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07:19 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=48264fb8 Michael Folkson: Add Michael Flaxman on security guide >> http://diyhpl.us/diyhpluswiki/transcripts/stephan-livera-podcast/2020-09-28-michael-flaxman-security-guide/
07:19 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=899627fa Michael Folkson: Merge pull request #183 from michaelfolkson/flaxman-slp >> http://diyhpl.us/diyhpluswiki/
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10:43 < kanzure> hmph
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11:29 < fenn> .title https://www.youtube.com/watch?v=fAJ11GPfk9c&t=1m45s
11:29 < saxo> YouTube
11:29 < fenn> "Prosthetic Chainsaw!"
11:29 < fenn> too bad he's such a dork
11:37 < fenn> .title http://youtube.com/embed/UiWjCDgg7GE
11:37 < saxo> Milwaukee 1/4' impact partial hand prosthetic device - YouTube
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12:37 < kanzure> https://unchained-capital.com/blog/law-of-hash-horizons/
12:49 < kanzure> .tw https://twitter.com/SenguptaLab/status/1327630055015636995
12:49 < saxo> @AdamMarblestone @StearnsLab @UtopianCynic @jmcin9 Here's a cool pic from @lauren__tea showing cilia in the primary cortex in a postnatal rat brain. Stay tuned for a preprint very soon from her and collaborator @TurrigianoLab about what cilia do in the brain! https://pbs.twimg.com/media/EmywIn_WMAsPVw2.jpg (@SenguptaLab, in reply to tw:1327627633354567683)
12:49 < kanzure> .tw https://twitter.com/ArtirKel/status/1332839365538586624
12:49 < saxo> TIL all cells have tiny antennas in them https://www.nature.com/scitable/topicpage/the-primary-cilium-an-orphan-organelle-finds-14228249/ https://www.google.com/search?q=,+primary+ciliums&rlz=1CAKDZI_enGB891&sxsrf=ALeKk01XvzVvg91Fq-9XkTuMC2wspo7vzQ:1606608445845&source=lnms&tbm=isch&sa=X&ved=2ahUKEwi6odTtuqbtAhVCqZ4KHXU5AEkQ_AUoAnoECBEQBA&biw=1920&bih=929 (@ArtirKel)
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12:53 < kanzure> https://jsomers.net/i-should-have-loved-biology/
12:54 < fenn> "In addition to acting as mechanoreceptors, there are examples of primary cilia being used to detect chemicals, light, osmolarity, temperature, and gravity"
12:54 < fenn> i wouldn't call any of that "antennas"
12:55 < kanzure> "primary cilia" in the brain https://www.nature.com/articles/npp2013203
12:55 < kanzure> yeah agreed
12:56 < kanzure> tell me when they start broadcasting on electromagnetic spectrum
13:00 < kanzure> .tw https://twitter.com/avweigel/status/1328688972793585664
13:00 < saxo> We are proud to share our work on segmenting up to 35 organelles & macromolecular structures in whole cell isotropic FIB-SEM at 4 & 8nm resolution https://www.biorxiv.org/content/10.1101/2020.11.14.382143v1 1/12 https://video.twimg.com/ext_tw_video/1328688838416461824/pu/vid/696x360/ZLXl0NN1_VcpEefd.mp4?tag=10 (@avweigel)
13:00 < kanzure> "Automatic whole cell organelle segmentation in volumetric electron microscopy" https://www.biorxiv.org/content/10.1101/2020.11.14.382143v1
13:01 < kanzure> with apologies for linking to tedtalk, https://www.ted.com/talks/leor_weinberger_can_we_create_vaccines_that_mutate_and_spread/transcript?language=en
13:02 < kanzure> https://healthitsecurity.com/news/hackers-hit-covid-19-biotech-firm-cold-storage-giant-with-cyberattacks
13:05 < kanzure> "Targeted degradation of transcription factors by TRAFTACs: Transcription factor targeting chimeras" https://www.biorxiv.org/content/10.1101/2020.10.12.336529v1
13:06 < kanzure> "In vivo mRNA display enables large-scale proteomics by next generation sequencing" https://www.pnas.org/content/117/43/26710
13:06 < kanzure> "A glitch in the matrix: Age‐dependent changes in the extracellular matrix facilitate common sites of metastasis" https://onlinelibrary.wiley.com/doi/10.1002/aac2.12013
13:58 < kanzure> "Precise T cell recognition programs designed by transcriptionally linking multiple receptors" https://science.sciencemag.org/content/370/6520/1099
13:59 < kanzure> "A logic-gated nanorobot for targeted transport of molecular payloads" https://science.sciencemag.org/content/335/6070/831
14:01 < lsneff> https://www.izhikevich.org/publications/spikes.pdf
14:02 < lsneff> > Simple Model of Spiking Neurons
14:08 < lsneff> I wonder how well this could be implemented in hardware...
