--- Log opened Fri Jul 22 00:00:27 2022
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10:53 < fenn> .wik Z-80 SoftCard
10:53 < saxo> "The Z-80 SoftCard is a plug-in Apple II processor card developed by Microsoft to turn the computer into a CP/M system based upon the Zilog Z80 central processing unit (CPU)." - https://en.wikipedia.org/wiki/Z-80_SoftCard
10:54 < fenn> why not just build a Z-80 based PC
10:54 < fenn> "Its original purpose was to simplify porting Microsoft's computer-language products to the Apple II."
12:13 < kanzure> asteroid mining venture thing https://www.amiexploration.com/
12:19 < fenn> https://mitrix.bio " In these tests, “young” highly functional mitochondria are grown in prototype bioreactors and transfused into the bloodstream. Cells absorb them to help supplement old, dysfunctional mitochondria and reverse energetic decline. These tests showed apparent age reversal in multiple endpoints in animal disease models in-vivo and human cells in-vitro."
12:19 < kanzure> https://www.borderwallets.com/docs/the-solution
12:19 < kanzure> mitochondrial suplementation sounds cool
12:20 < fenn> hard to believe that it's even possible
12:21 < fenn> just bend over and we're going to cram this powerhouse into you
12:22 < fenn> it sounds very difficult compared to just inserting a plasmid, which barely works
12:22 < fenn> there ought to be some law saying you have to have a globally unique name
12:23 < fenn> how the hell do people get through life with these generic names
12:23 < fenn> "Thomas Rando"
12:23 < fenn> no, no, Thomas *J* Rando
12:24 < fenn> apologies to Dr. Rando
12:24 < fenn> Dr. Dr. Rando
12:25 < fenn> but really i'm mad at George Wu for having such a boring and impossible to google name
12:28 < fenn> "recently discovered blood components called "Mitlets," small vesicles containing mitochondria,
12:28 < fenn> ejected by platelets"
12:28 < fenn> "first discovered in 2014 by Mitrix partner researcher Dr. Eric Boilard"
12:32 < fenn> i wonder if you even need to use human mitochondria
12:35 < fenn> "Octoarginine (R8) cell penetrating peptide" simulates cellular internalization by macropinocytosis
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12:51 < muurkha> lsneff: the standard approach to a type of storage that can't be read by an attacker is for the device to melt itself down with thermite or similar upon detecting ingress attempts
12:52 < kanzure> or use ambient energy or battery to self-wipe
12:53 < lsneff> Sounds like there would be a lot of edge cases there
12:53 < muurkha> fenn: the Apple II made a much, much better graphics output device for a Z80 PC than most Z80 PCs had
12:54 < muurkha> lsneff: yes, engineering is full of edge cases
13:08 < fenn> https://github.com/azonenberg/pcb-checklist "nearly every line item here came from the school of hard knocks."
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13:17 < fenn> i think you'd have to store single-atom storage media at very low temperatures to reduce stochastic errors due to thermally induced dislocation of the bit-storing atoms
13:19 < kanzure> snake pit https://forum.effectivealtruism.org/
13:20 < fenn> psychohazard?
13:20 < kanzure> fidget spinner
13:20 < fenn> will i become paralyzed if i look at the basilisk?
13:20 < kanzure> only if you allow it
13:22 < fenn> let's say you memorize a bitcoin wallet passphrase and then have your brain preserved. what actions could you have taken while alive to encourage someone to simulate you in the future rather than simply extract the passphrase and dump the rest?
13:23 < fenn> is it just emulated dystopia all the way down?
13:28 < fenn> "The idea of logic-locking is to add XOR gates (or a more complex type of gate) to the circuit on well-chosen logic paths. To make the circuit behave correctly, it's required to know the value to be sent to each inserted XOR. These values may be generated by an RNG circuit that is seeded by a secret key.
