--- Log opened Sun Mar 22 00:00:29 2020 00:26 -!- hehelleshin [~talinck@98.29.27.253] has joined ##hplusroadmap 00:29 -!- helleshin [~talinck@98.29.27.253] has quit [Ping timeout: 264 seconds] 00:52 -!- helleshin [~talinck@98.29.27.253] has joined ##hplusroadmap 00:54 -!- Human_G33k [~HumanG33k@62.147.242.8] has joined ##hplusroadmap 00:54 -!- hehelleshin [~talinck@98.29.27.253] has quit [Ping timeout: 264 seconds] 00:57 -!- HumanGeek [~HumanG33k@62.147.242.8] has quit [Ping timeout: 264 seconds] 01:08 < nmz787> made an attempt at a vacuum control system, including vacuum and thermal sensor feedback, and vacuum valve control on reagent introduction via relay switched pneumatics: https://github.com/nmz787/vacuum/blob/master/main_system_control.py 01:16 -!- CRM114 [~urchin@unaffiliated/urchin] has joined ##hplusroadmap 01:19 -!- Urchin [~urchin@unaffiliated/urchin] has quit [Ping timeout: 240 seconds] 01:42 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 246 seconds] 02:09 < fenn> .title https://www.medrxiv.org/content/10.1101/2020.03.17.20037713v1 02:09 < saxo> A serological assay to detect SARS-CoV-2 seroconversion in humans | medRxiv 02:10 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 03:00 -!- Jay_Dugger [~Whickety@47.185.202.217] has quit [Ping timeout: 256 seconds] 03:21 -!- hehelleshin [~talinck@98.29.27.253] has joined ##hplusroadmap 03:24 -!- helleshin [~talinck@98.29.27.253] has quit [Ping timeout: 250 seconds] 03:43 -!- TC [~talinck@98.29.27.253] has joined ##hplusroadmap 03:44 -!- TC is now known as Guest97000 03:46 -!- hehelleshin [~talinck@98.29.27.253] has quit [Ping timeout: 246 seconds] 03:53 < fenn> .title https://www.nurx.com/coronavirus-testing/ 03:53 < saxo> COVID-19 At Home Test Kit - Nurx ™ 03:53 < fenn> probably booked solid for a while but might be worth looking into later at $181 03:55 < fenn> "at home" means you swab yourself, not run the PCR yourself 04:02 -!- CRM114 [~urchin@unaffiliated/urchin] has quit [Remote host closed the connection] 04:36 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:5421:50c2:d94a:eb] has joined ##hplusroadmap 05:00 < fenn> wow they built a hospital in 10 days in wuhan http://emag.medicalexpo.com/qa-behind-the-scenes-of-chinas-prefab-hospitals-against-coronavirus/ 05:00 < fenn> we should build everything like this 05:16 < nsh> -- 05:16 < nsh> To assess potential applications, Army scientists conducted an analysis of the Rydberg sensor's sensitivity to oscillating electric fields over an enormous range of frequencies—from 0 to 1012 Hertz. The results show that the Rydberg sensor can reliably detect signals over the entire spectrum and compare favorably with other established electric field sensor technologies, such as electro-optic crystals and dipole antenna-coupled passive electronics. 05:16 < nsh> "Quantum mechanics allows us to know the sensor calibration and ultimate performance to a very high degree, and it's identical for every sensor," Meyer said. "This result is an important step in determining how this system could be used in the field." 05:16 < nsh> -- https://phys.org/news/2020-03-scientists-quantum-sensor-entire-radio.amp 05:16 < nsh> -> https://sci-hub.tw/https://iopscience.iop.org/article/10.1088/1361-6455/ab6051 05:29 < TMA> fenn: with 30 or 50 years write-off period and 5 to 10 years of useful service life it makes little economic sense 05:29 < fenn> what's a write-off period? 05:31 < fenn> just because something is quick to assemble doesn't mean it will be quick to fall apart 05:31 < fenn> however, even if it does fall apart, it will be quick to replace 05:31 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 260 seconds] 05:32 < fenn> it's a low density construction method as you're limited to realistically 2 or 3 floors 05:32 < TMA> fenn: I need to find the proper terms, English is not my native language 05:32 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 05:34 < TMA> In income tax calculation, a write-off is the itemized deduction of an item's value from a person's taxable income. [https://en.wikipedia.org/wiki/Write-off] 05:34 -!