--- Log opened Wed Sep 14 00:00:18 2022 01:59 -!- darsie [~darsie@84-113-55-200.cable.dynamic.surfer.at] has joined #hplusroadmap 02:16 < nsh> "the first volley"? 02:16 < nsh> do you ever, like, read twitter? 02:17 < nsh> the illusion of authentic discourse was out of the window already 6 years ago 02:18 < nsh> furthermore the most dangerous situation is the liminal period where it can still be pretended 02:19 < nsh> when it becomes clear that without efforts to leverage cryptography to provide a trustworthy signal of civic status we at least have some realistic prospect of rising to the occassion 02:19 < nsh> *occasion 03:14 < L29Ah> maaku: the citizenship price is too expensive for me, i prefer to go the LLC way, it's about 100x cheaper 03:49 < muurkha> L29Ah: LLCs are easier for politics to shut down later 03:49 < muurkha> revoking citizenship is generally a fairly high bar 03:55 < L29Ah> muurkha: indeed, but for now they can't even demand visas for russians due to the fear of losing tourism profit 03:56 < L29Ah> and after five years of LLC one can get a permanent residence permit that is a bit higher bar (and can trash the LLC) 03:57 < L29Ah> so the immigrant community shouldn't start looking like a menace and that's it, i guess 03:59 < L29Ah> maaku: "here" is where? 04:48 < muurkha> 5 years ago nobody had heard of covid (the big disease worry was cholera in Yemen), the war in Ukraine had pretty much ended (Eurovision was in Kyiv that year), Donald Trump had just become president of the US, the big humanitarian crisis was potential famine in Nigeria and East Africa, the UK was part of the EU, the big worry in US-Russian relations (the Intermediate-Range Nuclear Forces Treaty was 04:48 < muurkha> still in effect) was the US blowing things up in Syria (where Daesh was operating freely; Daesh also controlled Mosul until July), the US puppet regime still ruled Afghanistan, Montenegro had only just joined NATO, Jeremy Corbyn led Labour in the UK, North Korea did its first ICBM tests, the humans detected gravitational waves for the first time, Catalonia declared independence from Spain, Robert 04:48 < muurkha> Mugabe still ruled Zimbabwe, the humans had never observed an interstellar object, monkeys had not yet been cloned, the Falcon Heavy had not flown, the presidency of China and the leadership of the Kazakh Security Council had term limits, people outside Russia hadn't heard of "novichok", the US was still part of the Iranian nuclear agreement, there was no GDPR and no cookie acceptance nagbanners, 04:48 < muurkha> abortion was illegal in Ireland and Argentina, the US was still part of the UN Human Rights Council, marijuana was illegal in Canada (and selling it was illegal everywhere except Uruguay), women weren't allowed to drive in Saudi Arabia, Eritrea and Ethiopia were still at war, the press still loved Elon Musk and he'd never publicly called anyone a "pedo guy", no company had ever had a market cap of 04:48 < muurkha> US$1T, Greta Thunberg was still a private citizen, gay sex was still a crime in India, Bolsonaro had never been elected president, no genetically edited humans had been born yet, the Yellow Vests hadn't yet appeared in Paris, less than half of the world's population were using the internet, Ingvar Kamprad still ran IKEA, Stephen Hawking was still alive, the US hadn't yet imposed punitive tariffs on 04:48 < muurkha> Chinese solar panels, NAFTA was still in effect, the Armenian Revolution hadn't happened yet, Hong Kong still retained its pre-handover protections for human rights, the 02019 uprisings across the Middle East hadn't happened yet, Cuba still had its Castro-era constitution, the president of Chile was a Socialist, CRISPR had not yet been publicly used on a human, the Notre Dame hadn't burned, and 04:48 < muurkha> Venezuela's civil war with US-backed Juan Guaidó hadn't started 04:48 < muurkha> a lot can happen in 5 years. it may not, but I'd expect the next 5 years to be more exciting than the last 5 years 04:50 < muurkha> oh, and Assange was still enjoying asylum in the Ecuadorean embassy 05:01 < muurkha> Hungary was still a free country 05:31 -!