--- Log opened Mon Jul 29 00:00:23 2019 00:13 -!- Urchin [~urchin@unaffiliated/urchin] has quit [Ping timeout: 244 seconds] 00:25 -!- ebowden_ [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap 02:22 -!- MarkOtaris [mark-otari@wikimedia/Mark-Otaris] has quit [Write error: Connection reset by peer] 02:22 -!- kun0[m] [kun0matrix@gateway/shell/matrix.org/x-vaykwvayrexznwhu] has quit [Write error: Connection reset by peer] 02:31 -!- MarkOtaris [mark-otari@wikimedia/Mark-Otaris] has joined ##hplusroadmap 02:54 -!- kun0[m] [kun0matrix@gateway/shell/matrix.org/x-pduiitojkdperncj] has joined ##hplusroadmap 04:01 -!- spacetechnician [40deb514@64.222.181.20] has quit [Remote host closed the connection] 04:11 -!- yoleaux [~yoleaux@xn--ht-1ia18f.nonceword.org] has quit [Quit: made me do it!] 04:52 < adlai> how'd y'all respond to someone who says upcoming advances in biology will enable regrowing limbs? 04:53 * adlai is deeply unsatisfied with his own response, which was roughly "being able to melt down this glass pane and sculpt the goo into a hand, does not mean you can get the glass to sprout a hand on its own" 05:20 < fenn> it's possible but we're a long way from actually doing it 05:21 < fenn> a limb is actually pretty complicated, if you're going to try to assemble it from tissue cultured pieces 05:21 < fenn> it takes a long time for a nerve cell to grow several feet 05:24 < fenn> by 3d printing biocompatible scaffolding gel and seeding it with different cell types, pieces of tissue can be formed in the approximate shape 05:24 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 05:24 < fenn> cells self organize, and can be directed with growth factor gradients and electric fields 05:25 < fenn> keeping it sterile is the hardest part 05:26 < fenn> there's also the risk of pluripotent cells left over from the tissue culture step getting into the host and causing teratomas or other trouble 05:27 < fenn> maybe there's a way to make a tiny bud limb by giving a blob of pluripotent cells the appropriate growth factors, but i don't think anyone's figured out how to do that yet 05:28 < fenn> and even so, it would take years before it's useful 05:28 < fenn> after implanting the bud 05:29 < fenn> and the bud wouldn't necessarily match up to anything on the other end, like a shoulder 05:29 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Ping timeout: 246 seconds] 05:59 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 06:11 -!- Urchin [~urchin@unaffiliated/urchin] has joined ##hplusroadmap 06:19 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Ping timeout: 248 seconds] 07:34 -!- nijak_ [nijak@gateway/vpn/mullvad/nijak] has joined ##hplusroadmap 07:35 -!- nijak [nijak@gateway/vpn/mullvad/nijak] has quit [Ping timeout: 244 seconds] 07:40 -!- yashgaroth [~ffffffff@2606:6000:ca84:b300:dd1f:6026:a994:8911] has joined ##hplusroadmap 07:42 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=0f2d6a46 Michael Folkson: Add transcript of LTB podcast with Pieter and Jonas >> http://diyhpl.us/diyhpluswiki/transcripts/lets-talk-bitcoin-podcast/2019-06-09-ltb-pieter-wuille-jonas-nick/ 07:42 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=1a190ed8 Bryan Bishop: Merge pull request #47 from michaelfolkson/add-ltb-pieter-jonas >> http://diyhpl.us/diyhpluswiki/ 07:46 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=10f05e9d Bryan Bishop: add tweeter link, fix things >> http://diyhpl.us/diyhpluswiki/transcripts/lets-talk-bitcoin-podcast/2019-06-09-ltb-pieter-wuille-jonas-nick/ 08:37 < archels> adlai: yes of course advances will enable it, but there are very few people looking specifically into that, so it'll take a long time to develop 08:38 < archels> "(re)growing organ X in the lab" is really very dependent on what is X 08:40 < archels> unless we find a magic (epi)genetic master switch from a lizard or something, and by an additional feat of magic it translates to humans 08:40 < archels> but still, if no one is looking specifically into regrowing limbs, things aren't going to move very fast 09:07 -!- helleshin [~talinck@98.29.27.253] has joined ##hplusroadmap 09:10 -!- hehelleshin [~talinck@98.29.27.253] has quit [Ping timeout: 258 seconds] 09:32 -!- spaceangel [~spaceange@ip-62-24-76-6.net.upcbroadband.cz] has joined ##hplusroadmap 10:17 -!- yashgaroth [~ffffffff@2606:6000:ca84:b300:dd1f:6026:a994:8911] has quit [Read error: Connection reset by peer] 10:19 -!- yashgaroth [~ffffffff@cpe-76-176-31-235.san.res.rr.com] has joined ##hplusroadmap 10:53 -!