--- Log opened Fri Aug 05 00:00:41 2022
02:35 -!- darsie [~darsie@84-113-55-200.cable.dynamic.surfer.at] has joined #hplusroadmap
03:05 -!- spaceangel [~spaceange@ip-78-102-216-202.bb.vodafone.cz] has joined #hplusroadmap
05:39 < kanzure> "Cellular recovery after prolonged warm ischaemia of the whole body" https://www.nature.com/articles/s41586-022-05016-1
05:41 < kanzure> an instance of in vitro selection plus machine learning to generate aptamers (or something like an aptamer) https://www.nature.com/articles/s41467-022-31955-4
08:05 -!- spaceangel [~spaceange@ip-78-102-216-202.bb.vodafone.cz] has quit [Remote host closed the connection]
08:06 < lsneff> today’s my last day at my summer internship
11:44 < kanzure> .tw https://twitter.com/jpsenescence/status/1555574320646193153
11:44 < saxo> Another great study questioning the role of mutations in aging. // Patients carrying germline mutations in MUTYH, a gene involving in DNA repair, have increased somatic mutation rates and more cancer. // Yet they do not show signs of premature aging. // https://www.nature.com/articles/s41467-022-31341-0 (@jpsenescence)
12:36 -!- darsie [~darsie@84-113-55-200.cable.dynamic.surfer.at] has quit [Ping timeout: 255 seconds]
12:38 < kanzure> "effective benevolence"
12:54 -!- darsie [~darsie@84-113-55-200.cable.dynamic.surfer.at] has joined #hplusroadmap
13:26 < kanzure> "The music box was probably invented about 1770 in Switzerland. The earliest music boxes were small enough to be enclosed in a pocket watch, but they were gradually built in larger sizes and housed in rectangular wooden boxes."
13:26 < kanzure> nearly a computer...
13:28 < L29Ah> perl -e 'use bytes; for($t=0;;$t++){ print chr($t*(($t>>12|$t>>8)&63&$t>>4)); }' | play -t raw -b8 -r8k -e un -
13:28 < L29Ah> 111 bytes-large music box
14:26 < kanzure> post-quantum cryptography lawsuit http://blog.cr.yp.to/20220805-nsa.html
14:28 < L29Ah> git init --object-format=sha256
14:38 < fenn> nmz787, L29Ah, i'm pretty sure that soap kills some beneficial bacteria that tend to keep the stink down, and it takes a week or so for their population to recover after using soap. most civilized people don't know this and haven't gone for weeks without soap to even be able to discover it
14:39 < fenn> there was some skin microbiome product that contained the bacteria, and also magnesium (chloride?) but unsure if the benefit was due to the bacteria, refraining from soap, or the magnesium being somewhat antimicrobial
14:39 < L29Ah> i couldn't discover it as i don't have talkative sniffers ready to present their findings when i'm weeks out of soap
14:39 < L29Ah> so sounds sus, [citation needed]
14:39 < fenn> well you can still rinse with water, which seems to do at least a 1 log reduction in stink
14:40 < L29Ah> my feet get stinky after 5 hours of wearing footwear tho
14:40 < fenn> leather sandals?
14:40 < L29Ah> sneakers
14:40 < L29Ah> sandals are nice but i don't live in a tropical climate
14:41 < L29Ah> also they suck for mountaineering and other heavy-duty jobs
14:41 < fenn> personally i use lactic acid ('bathroom disinfectant' spray with limonene is the only way to buy it)
14:42 < fenn> haven't had any athletes foot since starting to use that
14:42 < L29Ah> also i found that if i don't wash my feet a few times a week at least, the skin between fingers gets eaten by some fungi
14:42 < L29Ah> tho 10 years ago it wasn't like this
14:42 < L29Ah> fuken aging!
14:42 < fenn> yeah try applying ~1% lactic acid solution after washing feet
14:42 < L29Ah> (or i just contracted a badass strain in the meantime that still lives somewhere on me)
14:43 < fenn> i guess that whey-like liquid on top of yogurt could work
14:43 < fenn> i'm just annoyed that i can't go to the corner chemist and buy lactic acid
14:44 < fenn> first of all, there is no corner chemist...
14:45  * L29Ah is in a megacity withdrawal syndrome since he left .ru // https://rushim.ru/product_info.php?products_id=1372
14:48 < L29Ah> 23:42:56]<fenn> yeah try applying ~1% lactic acid solution after washing feet
14:48 < L29Ah> if i wash feet with soap daily, the fungi get the fuck out, and the lesions gradually heal
14:48 < L29Ah> slower than with terbinafine but still resolves completely-ish
14:49 < L29Ah> with terbinafine the effect on lesions is noticeable after 24h
14:51 < kanzure> posted webcash to bitcointalk: https://bitcointalk.org/index.php?topic=5408873.0
14:53 < L29Ah> 23:38:09]<fenn> nmz787, L29Ah, i'm pretty sure that soap kills some beneficial bacteria that tend to keep the stink down, and it takes a week or so for their population to recover after using soap. most civilized people don't know this and haven't gone for weeks without soap to even be able to discover it
14:53 < L29Ah> so, what experiments can you quote that confirm this?
14:54 < fenn> defending this is probably a bad use of my time
14:55 < kanzure> some #lesswrong user is talking about how he was prescribed 90mg adderall daily
14:57 < fenn> https://www.aobiome.com/aob-inflammatory-conditions-and-systemic-effects/
14:59 < L29Ah> kanzure: did it involve a bribe?
15:01 < fenn> "AO+ Restorative Mist
15:01 < fenn> Water, Nitrosomonas Eutropha, Disodium Phosphate, Magnesium Chloride (natural salts)"
15:01 < kanzure> L29Ah: narcolepsy!