13:28 < fenn> At manufacturing time the key is kept secret, so it's not possible for the fab to reverse engineer your circuit logic to introduce a backdoor."
13:28 < kanzure> unfortnuately along the way to human brain emulation/simulation you have pretty good ape-level knowledge worker software and the economic incentive to continue developing would be limited
13:29 < fenn> i'm pretty sure that traditional understanding of economics gets blown out of the water by ape-level knowledge workers, so it's hard to make predictions beyond that point
13:30 < fenn> but why stop at 10 trillion emulated neurons?
13:31 < fenn> 10 billion*
13:31 < fenn> humans are only 20 billion cortical neurons
13:32 < fenn> gorilla = 10 billion cortical neurons
13:33 < fenn> i was asking if there were some way in the present to incentivize future technology development for not only recovering memories but to actually run the recovered brains
13:50 < lsneff> Don’t think that’s the case necessarily
13:51 < lsneff> We could have a very good understanding of how neurons/neural cells in human brains function without being able to train them well
13:51 < lsneff> And simulating existing humans might be the best way to do that if you don’t know how to train from scratch
13:51 < lsneff> Don’t think that’ll be the case though
14:00 < kanzure> i don't know if there's anything inside the brain itself that can incentivize running it
14:01 < kanzure> you'll just need to have kind hearted emulation overlords
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14:17 < kanzure> .tw https://twitter.com/jason_koebler/status/1550556939188285440
14:17 < saxo> A DIY medicine and biohacking collective has figured out how to put 3 doses of abortion pill misoprostol onto a business card and distributed them at a hacking conference today: "This Card is an Abortion" // https://www.vice.com/en/article/bvmn35/diy-collective-embeds-abortion-pill-onto-business-cards-distributes-them-at-hacker-conference (@jason_koebler)
14:25 < L29Ah> 22:22:51]<fenn> let's say you memorize a bitcoin wallet passphrase and then have your brain preserved. what actions could you have taken while alive to encourage someone to simulate you in the future rather than simply extract the passphrase and dump the rest?
14:25 < L29Ah> implying you can extract the passphrase w/o emulating the environment where the human would enter the passphrase
14:25 < L29Ah> // bonus points for using the passphrase enough that it is offloaded to your spinal cord and forgotten by the brain
14:27 < lsneff> I bet it'd be pretty difficult to extract a passphrase without waking the person
14:27 < lsneff> You can't exactly take a hexdump of someone's memories
14:35 < kanzure> dee hock has passed away
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15:23 < kanzure> smartcard teardown https://www.youtube.com/watch?v=RLbAViN7VXo&t=301s
15:23 < Muaddib> [RLbAViN7VXo] Credit Card Teardown: Secure Computing (6:10)
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15:32 < fenn> i get to go to the lessdeath.org afterparty this weekend *yay*
15:33 < superkuh> Don't get infected and die.
15:34 < fenn> i've already had covid and recovered weeks ago. is there anything else i should be aware of?
15:35 < superkuh> Probably not yet. Gotta wait for fall for air spread monkeypox to really take off.
15:59 < fenn> having called it monkeypox retroactively makes you guilty of thoughtcrime
15:59 < fenn> the disease to have formerly been known as m********x
16:09 < fenn> "the British Health Security Agency finding that of the 699 monkeypox cases for which there was available information, 97% were in gay, bisexual or other men who have sex with men. New York City, the U.S. epicenter, has seen only one woman diagnosed with the virus out of 639 cases"
16:10 < fenn> "95% of the cases were likely transmitted through sexual close contact."
16:10 < fenn> but it's "not an STD"
16:10 < fenn> :thinking face:
16:11 < superkuh> It can transmit by air.
16:11 < superkuh> Just not well, apparently.
16:11 < fenn> why don't all viruses transmit by air?
16:11 < fenn> surely there's evolutionary presure to do so
16:12 < superkuh> I don't think so. But I mean, in studies in monkeys kept in separate cages.
