--- Log opened Tue Sep 06 00:00:11 2022
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06:36 < kanzure> wonder what bitwarden is going to do with $100m https://news.ycombinator.com/item?id=32735479
06:36 < kanzure> would be nice to have a hardware-based password manager dongle
07:09 < kanzure> pick-and-place https://openpnp.org/hardware/
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08:12 < kanzure> .title https://github.com/karpathy/minGPT
08:12 < saxo> GitHub - karpathy/minGPT: A minimal PyTorch re-implementation of the OpenAI GPT (Generative Pretrained Transformer) training
10:21 < nmz787> kanzure: ref on yeast cell wall not healing after injection? it's interesting since electroporation does work. Maybe one thing you could do is package your DNA into a vessicle which you then do electrofusion on with your cell. Although you could also probably question whether you "suck up" all the DNA into your needle before injection, so it seems still somewhat questionable
10:23 < nmz787> kanzure: discord has picked up a handful of folks, who so far mostly just said 'hi'. I posted a bunch of stuff from my fave papers, but I think I need to write a google doc or something to better organize ideas and routes of experimentation, long-term goals as well as sub-goals to de-risk
10:24 < kanzure> ah it is your discord?
10:24 < kanzure> yeast cell wall ref is yashgaroth
10:24 < kanzure> i'm not sure why needle dna content is questioned but not electroporation dna uptake.... how do you know either way
10:25 < nmz787> yeah my discord, for bioMEMS
10:26 < kanzure> ok i'll join
10:30 < nmz787> kanzure: yeah I'm saying it's questionable in both 
10:30 < nmz787> without some proper QC metrics, like watching some fluorescent DNA get sucked up, then injected in
10:30 < nmz787> etc
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11:51 < fenn> thang010146 is very impressive
11:51 < fenn> does he post cad files as well?
11:55 < kanzure> don't think so
11:55 < kanzure> jrayhawk: maybe you can yoink a copy for us?
11:58 < fenn> just getting metadata for 3200 videos will probably trip google/youtube's bot detection
11:59 < kanzure> slooowly
11:59 < kanzure> "i'm binge watching"
12:04 < fenn> https://archive.org/details/thingiverse 2.4 million STL files, with a high proportion of nude models than i would have expected
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19:04 < fenn> .title https://neurosciencenews.com/axolotls-brain-regeneration-21355/
19:04 < saxo> Axolotls Can Regenerate Their Brains - Neuroscience News
19:22 < kanzure> do they have normal behavior afterwards?
19:23 < fenn> it does seem like an obvious thing to measure
19:24 < fenn> maybe they're saving it for the funding winter
19:25 < kanzure> spaz axolotl
19:27 < fenn> "no no no, we're the *quantitative* developmental biology lab, the qualitative lab is 50 meters down the hall"
19:38 < adlai> Muaddib: how big is your metaphorical hippocampus?
19:38 < Muaddib> adlai: well, my mom thinks it's about like this big. [extends arms about two feet in front of chest]
19:39 < adlai> Muaddib: will you remember these questions, when I bother you after the next Bitcoin reward halving?
19:39 < Muaddib> adlai: probably not, but my mom will remind me.
19:39 < adlai> Muaddib: why do you want me to talk about YOUR MOM
19:39 < Muaddib> adlai: Because she's always talking about me!
19:43 < fenn> his mom is... chidori?
19:51 < adlai> re: logs' discussion of cloacas, I must quote a joke, quoted by Kurt Vonnegut in one of his most overrated works of typistry:
19:51 < adlai> Q: What is the white stuff in bird poop? ... A: That is also bird poop.
19:52 < adlai> the next quote of a quote is from someone Dawkins quotes, in The Ancestor's Tale, which was peak Dawkins before he mistook "public understanding of science" for "public ridicule of pseudoscience":
19:52 < adlai> "The most significant phase of life is neither birth, nor conception, but gastrulation."
19:55 < adlai> is DOI:1804.03748 worth reading?
19:55 < fenn> no, nobody reads anymore
19:56 < fenn> also i can't resolve that DOI
19:56 < adlai> too many articles get dumped in here without any commentary beyond the title, which arguably is the least interesting kind of metadata, being too frequently editorialised by the publishers and not reflecting any opinion more nuanced than "hook! hook! why aren't you hyyyyuuuuuukkked!?"
19:56 < adlai> well, it's handwritten
19:56  * adlai is referring to... https://arxiv.org/abs/1804.03748
19:56 < adlai> .title
19:57 < saxo> [1804.03748] The Silurian Hypothesis: Would it be possible to detect an industrial civilization in the geological record?
19:57 < adlai> maybe that string is not, strictly speaking, a DOI; I must admit never bothering to learn much beyond "oh, ISBNs have checksums, cool"
19:58 < fenn> i thought it looked like an arxiv identifier but i was too lazy to think
19:58 < fenn> i mean it's obvious how to construct the url when you've seen one recently
19:59 < adlai> one of my drill sergeants advised me, when I took too long to build tents alone while he watched: "If you began thinking, don't."
19:59 < adlai> obviously it is a little late for such advice, after thinking has begun.
19:59 < fenn> thinking is an occupational hazard in the military
20:00 < fenn> you might get ideas, and then what
20:00 < adlai> it is quite important, except they only want people thinking in front of word processors. anyone thinking and simultaneously keeping the drafted plans secret is worse than terrorist.
20:01 < adlai> if you build crappy tents because you had no idea wtf you were doing, that's fine, then the drill sergeant can point out what was crappy about the tents and tell you what to do better.
20:01  * adlai thinks military logic gets too much hatred, from people who never had to deal with IQs lower than the proverbial homeostasis, let alone room temperature,
20:02 < adlai> is it time to normalize IQ to 300 yet?
20:03 < adlai> this could solve so many problems. "room temperature IQ" becomes Kelvin-compatible, and means... simply average, rather than few sigmas short of the hilltop.
20:05 < adlai> anyway, that 1804.03748 title caught my interest because one of my most frequent useless musings is whether velociraptors, and possibly other extinct social predators, had any culture beyond coordinated hunting.
20:06 < adlai> I guess I'll have to play peer reviewer, since nobody else here has, and it's not even from the academic publication mafia
20:34 < adlai> I hate it already... there's a semicolon-separated list, where the last item is only separated by a comma.
20:35 < adlai> HAS PROOFREADING YOUR OWN TURDS GONE THE WAY OF THE LINOTYPE !?
20:56 < adlai> well overall it's an interesting read, although I'd recommend thinking of it more as a review article than attempts to falsify some fresh hypothesis.
20:56 < adlai> it could be a good root tip introducing lots of citations for further reading about the anthropocene and micropaleontology
20:58 < adlai> namedrops ideas tangential to abiogenesis a few times, without saying much directly on the topic; it's mostly about extrapolations from the proverbial spillage of human civilisation.
20:58 < adlai> .w spillage
20:58 < saxo> spillage — noun: 1. The process or action of spilling, 2. That which has been spilled
20:58 < adlai> well those are both uselessly accurate defini... nah, not even. those are at best only glosses.
20:59 < adlai> 'spillage', the noun, doesn't only refer to crap sludged out of a factory. the same word also refers to the smell that perfume leaves in a room after the wearer leaves the room.
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--- Log closed Wed Sep 07 00:00:12 2022