--- Log opened Tue Nov 10 00:00:12 2020 00:40 -!- allkindsofscum [~kvirc@84-113-55-200.cable.dynamic.surfer.at] has joined ##hplusroadmap 00:40 -!- spaceangel [~spaceange@ip-89-177-56-55.net.upcbroadband.cz] has quit [Remote host closed the connection] 02:03 -!- filipepe [uid362247@gateway/web/irccloud.com/x-zgpmvmpgvarhxvds] has joined ##hplusroadmap 02:24 -!- yonkunas [uid403824@gateway/web/irccloud.com/x-xjlgfrxtqkehpyto] has quit [Ping timeout: 260 seconds] 02:25 -!- nickjohnson [sid789@gateway/web/irccloud.com/x-rofdnbcteltmkvsl] has quit [Ping timeout: 260 seconds] 02:26 -!- yonkunas [uid403824@gateway/web/irccloud.com/x-xdpcmhfiptrutsit] has joined ##hplusroadmap 02:26 -!- pointfree [sid204397@gateway/web/irccloud.com/x-cjqbmupqcqxrjreh] has quit [Ping timeout: 272 seconds] 02:26 -!- nickjohnson [sid789@gateway/web/irccloud.com/x-yzxjfqouiyutfexj] has joined ##hplusroadmap 02:27 -!- cannedprimates_ [sid16585@gateway/web/irccloud.com/x-ydhhzregdoeestks] has quit [Read error: Connection reset by peer] 02:28 -!- pointfree [sid204397@gateway/web/irccloud.com/x-wyzowclsjqxkkqrx] has joined ##hplusroadmap 02:28 -!- cannedprimates_ [sid16585@gateway/web/irccloud.com/x-fnhnzqeinkakkzzz] has joined ##hplusroadmap 04:13 -!- filipepe [uid362247@gateway/web/irccloud.com/x-zgpmvmpgvarhxvds] has quit [Quit: Connection closed for inactivity] 05:47 -!- CryptoDavid [uid14990@gateway/web/irccloud.com/x-frptknnkpiqgrmnl] has joined ##hplusroadmap 06:48 < kanzure> .tw https://twitter.com/kanzure/status/1326174563428917249 06:48 < saxo> Here's a manuscript describing a possible mechanical basis of biological memory using mechanosensitive protein switches https://www.preprints.org/manuscript/202005.0118/v1 cc @bengoult @KennethHayworth (@kanzure) 06:49 < kanzure> perhaps looking at talin molecular evolution across species would reveal something. but somehow i doubt it, any sort of behavioral or intellectual changes would be either upstream or downstream, like cytoskeletal modifications, changes in action potential behavior, changes in synapse/receptor refresh cycling, etc. 06:51 < kanzure> perhaps superkuh will comment on the idea, seeing as how he is our resident expert on action potential physics 06:51 < superkuh> Also did an undergrad project on integrins and the cytoskeleton. 06:52 < kanzure> now you're just showing off 06:52 < superkuh> Yeah, I opened all those tabs last night and started reading. Not through yet. 06:55 < kanzure> i wonder if there have been any single neuron electrophysiology studies that have collected enough data to estimate how many bits of data a simple neuron model can store, and whether that conforms to these numbers in this work 06:55 < kanzure> seems like even simple confirmation or evidence gathering of this data storage mechanism is pretty difficult... even a knockout study wouldn't necessarily be enough, because a neuron without talins could probably still spike. 07:00 < kanzure> "Topological features of integrin adhesion complexes revealed by multiplexed proximity biotinylation" https://rupress.org/jcb/article/219/8/e202003038/151896/Topological-features-of-integrin-adhesion 07:16 -!- filipepe [uid362247@gateway/web/irccloud.com/x-xbmifzpeggwvaloh] has joined ##hplusroadmap 07:54 < lsneff> Could glutaraldehyde fix the talin scaffolds? 09:02 -!- chico [~chico@2a02:2121:34b:f38:15d1:cab5:65ee:54db] has joined ##hplusroadmap 09:29 < kanzure> lsneff: most likely yes. glutaraldehyde should be able to fix certain kinds of protein conformational structures. 09:29 < kanzure> although i could imagine smaller conformational changes are difficult to affix 09:29 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:b950:9265:ebc2:e4a7] has joined ##hplusroadmap 09:30 < kanzure> actually, it might mess with the state of the molecule 09:57 < chico> Any thoughts about RNA vaccines? More or less effective?More or less safe? 10:02 -!- chico [~chico@2a02:2121:34b:f38:15d1:cab5:65ee:54db] has quit [Quit: Leaving] 10:12 < fenn> "individuals who received two injections of the [pfizer/biontech] vaccine three weeks apart experienced more than 90% fewer cases of symptomatic Covid-19 than those who received a placebo." 10:13 < fenn> https://www.statnews.com/2020/11/09/covid-19-vaccine-from-pfizer-and-biontech-is-strongly-effective-early-data-from-large-trial-indicate/ 10:14 -!- spaceangel [~spaceange@ip-89-177-56-55.net.upcbroadband.cz] has joined ##hplusroadmap 11:12 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Quit: WeeChat 2.9] 11:13 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 11:25 -!- CryptoDavid [uid14990@gateway/web/irccloud.com/x-frptknnkpiqgrmnl] has quit [Quit: Connection closed for inactivity] 11:32 -!- shawwwn [uid6132@gateway/web/irccloud.com/x-zpboeygefavkxele] has joined ##hplusroadmap 11:35 -!- filipepe [uid362247@gateway/web/irccloud.com/x-xbmifzpeggwvaloh] has quit [Quit: Connection closed for inactivity] 12:22 -!