--- Log opened Mon Nov 09 00:00:11 2020
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09:50 < lsneff> .t https://www.kernel.com/hello-humanity#Sound-ID
09:50 < saxo> Kernel: Hello Humanity
09:52 < superkuh> It's weird to hear MEG called cheap but I guess nitrogen vacancy sensors have replaced the old superconductor stuff?
09:56 < lsneff> DSP has gotten very advanced in the last decade or two, but I wonder how they're doing it without a passively or actively shielded room.
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10:25 < kanzure> so "time-domain near-infrared spectroscopy (TD-NIRS) system" and "a collection of alkali vapor sensors (optically pumped magnetometers, OPMs, OP-MEG)" magnetoencephalography stuff
10:50 < fltrz> they just use high enough channel count: "A 48-module, full-head-coverage Flux system (as illustrated in Fig. 14) provides 720 channels of magnetometer data and operates without a multilayer, sealed-door magnetically-shielded room. The large number of channels provided by Flux allows for high-performance noise rejection in environments with head motion and extensive audio-visual peripherals."
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12:12 < lsneff> Ah, that makes sense. I was thinking they were using lock-in amplifiers or something along those lines.
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13:13 < lsneff> .t https://solidproject.org/
13:13 < saxo> Home · Solid
13:15 < L29Ah> >  when you log into any web site, instead of having to log in with the usual 'f' and 'g', etc, blue buttons, and then be tracked by Facebook, Google, or some other large social network, instead you can log in with any Solid provider you trust, and that won't track you.
13:15 < L29Ah> lol
13:18 < fenn> what happened to OAuth, OpenID, etc
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16:56 < kanzure> .title https://www.preprints.org/manuscript/202005.0118/v1
16:56 < saxo> The Mechanical Basis of Memory - the MeshCODE Theory[v1] | Preprints
16:58 < kanzure> not hameroff, at least...
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19:17 < kanzure> .wik talin (protein)
19:17 < saxo> "Talin is a high-molecular-weight cytoskeletal protein concentrated at regions of cell–substratum contact and, in lymphocytes, at cell–cell contacts.  Discovered in 1983 by Keith Burridge and colleagues, talin is a ubiquitous cytosolic protein that is found in high [...]" - https://en.wikipedia.org/wiki/Talin_(protein)
19:19 < kanzure> "Force-dependent binding constants" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007008/
19:21 < kanzure> "Talin as a mechanosensitive signaling hub" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219721/
19:22 < kanzure> "Cell adhesion to the extracellular matrix (ECM), mediated by transmembrane receptors of the integrin family, is exquisitely sensitive to biochemical, structural, and mechanical features of the ECM. Talin is a cytoplasmic protein consisting of a globular head domain and a series of α-helical bundles that form its long rod domain. Talin binds to the cytoplasmic domain of integrin β-subunits, ...
19:22 < kanzure> ...activates integrins, couples them to the actin cytoskeleton, and regulates integrin signaling. Recent evidence suggests switch-like behavior of the helix bundles that make up the talin rod domains, where individual domains open at different tension levels, exerting positive or negative effects on different protein interactions. These results lead us to propose that talin functions as a ...
19:22 < kanzure> ...mechanosensitive signaling hub that integrates multiple extracellular and intracellular inputs to define a major axis of adhesion signaling."
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--- Log closed Tue Nov 10 00:00:12 2020