--- Log opened Fri Jul 08 00:00:14 2022
00:21 < nmz787> "Electronic control of the microelectrode array is achieved via peripheral component interconnect express (PCIe) connectors exposed outside of the flow cell"
00:21 < nmz787> kanzure: nice paper link, thanks
00:26 < nmz787> more (recent) here https://www.microsoft.com/en-us/research/people/kstrauss/publications/
00:32 < nmz787> "In a particle storage experiment, after driving droplets to a designated location on the electrode array, they were allowed to dry. This resulted in particle pellets that were hard to dissolve by using BOE only."
00:32 < nmz787> ""
00:32 < nmz787> To achieve a more reliable retrieval process in combination with the DMF device, we used 20 wt% sodium hydrogen carbonate (NaHCO3) mixed directly in the particle dispersion. The auxiliary compound was chosen to react with the protons in the acidic BOE, forming Na+ ions, water, and carbon dioxide (CO2). The gaseous CO2 bubbles assisted the redispersion process by providing agitation. A similar concept 
00:32 < nmz787> is applied to effervescent tablets, where NaHCO3 usually reacts with citric acid to facilitate the efficient dissolution of otherwise poorly soluble compounds.
00:33 < nmz787> man, how dumb I am, I have just been thinking those effervescent tablets were just "fake" or "for fun"
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03:32 < L29Ah> https://survivalandflourishing.fund/sff-2022-h1-recommendations i love the "Purpose" column
03:33 < L29Ah> We are a nonprofit organization dedicated to exploring the world's caves and helping others in pursuit of the same.
03:34 < L29Ah> ok, so what is "flourishing" about? there are no plants in caves
03:37 < L29Ah> https://nitter.42l.fr/pic/orig/media%2FFExH8nLVIAA43pU.jpg
04:04 < TMA> now it says "General support"
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09:47 < nmz787> L29Ah: that's for mental flourishing of the privileged... or possibly in a less dystopian view, for encouraging poor city kids access to great natural wonders 
09:48 < nmz787> "During the electrochemical deprotection process, acid was generated from a two-electron oxidation of hydroquinone to quinone at each activated anode, and methoxide anion was generated from reduction of methanol at each cathode (Figure S1(b)) (22, 34). The electrochemically generated acid was free to diffuse until it reached a basic methoxide anion in solution and was neutralized, effectively 
09:49 < nmz787> confining the acid to the region immediately around the generating electrode. Only where sufficient acid was present would significant deblocking of oligonucleotides occur."
09:50 < nmz787> <screenshot of mathematica code used for acid diffusion simulation>
09:50 < nmz787> how the hell is that permissible
09:56 < nmz787> "50 μm electrodes in a fully addressable-array, synthesis on agarose coating"
09:56 < nmz787> micron
09:56 < nmz787> no reference seemingly to that technique?
10:23 < nmz787> .title https://patents.justia.com/patent/11305253
10:23 < saxo> US Patent for High surface area coatings for solid-phase synthesis Patent (Patent #  11,305,253 issued April 19, 2022) - Justia Patents Search
10:24 < nmz787> "Hydroxyl groups are present on some polysaccharides such as agarose. An"
10:25 < nmz787> "Functionalization may not be necessary for some types of coatings such as polysaccharides (e.g., agarose) and metal oxides. "
10:25 < nmz787> "For example, the phosphoramidite method of synthesizing DNA uses harsh chemicals including acetonitrile which can damage some types of coatings such as organic polymers (e.g., agarose)."
10:26 < L29Ah> are there polysaccharides where there aren't hydroxyl groups?
10:28 < nmz787> https://patents.google.com/patent/US10936953B2/en
10:28 < nmz787> .title
10:28 < saxo> US10936953B2 - DNA-based digital information storage with sidewall electrodes         - Google Patents
10:30 < nmz787> L29Ah: not exactly answering your question, but chitosan is also mentioned, but it has HO and NH2 groups
10:36 < L29Ah> Haydn Belfield 	$141,564 	2021-10-03 to 2024-06-30 	Earning a DPhil in International Relations from Oxford University focussed on arms control.
