--- Log opened Wed Dec 23 00:00:55 2020 00:24 -!- spaceangel [~spaceange@ip-89-177-48-202.net.upcbroadband.cz] has joined ##hplusroadmap 00:49 -!- darsie [~kvirc@84-113-55-200.cable.dynamic.surfer.at] has joined ##hplusroadmap 01:30 -!- ThermoDae [~Malvolio@unaffiliated/malvolio] has quit [Ping timeout: 240 seconds] 02:38 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 268 seconds] 03:14 < archels> kanzure: any particular reason? 03:43 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 05:31 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has joined ##hplusroadmap 05:32 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 240 seconds] 05:34 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 05:54 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Read error: Connection reset by peer] 05:57 -!- preview [~quassel@2407:7000:8423:b00::2] has quit [Ping timeout: 260 seconds] 05:59 -!- preview [~quassel@2407:7000:8423:b00::2] has joined ##hplusroadmap 06:32 -!- shawwwn [uid6132@gateway/web/irccloud.com/x-eyfuiztwbepuhgyf] has joined ##hplusroadmap 06:33 < kanzure> archels: no time 06:51 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 06:58 -!- yashgaroth [~ffffffff@2601:5c4:c780:6aa0:3114:4ca5:8c58:81e] has joined ##hplusroadmap 07:03 < kanzure> hmph 07:23 < kanzure> https://bitcoinops.org/en/newsletters/2020/12/23/ 07:33 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 240 seconds] 08:20 -!- chico [~chico@2a02:2121:30a:d0c4:b0d3:b534:55f4:28af] has joined ##hplusroadmap 09:20 -!- ccdle12 [~ccdle12@gateway/tor-sasl/ccdle12] has joined ##hplusroadmap 09:27 -!- chico [~chico@2a02:2121:30a:d0c4:b0d3:b534:55f4:28af] has quit [Quit: Leaving] 09:43 -!- Alchemical_ [~al@unaffiliated/alchemical] has quit [Ping timeout: 265 seconds] 10:17 < fltrz> hmm would Ghz sampling make the emptying of the neurotrasnmitter vacuole's register? 10:19 < kanzure> you can probably tie in a fluorophore 10:21 < fltrz> prefer non-invasive type BCI 10:52 -!- nmz787 [~nmz787@bryan.fairlystable.org] has quit [Ping timeout: 260 seconds] 10:52 -!- nmz787 [~nmz787@bryan.fairlystable.org] has joined ##hplusroadmap 10:53 -!- ccdle12 [~ccdle12@gateway/tor-sasl/ccdle12] has quit [Remote host closed the connection] 11:22 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has quit [Quit: PHSPHRNL] 11:54 < apotheon> Exapunks seems like a cool idea, but my favorite video game is C programming. 11:55 < L29Ah> apotheon: but it lacks gfx! even debugging isn't flashy :( 11:57 < apotheon> L29Ah: My idea for how to use an EEG is to monitor sleep state for the sake of logging sleep quality and perhaps using it in a feedback loop with techniques for improving sleep quality (e.g. the whole thing about metronomic ticking timed to coincide with brainwave speed to enhannce the deep sleep stage). 11:57 < apotheon> L29Ah: Zork didn't need graphics. 11:59 < L29Ah> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679648/ interesting 11:59 < L29Ah> i wonder what would be side effects of such an intervention 12:01 < kanzure> .title 12:01 < saxo> Reinforcing rhythms in the sleeping brain with a computerized metronome 12:01 -!- filipepe_ [uid362247@gateway/web/irccloud.com/x-kcsqrfcyusnxjuwr] has joined ##hplusroadmap 12:01 < apotheon> Yeah, that's basically what I was trying to say. 12:25 -!- CryptoDavid [uid14990@gateway/web/irccloud.com/x-bnntebqyeedlpigr] has joined ##hplusroadmap 12:37 -!- CryptoDavid [uid14990@gateway/web/irccloud.com/x-bnntebqyeedlpigr] has quit [] 12:40 -!- spaceangel_ [~spaceange@ip-89-177-48-202.net.upcbroadband.cz] has joined ##hplusroadmap 12:40 -!- spaceangel [~spaceange@ip-89-177-48-202.net.upcbroadband.cz] has quit [Read error: Connection reset by peer] 13:58 -!- L29Ah [~L29Ah@unaffiliated/l29ah] has quit [Ping timeout: 240 seconds] 14:01 -!- shawwwn [uid6132@gateway/web/irccloud.com/x-eyfuiztwbepuhgyf] has quit [Quit: Connection closed for inactivity] 14:06 -!