--- Log opened Fri Apr 03 00:00:41 2020 00:12 -!- helleshin [~talinck@98.29.27.253] has joined ##hplusroadmap 00:13 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:147b:bb49:5c9b:67f5] has joined ##hplusroadmap 00:14 -!- TC [~talinck@98.29.27.253] has joined ##hplusroadmap 00:15 -!- TC is now known as Guest52316 00:15 -!- hehelleshin [~talinck@98.29.27.253] has quit [Ping timeout: 264 seconds] 00:17 -!- helleshin [~talinck@98.29.27.253] has quit [Ping timeout: 258 seconds] 00:18 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:147b:bb49:5c9b:67f5] has quit [Ping timeout: 246 seconds] 00:54 -!- Codaraxis [~Codaraxis@ip68-5-175-208.oc.oc.cox.net] has quit [Ping timeout: 240 seconds] 00:56 -!- Codaraxis [~Codaraxis@ip68-5-175-208.oc.oc.cox.net] has joined ##hplusroadmap 01:00 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:147b:bb49:5c9b:67f5] has joined ##hplusroadmap 01:18 -!- darsie [~kvirc@84-114-73-160.cable.dynamic.surfer.at] has joined ##hplusroadmap 01:19 -!- helleshin [~talinck@98.29.27.253] has joined 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mauz555 [~mauz555@2a01:e0a:56d:9090:147b:bb49:5c9b:67f5] has joined ##hplusroadmap 06:44 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:147b:bb49:5c9b:67f5] has quit [Ping timeout: 272 seconds] 07:04 < lsneff> https://www.cg.tuwien.ac.at/research/publications/2018/koch_bernhard_2018-1/koch_bernhard_2018-1-video.mp4 07:04 < lsneff> https://www.cg.tuwien.ac.at/cellview/ 07:04 < kanzure> .title 07:04 < saxo> cellVIEW 07:04 < kanzure> oh 07:05 -!- Human_G33k [~HumanG33k@62.147.242.8] has quit [Ping timeout: 258 seconds] 07:11 -!- HEx1 [~HEx@hexwab.plus.com] has quit [Remote host closed the connection] 07:12 -!- FourFire [33af727d@125.51-175-114.customer.lyse.net] has joined ##hplusroadmap 07:13 < FourFire> What projects are you currently working on/recently finished with kanzure? 07:18 < kanzure> FourFire: https://www.coindesk.com/caitlin-longs-wyoming-crypto-bank-announces-c-suite-including-bitcoin-core-dev 07:18 < kanzure> running a bank 07:21 < FourFire> Now that's neat 07:22 < FourFire> Any longterm transhumanist projects you plan on funding, or that you could recommend? 07:28 < kanzure> well, i still think that germline genetic engineeirng is under utilized 07:32 < FourFire> naturally. 07:33 < FourFire> I've heard that there's a bottleneck in researching more advanced delivery methods due to an oligarchy of retrovirus producers, but germline is not done using viral vectors 07:35 -!- yashgaroth [~ffffffff@172.58.19.12] has joined ##hplusroadmap 07:43 < kanzure> an oligarchy of retrovirus producers... making viruses isn't that hard. 07:51 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:147b:bb49:5c9b:67f5] has joined ##hplusroadmap 07:52 -!- filipepe [uid362247@gateway/web/irccloud.com/x-uijoepeurzspkroa] has joined ##hplusroadmap 07:55 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:147b:bb49:5c9b:67f5] has quit [Ping timeout: 246 seconds] 08:10 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 272 seconds] 08:12 -!- dr-orlovsky 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[~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 258 seconds] 15:07 -!- darsie [~kvirc@84-114-73-160.cable.dynamic.surfer.at] has quit [Ping timeout: 264 seconds] 15:07 -!- Urchin [~urchin@unaffiliated/urchin] has quit [Remote host closed the connection] 15:25 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:147b:bb49:5c9b:67f5] has joined ##hplusroadmap 15:27 -!- hehelleshin [~talinck@98.29.27.253] has joined ##hplusroadmap 15:31 -!- Guest63904 [~talinck@98.29.27.253] has quit [Ping timeout: 258 seconds] 15:34 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:147b:bb49:5c9b:67f5] has quit [Remote host closed the connection] 15:34 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:147b:bb49:5c9b:67f5] has joined ##hplusroadmap 15:40 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:147b:bb49:5c9b:67f5] has quit [Ping timeout: 265 seconds] 16:21 -!- filipepe [uid362247@gateway/web/irccloud.com/x-uijoepeurzspkroa] has quit [Quit: Connection closed for inactivity] 16:38 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 16:45 -!