--- Log opened Sun Sep 04 00:00:09 2022
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02:31 < maaku> lsneff: I was under the impression blue origin paid slightly better
02:32 < maaku> but I would say interview for a tech industry job, and use that way higher offer in negotations
02:32 < maaku> spacex probably won't budge much on their offer though
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08:58 < lsneff> They apparently matched one of my coworkers offers from msft and google
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14:26 < L29Ah> where does scihub live today?
14:26  * L29Ah wants to donate monies to scihub but isn't sure if the url he knows is legit
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14:50 < Llamamoe> I think it's .se 
14:50 < Llamamoe> But not sure
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15:15 < kanzure> why isn't there a ribosome made out of all protein?
15:20 < kanzure> .wik nonribosomal peptide synthetases
15:20 < saxo> "Nonribosomal peptides (NRP) are a class of peptide secondary metabolites, usually produced by microorganisms like bacteria and fungi." - https://en.wikipedia.org/wiki/Nonribosomal_peptide_synthetases
15:36 < nsh> .se worked for me today
15:36 < nsh> (.st didn't)
15:37  * nsh mumbles something about ideally not founding trust about donation recipient information on domain control
15:37 < nsh> sci-hub people could cryptographically sign a message with information about how to donate
15:37 < nsh> and should
15:46 < L29Ah> very
16:31 < kanzure> drexler on "molecular imprinting" https://arxiv.org/pdf/1807.07065.pdf
16:39 < kanzure> "Evolving enzymatic electrochemistry with rare or unnatural amino acids" https://www.sciencedirect.com/science/article/pii/S2451910322001673
16:43 < kanzure> .wik cyclodipeptide synthases
16:43 < saxo> "Cyclodipeptide synthases (CDPSs) are a newly defined family of peptide-bond forming enzymes that are responsible for the ribosome-independent biosynthesis of various cyclodipeptides, which are the precursors of many natural products with important biological activities." - https://en.wikipedia.org/wiki/Cyclodipeptide_synthases
16:48 < kanzure> "CDPSs' catalytic cycle begins with the binding of the first aa-tRNA, with its aminoacyl transferred onto a conserved serine residue to form an aminoacyl-enzyme intermediate. The second aa-tRNA interacts with this intermediate so that its aminoacyl is transferred to the aminoacyl-enzyme to form a dipeptidyl-enzyme intermediate. Finally, the dipeptidyl goes through an intramolecular cyclization ...
16:48 < kanzure> ...leading to the final cyclodipeptide."
16:54 < kanzure> this is an alternative to "nonribosomal peptide synthetases"
17:07 < kanzure> "Development of synthetic de novo designed proteins catalyzing acyl transfer reactions" https://tel.archives-ouvertes.fr/tel-03499138/document
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17:09 < kanzure> we need img2img for alphafold (draw a structure and get a protein)
17:10 < nsh> hm
17:16 < kanzure> language models for protein design https://www.nature.com/articles/s42256-022-00499-z
17:28 < kanzure> .title https://github.com/hpcaitech/FastFold
17:28 < saxo> GitHub - hpcaitech/FastFold: Optimizing AlphaFold Training and Inference on GPU Clusters
17:29 < kanzure> https://github.com/dptech-corp/Uni-Fold
17:30 < kanzure> 33,000 hours of GPU training time?
17:32 < L29Ah> mfw people use special syntax for delimiting packs of zeroes when there are metric prefixes
17:35 < kanzure> 'protein design which predicts protein sequences from their 3D structures' "AlphaDesign" https://arxiv.org/abs/2202.01079
17:43  * L29Ah demands AlphaPorn
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19:38 < fenn> hours are not SI
21:30 < lsneff> wish they were
21:30 < lsneff> kiloseconds, megaseconds, gigaseconds
--- Log closed Mon Sep 05 00:00:10 2022