- L29Ah [~L29Ah@unaffiliated/l29ah] has joined ##hplusroadmap 14:12 -!- galambo_ [galambo@gateway/vpn/protonvpn/galambo] has joined ##hplusroadmap 15:09 -!- spaceangel_ [~spaceange@ip-89-177-48-202.net.upcbroadband.cz] has quit [Remote host closed the connection] 15:09 -!- spaceangel_ [~spaceange@ip-89-177-48-202.net.upcbroadband.cz] has joined ##hplusroadmap 15:16 -!- spaceangel_ [~spaceange@ip-89-177-48-202.net.upcbroadband.cz] has quit [Remote host closed the connection] 15:20 -!- filipepe_ [uid362247@gateway/web/irccloud.com/x-kcsqrfcyusnxjuwr] has quit [Quit: Connection closed for inactivity] 15:29 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 15:34 -!- filipepe_ [uid362247@gateway/web/irccloud.com/x-zroyexnidfgzswts] has joined ##hplusroadmap 15:47 -!- Jayson_Virissimo [~Jayson@ip98-165-142-10.ph.ph.cox.net] has joined ##hplusroadmap 15:49 < Jayson_Virissimo> https://www.lesswrong.com/posts/5BikXJnAJpSzDD9Qv/how-hard-would-it-be-to-make-a-covid-vaccine-for-oneself 15:50 < Jayson_Virissimo> One of the commenters says it can take 4-5 weeks to get the relevant peptides from a lab. Anyone happen to know what the bottleneck is and if there are any ways around them? 15:53 < kanzure> Jayson_Virissimo: yashgaroth can comment 15:58 < yashgaroth> the idea that the Moderna vaccine is "simple" and thus easy to make is moronic, so I'll ignore the main post, but for the Radvac comment yeah sourcing the peptides outlined in their paper would be (relatively) easier, though they have no efficacy data and I doubt it'd be at all effective anyway 15:59 < yashgaroth> that main post is just...look, if I program a target into an ICBM's computer, it doesn't mean the ICBM was easy to make 15:59 < Jayson_Virissimo> Yeah, sorry. Was much more interested in the claim about peptide sourcing specifically. 16:00 < Jayson_Virissimo> Is that 4-5 weeks duration normal? How flexible is it, if at all? 16:01 -!- Malvolio [~Malvolio@unaffiliated/malvolio] has joined ##hplusroadmap 16:01 < yashgaroth> some of them might offer expedited service, though I've never had cause to find out when ordering peptides and am not bothered to check...and it'd save you a week or two at most 16:02 < Jayson_Virissimo> What would you guess as to the main cause? Does it really take that long to manufacture or is it slow to ship, or is there some legal check that happens that isn't instantaneous? 16:04 < yashgaroth> the legal check isn't an issue, though I'm sure all the major synthesis houses are aware of the Radvac peptide sequences and may hassle you about them - especially if you're not ordering as a company...shipping's not a problem since overnight is standard, so I'd say manufacturing time combined with the people ahead of you in the queue 16:04 < yashgaroth> and manufacturing includes purification, which is an important step for something you're ingesting, even if you're just snorting a line of it 16:07 < Jayson_Virissimo> yashgaroth: do the labs have any legal risk of their own if you are ordering something like Radvac sequences as a private person, or are they "hassling you for your own good"? 16:09 < yashgaroth> nah they're usually okay legally on their end, though most of them won't risk selling a small quantity to an individual since 'plausible deniability' wears a little thin on their end when you're buying sequences that match the Radvac ones 16:09 < yashgaroth> though I'm unsure of how much weeks matter at this point, a year into the pandemic 16:10 < yashgaroth> I recommend the ol' social engineering tricks, just find an Essential Worker who's scheduled to be vaccinated and who's already had covid (or is afraid of the vaccine) and swap places with them for vaccination day 16:11 < Jayson_Virissimo> I'm mainly thinking about COVID-19+, whatever that ends up being, more so than trying to panic buy. 16:12 < Jayson_Virissimo> Appreciate your helping a newb out yashgaroth. 