--- Log opened Fri Jan 17 00:00:08 2020
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04:58 < kanzure> you can't buy rapid service like that https://github.com/kallewoof/btcdeb/pull/34
04:58 < kanzure> and my ticket yesterday https://github.com/kallewoof/btcdeb/issues/32
05:30 < kanzure> .tw https://twitter.com/DNAScript/status/1217492716956852225
05:31 < EmmyNoether> IARPA Funds Team Involving DNA Script, the Broad Institute, and Harvard University / for DNA Data Storage Research and Development @IARPAnews / @broadinstitute @Harvard @illumina #dna #datastorage http://dnascript.co/pr-iarpa (@DNAScript)
05:31 < kanzure> .tw https://twitter.com/TwistBioscience/status/1217500692937613312
05:31 < EmmyNoether> We are thrilled to have been selected as a subcontractor to @GTRI to undertake the #DNA synthesis portion of the Molecular Information Storage (MIST) program through a contract with @IARPAnews. #WeMakeDNA / Twist Bioscience Selected as DNA Synthesis Provider https://buff.ly/38bN4ym https://pbs.twimg.com/media/EOVubYYXkAAF1Ev.jpg (@TwistBioscience)
05:31 < kanzure> https://www.gtri.gatech.edu/newsroom/25-million-project-will-advance-dna-based-archival-data-storage
05:32 < kanzure> "A proteomic atlas of senescence-associated secretomes for aging biomarker development" https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000599
05:33 < kanzure> "Correlative three-dimensional super-resolution and block-face electron microscopy of whole vitreously frozen cells" https://science.sciencemag.org/content/367/6475/eaaz5357
05:34 < kanzure> "Cell-surface proteomic profiling in the fly brain uncovers wiring regulators" https://www.cell.com/cell/fulltext/S0092-8674(19)31391-1
05:36 < kanzure> "Using natural language processing to learn the grammar of glycans" https://www.biorxiv.org/content/10.1101/2020.01.10.902114v1
05:38 < kanzure> "Recording mobile DNA in the gut microbiota using an Escherichia coli CRISPR-Cas spacer acquisition platform" https://www.nature.com/articles/s41467-019-14012-5
05:38 < kanzure> "Cell-specific non-canonical amino acid labelling identifies changes in the de novo proteome during memory formation" https://elifesciences.org/articles/52990
05:39 < kanzure> "..  we generated a novel mouse strain, which enables cell-type-specific labelling of newly synthesised proteins with non-canonical amino acids (NCAAs) by genetically restricting the expression of the mutant tRNA synthetase, NLL-MetRS, to hippocampal neurons. By combining this labelling technique with an accelerated version of the active place avoidance task and bio-orthogonal non-canonical ...
05:39 < kanzure> ...amino acid tagging (BONCAT) followed by SWATH quantitative mass spectrometry, we identified 156 proteins that were altered in synthesis in hippocampal neurons during spatial memory formation. In addition to observing increased synthesis of known proteins important in memory-related processes, such as glutamate receptor recycling, we also identified altered synthesis of proteins associated ...
05:40 < kanzure> ...with mRNA splicing as a potential mechanism involved in spatial LTM formation."
05:41 < kanzure> http://thinkingcomplete.blogspot.com/2020/01/characterising-utopia.html
05:44 < kanzure> "Dendritic action potentials and computation in human layer 2/3 cortical neurons" https://science.sciencemag.org/content/367/6473/83
05:44 < kanzure> .tw https://twitter.com/jaaanaru/status/1212810741549600768
05:44 < EmmyNoether> Brains are amazing. Our lab demonstrates that single human layer 2/3 neurons can compute the XOR operation. Never seen before in any neuron in any other species. Out now in @sciencemagazine. Congrats Albert, Tim @mattlark @YiotaPoirazi & CO https://science.sciencemag.org/content/367/6473/83 (@jaaanaru)
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05:46 < kanzure> "One year, 1 lab, 16 spinouts" https://www.nature.com/articles/s41587-019-0369-7 (or: "a singularity of church-sponsored startups")
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05:57 < kanzure> .title https://www.youtube.com/watch?v=ojmxAAsFNKw
05:57 < EmmyNoether> The case for insect brain emulation - Logan Thrasher Collins - YouTube
05:59 < kanzure> .tw https://twitter.com/bencbartlett/status/1203789680065466368
05:59 < EmmyNoether> Turbomolecular pumps are used together with a secondary pump to pull very high vacuums (up to 10^-13 atm!) // The pumping mechanism only works if blade spacing is < mean free path of air, so the separation and angle of the blades decreases as pressure increases toward the bottom https://video.twimg.com/ext_tw_video/1203789621168984065/pu/vid/480x270/IGjGeSjn67tlUHY7.mp4?tag=10 (@bencbartlett)
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06:00 < kanzure> "High-throughput microcircuit analysis of individual human brains through next-generation multineuron patch-clamp" https://elifesciences.org/articles/48178 https://twitter.com/YangfanPeng/status/1202973083386208256
06:00 < kanzure> "Comparing neuronal microcircuits across different brain regions, species and individuals can reveal common and divergent principles of network computation. Simultaneous patch-clamp recordings from multiple neurons offer the highest temporal and subthreshold resolution to analyse local synaptic connectivity. However, its establishment is technically complex and the experimental performance is ...