- Malvolio [~Malvolio@idlerpg/player/Malvolio] has quit [Quit: smwht baffled COV noled to boom in ventilation, air quality & breathing accessories; Eur must surely be occupied with Solar concentrators &c] 05:56 < kanzure> what 05:59 < kanzure> more hplus less geopol 06:05 < muurkha> there's significant h+ content there, but the issue at hand is that to put h+ into practice, we need to weather the near future geopol situation, for which we need an accurate assessment of what it is likely to be like 06:06 < muurkha> I was just pointing out that it's a bit of a risky bet to expect .me's immigration policy to remain unchanged for the next 5 years 06:15 < L29Ah> i can face this risk without much losses while i can't surmount the upfront cost of the citizenship 06:16 < L29Ah> even the illegal way to obtain the citizenship that i heard about costs ~50ke, and that's much more than i'm ready to pay 06:17 < muurkha> yeah, and you also probably have a more realistic understanding of political instability than ... people who have lived in the US or UK or Argentina all their lives, which is who I talk to most often 06:19 < L29Ah> the political instability mainly hits local stationary long-term businesses, and i'm not investing in these; this is sad but it is the reality i got used to in .ru 06:20 < muurkha> well, in the US during the Obama and Trump years, it hit several million illegal immigrants 06:21 < kanzure> sigh 06:21 < muurkha> and as you know better than I do, it's now hitting everyday people in Russia 06:21 < muurkha> the Argentine customs situation makes it near-impossible for me to import supplies 06:22 < L29Ah> muurkha: find a legal fren at some even, problem solved 06:22 < L29Ah> event 06:22 < muurkha> fren? 06:22 < L29Ah> friend 06:23 < muurkha> oh, even for normal people, importing supplies is touch-and-go at best 06:23 < muurkha> on one hand, most of the supplies I would like to buy haven't been invented yet; but on the other hand, it's a real handicap to try to improvise them without access to the existing global economy, primitive as it is 06:24 < kanzure> muurkha: do you know any chemistry 06:24 < muurkha> kanzure: only the most basic stuff 06:25 < muurkha> chemistry is considered very suspicious here 06:25 < muurkha> basic materials like lye and sulfuric acid are tightly regulated as "drug precursors" 06:25 < muurkha> hardware stores still sell lye, but unlabeled 06:26 < muurkha> I did find a local supplier of synthetic ruby though! 06:28 < muurkha> kanzure: what do you have in mind? 06:30 < L29Ah> i have a RV-owner fren who told me that customs officials never shuffle through his car-home, don't even enter usually, so he manages to sneak innocuous stuff, that would be annoying to get through legally, through state borders during his travel 06:33 < muurkha> yeah, smuggling has been a big business in Argentina for centuries 06:33 < muurkha> the country was founded on it, really 06:34 < kanzure> this is painful 06:34 < kanzure> is anyone else in pain 06:34 < muurkha> yes, I am 06:36 < muurkha> unfortunately we need to deal with a lot of pain caused by the current state of affairs in order to figure out how to change them 06:37 < muurkha> not by wasting our time on partisan squabbling, of course, but by figuring out where partisan squabbling hasn't yet blocked the opportunities for progress 06:38 < L29Ah> we at Montelibero hope to influence the .me citizens to push the squabbling into libertarianism 06:39 < muurkha> we'll see, libertarianism often gets co-opted by partisan squabbling pretty quickly 06:40 < muurkha> here in Argentina a "libertarian" community center just got raided by the police after one of its members tried to assassinate the vice president (who is the former president and likely next president) last week 06:40 < muurkha> and a "libertarian" got elected to Congress — largely on his opposition to the legalization of abortion 06:40 < L29Ah> so far it's more like an agorist community as we have about 50 members locally yet 06:40 < muurkha> nice 06:41 < muurkha> hopefully it works out well! 06:41 < L29Ah> and it takes about ~600 citizens to get a representative in the parliament 06:42 < L29Ah> er, 6000 06:42 < muurkha> yeah, but once you get entangled in Parliament, you can't avoid being targeted by partisan politics 06:42 < muurkha> and then it's a waste of time forever 06:46 < L29Ah> muurkha: what would you consider a more effective strategy for living in a libertarian country? 07:00 -!- Malvolio [~Malvolio@idlerpg/player/Malvolio] has joined #hplusroadmap 08:33 < muurkha> I don't know of an effective strategy for that, since nobody has managed to do it yet 08:34 < muurkha> but in general effective strategies in politics seem to be variants of "let's you and him fight" 08:35 < muurkha> the people who actually do the fighting — infantry troops, voters, members of Parliament, etc. — never win 08:35 < muurkha> it's the people who manipulate them into fighting who win 08:37 < muurkha> if you can manipulate all the non-libertarians into fighting with each other instead of with libertarians, and keep the libertarians from wasting energy on fighting (with each other or anyone else), the libertarians will probably win 08:40 < muurkha> but you have to keep in mind that any political faction who sees libertarians as significant potential opposition will work hard to divert the libertarians' energy into fighting — ideally, with each other, but at least with some other group. right now the wokists are probably the most promising target; if the conservatives