--- Log opened Sat Sep 10 00:00:15 2022
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08:21 < kanzure> "Ribosome repurposing: maybe we could convert a ribosome to construct DNA molecules or oligos or RNA or something; the tRNA synthetase machinery already translates from codons (3 bp) to a single amino acid. This is similar to mechanisms required for information decoding or error correction codes." - me from 2017
08:21 < kanzure> i don't really see how to make a ribosome polymerize RNA in its peptide exit tunnel
08:26 < kanzure> looks like i was close to https://patents.google.com/patent/US7923533B2/en here in 2014 https://groups.google.com/g/enzymaticsynthesis/c/3YEEv0OULo0 also i notice cathal posted the solution.....
08:27 < kanzure> "How about this: degenerate mRNA nucleotides and orthologous tRNAs, so an arbitrary "next triplet" can be loaded with a chosen amino? To avoid repeats have two incompatible triplets staggered and two sets of 21 aminos per triplet. Feed charged tRNA stepwise, wash between. No modified ribosome required, minimal modified tRNAs."
08:32 < kanzure> there should be interactive 3d animations of molecular biology processes, where the animation plays and you can probe little parts to see what the different pieces are called
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11:14 < kanzure> smarter people are capable of better ethical thinking, therefore smarter people are more ethical
11:43 < jrayhawk> potentially
11:44 < jrayhawk> smart is as smart does
11:53 < kanzure> https://pbs.twimg.com/media/FaNwxKlVUAE-cqa?format=jpg&name=small
11:58 < nsh> richer people are capable of better ethical influence, therefore richer people are more ethical
12:01 < nsh> smarts is not even intelligence insofar as we can imagine it being general. general intelligence is not even wisdom insofar as wisdom is the faculty for acting in the world in some universalised sense of "better". wisdom is not even compassion insofar as compassion is considered a universal influence on action tending towards benificience
12:01 < nsh> i could go on but it might be unkind to belabour the point. kindness being a way to universalise the application of compassion in action
12:01 < nsh> etc.
12:02 < nsh> to be street-smart is often to refrain from compassion in an environment of dog-eat-dog. to be prudent in an environment of business might require making decisions that when viewed from a humanitarian perspective are difficult to reconcile with more or less universally acceded values of ethics and morality
12:03 < nsh> to be scientific requires the limited and prudent application of reductivism such as in the statement occasioning this rant. where of course it is generally accepted that in reductivism as in all things there can be too much of a good thing
12:05 < nsh> the sun is good in the sense that it acts with universal munificence in equal measure to all without conditionality
12:05 < nsh> thus without judgement or discernment
12:06 < nsh> but indirectly it influences the weather which acts relatively and in extremis calamitously
12:06 < nsh> to build a dwelling cheaply might be considered prudent financially modulo the externality of robustness against the weather
12:06 < nsh> at this stage the point might well be considered belaboured :)
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13:36 < kanzure> .wik david r. liu
13:36 < saxo> Article not found: https://en.wikipedia.org/wiki/David_r._liu gave 404 | Searched en for 'david r. liu' | https://en.wikipedia.org/wiki/No_result_found gave 404 | Searched en for 'No result found'
13:36 < kanzure> .wik David R. Liu
13:36 < saxo> "David Ruchien Liu (born 1973) is an American chemist and biologist. He is the Richard Merkin Professor, Director of the Merkin Institute of Transformative Technologies in Healthcare, and Vice-Chair of the Faculty at the Broad Institute of Harvard and MIT; Thomas Dudley Cabot [...]" - https://en.wikipedia.org/wiki/David_R._Liu
14:02 < kanzure> https://scholar.archive.org/
14:14 < kanzure> "Enzyme-free translation of DNA into sequence-defined synthetic polymers structurally unrelated to nucleic acids" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277153/
15:06 < kanzure> "Producing molecular biology reagents without purification" https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0252507
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--- Log closed Sun Sep 11 00:00:16 2022