06:01 < kanzure> ...limited by high failure rates, long experimental times and small sample sizes. We introduce an in vitro multipatch setup with an automated pipette pressure and cleaning system facilitating recordings of up to 10 neurons simultaneously and sequential patching of additional neurons. We present hardware and software solutions that increase the usability, speed and data throughput of multipatch ...
06:01 < kanzure> ...experiments which allowed probing of 150 synaptic connections between 17 neurons in one human cortical slice and screening of over 600 connections in tissue from a single patient. This method will facilitate the systematic analysis of microcircuits and allow unprecedented assessment of inter-individual variability."
06:02 < kanzure> .tw https://twitter.com/elonmusk/status/1203113955813511169
06:02 < EmmyNoether> @neiltyson If we create a city on Mars, Earth-Mars travel will be a powerful forcing function for inventing something like warp drive (@elonmusk, in reply to tw:1203076122243715072)
06:03 < kanzure> "Comprehensive AAV capsid fitness landscape reveals a viral gene and enables machine-guided design" https://science.sciencemag.org/content/366/6469/1139 https://twitter.com/PierceOgdenJ/status/1200434089628721152
06:04 < kanzure> possibly no overall cosmological acceleration https://twitter.com/anderssandberg/status/1200187647983079425
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06:05 < kanzure> "Enabling FIB-SEM systems for large volume connectomics and cell biology" https://www.biorxiv.org/content/10.1101/852863v1
06:06 < kanzure> "Isolating live cells after high-throughput, long-term, time-lapse microscopy" https://www.nature.com/articles/s41592-019-0620-7
06:07 < kanzure> "Deep neuroethology of a virtual rodent" https://arxiv.org/abs/1911.09451
06:08 < kanzure> "Gas cluster ion beam SEM for imaging of large tissue samples with 10 nm isotropic resolution" https://www.nature.com/articles/s41592-019-0641-2  from hayworth et al
06:09 < kanzure> "In situ readout of DNA barcodes and single base edits facilitated by in vitro transcription" https://www.nature.com/articles/s41587-019-0299-4
06:09 < kanzure> "Time-resolved imaging-based CRISPRi screening" https://www.nature.com/articles/s41592-019-0629-y
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06:39 < kanzure> shit academics say https://twitter.com/AcademicsSay
06:40 < kanzure> .title https://twitter.com/AcademicsSay/status/1214895436839968774
06:40 < EmmyNoether> Shit Academics Say auf Twitter: 'Final_mar4_rev3_finalfinal2r_rev5r_edit4_edit6_v13_rr2jun13_[shortv]finalrev22_resub4_nearfinalresp4r_newsubnov23_rev2_ifeelsad[2]_2020r.docx'
06:46 < kanzure> mammalian acoustic reporter genes https://science.sciencemag.org/content/365/6460/1469.long
06:46 < kanzure> other cool things https://www.linkedin.com/pulse/top-10-technologies-2019-biologists-should-know-dino-di-carlo/
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06:55 < kanzure> chemical synthesis machine software in python https://github.com/croningp/ChemputerSoftware/tree/master/platform_server/tools/module_execution
06:56 < kanzure> "Biolinguistics: Monkeys break through the syntax barrier" https://www.cell.com/current-biology/fulltext/S0960-9822(18)30559-1
06:57 < kanzure> https://panlingua.rxivist.org/?lang=en
06:57 < kanzure> "A genetic model of the connectome" https://www.sciencedirect.com/science/article/abs/pii/S0896627319309262
07:03 < kanzure> .tw https://twitter.com/KordingLab/status/1216916249046867969
07:04 < EmmyNoether> @mioana Sartre described the human condition in summary form: freedom entails total responsibility, in the face of which we experience anguish, forlornness, and despair; genuine human dignity can be achieved only in our active acceptance of these emotions. (@KordingLab, in reply to tw:1216915524136902656)
07:04 < kanzure> .tw https://twitter.com/kanzure/status/1218186575269584896
07:04 < EmmyNoether> @KordingLab @mioana Genuine human dignity is picking ourselves up out of the freaking mud, after "accepting" those emotions. We should reject Sartre's limited notion of dignity. // Is dementia diginfied? The decrepitude of aging? // wtf (@kanzure, in reply to tw:1216916249046867969)
07:04 < kanzure> wait maybe i misinterpreted
07:04 < kanzure> oh, he referenced being worried about improving "the human condition"
07:05 < kanzure> "Can we travel to the past? Irreversible physics along closed timelike curves" https://arxiv.org/abs/1912.04702
07:05 < kanzure> and its analysis https://twitter.com/FrancesVidotto/status/1204606439056121856
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07:09 < kanzure> "Expansion microscopy of lipid membranes" https://www.biorxiv.org/content/10.1101/829903v1