14:15 < kanzure> ibm put a bunch of money into that
14:17 < lsneff> Neuromorphic computing stuff?
14:21 < lsneff> .t https://www.research.ibm.com/articles/brain-chip.shtml
14:21 < saxo> IBM  Research: Brain-inspired Chip
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15:12 < ap4lmtree> is pramiracetam or fasoracetam or coluracetam anything like aniracetam or noopept?
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15:29 < kanzure> apparently C.UTF-8 is not a well-defined locale https://twitter.com/carl_dong/status/1332900241205563392
15:36 < fenn> how do i move to this country
15:38 < lsneff> The C county?
15:38 < fenn> technically it's a principality?
15:42 < lsneff> What does the C stand for anyhow?
15:42 < lsneff> I was thinking the language, but maybe "computer"?
15:43 < fenn> lol
15:43 < fenn> it stands for the third ish computer language
15:43 < fenn> or what have you
15:45 < fenn> "APL (named after the book A Programming Language) is a programming language developed in the 1960s"
15:45 < fenn> B is a programming language developed at Bell Labs circa 1969. It is the work of Ken Thompson with Dennis Ritchie.
15:45 < fenn> B was derived from BCPL
15:46 < fenn> BCPL is no longer in common use. However, its influence is still felt because a stripped down and syntactically changed version of BCPL, called B, was the language on which the C programming language was based.
15:47 < fenn> ("Basic Combined Programming Language")
15:47 < lsneff> Ah, I meant the C in C.UTF-8. I now see that it's referring to the C programming language.
15:49 < fenn> "BCPL has been rumored to have originally stood for "Bootstrap Cambridge Programming Language", but CPL was never created since development stopped at BCPL, and the acronym was later reinterpreted for the BCPL book."
15:52 < fenn> jargon file says "“Basic Combined Programming Language”) A programming language developed by Martin Richards in Cambridge in 1967"
15:54 < fenn> that's cambridge university in the UK
15:55 < fenn> clearly wizards were involved
16:02 < kanzure> https://www.overcomingbias.com/2020/11/why-we-fight-over-fiction.html
16:17 < fenn> "Ye who walk with the Path of Bacon shall be with dinner blessed. Yet ye who follow the Way of Necktie shall be for dinner dressed."
