--- Log opened Sat Feb 08 00:00:33 2020 00:37 -!- filipepe [uid362247@gateway/web/irccloud.com/x-hdlwybnseaeqrocp] has quit [Quit: Connection closed for inactivity] 00:47 -!- lewlx [~lewlx@0526D95A.dsl.pool.telekom.hu] has joined ##hplusroadmap 00:49 -!- lewlx [~lewlx@0526D95A.dsl.pool.telekom.hu] has quit [Remote host closed the connection] 01:40 -!- lewlx [~lewlx@0526D95A.dsl.pool.telekom.hu] has joined ##hplusroadmap 01:43 -!- Human_G33k [~HumanG33k@62.147.242.8] has quit [Quit: Leaving] 02:47 -!- darsie [~kvirc@84-114-73-160.cable.dynamic.surfer.at] has joined ##hplusroadmap 02:55 -!- filipepe [uid362247@gateway/web/irccloud.com/x-wzvntzbzuvfkxhby] has joined ##hplusroadmap 03:25 -!- l_wl [~lewlx@0526D95A.dsl.pool.telekom.hu] has joined ##hplusroadmap 03:25 -!- lewlx [~lewlx@0526D95A.dsl.pool.telekom.hu] has quit [Read error: Connection reset by peer] 03:25 -!- l_wl [~lewlx@0526D95A.dsl.pool.telekom.hu] has quit [Client Quit] 04:45 < adlai> fenn: this is why cold climates are fun; it's easier to conceal a vest (or a flask, or a pistol, or ... almost anything) under halfadozen layers of thermal insulation 04:47 < adlai> naturally, "almost anything" does not include baseball bats, hockey sticks, and most effective rifles. c'est la vie! 06:06 -!- Urchin [~urchin@unaffiliated/urchin] has quit [Ping timeout: 272 seconds] 06:50 < kanzure> "In vivo RNA editing of point mutations via RNA-guided adenosine deaminases" https://www.nature.com/articles/s41592-019-0323-0 07:41 < docl> at least with anders and phil metzger we have a few smart academia people are clamoring for open source machine ecology type stuff. nobody with money is though. 07:44 < docl> bezos has said some stuff about off-earth manufacturing, and elon has talked about the machines to make the machines. I think they have the basic understanding of what's possible, but they haven't made it a part of their public facing personas. 07:45 < docl> maybe there'll be a new hype train when anders book comes out 07:48 < kanzure> docl: what is his book about? 07:49 < docl> He mentioned it in the twitter thread, said 3 chapters are about the topic. Lemme look it up 07:50 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=7146cc49 Bryan Bishop: add RNA-guided adenosine deaminases >> http://diyhpl.us/diyhpluswiki/gene-editing/ 07:52 < docl> https://twitter.com/anderssandberg/status/1225225761650618369 07:53 < docl> referring to https://twitter.com/anderssandberg/status/1225136823166521344 07:54 < adlai> if you're linking tweets on a day when the bot is MIA, please quote the tweet itself 07:54 < kanzure> nsh: show me your titlebot and maybe i'll run it on something? 07:55 < kanzure> adlai: yeah or we can just fix the problem... 07:55 * adlai is still trying extinguish a printer 07:58 < docl> "This was actually a topic of my talk at UCL yesterday: can we formalize lifecycle of space habitats enough to show positive growth rate? (My answer: still need to demonstrate space mining, manufacturing and human reproduction, but looks good; even a tiny rate eats solar system)" 07:59 < docl> https://twitter.com/anderssandberg/status/1224981473238945794 07:59 < docl> "I only had one hour to explain solar, interstellar and intergalactic settlement plus my big theory of what makes it "easy", so it was a bit rushed. (The faces of the students waiting outside the glass door for their own lecture when they saw some of my slides were fun!)" 07:59 < docl> https://twitter.com/anderssandberg/status/1225136823166521344 07:59 -!- fox2p [~fox2p@cpe-66-108-32-173.nyc.res.rr.com] has quit [Ping timeout: 268 seconds] 08:00 < docl> "Tricky, since it is about three chapters in my book manuscript. But I am seriously thinking of making it a course at Oxford and record it." 08:00 < docl> https://twitter.com/anderssandberg/status/1225225761650618369 08:00 -!- fox2p [~fox2p@cpe-66-108-32-173.nyc.res.rr.com] has joined ##hplusroadmap 08:02 < docl> "Do we know how to go about the study needed? Is there a straightforward idea of how one could find out relatively firmly what is needed, or would it be "put X engineers together for Y weeks and hope they sort it out?" Seems worth knowing." 08:02 < docl> https://twitter.com/anderssandberg/status/1224301461980483584 08:05 -!- Urchin [~urchin@unaffiliated/urchin] has joined ##hplusroadmap 08:13 < docl> BTW, the CubeSpawn guy is active lately 08:15 < lsneff> CubeSpawn looks quite cool. 08:52 -!- juri_ [~juri@178.63.35.222] has quit [Ping timeout: 252 seconds] 08:52 -!- juri_ [~juri@79.140.121.197] has joined ##hplusroadmap 08:57 -!- juri_ [~juri@79.140.121.197] has quit [Ping timeout: 240 seconds] 08:58 -!- juri_ [~juri@178.63.35.222] has joined ##hplusroadmap 09:19 < adlai> thank you, docl, for tolerating unfixed problems 09:21 -!