--- Log opened Sat Aug 27 00:00:01 2022
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01:27 < Llamamoe> > i wonder if it's possible to make a capsaicin that doesn't cause downregulation of TRPV1 receptor
01:27 < Llamamoe> Capsaicin isn't the only natural agonist, is it? I'd say look at those first 
01:27 < Llamamoe> If there's no data you could probably test most of them yourself on a willing no-tolerance acquaintance 
01:27 < L29Ah> are there whatever-agonists that don't cause downregulation?
01:28 < Llamamoe> Plenty of functionally selective molecules out there
01:29 < Llamamoe> It's not uncommon for a receptor to form complexes with multiple different proteins, each of which is responsible for different cellular responses
02:11 < maaku> lsneff: I was just reading the part in Liftoff! about how quick onboarding was at SpaceX so engineers didn't waste any time getting started
02:12 < maaku> guess things have changed
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04:23 < lsneff> Oh, it was just a bug in their hr software
04:23 < lsneff> they got someone to manually change something in the underlying database
04:23 < lsneff> again, I haven't started the job yet
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11:06 < otoburb> lsneff: Are you working at T-Mobile or SpaceX? Somehow felt related to the recent announcement. 
11:20 < lsneff> SpaceX
11:20 < lsneff> Actually, starting on monday
11:48 < kanzure> i don't understand https://hyperbeam.com/
11:51 < kanzure> https://mailchi.mp/574276e3c9d7/tinytapeout "get your 2-300 transistor designs on a real chip" (efabless shuttle i assume)
11:51 < kanzure> https://news.ycombinator.com/item?id=32617620
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--- Log closed Sun Aug 28 00:00:02 2022