- HEx1 [~HEx@hexwab.plus.com] has joined ##hplusroadmap 16:47 -!- filipepe [uid362247@gateway/web/irccloud.com/x-ualuvjjlkdailfnl] has joined ##hplusroadmap 17:22 -!- HEx1 [~HEx@hexwab.plus.com] has quit [Ping timeout: 265 seconds] 17:41 -!- rodarmor [sid210835@gateway/web/irccloud.com/x-uzntgrefkdfhngsx] has quit [Ping timeout: 272 seconds] 17:44 -!- rodarmor [sid210835@gateway/web/irccloud.com/x-unzvjwvvprhrbggb] has joined ##hplusroadmap 18:16 < kanzure> this channel should be less boring, i know you guys are all home with nothing better to do than post awesome shit 18:17 < kanzure> https://reperiendi.wordpress.com/2020/04/03/how-i-recovered-over-300k-of-bitcoin/ 18:17 < kanzure> .tw https://twitter.com/The_Lagrangian/status/1245924568922877963 18:17 < saxo> Shipping container filled with vapor phase hydrogen peroxide sterilizes 80k N95 masks/day. Very cool stuff https://twitter.com/JoeCurtatone/status/1245806975096631298 (@The_Lagrangian) 18:18 < kanzure> .tw https://twitter.com/bewersdorflab/status/1239247844223135749 18:18 < saxo> Our most recent super-resolution development is now on bioRxiv: pan-ExM generates images which look remarkably similar to FIB-SEM but require just a normal confocal microscope. (1/2) #panExM @OnsMSaad1 / https://www.biorxiv.org/content/10.1101/2020.03.13.989756v1 (@bewersdorflab) 18:21 < kanzure> "SpaceX is building a factory to churn out a Starship—the most powerful and most advanced launch vehicle in history, capable of taking 150 tons to Mars—every 72 hours. For $5M/each." 18:35 < fenn> i've been busy elsewhere 18:35 < fenn> .title http://youtu.be/wFXQ5SRCy74 18:35 < saxo> SpaceX's Starship SN3 prototype fails cryogenic proof test - YouTube 18:35 < fenn> i'm bullish on starship :D 18:36 < fenn> https://www.spacex.com/sites/spacex/files/starship_users_guide_v1.pdf 18:38 < fenn> this much tonnage into orbit will completely upend the space industry and obliterate existing players as their technology and expertise will become mostly unnecessary 18:41 < fenn> when you can throw extra payload mass at a problem, you don't need to spend millions or hundreds of millions on making it lighter 18:42 < fenn> it will not be surprising to watch the death throes of boeing and dick shelby's attempts to stop spacex by legal means 18:43 < fenn> like suddenly we will be super concerned about sonic boom noises over the ocean or something equally stupid 18:51 < fenn> why has nobody been talking about https://en.wikipedia.org/wiki/DRACO_(antiviral) 18:53 -!- TC [~talinck@98.29.27.253] has joined ##hplusroadmap 18:54 -!- TC is now known as Guest70634 18:57 -!- hehelleshin [~talinck@98.29.27.253] has quit [Ping timeout: 265 seconds] 19:27 -!- mrdata [~mrdata@unaffiliated/mrdata] has quit [Ping timeout: 250 seconds] 19:27 < kanzure> .title https://www.biorxiv.org/content/10.1101/2020.02.27.968883v1 19:28 < saxo> Molecular goniometers for single-particle cryo-EM of DNA-binding proteins | bioRxiv 19:28 < kanzure> .tw https://twitter.com/jsantoyo/status/1230609529471197191 19:28 < saxo> CoolMPS™: Advanced massively parallel sequencing using antibodies specific to each natural nucleobase. / https://www.biorxiv.org/content/10.1101/2020.02.19.953307v1 (@jsantoyo) 19:30 -!- mrdata [~mrdata@unaffiliated/mrdata] has joined ##hplusroadmap 19:31 < kanzure> "Light microscopy based approach for mapping connectivity with molecular specificity" https://www.biorxiv.org/content/10.1101/2020.02.24.963538v1 https://twitter.com/fshen11/status/1232329550350057472 19:31 < fenn> Firefly plans to build the Genesis lander at one of the company’s facilities near Austin https://spaceflightnow.com/2020/04/01/in-parallel-with-rocket-development-firefly-offers-details-on-lunar-lander-initiative/ 19:31 < fenn> israel aerospace industries beresheet #2 19:31 < kanzure> "Automated continuous evolution of proteins in vivo" https://www.biorxiv.org/content/10.1101/2020.02.21.960328v1 19:31 -!