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16:41 < kanzure> "In vivo reprogramming ameliorates aging features in dentate gyrus cells and improves memory in mice" https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(20)30385-4
16:42 < kanzure> .title https://www.youtube.com/watch?v=JKVquoIecd0
16:42 < saxo> 4 simultaneous gene edits!! Base editing in BEAM-201 (Beam Therapeutics) - YouTube
16:43 < kanzure> https://www.openphilanthropy.org/informal-writeup-dracos-potential-antiviral-treatment
16:45 < kanzure> https://centaura-science.medium.com/the-human-artificial-chromosome-a-key-to-healthy-longevity-5d552cb7e8c9
16:47 < kanzure> "Innovation by Evolution: Bringing New Chemistry to Life (Nobel Lecture)" https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201907729
16:48 < kanzure> https://medium.com/xanaduai/on-the-road-to-room-temperature-quantum-computation-d1bd356dcf57
17:00 < kanzure> some weird vassar-related drama https://www.greaterwrong.com/posts/u8GMcpEN9Z6aQiCvp/rule-thinkers-in-not-out
17:00 < kanzure> i guess specifically this one https://www.greaterwrong.com/posts/u8GMcpEN9Z6aQiCvp/rule-thinkers-in-not-out#comment-jqX6jbw5Nui3Spwom
17:04 < kanzure> humans are hard to exterminate https://www.greaterwrong.com/posts/sT6NxFxso6Z9xjS7o/nuclear-war-is-unlikely-to-cause-human-extinction
17:05 < lsneff> cockroaches, the lot of them
17:20 < fenn> well the actual post itself by scott alexander was a lot more interesting than some random vassar drama bs
17:21 < fenn> "don't throw away newton just because he did some cranky research into bible codes"
17:22 < fenn> retracted drama, no less
17:39 < lsneff> .t https://news.ycombinator.com/item?id=25249418
17:39 < saxo> The M1 represents Apple’s best effort running on the world’s most advanced manuf... | Hacker News
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17:48 < fltrz> just saw a cheesy peak 90's propaganda film for ##hplusroadmap: W.E.I.R.D. WORLD. has a bunch of references to actual sick stuff like foreskin skin grafts
17:48 < fltrz> also, bat guano 'rona virus
17:49 < fenn> time travel confirmed?
17:49 < fltrz> fenn, in that movie yes
17:50 < fenn> Western, Educated, Industrialized, Rich, And Democratic
17:50 < fltrz> no, the initials stood for something else
17:50 < fenn> pshaw
17:51 < fenn> whatever it is, is clearly a veil of plausible deniability
17:51 < fenn> we all know the score
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18:37 < kanzure> "unlimited progress in all directions" (j storrs hall) https://rootsofprogress.org/where-is-my-flying-car
18:55 < fenn> "a good explanation for technological stagnation is that the only technological revolution of the last 50 years, computing, was the only one that didn’t need more power than could be provided by the technology of the 1970s."
18:57 < kanzure> hrm.
18:58 < fenn> it certainly explains why we still build houses out of wood
19:06 < fenn> why am i just now hearing about "the Great Stagnation"?
19:07 < fenn> i've been ranting about this for years and never heard this phrase before
19:07 < lsneff> It's come up in this channel before I believe. At least, I've mentioned it.
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19:11 < fenn> grep -i "great stagnation" ~/irclogs/gnusha.org/logs/20*
19:11 < fenn> nothin
19:12 < lsneff> I've linked to that article before.
19:12 < fenn> yes on nov 12, and a tweet mentioning the great stagnation on nov 26
19:12 < lsneff> Indeed
19:12 < fenn> but people are throwing this around like it's a commonly used phrase that everybody ought to know
19:15 < fenn> apparently it came from a tyler cowen book published in 2011
19:15 < lsneff> title?
19:15 < fenn> "The Great Stagnation: How America Ate All the Low-Hanging Fruit of Modern History, Got Sick, and Will Feel Better is a pamphlet by Tyler Cowen"
19:15 < fenn> though i happen to disagree with the premise of this book
19:16 < lsneff> How so?
19:17 < fenn> i don't agree that the cause of lack of progress in most areas for the past four or five decades is due to "having eaten all the low hanging fruit"
19:18 < fenn> "The Great Divergence is a term given to a period, starting in the late 1970s, during which income differences increased in the US and, to a lesser extent, in other countries. The term originated with the Nobel laureate, Princeton economist and New York Times columnist Paul Krugman,[1] and is a reference to the "Great Compression", an earlier era in the 1930s and the 1940s when incomes became
19:19 < fenn> more equal in the US and elsewhere."
19:20 < fenn> i see tons of stuff that COULD be done, but ISN'T being done
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22:51 < fenn> lsneff: it was bugging me, so i made a list of random "low hanging fruit" that was not grabbed: http://fennetic.net/irc/things_that_could_have_been_done_in_the_1990s.txt
22:52 < fenn> some of them have "reasons" they didn't happen, but not good reasons really
22:53 < fenn> teledesic for example
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--- Log closed Mon Nov 30 00:00:31 2020