--- Log opened Sun Sep 08 00:00:05 2019
00:33 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=6368884b Bryan Bishop: prep for dfa2019.bitcoinedge.org >> http://diyhpl.us/diyhpluswiki/transcripts/bitcoinedge/devplusplus/
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01:04 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=f7a573d2 Bryan Bishop: transcript: intro to DFA workshop >> http://diyhpl.us/diyhpluswiki/transcripts/bitcoinedge/decentralized-financial-architecture-workshop/introduction/
01:48 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=b75ca68e Bryan Bishop: more words >> 
01:48 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=f281da4a Bryan Bishop: transcript: implications for regulation (financial services agency, japan) >> http://diyhpl.us/diyhpluswiki/transcripts/bitcoinedge/decentralized-financial-architecture-workshop/implications/
02:28 < pasky> Is it possible https://www.nature.com/articles/d41586-019-02638-w (https://www.gwern.net/docs/longevity/2019-fahy.pdf) hasn't been mentioned here yet?
02:38 < kanzure> https://gnso.icann.org/sites/default/files/file/field-file-attach/presentation-pre-icann65-policy-report-13jun19-en.pdf
02:39 < kanzure> or what about that organ one, where's that reference
02:58 < fenn> "A person’s biological age, measured by the epigenetic clock, can lag behind or exceed their chronological age"
02:58 < fenn> this is news? really?
03:05 < kanzure> perhaps evidence of such is news
03:13 < fenn> the real surprising thing is that epigenetic clock measurement is precise enough in general, so that it's unusual to see a discrepancy like this
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04:05 < pasky> the real point i think is that they have shown biological age reversal (at least as indicated by this clock) by thymus therapy
04:06 < pasky> well, not shown, but suggested
04:29 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=cb20424a Bryan Bishop: more text >> http://diyhpl.us/diyhpluswiki/transcripts/bitcoinedge/decentralized-financial-architecture-workshop/implications/
04:29 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=4234376c Bryan Bishop: transcript: beam and compliance and confidentiality >> http://diyhpl.us/diyhpluswiki/transcripts/bitcoinedge/decentralized-financial-architecture-workshop/perspective/
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06:01 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=874c7f3d Bryan Bishop: transcript: custody working group notes >> http://diyhpl.us/diyhpluswiki/transcripts/bitcoinedge/decentralized-financial-architecture-workshop/custody-group/
06:03 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=db098489 Bryan Bishop: more links >> http://diyhpl.us/diyhpluswiki/transcripts/bitcoinedge/decentralized-financial-architecture-workshop/custody-group/
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07:52 < JayDugger> Global cooling paints too broadly to short real estate markets. Urban value depends on many other things beside temperature.
07:54 < JayDugger> BUT--you could do this in some particular places. St. Petersburg comes to mind as an example of a year-round warm-water port.
07:54 < JayDugger> Novorossiysk
07:55 < JayDugger> https://en.wikipedia.org/wiki/Port#Warm-water_port
07:57 < JayDugger> That scheme might work better if it focused on the interaction between global cooling and some other attribute of a particular real estate market. Inclement weather probably wouldn't do it alone. I doubt migration patterns would change in under a generation.
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13:09 < kanzure> aaaaaaaa (but in israeli)
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13:13 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=6bc5dd41 Bryan Bishop: fix name typo >> http://diyhpl.us/diyhpluswiki/transcripts/bitcoinedge/decentralized-financial-architecture-workshop/compliance-and-confidentiality/
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13:57 < kanzure> .tw https://twitter.com/lsparrish/status/1168569846465908743
13:58 < EmmyNoether> Wow. The information-theoretic death entry on Wikipedia was pretty much deleted wholesale. https://en.wikipedia.org/wiki/Information-theoretic_death (@lsparrish)
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14:35 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=61a0d968 Bryan Bishop: transcript: bip32 hierarchical deterministic wallets (2018) >> http://diyhpl.us/diyhpluswiki/transcripts/scalingbitcoin/tokyo-2018/edgedevplusplus/hierarchical-deterministic-wallets/
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15:07 < fenn> User:JzG Pages deleted 16586
15:07 < fenn> This user is a
15:07 < fenn> Rouge admin.
15:07 < fenn> This user has been on Wikipedia for 15 years and 19 days.