- orlovsky [~dr-orlovs@xdsl-188-155-1-200.adslplus.ch] has quit [Quit: Textual IRC Client: www.textualapp.com] 09:29 < docl> of course :) 09:31 -!- abetusk [~abe@68.175.143.22] has quit [Ping timeout: 260 seconds] 09:46 -!- yashgaroth [~ffffffff@2606:6000:ca84:b300:addb:18a2:a7bb:c99] has joined ##hplusroadmap 11:07 < fenn> http://gofundme.com/f/making-a-live-dinosaur 11:07 < fenn> real life jurassic park 11:48 < fenn> adlai: for all they know, you're completely naked under all those clothes 12:05 -!- filipepe [uid362247@gateway/web/irccloud.com/x-wzvntzbzuvfkxhby] has quit [Quit: Connection closed for inactivity] 12:50 -!- Codaraxis [~Codaraxis@ip68-5-175-208.oc.oc.cox.net] has quit [Ping timeout: 268 seconds] 13:00 -!- Codaraxis [~Codaraxis@ip68-5-175-208.oc.oc.cox.net] has joined ##hplusroadmap 13:01 < lsneff> kanzure: you mentioned on twitter that you feel that molecular biology is the quickest way to nanofactories/etc. Do you mean legitimately reprogramming ribosomes and figuring out how to reprogramming cellular processes or just coercing biology to make mechanical structures that we can more easily use directly (DNA origami for instance)? 13:40 * juri_ continues to write a slicer in haskell. wheee... 13:40 -!- abetusk [~abe@68.175.143.22] has joined ##hplusroadmap 13:40 -!- abetusk is now known as Guest71022 13:49 < kanzure> lsneff: both. but in particular, protein engineering is going to be turned into an art of reproducible components that get glued together to make molecular nanostructures. 14:47 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 272 seconds] 14:49 < nsh> kanzure, it's saxo: https://github.com/sbp/saxo/ 14:49 < nsh> so, biohackers: 14:50 < nsh> what would be so challenging about making a visible marker for presymptomatic coronavirus infections? 14:50 < nsh> never-mind a vaccine or any kind of paliative, just knowing that people are infected before the present would be massive help 14:51 < nsh> *they 14:51 < nsh> if it can be mass produced and taken without complications 14:52 < nsh> something something capsid results in protein deformation that triggers a cascade resulting in a human-observable biomarker activation 14:56 < fenn> werent we supposed to have cheap PCR doodads 10 years ago 15:02 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 15:08 -!- darsie [~kvirc@84-114-73-160.cable.dynamic.surfer.at] has quit [Quit: bye bye] 15:09 -!- darsie [~kvirc@84-114-73-160.cable.dynamic.surfer.at] has joined ##hplusroadmap 15:30 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 256 seconds] 15:46 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Quit: leaving] 15:46 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 15:47 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 16:26 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Quit: leaving] 16:26 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 16:28 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Client Quit] 16:31 -!- turona_ [~quassel@2a01:c22:b039:e500:9f0d:2992:9915:d8aa] has quit [Ping timeout: 272 seconds] 16:32 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 16:33 -!- turona [~quassel@2a01:c23:6407:2f00:916c:cfaf:ad2a:285e] has joined ##hplusroadmap 16:34 < aeiousomething> you guys are banned by the MIT media lab 16:34 < aeiousomething> ? 16:34 < aeiousomething> why 16:35 < kanzure> i think it was this? https://github.com/kanzure/diyhpluswiki/commit/8ca201b5799f5e8e622ca99c32b9d73c1b192aa1#diff-9736691f6cf53e4a8ed17847c1cfb1f4 16:38 < aeiousomething> trying to understand this 16:39 < kanzure> they were upset aobut some transcripts 16:39 < aeiousomething> transcripts of what 16:39 < kanzure> i just gave you the link...? 16:40 < aeiousomething> can you please explain I don't understand what the link is pointing to 16:41 < kanzure> they were upset that my live transcript was inaccurate and incorrectly documented someone as saying "libra will be managed by vampires" instead of "managed by facebook". 16:41 < aeiousomething> also did you mean to point to a specific paragraph in the commit 16:41 < aeiousomething> kanzure: have you tried asking them if there's a difference 16:41 < kanzure> they seem to think so, and they got rather upset about it. 16:42 < aeiousomething> well even MIT can be sometimes wrong I guess 16:42 < kanzure> MIT is very focused on wokeness. 16:43 < aeiousomething> if by woke you mean not wanting to destroy relationship with dracula 16:43 < aeiousomething> sure 16:45 < aeiousomething> I sometimes wonder how I ended up in this channel 16:46 < aeiousomething> can I ask a quesiton about this noopept everyone keeps talking about 16:47 < aeiousomething> some people think that as a peptide based stimulant, it triggers the immune system and sends it into overdrive 16:47 < aeiousomething> can someone help me understand if this is a possibility 16:47 < fenn> some people thin kthe earth is flat 16:47 < kanzure> here's something from the weirdnet https://new-god-argument.com/ 16:47 < aeiousomething> fenn: are you calling them idiots 16:48 < fenn> do they have reasons? 