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07:58 < nsh> "Earth-Mars travel will be a powerful forcing function"
07:58 < nsh> that is not what those words mean
07:58 < nsh> ah, or maybe it's been diluted to the point where you can just use it as a smartarse way to say 'incentive'
08:00 < kanzure> yeah it's just gibberish
08:00 < kanzure> why not "incents giant rocket development kthx"
08:02 < nsh> the analysis is reasonable enough: the more compounded economic pressure there is on the efficiency of a function (getting [stuff] from Earth<->Mars) the more likely that finite resources of innovation and investment will be turned to its economisiation
08:02 < nsh> so maybe he was just [ab]using the technical term to try and signal that this was the consideration
08:02 < nsh> but it's still annoying
08:04 < kanzure> why wouldn't ordinary everyday transportation requirements be a sufficient motivation to develop instantaneous transportation engines?
08:04 < kanzure> beam me to the kitchen
08:04 < kanzure> or, rather, grow a clone closer to the kitchen and teach it everything i know so that it may continue my mortal life-- in the kitchen-- such that i don't have to go there myself
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08:26 < fenn> one would have expected suborbital rockets many decades ago, to reduce trans-continental flight times
08:27 < fenn> er, inter-continental
08:42 < TMA> well, the lack of fast intercontinental travel is not the reason I am not keen to travel
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08:50 < Urchin> fenn: the problem was making suborbital rockets
08:51 < fenn> rocket mail could have bootstrapped the industry
08:51 < Urchin> I've read some market research indicating that suborbital trafic should go up to 20k people per year 20 years after suborbital tourists start flying (and that much of that is expected to be intercontinental)
08:52 < Urchin> fenn: IIRC, that failed miserably
08:52 < fenn> there's no reason for such a delay
08:52 < Urchin> what delay?
08:52 < fenn> "20 years after suborbital tourists start"
08:53 < fenn> oh. nevermind
08:53 < Urchin> well, that's starting with essentially toy systems like NG and SS2
08:53  * fenn read that as orbital tourists
08:53 < Urchin> it would take a while for the market to grow in any case
08:53 < fenn> yeah i guess. people already voluntarily cram themselves in airtight tubes to go to the other side of the planet
08:54 < fenn> it could ramp up very quickly
08:54 < fenn> 20 years though? no way
08:54 < fenn> that's entirely dependent on the supply side of things
08:55 < Urchin> 20k people flying through space in a year is what? 400 times more than have flown so far?
08:55 < fenn> also many of the passengers will be repeat customers, so you have to convince less than 20k people that it's safe
08:56 < Urchin> tbh, I'd expect far more than 20k people being both able to pay and willing to fly just in USA, and that's being pessimistic about just pleasure hops
08:56 < fenn> i have no idea
08:56 < Urchin> assuming 1% of people can afford it, and 1% of those would be interested
08:57 < Urchin> that's still tens of thousands of people in USA
08:57 < Urchin> however, I consider it an unrealistically pessimistic assumption
08:58 < Urchin> if you think about the size of global population, a group of "few people" by a shared trait is usually numbered in millions globally
08:59 < fenn> it really depends on the cost more than anything
08:59 < Urchin> not *that* much for start, tbh
09:00 < fenn> i'm not talking about going up to 100km and straight back down
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09:00 < Urchin> there will have to be toy systems like NG and SS2 before people would be willing to go on a Starship intercontinental
09:00 < fenn> they're completely different in almost every way
09:02 < fenn> besides, starship actually has a chance of being affordable
09:03 < fenn> the set of people willing to check the "by rocket" box for their intercontinental trip is much greater than the set of people willing to shell out thousands of dollars for a joyride
09:03 < Urchin> I'm honestly still not thrilled with the idea of using Starship for intercontinental travel, acceleration for the proposed travel times would be nasty
09:04 < fenn> did we ever do the calculations for fuel usage by rocket vs airplane? i don't know which would use more fuel
09:04 < kanzure> iirc the cost estimates per passenger-trip on these rockets was at least $50k
09:05 < fenn> nobody knows anything
09:05 < kanzure> https://www.reddit.com/r/spacex/comments/736po1/some_quick_calculations_about_point_to_point/