16:12 < yashgaroth> ehh I'm on christmas break from the vaccine factory so I'm just drinking and watching the expanse 16:13 < kanzure> is it any good? 16:13 < yashgaroth> the show? I'm starved of decent sci-fi, and there's not much better that's currently in production 16:14 < yashgaroth> re: preparing for covid-20, the current vaccines should be effective enough against it, though the UK strain has a worryingly high number of seemingly-simultaneous mutations 16:18 < fenn> i saw the first couple seasons of "the expanse" and like it so far 16:19 < fenn> it's the closest thing to "hard sci-fi" on TV in decades 16:21 < yashgaroth> yeah they take a few liberties with the propulsion system, but otherwise it's refreshingly hard 16:22 < apotheon> I think I saw only one episode. The very "police procedural" feel of it turned me off. I'll probably give it a shot again, though. 16:26 < yashgaroth> yeah the first season is slow and not really representative iirc 16:40 < apotheon> I guess I just need to slog through the first season to get to the good stuff, maybe. 16:40 < apotheon> I'm rewatching Altered Carbon season one, very slowly, before I try season two. 16:41 < fenn> it has to describe the structure of the world and its inhabitants 17:50 -!- galambo__ [galambo@gateway/vpn/protonvpn/galambo] has joined ##hplusroadmap 17:52 -!- galambo_ [galambo@gateway/vpn/protonvpn/galambo] has quit [Ping timeout: 240 seconds] 17:54 -!- yashgaroth [~ffffffff@2601:5c4:c780:6aa0:3114:4ca5:8c58:81e] has quit [Read error: Connection reset by peer] 18:47 -!- darsie [~kvirc@84-113-55-200.cable.dynamic.surfer.at] has quit [Ping timeout: 260 seconds] 18:48 -!- Sir_Alexei [uid348072@gateway/web/irccloud.com/x-lfskbsonxirfwuvn] has joined ##hplusroadmap 19:11 -!- Sir_Alexei [uid348072@gateway/web/irccloud.com/x-lfskbsonxirfwuvn] has quit [] 19:50 -!- filipepe_ [uid362247@gateway/web/irccloud.com/x-zroyexnidfgzswts] has quit [Quit: Connection closed for inactivity] 20:29 -!- Urchin[emacs] [~user@unaffiliated/urchin] has quit [Ping timeout: 272 seconds] 20:35 -!- balrog [~balrog@unaffiliated/balrog] has quit [Quit: Bye] 20:39 -!- Jayson_Virissimo [~Jayson@ip98-165-142-10.ph.ph.cox.net] has quit [] 21:21 -!- cannedprimates_ [sid16585@gateway/web/irccloud.com/x-acjdluhpycdaqmdv] has quit [Ping timeout: 260 seconds] 21:23 -!- cannedprimates_ [sid16585@gateway/web/irccloud.com/x-qfcogkwjgblrdnyy] has joined ##hplusroadmap 21:31 < fltrz> has UV weakening coronavirus even been attempted? like how the first vaccine was made? 21:32 < L29Ah> sounds hazardous 21:32 < L29Ah> also the first vaccine ever was made from cattle smallpox afair 21:35 < fltrz> apparently wikipedia conflicts with whatever I read about first rabies vaccine by pasteur elsewhere, according to wikipedia he just dried the nerves, but according to what I read previously he laid thee nerves in the sun, with UV-B damage 21:38 < fltrz> so apparently Pasteur didn't even intentionally create his first vaccine (for chicken cholera), its just that he accidentally neglected one of his cholera cultures, tried to infect chickens with it, since they didn't go sick, he tried again but with one of his proper cholera cultures, and reused those still living chickens, then discovered these couldn't get cholera... 21:39 < fltrz> I still think using ever decreasing doses of UV-C on some source of rona, then snorting it would have immunized me, its just that I have no reliable source of rona 21:40 < apotheon> "rona" 21:41 < fltrz> to avoid confusion with wider class of coronaviridae 21:43 < L29Ah> cholera isn't a virus :/ 21:45 < fltrz> did i say so?? 21:46 < L29Ah> nah it's just the approaches aren't really portable 21:47 < fltrz> bacteria have more opportunity for repair 21:47 < L29Ah> in fact seems like only smallpox was successfully eradicated using a vaccine --- Log closed Thu Dec 24 00:00:55 2020