16:48 < aeiousomething> https://www.reddit.com/r/Nootropics/comments/2kskni/a_word_of_caution_about_noopept_and_autoimmune/ 16:48 < aeiousomething> I know 16:48 < aeiousomething> don't frown just yeat 16:48 < aeiousomething> this is important to me and I'm doing whatever shitty research I can 16:49 < kanzure> you came here because some asshole put this channel in the /topic of #reddit-nootropics 16:49 < aeiousomething> hmm 16:49 < aeiousomething> I don't think so 16:49 < aeiousomething> I think it was another forum 16:49 < aeiousomething> but you might be right 16:49 < aeiousomething> I have no memory of how I actually got here and I am on r/nootropics 16:50 < aeiousomething> is that a bad thing 16:51 < aeiousomething> I also may completely lack the knowledge to understand some of the things being discussed here.. and with ADD and recently diagnosed chronic illness I would at least want to forward some of the things to my sister who's a surgeon 16:51 < aeiousomething> help preventing my inevitable early death 16:51 < fenn> learn you a science 16:51 < fenn> get thee to a library! 16:52 < aeiousomething> fenn: do you think there's a reason for me to not take noopept .. I have IGA Nephropathy which is an immune mediated disease 16:52 < aeiousomething> I'm not asking you this as medical advice of course 16:52 < fenn> "one guy with MS had a flare up once" is not data 16:52 < aeiousomething> true 16:53 < aeiousomething> what about peptides being misconstrued to be viruses 16:53 < aeiousomething> which was one of the reasons listed as to why this could happen 16:53 < fenn> well it's possible to become allergic to just about anything 16:54 < aeiousomething> so you're saying an inherent peptide allergy would cause something like this 16:54 < aeiousomething> but not everyone is inherently allergic to peptides 16:54 < fenn> i don't even know what that means 16:54 < aeiousomething> neither do I 16:54 < aeiousomething> because the guy on the page says that peptides are confused for viruses by the immune system 16:54 < aeiousomething> idk how this works 16:54 < aeiousomething> or if I even read it right 16:55 < fenn> "Well if you think about it a virus is a protein fragment like a peptide that replicates" <- this is factually wrong 16:55 < aeiousomething> ok good 16:58 < aeiousomething> so your'e saying peptides and viruses are in no way related 16:58 < fenn> well houses are made out of wood, and sometimes trees fall on houses, and trees are made out of wood, but that doesn't mean your house will get crushed if you build a bookshelf out of wood 16:59 < fenn> but i wouldn't go so far as to say that trees and wood are unrelated 16:59 < aeiousomething> ok cool 16:59 < aeiousomething> that makes sense 17:27 < aeiousomething> fenn: what do you think of this https://www.ncbi.nlm.nih.gov/pubmed/18256750 17:35 < kanzure> huh, an old friend of mine (from like 2005?) composed the music for emerald cloud labs' trailer https://www.youtube.com/watch?v=DK2uhXYizEg 17:36 < aeiousomething> kanzure: are you not convinced we will evolve to superhumanity before 600 million years when the oceaons evaporate and plants die 17:37 < yashgaroth> no one is inherently allergic to peptides, and anyway noopept is small enough that I'd classify it as a small molecule drug rather than a peptide; if someone wanted to study inflammation with noopept there's plenty of easy blood assays to quantify inflammation 17:37 < yashgaroth> or just inject endotoxin into your bloodstream and see if you get smarter 17:40 < aeiousomething> there are articles 17:40 < aeiousomething> that noopept reversed the effects of cyclophosphamide 17:41 < aeiousomething> with the immune system 17:41 < aeiousomething> I was on steroids last year in a last ditch attempt by my doctors to "calm down my immune system" to prevent IgA from doing more damage 17:42 < aeiousomething> last thing i want to do at 33% kidney function is to take a drug that will accelerate it to 0 17:42 < aeiousomething> in a matter of weeks or months as opposed to years 17:42 < aeiousomething> because this is inevitable 17:46 < yashgaroth> regarding that study, fixing a broken car is different than installing a turbocharger, if their results are even to be believed; and if your kidneys are at risk of failing, don't be slamming down nootropics 17:46 < aeiousomething> fair 17:46 < aeiousomething> and I understand the turbocharger analogy 17:46 < aeiousomething> it is literally what I'm trying to avoid 17:46 < aeiousomething> while simultaneously trying to turbocharge my brain obviously 17:47 < aeiousomething> so this might just be a lost cause 17:47 < aeiousomething> the only reason I would investigate this is if I thought that my ADD is making worth risking death. 