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09:06 < fenn> 100 tons of payload is 1000 passengers; vague handwavy estimates for total marginal flight costs for starship is $5M/flight, so that would be $5k/passenger if you stuff it to the gills
09:06 < kanzure> dunno where i got $50k from, nevermind
09:06 < kanzure> is my martian trip cost estimate wrong too? i heard like $300k/person
09:07 < fenn> that's what elon has been saying but it's "aspirational"
09:07 < fenn> i mean, it's not impossible
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09:27 < kanzure> .tw https://twitter.com/eturner303/status/1216476218603630592
09:27 < EmmyNoether> The funny thing about AIDungeon is due to all the GPT-2 pre-training on swaths of random web text, you can create an adventure game about literally anything. Here's one about installing OpenCV from source: https://pbs.twimg.com/media/EOHKqn5UUAAm0E9.jpg https://pbs.twimg.com/media/EOHKq_sU0AAYL1E.jpg (@eturner303)
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09:34 < Urchin> don't you need like 4-5 cargo ships per passenger ship to Mars? a passenger would have to pay, in addition to own specific seat, own share in supplies of 4-5 other spaceships
09:38 < nsh> this reminds me, i should submit some talktotransformer poetry to various poetry places
09:38 < nsh> and try to get published
09:38 < nsh> maybe use fiverr or mturk to whittle down for poetic quality
09:39 < nsh> although i don't actually want to spend money on such silliness
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09:54 < kanzure> .tw https://twitter.com/lopp/status/1217445335133556737
09:54 < EmmyNoether> Google engineer @maddiestone reveals Android phone OEMs: / * Disabled Google Play Protect / * Shipped remote code execution tools / * Modified the OS & APIs to allow them to view every URL that was accessed on the device / * Were tricking into shipping botnet code / https://www.youtube.com/watch?v=U6qTcpCfuFc (@lopp)
09:54 < kanzure> .title https://www.youtube.com/watch?v=U6qTcpCfuFc
09:54 < EmmyNoether> Securing the System: A Deep Dive into Reversing Android Pre-Installed Apps - YouTube
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13:20 < nmz787> kanzure: usually turbomolecular pumps are insufficient to get to 10^-13 atm... you also need ion getter pumps too
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14:17 < kanzure> where was that tweet about programmers being optimized to turn oxygen into shitty javascript?
14:18 < LeoTal> kanzure: https://twitter.com/mspowahs/status/957995279092875264 ?
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14:22 < kanzure> yeah that's close enough
14:22 < LeoTal> Personally I disagree with the tweet: both demographics say both things. A lot. While I'm trying to work. Help.
14:22 < kanzure> there was another one but it's lost i guess.
14:23 < kanzure> .tw
14:23 < EmmyNoether> Trans transhumanists: omg what if hot-swappable body parts? Real functioning tails and cat ears? Permanently purple hair? / Cis transhumanists: with this nootropic stack and optimized nutrient slurry my tragic meat machine is 8% more efficient at converting calories into javascript (@mspowahs)
14:24 < Urchin> lol
14:25 < LeoTal> Also, how dare you, I convert calories into *typescript*
14:25 < Urchin> I want cyborg eyes
14:25 < LeoTal> Glasses
14:26 < Urchin> have those
14:26 < Urchin> need upgrade
14:26 < LeoTal> Lasik?
14:26 < Urchin> with spam filter
14:26 < Urchin> I mean, online, blocking adds is relatively easy
14:27 < Urchin> but IRL you have to deal with billboards and s***
14:27 < Urchin> visual spam filters, killer app
14:27 < Urchin> (seeing into IR spectrum would be cool too)
14:28 < LeoTal> I love the idea of uBlock Origin: Visual Cortex Edition, but vision is enough of a mess that I don't really want more layers discarding almost everything from the previous layer and confabulating an entire visual field
14:28 < Urchin> people have made it work in the past
14:29 < Urchin> I'd prefer to do the filtering way before visual cortex :P
14:29 < Urchin> makes more sense, and is easier
14:31 < LeoTal> It's easier but it's a little inefficient to convert raw light to a 3d scene, transform it, convert back to raw light, and feed to a different system
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16:05 < abetusk> http://gaudi.ch/PocketPCR/
16:05 < abetusk> .title http://gaudi.ch/PocketPCR/
16:05 < EmmyNoether> PocketPCR - The thermocycler for the rest of us
16:05 < abetusk> https://github.com/GaudiLabs/PocketPCR
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--- Log closed Sat Jan 18 00:00:10 2020