15:07 < fenn> This user has been an admin for
15:07 < fenn> 13 years, 7 months, and 22 days.
15:07 < fenn> This user resists the POV pushing of lunatic charlatans.
15:07 < fenn> This user is one of the 532 left-wing thought police who aggressively force their biased perspective on the rest of the world.
15:08 < fenn> are they proud of this?
15:21 < Hooloovo0> if you follow any of those links, they're all humorous
15:21 < fenn> i'm sure there's reasons they are there
15:22 < fenn> "Ha ha only serious"
15:24 < fenn> the edits don't make sense anyway
15:25 < fenn> why keep paragraph 1 and delete paragraph 3 which says basically the same thing
15:25 < fenn> and somehow citing ethics journals counts as "original research"
15:26 < fenn> it's almost like they actually have an agenda!
15:26 < Hooloovo0> I'm confused what you're referring to
15:26 < fenn> https://en.wikipedia.org/w/index.php?title=Information-theoretic_death&action=history
15:26 < fenn> look at the edits by JzG
15:30 < Hooloovo0> he said it was SYN, sythesis of orignal research, not original research
15:31 < fenn> i haven't actually looked at the references (i'm allergic to ethics)
15:32 < Hooloovo0> I would remove the bit the bit on the bottom, doesn't actually say anything about the topic, just adds sources to make the sources section look big
15:32 < Hooloovo0> "x has been discussed here" is irrelevant
15:33 < Hooloovo0> and if two paragraphs say the same thing, why keep both?
15:33 < fenn> this was an attempt to demonstrate the notability of the topic, as it had been proposed for deletion
15:34 < fenn> this discussion probably explains it better than the raw edit log: https://en.wikipedia.org/wiki/Wikipedia:Articles_for_deletion/Information-theoretic_death_(2nd_nomination)
15:35 < fenn> so, we "kept" the article but hacked off all its limbs, yay
15:35 < fenn> fucking deletionists
15:36 < Hooloovo0> only the two dangly useless limbs were removed, right?
15:48 < fenn> huh, Ralph Merkle is the son of Theodore Charles Merkle, director of Project Pluto
15:55 < fenn> i can't believe in 2019 we're still discussing whether cryonics is a fringe theory
16:13 < docl> apparently what matters for wikipedia is what gets published in newspapers
16:14 < docl> well, scientific journals count. but only if they aren't arguably fringe journals
16:14 < fenn> if only newspapers existed
16:15 < fenn> the admin clearly has a grudge against "fringe" topics in general, and it has nothing to do with notability
16:15 < docl> yeah
16:15 < docl> there's about 5 such admins camped on the cryonics page right now
16:25 < docl> sorry, not admins, editors. pretty sure only a few are admins.
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17:50 < docl> https://www.ncbi.nlm.nih.gov/pubmed/30458175
17:50 < docl> .title
17:50 < EmmyNoether> Genetic suppression of cryoprotectant toxicity.  - PubMed - NCBI
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23:43 < kanzure> docl: very neat.
23:46 < kanzure> "We report here a new, unbiased forward genetic method that uses transposon-mediated mutagenesis to enable the identification of mutations that confer cryoprotectant toxicity resistance (CTR). Our method is to select for resistance to the toxic effects of M22, a much-studied whole-organ vitrification solution. We report finding and characterizing six mutants that are resistant to M22. These ...
23:46 < kanzure> ...mutants fall into six independent biochemical pathways not previously linked to cryoprotectant toxicity (CT). The genes associated with the mutations were Gm14005, Myh9, Nrg2, Pura, Fgd2, Pim1, Opa1, Hes1, Hsbp1, and Ywhag. The mechanisms of action of the mutations remain unknown, but two of the mutants involve MYC signaling, which was previously implicated in CT"
23:46 < kanzure> "Several of the M22-resistant mutants were also resistant to dimethyl sulfoxide (Me2SO), and many of the mutants showed significantly improved survival after freezing and thawing in 10% (v/v) Me2SO."
23:50 < kanzure> "Mutant 2.1, containing a pB insertion in Gm14005, displayed particularly high survival after freezing and thawing as measured by trypan blue exclusion (Fig. 6A–C). In Fig. 6A, mutant M2.1 showed a 12.7-fold increase over control survival (indicated as being outside the range of all other mutants in multiple experiments)"
--- Log closed Mon Sep 09 00:00:05 2019