- spaceangel [~spaceange@ip-89-177-23-46.net.upcbroadband.cz] has joined ##hplusroadmap 05:35 < TMA> fenn: you cannot deduce the full amount of the expense for bigger investments legally 05:36 < fenn> if the building depreciates to $0 value in 10 years, isn't that its "write-off period"? 05:38 < TMA> you can still recognize only one third (or one fifth) of the cost as an tax-reducing expense by then 05:40 < fenn> it's probably still worth it, because of the huge drop in labor costs 05:41 < fenn> also you're not sitting on real estate for years during the construction 05:41 < fenn> anyway something like building a hospital in 10 days could never happen in the USA, even with all the technology in the world 05:42 < TMA> neither here in the czech republic 05:43 < TMA> only the permit will take three to five years if everything goes well 05:43 < fenn> wanna go to mars? 05:43 < fenn> this planet's all colonized 05:45 -!- jenelizabeth [~jenelizab@85.203.44.214] has quit [Ping timeout: 256 seconds] 05:45 < TMA> I think I am too sickly to go to Mars. But yes, from time to time, I repeat the sentence from Futurama: "I don't want to live on this planet anymore." 05:47 < juri_> 3D print a new shell, THEN explore the stars. 05:54 < fltrz> TMA, in Belgium, they suspended the permit requirements for hospitals to build container expansions on parking lots, land, near the hospital 05:54 < fltrz> its a pure formality 05:57 < TMA> fltrz: that sounds like a "temporary" measure that is covid-19 related 05:59 < fltrz> TMA, right 05:59 -!- filipepe [uid362247@gateway/web/irccloud.com/x-nqzlynfptpgzpskg] has joined ##hplusroadmap 05:59 -!- jenelizabeth [~jenelizab@cpc155793-brmb11-2-0-cust474.1-3.cable.virginm.net] has joined ##hplusroadmap 06:00 < fltrz> also, I assume the hospitals are the biggest beneficiaries of these tight rules and regulations: they prevent competig 06:00 < fltrz> *competing hospitals to be built, draining their labor force 06:01 < fltrz> so it looks more like the typical pay-to-play payola lover setup 06:01 < fltrz> at least to me 06:45 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Ping timeout: 256 seconds] 07:56 -!- Jay_Dugger [~Whickety@47.185.202.217] has joined ##hplusroadmap 07:56 < Jay_Dugger> Hello, everyone. 07:56 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 246 seconds] 07:57 < fenn> good $time_of_day to you too 07:57 -!- hehelleshin [~talinck@98.29.27.253] has joined ##hplusroadmap 07:59 < kanzure> greeting protocol completed 08:00 -!- Guest97000 [~talinck@98.29.27.253] has quit [Ping timeout: 240 seconds] 08:02 -!- yashgaroth [~ffffffff@172.58.19.145] has joined ##hplusroadmap 08:18 < lsneff> Whoa, folding@home got to 470 petaflops a few days ago 08:21 < lsneff> Would be cool if msft and sony started deploying clients to xbox ones and ps4s 08:23 -!- CryptoDavid [uid14990@gateway/web/irccloud.com/x-wmbhebdumwhvjebu] has joined ##hplusroadmap 08:24 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 08:42 < fltrz> I'm unfolding TP at home for longevity 08:43 < fltrz> if I had a GPU to write home about I would contribute to the folding at home 08:53 < lsneff> It's really quite inspiring seeing all the computing power being dedicated to this. 08:53 < lsneff> I bet some larger cloud companies will start spinning up servers to work on it soon. 09:14 -!- spaceangel [~spaceange@ip-89-177-23-46.net.upcbroadband.cz] has quit [Ping timeout: 256 seconds] 09:18 < fenn> .wik ionophore 09:18 < saxo> "An ionophore is a chemical species that reversibly binds ions. Many ionophores are lipid-soluble entities that transport ions across a cell membrane. Ionophore means 'ion carrier' as these compounds catalyze ion transport across hydrophobic membranes such as liquid [...]" - https://en.wikipedia.org/wiki/Ionophore 09:19 -!- spaceangel [~spaceange@ip-89-177-23-46.net.upcbroadband.cz] has joined ##hplusroadmap 09:24 < fenn> quercetin, EGCG (green tea extract), chloroquine, and possibly macrolide antibiotics (zithromax, erythromycin), are zinc ionophores 09:25 < fenn> this video goes into the science about hydroxychloroquine and covid-19 http://youtu.be/vE4_LsftNKM 09:26 < fenn> (it has a bad title) 09:27 < fenn> MedCram coronavirus update 35 09:33 < archels_> I checked yesterday but could not find any place that would sell me chloroquine 09:33 < archels_> (not sure if it would be morally acceptable to buy some for personal stock right now anyway) 09:34 < fenn> surely you can get quercetin, egcg, and zinc 09:34 < fenn> apparently CoQ10 is a zinc ionophore too? (maybe?) 