- filipepe [uid362247@gateway/web/irccloud.com/x-apwlqybffazjzxxj] has joined ##hplusroadmap 14:11 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:b950:9265:ebc2:e4a7] has quit [Remote host closed the connection] 14:12 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:b950:9265:ebc2:e4a7] has joined ##hplusroadmap 14:17 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:b950:9265:ebc2:e4a7] has quit [Ping timeout: 240 seconds] 14:33 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:b950:9265:ebc2:e4a7] has joined ##hplusroadmap 14:39 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:b950:9265:ebc2:e4a7] has quit [Ping timeout: 272 seconds] 14:44 < archels> anyone else here transitioning away from Travis CI? 14:54 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:b950:9265:ebc2:e4a7] has joined ##hplusroadmap 14:59 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Quit: condemned to drown in filth and endless distractions] 14:59 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:b950:9265:ebc2:e4a7] has quit [Ping timeout: 268 seconds] 15:04 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has joined ##hplusroadmap 15:14 -!- yashgaroth [~ffffffff@2601:5c4:c780:6aa0:b977:50f0:c126:2805] has joined ##hplusroadmap 15:15 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:b950:9265:ebc2:e4a7] has joined ##hplusroadmap 15:19 -!- spaceangel [~spaceange@ip-89-177-56-55.net.upcbroadband.cz] has quit [Remote host closed the connection] 15:20 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:b950:9265:ebc2:e4a7] has quit [Ping timeout: 244 seconds] 15:36 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:b950:9265:ebc2:e4a7] has joined ##hplusroadmap 15:41 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:b950:9265:ebc2:e4a7] has quit [Ping timeout: 272 seconds] 15:47 -!- Urchin[emacs] [~user@unaffiliated/urchin] has quit [Ping timeout: 260 seconds] 15:55 -!- sanehatter [~sanehatte@141.98.255.152] has quit [Quit: -] 15:57 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:b950:9265:ebc2:e4a7] has joined ##hplusroadmap 16:02 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:b950:9265:ebc2:e4a7] has quit [Ping timeout: 264 seconds] 16:14 -!- nanotube [~nanotube@unaffiliated/nanotube] has quit [Ping timeout: 260 seconds] 16:19 -!- nanotube [~nanotube@unaffiliated/nanotube] has joined ##hplusroadmap 16:21 -!- allkindsofscum [~kvirc@84-113-55-200.cable.dynamic.surfer.at] has quit [Ping timeout: 258 seconds] 16:31 < kanzure> archels: i've used gitlab-ci, github actions, travis, teamcity, circleci, jenkins, hudson.. pick your poison. 16:45 < lsneff> Turns out the best CI is a pre-push git hook. 16:47 < kanzure> only if you want to fight everyone's unique environments 16:52 < lsneff> Haha yes. In all seriousness, I've had decent luck with github actions, though all ci seem to be infuriatingly user-unfriendly. 17:02 -!- christianbundy [~christian@209-172-27-121.heliobroadband.com] has joined ##hplusroadmap 17:02 -!- christianbundy [~christian@209-172-27-121.heliobroadband.com] has quit [Changing host] 17:02 -!- christianbundy [~christian@unaffiliated/christianbundy] has joined ##hplusroadmap 17:13 -!- yashgaroth [~ffffffff@2601:5c4:c780:6aa0:b977:50f0:c126:2805] has quit [Quit: Leaving] 17:31 -!- Urchin[emacs] [~user@unaffiliated/urchin] has joined ##hplusroadmap 17:36 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:b950:9265:ebc2:e4a7] has joined ##hplusroadmap 17:37 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:b950:9265:ebc2:e4a7] has quit [Read error: Connection reset by peer] 17:49 -!- christianbundy [~christian@unaffiliated/christianbundy] has quit [Quit: WeeChat 2.9] 17:50 -!- christianbundy [~christian@209-172-27-121.heliobroadband.com] has joined ##hplusroadmap 17:50 -!- christianbundy [~christian@209-172-27-121.heliobroadband.com] has quit [Changing host] 17:50 -!- christianbundy [~christian@unaffiliated/christianbundy] has joined ##hplusroadmap 18:09 < nmz787> gitlab CI hs been pretty easy, it definitely took some tweaking here and there for parallel job stuff, but that has been pretty much the most frustration. I just have it run batch files though, which then runs my tests and coverage reports 18:21 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 18:25 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 264 seconds] 19:05 -!- christianbundy [~christian@unaffiliated/christianbundy] has quit [Ping timeout: 260 seconds] 19:51 -!- Sir_Alexei [uid348072@gateway/web/irccloud.com/x-khfxzzwtmxewjvir] has joined ##hplusroadmap 20:35 -!- justan0theruser is now known as justanotheruser 20:47 -!- Sir_Alexei [uid348072@gateway/web/irccloud.com/x-khfxzzwtmxewjvir] has quit [] 22:25 -!- filipepe [uid362247@gateway/web/irccloud.com/x-apwlqybffazjzxxj] has quit [Quit: Connection closed for inactivity] --- Log closed Wed Nov 11 00:00:13 2020