can waste the libertarians' and wokists' energy by getting them to 08:40 < muurkha> fight one another, they can put their policies into effect, as they recently did in the US by striking down the Roe v. Wade prohibition on abortion 08:42 < muurkha> right now in the US anyone with even vaguely radical or socialist sympathies is freaking the fuck out about "fascists", and they identify libertarians (or "libertarians") as fascists; as in Ukraine, some of the libertarians oblige by using fascist rhetoric and symbology or even shifting away from libertarian policies toward fascist policies 08:45 < muurkha> the US is a good distance down the slippery slope toward a Cultural Revolution, and if that happens the victors will be Xi, Putin, and nobody in the US 08:45 * L29Ah waits for the US civil war for over five years and it's still nowhere near 08:46 < muurkha> yeah, it probably won't get there. but it might 08:46 < muurkha> did you see somene bombed the Georgia Guidestones? 08:46 < muurkha> *someone 08:46 < muurkha> .t Georgia Guidestones 08:46 < saxo> InvalidURL: URL can't contain control characters. '/r/tw/Georgia Guidestones' (found at least ' ') (tw:17) 08:46 < muurkha> .wik Georgia Guidestones 08:46 < saxo> "The Georgia Guidestones was a granite monument that stood in Elbert County, Georgia, United States, from 1980 to 2022. It was 19 feet 3 inches (5.87 m) tall and made from six granite slabs weighing a total of 237,746 pounds (107,840 kg)." - https://en.wikipedia.org/wiki/Georgia_Guidestones 08:48 < muurkha> I think there's about a 60% chance the US will pull out of this dive toward a renewal of its civil war, and about a 20% chance it'll be in outright war within 9 years (defined as "more than 1 million dead") 08:48 < kanzure> sigh 08:49 < kanzure> you have incurred a great debt which you can only repay with awesome science and technology progress 08:49 < muurkha> I'm working on it! but the humans aren't making it easy 08:50 < kanzure> if i wanted to read about politics i would just browse twitter 08:52 < muurkha> on twitter all you'll find is the people fighting each other 08:58 < kanzure> yes exactly 08:58 < kanzure> that's politics, so stop putting that in here 09:07 < muurkha> politics is a very significant obstacle to H+ efforts. a roadmap needs to document the obstacles in the territory it covers, doesn't it? 09:30 < nmz787> .title https://www.nature.com/articles/srep12066 09:30 < saxo> Polymerase/DNA interactions and enzymatic activity: multi-parameter analysis with electro-switchable biosurfaces | Scientific Reports 09:30 < nmz787> Here we report a method that utilizes a stimuli-responsive molecular interface for the investigation of polymerization processes and does not require the labelling of nucleotides or polymerases. The functional elements are oligonucleotide probes which are assembled at a very low density on gold microelectrodes. By applying alternating electrical potentials these probes are set in motion and perform 09:31 < nmz787> an oscillatory orientation switching from which two types of measurement variables are obtained in real-time: The switching speed depends on the hydrodynamic friction of the probes and thus indicates the presence of a bound polymerase, its position along the DNA and its conformation. At the same time, the extension of electrically aligned “standing” DNA molecules is measured, revealing how many 09:31 < nmz787> base-pairs have formed in the course of polymerization activity. 09:31 < nmz787> This is demonstrated for the Taq DNA polymerase from T. Aquaticus and the Klenow fragment of Pol I from E. coli. The described assay is applicable to DNA and RNA polymerases and is performed using commercially available chips and instruments. 10:06 -!- CryptoDavid [uid14990@id-14990.uxbridge.irccloud.com] has joined #hplusroadmap 11:34 -!- spaceangel [~spaceange@ip-78-102-216-202.bb.vodafone.cz] has joined #hplusroadmap 13:02 -!- flooded [flooded@gateway/vpn/protonvpn/flood/x-43489060] has quit [Remote host closed the connection] 13:03 -!- flooded [flooded@gateway/vpn/protonvpn/flood/x-43489060] has joined #hplusroadmap 14:38 -!- spaceangel [~spaceange@ip-78-102-216-202.bb.vodafone.cz] has quit [Remote host closed the connection] 16:01 -!- CryptoDavid [uid14990@id-14990.uxbridge.irccloud.com] has quit [Quit: Connection closed for inactivity] 16:59 -!- darsie [~darsie@84-113-55-200.cable.dynamic.surfer.at] has quit [Ping timeout: 268 seconds] 17:38 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=a30229ba Bryan Bishop: transcripts: silicon salon 2 >> http://diyhpl.us/diyhpluswiki/transcripts/silicon-salon/validating-lightning-signer/ 17:41 < kanzure> https://diyhpl.us/wiki/transcripts/silicon-salon/precursor/ 23:48 -!- darsie [~darsie@84-113-55-200.cable.dynamic.surfer.at] has joined #hplusroadmap --- Log closed Thu Sep 15 00:00:19 2022