09:34 < lsneff> fenn: Do you think it's apparent effectiveness has to do with it being a zinc ionophore? 09:34 < lsneff> *its 09:41 < archels_> zinc ✓ 09:41 < fenn> i'm not sure why MedCram jumped to that conclusion 09:42 < fenn> zithromax improved outcomes when given in combination with hydroxychloroquine to covid-19 patients 09:42 < fenn> 5 days ago (when the video was posted) it may have been just an idea... i'll have to watch the rest of their videos 09:43 < fenn> a commenter says quercetin raises cytokine levels and therefore we should have caution as it might contribute to the cytokine storm 09:47 < fenn> archels they're common dietary supplements in the category of: polyphenols, flavonoids, green tea extract, kale extract, red onion 09:47 < fenn> i think beef heart is high in coq10 09:49 < fenn> .wik ubiquinol 09:49 < saxo> "Ubiquinol is an electron-rich (reduced) form of coenzyme Q10. / The natural ubiquinol form of coenzyme Q10 is 2,3-dimethoxy-5-methyl-6-poly prenyl-1,4-benzoquinol, where the polyprenylated side-chain is 9-10 units long in mammals." - https://en.wikipedia.org/wiki/Ubiquinol 09:58 -!- filipepe [uid362247@gateway/web/irccloud.com/x-nqzlynfptpgzpskg] has quit [Quit: Connection closed for inactivity] 09:58 < fenn> Cooking by frying reduces CoQ10 content by 14–32% 10:06 -!- filipepe [uid362247@gateway/web/irccloud.com/x-frgwbswkxlzxxwub] has joined ##hplusroadmap 10:14 < fenn> malaria in indonesia and malaysia has become resistant to chloroquine 10:15 < fenn> so life is probably gonna take a big dump on them in the next month 10:15 -!- dr-orlovsky [~dr-orlovs@xdsl-188-155-161-135.adslplus.ch] has joined ##hplusroadmap 10:17 < fenn> hello orlovsky 10:24 < dr-orlovsky> Hi! 10:36 -!- dr-orlovsky [~dr-orlovs@xdsl-188-155-161-135.adslplus.ch] has quit [Quit: My MacBook has gone to sleep. ZZZzzz…] 10:38 -!- urkk_ [~urkk@144.243.17.95.dynamic.jazztel.es] has joined ##hplusroadmap 10:38 -!- urkk [~urkk@119.133.239.188.dynamic.jazztel.es] has quit [Ping timeout: 246 seconds] 10:48 -!- dr-orlovsky [~dr-orlovs@xdsl-188-155-161-135.adslplus.ch] has joined ##hplusroadmap 10:55 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 246 seconds] 11:09 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 11:11 -!- dr-orlovsky [~dr-orlovs@xdsl-188-155-161-135.adslplus.ch] has quit [Quit: My MacBook has gone to sleep. 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That’s because even if you try to use CRISPR to perform gene correction - meaning that you aim to exploit the Homologous DNA Directed Repair to correct the target - most of the events of DSBs ( double strand break ) are repaired via the error prone Non Homologous End Joining (NHEJ) which results in insertion or deletion at the targe 13:58 < nsh> t site. These are colloquially called “ scars “ and as the term suggests they are evidence that a DNA lesion occurred at that site and of course compared to an untreated sample you can exclude the lesions that are a “ natural/ stochastic “ event. 13:58 < nsh> -- https://www.quora.com/Does-CRISPR-Cas9-leave-any-trace-that-it-has-been-used-in-an-organism 13:58 < nsh> feels like this would have been pointed out by more reputable sources if there were any evidence 14:10 < fltrz> nsh, seems like if there were a scientific article source for that claim, the authors would have code to detect such crispr artifacts, which one could then use to verify the claim made 14:12 < nsh> the claim is being made a martial arts and traditional chinese medicine enthusiast and 'radical iconoclast' so pretty much bullshit probably 14:12 < nsh> but it's an interesting question 14:12 < nsh> ( https://www.youtube.com/watch?v=O1Vofr7IpY8 ) 14:12 < nsh> the guy doesn't seem stupid but he clearly doesn't know the limits of his knowledge 14:12 < jrayhawk> FRTs would presumably be pretty easy to spot in the published sequences 14:13 < jrayhawk> and yeah, those FRTs would almost assuredly be pointed out