641280)
02:30 < docl> The article he cites there shows site by side of HPF (not really freezing, that's just what it is called) vs glutaraldehyde fixation
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02:41 < docl> The big breakthrough of ASC was glutaraldehyde quality + indefinite time (through vitrifying) + whole brain
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08:02 < kanzure> docl: man, robert just can't catch a break- the cryonics people think he's neuroscience, and the neuroscience people think he's cryonics.
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16:28 < docl> er, I was thinking about this paper that he linked in a different tweet: https://cdn.elifesciences.org/articles/05793/elife-05793-v1.pdf
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18:46 < kanzure> docl: what's up
18:51 < docl> Not a whole lot. I'm chilling in Idaho for the summer. Recovering from the shock of my dad dying in February.
18:52 < docl> My current job is cleaning at a dermatology clinic, just normal janitorial stuff
18:52 < kanzure> sorry to hear that
18:52 < kanzure> if you have a project proposal i'd be interested in throwing money at the right thing
18:53 < docl> Yeah it sucks. I asked to have his brain preserved but couldn't push it because he didn't consent unambiguously and nobody had a clue what I was talking about
18:54 < kanzure> mine passed two days before i learned about bitcoin http://gnusha.org/logs/2009-01-10.log
18:54 < docl> Sucks :(
18:54 < docl> That would be cool. I don't have anything drafted up but I'll give it some thought and get back to you.
18:55 < kanzure> good
18:55 < docl> Are you still mainly interested in bio related stuff or is robotics likely to be just as interesting?
18:55 < kanzure> docl: i suppose you have heard about https://www.technologyreview.com/s/612838/the-transhumanist-diy-designer-baby-funded-with-bitcoin/
18:55 < kanzure> for robotics i'll probably defer proposal evaluation to fenn but sure whatever.
18:56 < docl> For some reason I missed that article. I'll check it out.
18:57 < docl> Cool. I'll try to narrow down what I can most productively work on.
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--- Log closed Thu Jun 27 00:00:53 2019