--- Log opened Wed Sep 07 00:00:12 2022
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09:26 < muurkha> .wik gastrulation
09:27 < saxo> "Gastrulation is the stage in the early embryonic development of most animals, during which the blastula (a single-layered hollow sphere of cells) is reorganized into a multilayered structure known as the gastrula." - https://en.wikipedia.org/wiki/Gastrulation
09:28 < muurkha> adlai: trying shit is often a more effective way to learn than theorizing about shit, depending on many factors
09:29 < muurkha> IQ is not the only one
09:55 < fenn> .title https://cen.acs.org/acs-news/acs-meeting-news/Stretchy-conductive-electrodes-keep-octopus/100/i30
09:55 < saxo> No title found
09:55 < fenn> bah
09:55 < fenn> .title https://www.science.org/doi/10.1126/science.abj7564
09:55 < saxo> Just a moment...
09:55 < fenn> "Topological supramolecular network enabled high-conductivity, stretchable organic bioelectronics"
09:56 < fenn> "The best polymer design started with a polyethylene glycol (PEG) backbone strung with sliding cyclodextrin rings, which were decorated with conductivity-boosting side chains and functional groups that make the material compatible with photolithography. The researchers then cross-linked this polymer with the conductive polymer PEDOT:PSS."
09:56 < fenn> “You have something whose conductivity is comparable to inorganic materials, but it’s also stretchable,”
09:57 < fenn> "We obtained simultaneously high conductivity and crack-onset strain in a physiological environment, with direct photopatternability down to the cellular scale. We further collected stable electromyography signals on soft and malleable octopus and performed localized neuromodulation down to single-nucleus precision for controlling organ-specific activities through the delicate brainstem." zhenan
09:57 < fenn> bao
09:58 < fenn> zhenan bao
10:32 < kanzure> .wik lithoredo
10:32 < saxo> "Lithoredo is a genus of shipworm native to the Abatan River in the Philippines. It contains a single species, Lithoredo abatanica, described in June 2019.  The species is unusual because, unlike other shipworms which mainly bore into wood, it tunnels into and excretes [...]" - https://en.wikipedia.org/wiki/Lithoredo
10:32 < kanzure> "The species is unusual because, unlike other shipworms which mainly bore into wood, it tunnels into and excretes limestone. It lacks the cecum which in other shipworms holds symbiotic bacteria which digest wood. Compared to other shipworms, lithoredo have differently shaped teeth which can finely grind stone. The worms use the tunnels to live in but their method of eating is not yet known. ...
10:33 < kanzure> ...They may get nutrition from bacteria in their gills."
10:53 < kanzure> desktop oligonucleotide synthesizer https://kilobaser.com/  $0.50/bp and the machine is $30k.. not particularly improved over the models from 20-30 years ago.
10:53 < kanzure> looks like for custom primers really.. 20-40 bp
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11:00 < muurkha> do you mean "not particularly cheaper", or not improved in any way other than being much cheaper?
11:02 < kanzure> huh, you can't get streaming satellite imagery yet? this says the images are delivered "within hours" https://albedo.com/product-specs
11:02 < kanzure> muurkha: it is more expensive actually.
11:04 < muurkha> oh interesting
11:06 < kanzure> actually i don't remember what the ABI synthesis costs per bp were. maybe it was as high as $1-2/bp for some time.
11:26  * L29Ah almost received realtime weather satellite imagery with his rtlsdr
11:26 < L29Ah> SNR sucks, need a RF filter
11:37 < muurkha> aw
11:38 < muurkha> out-of-band interference that's aliasing into the band you're trying to capture?
11:47 < L29Ah> muurkha: likely yes
11:47 < L29Ah> i have a powerful FM radio transmitter nearby
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13:30 < kanzure> .wik theoretical minimum RNA rings
13:30 < saxo> Article not found: https://en.wikipedia.org/wiki/Theoretical_minimum_RNA_rings gave 404 | Searched en for 'theoretical minimum RNA rings' | https://en.wikipedia.org/wiki/No_result_found gave 404 | Searched en for 'No result found'
13:36 < kanzure> weird "RNA world hypothesis" about RNA rings https://www.mdpi.com/2079-7737/9/5/88/htm
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16:57 < kanzure> "A self-replicating peptide" https://cba.mit.edu/events/03.11.ASE/docs/Lee.pdf
17:00 < muurkha> Muaddib: your mom is a self-replicating peptide
17:00 < Muaddib> muurkha: your mom is an RNA ring
17:04 < kanzure> "The Central Dogma revisited: Insights from protein synthesis, CRISPR, and beyond" https://wires.onlinelibrary.wiley.com/doi/10.1002/wrna.1718
17:04 < kanzure> does anyone have access to this?
17:10 < kanzure> .wik prime editing
17:10 < saxo> "Prime editing is a ‘search-and-replace’ genome editing technology in molecular biology by which the genome of living organisms may be modified." - https://en.wikipedia.org/wiki/Prime_editing
17:10 < kanzure> it's not clear to me that this would work at all, looks neat
17:11 < kanzure> definitely a divergence from traditional cas9 editing
17:39 < kanzure> i don't understand prime editing
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19:51 < kanzure> chemical DNA editing technique "ARCUT" https://pubmed.ncbi.nlm.nih.gov/23385238/ "artificial restriction DNA cutter"
20:06 < kanzure> "The RNA/protein symmetry hypothesis: experimental support for reverse translation of primitive proteins" https://pubmed.ncbi.nlm.nih.gov/11401460
20:15 < kanzure> "Methods and compositions for reverse translation [of proteins]" https://patents.google.com/patent/US20070087377A1/en
20:42 < kanzure> had an idea today about using aa-tRNA with a library of mismatched anticodons (eg 1 anticodon but each tRNA using that same anticodon is attached to each possible amino acid) and an mRNA template that has alternating codons
20:42 < kanzure> so in this method there would be two codons in alternating sequence in the mRNA template
20:43 < kanzure> which is what would allow for a wash step between amino acid additions into the protein
20:43 < kanzure> with the reverse translation method (which looks really sketch because it relies on solid phase oligonucleotide chemistry), you could decode the protein back into DNA which is nifty
20:45 < kanzure> unfortunately there seems to be no good way to convert the synthetic protein to RNA or DNA
20:46 < kanzure> a possibly similar ribosomal protein synthesis patent can be found because it cites that "reverse translation" patent: https://patents.google.com/patent/US7923533B2/en
20:52 < kanzure> http://bytesizebio.net/2011/04/01/reverse-translation-discovered/ (note the date...)
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21:35 < lsneff> I hadn’t realized how large the gen2 sats were until I saw them in person today
21:37 < fenn> are they bigger than gen1?
21:38 < fenn> hm. "Gen2 satellites are 22 feet long and weigh 2,755 pounds" quite a lot bigger
21:39 < fenn> that's a rather precise number of pounds
21:40 < fenn> 1250kg
21:40 < lsneff> Yea, they’re absolutely massive
21:40 < lsneff> The solar array is as long as the building they’re in is wide
21:41 < fenn> good thing it's not much longer or there'd be no room to stretch out
21:42 < lsneff> Exactly lol
--- Log closed Thu Sep 08 00:00:13 2022