--- Log opened Fri Jun 19 00:00:54 2020
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10:31 < kanzure> "A gene called "ARHGAP11B" that is found in humans and in no other animal has long been thought to be at least partially responsible for humans having an extremely large brain with a high degree of cortical folding. All other primates have a similar gene, but a point mutation happened between 500,000 and 1.5 million years ago and a single C was changed to a G in the human version. In ...
10:31 < kanzure> ...yesterday's issue of the journal Science researchers report than when Genetic engineering was used to insert the human gene ARHGAP11B into the fertilized egg of a small monkey (a marmoset ) the result was a fetus with about 45% more neurons in the neocortex than a normal fetus and 3 times as many glial cells. A marmoset gestation period is 152 days but because it had a human gene in it the ...
10:31 < kanzure> ...fetus was aborted after just 101 days due to ethical guidelines, so it's not known how such an animal's behavior would change if it was allowed to come to term."
10:32 < kanzure> https://science.sciencemag.org/content/early/2020/06/17/science.abb2401
10:33 < L29Ah> in the next episode: the chinese have reproduced the experiment and teached the monkey to build iphones
10:33 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=98ed3b55 Bryan Bishop: add ARHGAP11B >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
10:35 < kanzure> that file will be 8 years old on the 13th
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10:39 < Llamamoe> kanzure: Someone living in the US could probably replicate the experiment and let it be born. Hope nobody does though.
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10:40 < kanzure> i think we should be more encouraging of these things
10:40 < kanzure> and help them treat the monkeys nicely.
10:40 < kanzure> if you push it away then they just do whatever in some weird country.
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10:58 < Llamamoe> I mean... idk.
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11:43 < jrayhawk_> L29Ah: oof, that's distressingly poignant joke
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11:48 < jrayhawk> the "45%" number is probably understimating the eventual effects; non-human terrestrial animal mothers, fetuses, and infants are relatively EFA-limited for encephalization
11:49 < jrayhawk> underestimating
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12:04 < jrayhawk> https://www.slideshare.net/ancestralhealth/ahs13-will-lassek-md https://www.omgwallhack.org/home/jrayhawk/vid/ahs/AHS13_Will_Lassek_MD_Why_Women_Need_Fat_Three_Evolutionary_Puzzles.mp4
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12:18 < Llamamoe> jrayhawk: EFA ?
12:19 < L29Ah> essential fatty acids i suppose
12:19 < L29Ah> n-3 and n-6 polyunsaturated ones
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12:22 < jrayhawk> Long-chain ones in particular, since human elongase and desaturase activity is pretty abysmal.
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14:47 < fenn> overestimating?
14:48 < fenn> should be easy enough to fix EFA metabolism
14:49 < fenn> add a bit of culture and they'll be growing coffee beans in no time
14:49 < fenn> fixing human omega-6 omega-3 stuff should be on the agenda anyway
14:51 < fenn> the super marmosets would get genocided immediately because "they took er jerbs"
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18:22 < kanzure> "the kevin bird guy is the founder of the grad student union pushing for Steve's removal, it's all falling in to place now"
18:23 < kanzure> "the “anti-eugenic because disabilities are interesting” conversation is almost tautologically dominated by people with interesting disabilities. The autistic people saying they wouldn’t trade their life for a neurotypical one aren’t the severe cases who can’t communicate or who have debilitating or injurious compulsive behaviors. The stories we hear about blind or deaf people are ...
18:23 < kanzure> ...largely the ones who overcame this disability in a notable way and now it’s a positive defining trait for them."
18:23 < kanzure> "I thought you were proud to be a hologram?" (to a hologram that has gained a physical form) "that's only because I had to be one!"F
18:25 < kanzure> i wonder if conference organizers would let someone disabled and suicidal speak
18:25 < kanzure> like even in Q&A providing a perspective
18:25 < kanzure> (well, i guess sufficiently-disabled people have a lot of friction towards getting to that point anyway- this is probably why it doesn't happen)
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23:27 < L29Ah> well we have whole cultures of people who live by the sea or ocean and eat a lot of fish, but they aren't exactly superhumans
23:29 < L29Ah> https://www.undercurrentnews.com/2019/10/18/scientific-review-shows-mothers-eating-seafood-gave-children-7-7-iq-bump/ nice but not spectacular
--- Log closed Sat Jun 20 00:00:55 2020