--- Log opened Thu Jul 04 00:00:00 2019
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01:54 < nmz787_> http://diyhpl.us/~nmz787/pdf/smi3200/pics/micrographs/xeon/
01:54 < nmz787_> including a hair and a xeon
01:55 < nmz787_> oops, hair is one dir up
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02:07 < nmz787_> easier viewing http://diyhpl.us/~nmz787/pdf/smi3200/pics.html#micrographs
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05:06 < archels> nmz787_: are you doing focus stacking?
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07:16 < kanzure> nmz787_: is your electron microscope also working?
07:20 < kanzure> "our laboratories produce highly hydrophobic lipophilic viral reservoir penetrating antiretroviral prodrugs coined as long-acting slow-effective release ART (LASER ART). LASER ART properties are defined by slow drug dissolution, enhanced lipophilicity, improved bioavailability and limited off-target toxicities, which directly affect the frequency of ART administration from daily to weeks."
07:21 < kanzure> OK so the idea is to flood the body with antiretroviral drugs before anything has a chance to respond, and simultaneously remove infectious genetic material from cells.
07:22 < kanzure> so the limited viral rebound is because of complete removal of infectious genetic material, or because the remaining population is too small to do anything?
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07:23 < guest-uohbzm__> hello
07:24 < kanzure> be greeted!
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07:28 < nsh> 'complete' removal is probably asymptotically improbable
07:29 < nsh> but there will be thresholds of viability of continued infection as function of viral load
07:29 < nsh> i would imagine
07:31 < kanzure> yeah i guess i don't really know about the effectiveness of a single viral capsid in the mammalian microenvironment.
07:35  * nsh nods
07:35 < nsh> highly variable i'd imagine and unclear if data will have been collected yet on a meaningful per virus basis controlled against the main factors favouring or disfavouring infection/cell apparatus co-option/replication
07:36 < nsh> nothing that couldn't be observed in principle though. just a case of when it becomes tractable to record observations that are meaningful enough to be worth recording
07:36 < nsh> also i know nothing in practice so i'm just musing
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07:53 < fenn> afaik no prior HIV therapies were able to remove retroviral inserted DNA from infected cells, because it's part of the genome
07:54 < fenn> presumably the lack of rebound is because you removed all the viral DNA, and prevented any intermediate forms from being made that could have inserted new DNA afterward
07:55 < fenn> and in the meanwhile the already existing capsids have been cleared
07:55 < fenn> by immune system or just general housekeeping
07:57 < fenn> "Once inside the host cell cytoplasm, the virus uses its own reverse transcriptase enzyme to produce DNA from its RNA genome, the reverse of the usual pattern, thus retro. The new DNA is then incorporated into the host cell genome by an integrase enzyme"
08:00 < fenn> it's probably better to emit some self-destruct signal if the viral sequences are found, rather than trying to cut it out, because the virus can insert inside an oncogene and cutting it out may not repair the gene in the process, leading to cancer
08:01 < fenn> better to do both i guess
08:01 < fenn> remove viral sequences and then self destruct
08:01 < fenn> because the self destruct method might be compromised
08:03 < kanzure> but presumably previous treatments still had strong antiretroviral drugs, so why wasn't that enough?
08:04 < fenn> because the drugs just halt replication, but the virus is still there in DNA form
08:04 < fenn> so as soon as you stop taking the drugs it begins replicating again
08:05 < fenn> https://en.wikipedia.org/wiki/Management_of_HIV/AIDS#Classes_of_medication
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08:47 < kanzure> .title https://www.youtube.com/watch?v=_NULFAItoBs
08:47 < yoleaux> Synthetic Meat - YouTube
08:53 < superkuh> Soon. http://superkuh.com/pictures/plif/wc263.gif
08:54 < fenn> dream bigger
08:57 < fenn> https://66.media.tumblr.com/c016d1b53ab2dc0d8438363b86701056/tumblr_omblt3QOVI1s39ht8o1_1280.jpg
09:05 < fenn> http://2.bp.blogspot.com/-CEL1ebPl288/U6WbRF6Z9dI/AAAAAAAAL1I/s1y3S156PxM/s1600/untitled.PNG
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09:57 < nmz787_> archels: it has a 'photo scan' mode where yeah it basically adds pixels/lines/frames, and yeah that's what I used to produce those
09:57 < nmz787_> kanzure: no, not yet, it's something I really need to get on
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14:40 < kanzure> "Encoding information in synthetic metabolomes" https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0217364
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--- Log closed Fri Jul 05 00:00:01 2019