- LeoTal [~Adium@25.170.86.79.rev.sfr.net] has joined ##hplusroadmap 11:05 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=dd9ec80a Bryan Bishop: WHO letter >> http://diyhpl.us/diyhpluswiki/transcripts/letter-who-germline-genetic-engineering-2019-07-29/ 11:13 < kanzure> "angry man shouts at wind" but whatever... 11:20 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=932d7b28 Bryan Bishop: add tweeter link >> http://diyhpl.us/diyhpluswiki/transcripts/letter-who-germline-genetic-engineering-2019-07-29/ 11:21 < kanzure> https://twitter.com/kanzure/status/1155903004853358594 11:57 -!- Urchin [~urchin@unaffiliated/urchin] has quit [Ping timeout: 272 seconds] 12:05 -!- spaceangel [~spaceange@ip-62-24-76-6.net.upcbroadband.cz] has quit [Ping timeout: 246 seconds] 12:22 < maaku> adlai: depends on your time horizon. regrowing limbs IS likely to happen this century 12:36 < kanzure> .title https://www.nature.com/articles/s41562-019-0651-1 12:36 < kanzure> maaku: welcome back! 13:01 -!- yashgaroth [~ffffffff@cpe-76-176-31-235.san.res.rr.com] has quit [Read error: Connection reset by peer] 13:04 -!- yashgaroth [~ffffffff@cpe-76-176-31-235.san.res.rr.com] has joined ##hplusroadmap 13:26 -!- LeoTal [~Adium@25.170.86.79.rev.sfr.net] has quit [Ping timeout: 248 seconds] 13:55 -!- LeoTal [~Adium@202.170.86.79.rev.sfr.net] has joined ##hplusroadmap 14:11 -!- transhumanist [~steven@2601:196:8800:6719:b8f5:fd90:10c8:acf0] has joined ##hplusroadmap 14:17 -!- Burninate [~Burn@pool-108-51-46-154.washdc.fios.verizon.net] has quit [Quit: Leaving] 14:33 -!- sektor [~sektor@95.87.234.241] has quit [Ping timeout: 272 seconds] 14:56 -!- LeoTal [~Adium@202.170.86.79.rev.sfr.net] has quit [Ping timeout: 245 seconds] 14:58 -!- yashgaroth [~ffffffff@cpe-76-176-31-235.san.res.rr.com] has quit [Read error: Connection reset by peer] 15:00 -!- yashgaroth [~ffffffff@cpe-76-176-31-235.san.res.rr.com] has joined ##hplusroadmap 15:03 -!- sektor [~sektor@95.87.234.241] has joined ##hplusroadmap 15:26 < kanzure> https://leapsmag.com/a-press-release-from-the-future-announces-service-for-parents-to-genetically-engineer-their-kids/ 15:30 < kanzure> https://blogs.bcm.edu/2019/07/19/is-biohacking-the-practice-of-medicine-regulators-might-think-so/ 15:37 -!- transhumanist [~steven@2601:196:8800:6719:b8f5:fd90:10c8:acf0] has left ##hplusroadmap [] 16:04 -!- yashgaroth [~ffffffff@cpe-76-176-31-235.san.res.rr.com] has quit [Ping timeout: 258 seconds] 17:25 -!- yashgaroth [~ffffffff@2606:6000:ca84:b300:e058:9a09:72d8:2aad] has joined ##hplusroadmap 17:37 < bwb_> I've been enjoying your twitter germline engineering stuff kanzure 17:37 -!- bwb_ is now known as bbrittain 17:59 -!- bbrittain is now known as bwb_ 18:58 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 19:15 -!- priontology [~scionce@66.205.192.140] has quit [Quit: https://quassel-irc.org - Chat comfortably. Anywhere.] 19:28 < kanzure> bwb_: good seeing you around 20:04 -!- LeoTal [~Adium@176.170.86.79.rev.sfr.net] has joined ##hplusroadmap 20:43 -!- preview [~quassel@2407:7000:8423:b75:5983:c203:baaa:a2a0] has joined ##hplusroadmap 21:10 -!- preview [~quassel@2407:7000:8423:b75:5983:c203:baaa:a2a0] has quit [Ping timeout: 276 seconds] 21:13 -!- preview [~quassel@2407:7000:8423:b75:5983:c203:baaa:a2a0] has joined ##hplusroadmap 21:22 -!- preview [~quassel@2407:7000:8423:b75:5983:c203:baaa:a2a0] has quit [Ping timeout: 276 seconds] 21:25 -!- preview [~quassel@2407:7000:8423:b75:5983:c203:baaa:a2a0] has joined ##hplusroadmap 21:29 < nmz787> .title https://www.nature.com/articles/s41592-019-0497-5 21:29 < nmz787> .title 21:30 < nmz787> A cryo-FIB lift-out technique enables molecular-resolution cryo-ET within native Caenorhabditis elegans tissue 21:30 < nmz787> .tw https://twitter.com/bengeliscious/status/1155878391578529792 21:30 < nmz787> (sweet video of c. elegans being frozen, then FIB 21:31 < nmz787> FIB (machined) then the section pulled out with a micromanipulator and TEMed 21:33 -!- preview [~quassel@2407:7000:8423:b75:5983:c203:baaa:a2a0] has quit [Ping timeout: 276 seconds] 21:37 -!- abetusk [~abe@68.175.143.22] has quit [Quit: Leaving] 22:18 -!- yashgaroth [~ffffffff@2606:6000:ca84:b300:e058:9a09:72d8:2aad] has quit [Quit: Leaving] 22:18 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Ping timeout: 245 seconds] 22:28 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 22:29 -!- LeoTal [~Adium@176.170.86.79.rev.sfr.net] has quit [Quit: Leaving.] 22:42 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Ping timeout: 246 seconds] --- Log closed Tue Jul 30 00:00:24 2019