17:48 < aeiousomething> making it* 17:48 < yashgaroth> I find it an apt analogy for most biology research where the researchers break something and then fix it, then proceed to extrapolate wildly 17:48 < aeiousomething> yes I understand that in that scenario they introduced antigens 17:48 < aeiousomething> which will most definitely trigger an inflammatory response 17:48 < aeiousomething> of some sort .. which may have then be amplified by noopept 17:49 < aeiousomething> also this is in rats 17:50 < yashgaroth> expansion of antibody-producing cells isn't necessarily inflammation; and I'd be wary of research out of russia since that's where most noopept is manufactured, not that I'm bothered to check the researchers for possible links to noopept manufacturing operations etc 17:51 < aeiousomething> yes an untested nootropic supplement originating in russia 17:51 < aeiousomething> is probably not the thing I need right now 17:51 < yashgaroth> and I'd be wary of russian research in general, especially printed in a russian journal with an impact factor of <1 17:54 < yashgaroth> people injected way dumber stuff than noopept, there's some cocktail of pig brain polypeptides that's way more dangerous and potentially inflammatory than noopept; though if you're from the nootropic community you've probably heard more of it than I have 17:54 < aeiousomething> I'm not part of it 17:54 < aeiousomething> I don't discuss anything over there 17:54 < aeiousomething> it's just an entry point 17:54 < aeiousomething> for me to do the research I want to do on something 17:55 < aeiousomething> I am not into it at the tender age of early 30s to enhance my performance 17:55 < aeiousomething> mostly because I've found my ADD to be very corrosive to my attempts at leading a healthy normal lifestyle 17:56 < yashgaroth> what's your experience been with amphetamines 17:56 < aeiousomething> very bad 17:56 < aeiousomething> they raise my heartrate 17:56 < aeiousomething> which is a huge nono 17:57 < aeiousomething> and the dysphoria from the comedown was terrible 17:57 < aeiousomething> I've switched to modafinil when I had access to it living in india and it was a godsend 17:57 < aeiousomething> but I've moved out of India since then and now I'm helpless 17:59 < yashgaroth> yeah a lot of the good modafinil vendors have dried up in the past few years, though if you're close to mexico you can pick it up at a corner shop there 17:59 < aeiousomething> no I am from India, I can have a friend mail it to me quite literally 17:59 < yashgaroth> even better 17:59 < aeiousomething> but he's too afraid that the interpol is going to hunt him down and imprison him 18:01 < yashgaroth> an unreasonable fear, but not one he's likely to be reasoned out of 18:01 < aeiousomething> yep 18:01 < aeiousomething> not for the lack of trying 18:03 < yashgaroth> well if you're looking at noopept as an ADD treatment, I doubt it'd be effective; jrayhawk probably has some good advice on anti-inflammatory diets 18:04 < aeiousomething> thanks 18:36 -!- Guest71022 is now known as abetusk 20:01 -!- darsie [~kvirc@84-114-73-160.cable.dynamic.surfer.at] has quit [Ping timeout: 260 seconds] 20:09 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Quit: leaving] 20:10 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 20:10 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Client Quit] 20:11 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 20:13 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Client Quit] 20:14 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 20:15 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Client Quit] 20:16 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 20:23 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Quit: leaving] 20:23 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 20:24 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Client Quit] 20:25 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 20:28 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Client Quit] 20:29 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 21:04 -!- Urchin [~urchin@unaffiliated/urchin] has quit [Remote host closed the connection] 21:30 -!- yashgaroth [~ffffffff@2606:6000:ca84:b300:addb:18a2:a7bb:c99] has quit [Quit: Leaving] 21:55 -!- filipepe [uid362247@gateway/web/irccloud.com/x-tchfrmfhlimvmmwz] has joined ##hplusroadmap --- Log closed Sun Feb 09 00:00:33 2020