- filipepe [uid362247@gateway/web/irccloud.com/x-ualuvjjlkdailfnl] has quit [Quit: Connection closed for inactivity] 19:33 < kanzure> https://andrewgyork.github.io/stimulated_emission_imaging/ 19:34 < kanzure> "Recording the age of RNA with deamination" https://www.biorxiv.org/content/10.1101/2020.02.08.939983v1 19:34 < kanzure> .tw https://twitter.com/aliceyting/status/1226943387569250309 19:34 < saxo> From Fei Chen @broadinstitute: ticker tape technology uses ADAR-editable RNA barcodes to record the age of individual RNAs within living cells. Age of each RNA in population can subsequently be read out by scRNA-seq. Temporal resolution ~3hr. Super clever! / https://tinyurl.com/qoldhoh (@aliceyting) 19:38 < kanzure> "Optically-controlled living electrodes with long-projecting axon tracts for a synaptic brain-machine interface" https://www.biorxiv.org/content/10.1101/333526v1 19:39 < kanzure> "... we have developed the first “living electrodes” comprised of implantable axonal tracts protected within soft hydrogel cylinders to enable biologically-mediated monitoring and modulation of brain activity. Here we demonstrate the controlled fabrication, rapid axonal outgrowth, reproducible cytoarchitecture, and axonal conduction of these engineered constructs in vitro. We also present ... 19:39 < kanzure> ...simultaneous optical stimulation and recording of neuronal activity in vitro, transplantation in rat cortex, and their survival, integration, and activity over time in vivo as a proof-of-concept for this neural interface paradigm. The creation and functional validation of living electrodes is a critical step towards developing a new class of neural interfaces using targeted, synaptic-based ... 19:39 < kanzure> ...integration with native circuitry." 19:39 < kanzure> https://neo.life/2018/10/the-next-brain-implant-is-a-real-live-wire/ 19:41 < kanzure> "Time cells in the human hippocampus and entorhinal cortex support episodic memory" https://www.biorxiv.org/content/10.1101/2020.02.03.932749v1 19:48 < kanzure> "BAcTrace a new tool for retrograde tracing of neuronal circuits" https://www.biorxiv.org/content/10.1101/2020.01.24.918656v1 19:48 < kanzure> "HySyn: A genetically-encoded synthetic synapse to rewire neural circuits in vivo" https://www.biorxiv.org/content/10.1101/2020.01.27.922203v1 19:49 < kanzure> "Achitecting discovery: A model for how engineers can help invent tools for neuroscience" http://syntheticneurobiology.org/PDFs/19.05.boyden.pdf 20:19 < kanzure> https://www.zerohedge.com/health/its-time-track-fdas-death-toll 20:19 < kanzure> "Dr. Kessler declared in 1992: "If members of our society were empowered to make their own decisions…then the whole rationale for the [FDA] would cease to exist." Kessler derided "freedom of choice" as an illusion unless people are presented only with government-approved choices. But the FDA “liberated” people by shielding them from information, devices, and drugs that could have saved ... 20:19 < kanzure> ...their lives." 20:23 < kanzure> "The FDA even suppressed medical textbooks as part of its attempt to restrict what Americans learned about new treatments. In 1992, the FDA cracked down on a company for distributing, for free, portions of Cancer, Principles and Practice of Oncology. In 1993, the FDA stopped a pharmaceutical company from distributing free copies of The Chemotherapy Source Book—even though the company had ... 20:23 < kanzure> ...already received FDA approval to give away thousands of copies. The FDA claimed that when a drug company gives doctors free textbooks that mention an off-label use of its products the drugs become subject to seizure." 20:45 -!- yashgaroth [~ffffffff@172.58.19.12] has quit [Quit: Leaving] 21:12 -!- helleshin [~talinck@98.29.27.253] has joined ##hplusroadmap 21:14 -!- Guest70634 [~talinck@98.29.27.253] has quit [Ping timeout: 256 seconds] 21:33 -!- hehelleshin [~talinck@98.29.27.253] has joined ##hplusroadmap 21:37 -!- helleshin [~talinck@98.29.27.253] has quit [Ping timeout: 265 seconds] 22:46 -!- CryptoDavid [uid14990@gateway/web/irccloud.com/x-nkmhnwzdtaduouzs] has quit [Quit: Connection closed for inactivity] 23:21 -!- helleshin [~talinck@98.29.27.253] has joined ##hplusroadmap 23:23 -!- hehelleshin [~talinck@98.29.27.253] has quit [Ping timeout: 260 seconds] 23:56 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Quit: leaving] --- Log closed Sat Apr 04 00:00:42 2020