10:36 < L29Ah> long-termism go brrr
10:42 < nmz787> .wik shear thinning
10:42 < saxo> "In rheology, shear thinning is the non-Newtonian behavior of fluids whose viscosity decreases under shear strain. It is sometimes considered synonymous for pseudo-plastic behaviour, and is usually defined as excluding time-dependent effects, such as thixotropy. /  Shear [...]" - https://en.wikipedia.org/wiki/Shear_thinning
10:42 < nmz787> .wik bingham plastic
10:42 < saxo> "A Bingham plastic is a viscoplastic material that behaves as a rigid body at low stresses but flows as a viscous fluid at high stress." - https://en.wikipedia.org/wiki/Bingham_plastic
10:42 < nmz787> whipped cream is an example, as is toothpaste
10:43  * nmz787 dreams up children's science experiments where we get to eat whipped cream as a reward
11:57 < fenn> .w gentoo
11:57 < saxo> Couldn't get any definitions for gentoo
11:57 < fenn> oh come on
11:57 < fenn>  A penguin ({Pygosceles t[ae]niata}). [Falkland Is.]
11:58 < fenn> L29Ah: presumably they are interested in using the caves to survive a nuclear war, asteroid impact, attack of the machines, etc
11:59 < L29Ah> Muaddib: what do you think of Gentoo Linux?
11:59 < Muaddib> L29Ah: it's okay, i guess.
12:13 < fenn> Muaddib: how would you go about hunting down the last surviving humans in a cave deep underground?
12:13 < Muaddib> fenn: I would send a trained chimp down with a flashlight.
12:14 < fenn> we're doomed
12:15 < L29Ah> Muaddib: how to destroy a bunker 500m under a mountain?
12:15 < Muaddib> L29Ah: with a nuke
12:15 < fenn> seem that's just not funny
12:15 < fenn> -m
12:16 < L29Ah> Muaddib: how to destroy a Mars colony from Earth?
12:16 < Muaddib> L29Ah: with enough nukes
12:16 < fenn> Muaddib: how to create a Mars colony from Earth?
12:17 < Muaddib> fenn: with a mother ship
12:17 < fenn> Muaddib: how to create a mother ship?
12:17 < Muaddib> fenn: with a Daddy ship
12:17 < L29Ah> Muaddib: how to colonize the asteroid belt?
12:17 < Muaddib> L29Ah: with a belt
12:18 < L29Ah> apparently literature features realistic destruction more often than creation
12:18 < L29Ah> Muaddib: what is better, emacs or vim?
12:18 < Muaddib> L29Ah: :P
12:19 < fenn> Muaddib: tabs or spaces?
12:19 < Muaddib> fenn: you
12:20 < L29Ah> Muaddib: how to solve the Arab–Israeli conflict?
12:20 < Muaddib> L29Ah: you
12:20 < L29Ah> it's broken!
12:20 < fenn> Muaddib: do you have a content filter?
12:20 < Muaddib> fenn: you
12:22 < L29Ah> Muaddib: Who do you blame for what you've become? What excuse do you have to hide your own shame? What lies do you tell to mask your misfortunes? Who is at fault and who is to blame?
12:22 < Muaddib> L29Ah: you
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14:52 < fenn> a 24 year longitudinal study of aging http://dx.doi.org/10.1155/2012/420637/
14:52 < fenn> .title
14:52 < saxo> Error: DOI Not Found
14:53 < fenn> ok what did i do wrong
14:53 < fenn> .title http://dx.doi.org/10.1155/2012/420637
14:53 < saxo> The Theory and Practice of Active Aging
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15:43 < nmz787> .wik atom probe tomography
15:43 < saxo> Article not found: https://en.wikipedia.org/wiki/Atom_probe_tomography gave 404 | Searched en for 'atom probe tomography' | https://en.wikipedia.org/wiki/No_result_found gave 404 | Searched en for 'No result found'
15:43 < nmz787> https://wcnt.wisc.edu/microscopy/atom-probe/#:~:text=Atom%20Probe%20Tomography%20(APT%20)%20is,%2D0.5nm%20lateral%20resolution).
15:43 < nmz787> "Atom Probe Tomography (APT ) is the only materials analysis technique that offers simultaneous 3D imaging and elemental composition measurements with atomic resolution (0.1-0.3nm depth resolution and 0.3-0.5nm lateral resolution)."
15:59 < fenn> are there sub-diffraction fluorescence imagine techniques for single inorganic atoms, like PALM/STORM?