16:12 < fenn> why^
16:13 < L29Ah> 01:11:28]<fenn> why don't all viruses transmit by air?
16:13 < L29Ah> the ecological niche for respiratory viruses is smaller than for viruses in general
16:13 < superkuh> Why what?
16:13 < L29Ah> and you can't produce much flying virions if you don't live in the air-exchanging part of the organism
16:14 < fenn> say i add a respiratory spread capability to another virus, even weakly effective at reproducing in that tissue, it could spread inside the host to another tissue type that it originally evolved for
16:14 < L29Ah> spreading inside host isn't easy too
16:14 < muurkha> it's "not an STD" because it *can* be transmitted by air
16:15 < L29Ah> by the time you get to spam your stuff through the blood supply, the adaptive immunity is already chasing for your stuff
16:15 < superkuh> https://twitter.com/mdc_martinus/status/1535199251466272769
16:16 < superkuh> Anyway, it's still in the early stages of spreading. I didn't know you'd recently been infected with sars-cov-2. Knowing that, yeah, going to the less death afterparty seems fine.
16:19 < L29Ah> 01:09:47]<fenn> "the British Health Security Agency finding that of the 699 monkeypox cases for which there was available information, 97% were in gay, bisexual or other men who have sex with men. New York City, the U.S. epicenter, has seen only one woman diagnosed with the virus out of 639 cases"
16:19 < L29Ah> so, are they going to quarantine/lockdown gays to prevent spread, or is this unthinkably intolerant?
16:19 < muurkha> okay, noping out of here right now
16:46 < fenn> yes L29Ah it's unthinkably intolerant
17:05 < muurkha> what's the thermodynamic limit on how little energy it requires to concentrate CO₂ from 400ppm air?
17:09 < muurkha> https://en.wikipedia.org/wiki/Direct_air_capture#Environmental_impact says 250 kWh/tonne CO₂
17:10 < muurkha> .units 250 kWh/tonne in J/kg
17:10 < saxo> 	250 kWh/tonne = 900000 J/kg 	250 kWh/tonne = (1 / 1.1111111e-06) J/kg 
17:27 < fenn> saxo's reciprocal units are wrong
17:28 < fenn> oh 1/1e-6 not 1e-6
17:28 < fenn> i still hate it
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18:28 < fenn> it's unreasonably difficult to find piracetam online now
18:28 < L29Ah> what do you do with piracetam?
18:30 < fenn> combine it with other mind altering drugs
18:31 < fenn> jan 25 2022 "most reputable companies have run out of stock of this compound and some completely removed it from their catalog. This happened after China — where most raw material suppliers are located — enacted recent regulations that restrict the production of many chemical compounds, one of which was phenylpiracetam."
18:32 < L29Ah> that's sad
18:33 < L29Ah> i remember piracetam being omnipresent in .ru pharmacies, but i'm not sure if the manufacturing of precursors is local enough
18:36 < fenn> i used to have jars of this stuff
18:41 < fenn> on piracetam i generally feel more in control of myself and my mind, able to say what i mean instead of mumbling and trying to come up with a wording
18:42 < fenn> it seems to reduce caffeine jitters and random thoughts
18:42  * L29Ah only bought it for reloading the capsules with more useful stuff
18:42 < fenn> lol
18:42 < fenn> by itself it's hard to detect any change
18:43 < fenn> i haven't noticed any effect of noopept
18:43 < L29Ah> piracetam taste is awful even by the illicit drug user standard
18:43 < L29Ah> and the effect is next to placebo
18:45 < fenn> it stops cats from dying when the blood supply to their brain is cut off
18:45 < fenn> for like 5x longer than the control group
18:45 < fenn> that's not a placebo effect
18:49 < muurkha> fenn: interesting, I wonder what its shelf life is
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22:33 < jrayhawk> i would expect *racetams to have no useful effect if you are choline deficient
--- Log closed Sat Jul 23 00:00:28 2022