by more reputable sources 14:13 < nsh> i'm trying to reason with this troofer idiot on facebook because these people are risking lives right now and i have no time for their credulous idiocy but it's very much an uphill struggle 14:13 * nsh nods 14:14 < fltrz> what is a troofer btw? 14:17 < jrayhawk> so i guess the solution is to ask for the location of the FRT scars in any of the sequenced variants and call them bullshitters if they can't provide that basic information 14:18 < nsh> 9/11 truther types whose hobby is pumping their ego by believing anything they hear/read in the alternative clique of their choosing and being proud of seeing through the ignorance of the mainstream narrative 14:18 < nsh> jrayhawk, sadly this would be above the heads of the people who'll believe the claims 14:19 < nsh> that's why it's so difficult countering these people, they clam up at the first sign of anything that threatens their ego-coddling alternative belief system 14:19 < nsh> and just respond emotionally 14:19 < nsh> "you can't reason people out of things they didn't reason themselves into" 14:19 < nsh> but you can sometimes berate them enough that they start to question their wisdom 14:23 < fltrz> nsh oh I see so its "truther" written like their pronounced somewhat 14:24 -!- yashgaroth_ [~ffffffff@2607:fb90:4afe:3b5a:e577:bb4f:c559:64e9] has joined ##hplusroadmap 14:24 < nsh> diminutive misspelling aye 14:24 < fltrz> does anyone have some good syllabus type material on how the immune system works? I am specifically trying to understand the trial and error system for generating antibodies 14:26 -!- yashgaroth [~ffffffff@172.58.19.145] has quit [Ping timeout: 250 seconds] 14:27 < fltrz> how do the cells that make antibodies generate variations of antibodies? is it actively varying the DNA that codes for antibodies? how does it limit this variation to that part of the genome that codes for antibodies? seems a bit unlikely 14:27 < fltrz> so I think it happens post translation, with modification of RNA sequences 14:28 -!- filipepe [uid362247@gateway/web/irccloud.com/x-frgwbswkxlzxxwub] has quit [Quit: Connection closed for inactivity] 14:28 < fltrz> this might also explain the immunity duration somewhat: if that trial and error modified RNA lingers around for a year or so 14:29 < fltrz> that still makes me wonder how exactly the RNA variation is implemented, and how the cell gets feedback on the utility of its variation 14:30 < fltrz> ^ is there any text or syllabus or book, that delves into this, and has toy models? 14:31 < jrayhawk> https://libgen.is/search.php?req=topicid156 you can probably do some searches in here 14:31 < fltrz> jrayhawk, great! thanks, how did you get that topicID? 14:31 < jrayhawk> all the big foundational textbooks in there, such as abbas, janeway, or paul 14:32 < jrayhawk> that's just libgen's immunology topic 14:32 < fltrz> this one looks promising https://libgen.is/book/index.php?md5=3D1D09D91CB695BC5D35E3ED867BCD2B 14:33 -!- darsie [~kvirc@84-114-73-160.cable.dynamic.surfer.at] has quit [Ping timeout: 250 seconds] 14:35 < fltrz> jrayhawk, thank you very much 14:36 < fltrz> jrayhawk, still don't see how you go from topic to topicID? is there a list of topics? 14:36 < jrayhawk> On every page, yeah. 14:36 < fltrz> jrayhawk, you mean on the page of a specific book? 14:37 < jrayhawk> curl https://libgen.is/ | grep -i immunology 14:39 < fltrz> oh I see 14:57 -!- HEx1 [~HEx@hexwab.plus.com] has quit [Remote host closed the connection] 15:10 -!- spaceangel [~spaceange@ip-89-177-23-46.net.upcbroadband.cz] has quit [Ping timeout: 265 seconds] 15:14 -!- filipepe [uid362247@gateway/web/irccloud.com/x-ujvlghvbboxvxrly] has joined ##hplusroadmap 15:49 -!- agile_prg [~nyb@c-73-126-2-192.hsd1.ma.comcast.net] has quit [Ping timeout: 256 seconds] 15:59 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Quit: ORGANS IN MAINS] 16:08 -!- _0bitcount [~Big_Byte@90.162.105.206] has quit [Quit: Leaving] 16:45 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 250 seconds] 16:53 -!- dr-orlovsky [~dr-orlovs@xdsl-188-155-161-135.adslplus.ch] has quit [Quit: My MacBook has gone to sleep. 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