15:59 < fenn> imaging*
16:00 < fenn> hit it with a high energy particle, then watch it fluoresce, then find the center of the gaussian blob to reconstruct the 3D position (depth of field = bokeh radius gives you some Z information, in optical microscopes at least)
16:02 < fenn> worth noting that atom probe tomography is a destructive scanning technique
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17:24 < muurkha> fenn: I don't think anything about antioxidants and health is as simple as "antioxidant X is probably good for your health"
17:24 < muurkha> or about nutrients in general
17:26 < muurkha> as for "it tastes bad, why would anyone eat it", the same could be said of lard, suet, canola oil, or even butter.  have you ever tried to eat a tablespoon of butter?
17:27 < L29Ah> caffeine
17:27  * muurkha caffeines
17:28 < L29Ah> Muaddib: what is the best caffeine dosage regimen for cognitive performance improvement?
17:28 < Muaddib> L29Ah: Two 2-liter bottles of Dr. Pepper per day.
17:29 < muurkha> Muaddib: what's the phosphoric acid content of Dr Pepper and does that dosage pose a risk of magnesium deficiency?
17:29 < Muaddib> muurkha: Dr Pepper has no magnesium.
17:29 < muurkha> (realistically idiotic response)
17:30 < muurkha> nmz787: interesting, I didn't realize that was a separate category from
17:30 < muurkha> .wik thixotropic
17:30 < saxo> "Thixotropy is a time-dependent shear thinning property. Certain gels or fluids that are thick or viscous under static conditions will flow (become thinner, less viscous) over time when shaken, agitated, shear-stressed, or otherwise stressed (time-dependent viscosity)." - https://en.wikipedia.org/wiki/Thixotropic
17:32 < muurkha> kanzure: isn't being an EA doing EA things actually a primary plan for having *others'* lives go well?  it sounds like KerryLVaughan has confused EA with Effective Egoism
17:34 < muurkha> Muaddib: indeed, Dr Pepper has no magnesium.  In fact, in effect it has negative magnesium.
17:34 < Muaddib> muurkha: negative magnesium? how is that possible?
17:34 < L29Ah> Muaddib: what do you think of the Effective Egoism movement?
17:35 < Muaddib> L29Ah: well, it's effective, but it's not egoism.
17:36 < muurkha> Muaddib: the phosphoric acid in Dr Pepper reacts with magnesium to form insoluble magnesium phosphates
17:36 < Muaddib> muurkha: ahh, that makes sense
17:36 < L29Ah> only 25 google results for "effective egoism" :(
17:36 < muurkha> probably "well, it's adjective, but it's not noun" is a good stock answer for "what do you think of the adjective noun movement"
17:37 < L29Ah> Muaddib: what do you think of the Absolute Transhumanism movement?
17:37 < Muaddib> L29Ah: I think it's adjective, but it's not noun.
17:37 < muurkha> hahahahaha
17:38 < L29Ah> pasky_: what exactly gets into the thing?
17:38 < muurkha> pasky_: so I guess Muaddib incorporates the non-Muaddib-addressed chat lines into its prompt, even if it doesn't respond to them?
17:38 < muurkha> because if not, that's an extremely impressive response
17:39 < muurkha> Muaddib: what do you think of the Permanent Thursday movement?
17:39 < Muaddib> muurkha: I think it's interesting, although I'm not sure it would work in practice.
17:39 < muurkha> Muaddib: what do you think of the Unusual Jacket movement?
17:39 < Muaddib> muurkha: I don't know, I'm not really into fashion.
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22:13 < fenn> "tried to eat a tablespoon of butter?" yes, all the time
22:13 < fenn> butter is awesome
22:13 < fenn> more difficult to eat a tablespoon of pure coconut oil, but not as bad as a tablespoon of red palm oil
22:15 < fenn> you're more likely to develop a magnesium deficiency from the hypertensive effect of the caffeine and subsequent urination, than from the phosphoric acid content
22:15 < fenn> actually i don't see why there would be a connection
22:17 < fenn> the language model AI correctly recognized the abstract categories of specific components of language...
22:18 < fenn> Muaddib: is what you just did there supposed to be impressive?
22:18 < Muaddib> fenn: no, i just wanted to see if the language model AI would correctly recognize the abstract categories of specific components of language...
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--- Log closed Sat Jul 09 00:00:15 2022