15:01 < fenn> AObiome and mother dirt have apparently added a bunch of products with additional ingredients of dubious utility (rose water, etc)
16:36 < kanzure> hmph
16:56 < fenn> "Even among the top 1% of people as measured by cognitive ability (evaluated at age thirteen), exceptional outcomes are strongly correlated with [IQ]. Compared with those who are in the bottom quartile of this top 1%, those who are in the top quartile are two to three times more likely to earn a doctoral-level degree, publish a book, or be granted a patent."
16:57 < fenn> .title https://link.springer.com/article/10.1007/s10519-009-9273-0
16:57 < saxo> Exceptional Cognitive Ability: The Phenotype | SpringerLink
16:59 < kanzure> fenn: what is your take on eidetic memory in children?
16:59 < kanzure> and why is it not further studied as something miraculous
17:00 < fenn> i think all people have the capacity but it is only triggered during moments of extreme stress
17:01 < fenn> what are life outcomes like for eidetic adults?
17:03 < fenn> " Eidetic memory has been found in 2 to 10 percent of children aged 6 to 12. It has been hypothesized that language acquisition and verbal skills allow older children to think more abstractly and thus rely less on visual memory systems."
17:04 < fenn> maybe the "hard drive" just fills up and then you stop using that method of storage
17:06 < fenn> "a lack of compelling evidence that eidetic memory exists at all among healthy adults"
17:06  * fenn mumbles something about chimpanzees
17:13 < kanzure> perhaps also things like eyeglasses negatively influencing that skill
17:14 < kanzure> i didn't see any studies that tested whether the trait had any correlation with child personality
17:15 < kanzure> or heritability....
17:16 < kanzure> why is there no long-term heritability study on these children? wtf?
17:17 < fenn> i'm assuming there's a time lapse video of this drawing process available on BBC or somewhere https://www.stephenwiltshire.co.uk/new-york-skyline-panorama
17:21 < fenn> 615 artworks like this, jeez
17:27 < L29Ah> > earn a doctoral-level degree, publish a book, or be granted a patent
17:27 < L29Ah> sounds like boring hard work, just like solving/training for an IQ test
17:27 < L29Ah> no surprise these are correlated!
17:28 < fenn> "We also offer the unique opportunity for collectors to view the artist in person while he creates the commissioned work. Our team also documents each commission with photographs and video footage, as the artwork is being created."
17:28 < fenn> training for an IQ test huh
17:38 < kanzure> maybe children are just under-studied
17:38 < kanzure> has anyone tested the cognitive abilities of children's imaginary friends?
17:42 < kanzure> nah this is totally normal and unworthy of investigation
17:43 < L29Ah> have fun applying for funding for such an investigation
17:49 < fenn> have them factor prime numbers
17:49 < fenn> "so you think you're a machine elf..."
17:52 < kanzure> .title http://shugendo.org/
17:52 < saxo> Welcome to Evil Geniuses for a Better Tomorrow!
17:52 < kanzure> and https://egfabt.tripod.com/
17:58 < fenn> too cool for school
18:03 < jrayhawk> IIRC i made three such websites/organizations in middle and highschool at about that time
18:04 < kanzure> is it a reference to something?
18:06 < jrayhawk> gradiosity combined with late 1990's chic ironic moral detachment
18:07 < kanzure> rather bland
18:07 < jrayhawk> tyler durden nihilism seemed more appealing than kurt cobain nihilism at the time
18:10 < jrayhawk> which in turn seemed *way* more appealing than boomer spiritualism
18:18 < jrayhawk> the next generation responded with wokeism. this is our ironic cosmic punishment.
18:25 < archels_> "What Ever Happened to the Transhumanists?" https://news.ycombinator.com/item?id=32359596 
18:26 < archels_> apparently the annual TransVision conferences are still happening, Madrid this year https://www.transvisionmadrid.com/en/2022.html
18:29 < kanzure> .tw https://twitter.com/anderssandberg/status/1554241599902584833
18:29 < saxo> My own main take is that (1) we are living in a fairly transhumanist world, albeit more in terms of technology than the eagerness to embrace diversity and change, (@anderssandberg, in reply to tw:1554241597591605250)
18:29 < kanzure> anders tweet thread
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18:30 < kanzure> .tw https://twitter.com/ESYudkowsky/status/1554353857060229120
18:30 < saxo> @anderssandberg @dvorsky Possibly I overestimate my own importance, existing as I do at the center of my own observables, but I kinda worry that *I* happened to transhumanism. (@ESYudkowsky, in reply to tw:1554241597591605250)
18:31 < archels_> "us old-timers" hehe
18:34 < archels_> transhumanism is more like a disposition or an attitude, why insist we need infrared vision yesterday or the whole shtick is pointless
18:34 < jrayhawk> .tw https://twitter.com/schulzb589/status/1554442761314656256#m
18:34 < saxo> @SarifYong Perhaps the existential risk from A.I. that he elevated in conversations woke people up to the fact that Transhumanism would not be able to make it very far, given the rates of progress for both. (@schulzb589, in reply to tw:1554394744935038976)
18:36 < kanzure> how would they know if they didn't try?
18:38 < archels_> jrayhawk: that's a fallacious argument imho, enhancement of the human would allow us to keep par with AI and actually avoid the XR of being taken over by it
18:38 < jrayhawk> yeah, it remains our only hope
18:39 < jrayhawk> yud was right to promote the x-risk, but FAI is a honeytrap designed to keep pro-human consequentialists from getting in the way of hard AI takeoff
18:39 < jrayhawk> all FAI research has achieved is confirming that we're fucked
--- Log closed Sat Aug 06 00:00:42 2022