--- Log opened Fri Sep 16 00:00:20 2022
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06:57 < kanzure> microfluidics does not seem to be appropriate for minimizing cross-contamination
07:12 < muurkha> often people minimize cross-contamination with microfluidics by using an apparatus once and discarding it
07:15 < kanzure> wouldn't that discard your ongoing reaction?
07:18 < kanzure> in particular the reused binary tree addressing/multiplexing scheme described here https://gnusha.org/logs/2018-01-15.log
07:18 < kanzure> in fact, it would seem i have the same question as i did then.
07:19 < kanzure> blocked address routes down the tree can still accumulate contaminants that will be sent down the tree to wrong reaction chambers when their valves open later
07:20 < kanzure> acoustic droplet ejection and inkjet printing is interesting because it uses an air interface to minimize cross-contamination
07:20 < muurkha> yes
07:22 < muurkha> also though I think the ridiculously low Reynolds numbers involved hurt our intuition about mixing
07:22 < kanzure> ah, i have not accounted for that.
07:22 < kanzure> visual evidence of cross-contamination: https://www.youtube.com/watch?v=skMgY5oyGsE
07:22 < Muaddib> [skMgY5oyGsE] Microfluidic multiplexer -- cycling inlets with single rinse [Folch lab] (0:40)
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09:19 < nmz787> kanzure: doesn't appear that they flush until the last 5 seconds
09:21 < kanzure> yea
09:42 < muurkha> .units 13 ml .572 g/cc
09:42 < saxo>  Definition: 0.007436 kg 
09:42 < muurkha> .units 2 MPa in psi
09:42 < saxo> 	2 MPa = 290.07548 psi 	2 MPa = (1 / 0.0034473786) psi 
11:45 < docl> I wonder how e-ink displays handle that? maybe the reactions aren't purity sensitive
11:49 < muurkha> what do you mean?
11:56 < docl> an e-ink display works via microfluidics, so I'm wondering how it avoids the pigments getting mixed up
12:01 < docl> might just use pigments that separate out easily, or contain them in different cells
12:09 < nmz787> pretty sure e-ink is just an array of isolated columns
12:09 < nmz787> ink moves up and down the column
12:19 < muurkha> yeah, and typically the white pigment is solid and insoluble, and the black pigment is liquid (or vice versa?) so they don't mix
12:28 < docl> quite a few different strategies it seems https://en.wikipedia.org/wiki/Electronic_paper
12:32 < muurkha> yeah, but I think that's the one that won out
13:48 < docl> I think I understand bernoulli's principle now
13:49 < docl> if you bounce something off a moving object like a passing train, the bounce is partly converted to sideways momentum
13:50 < docl> so if you have a flat object being dragged through the air, the air molecules that bounce off don't have as much force in the direction away from the movement, as it's getting converted to the same direction as movement
13:51 < muurkha> I don't think that is what's going on at all
13:52 < muurkha> you're describing viscous drag, not bernoulli's principle
13:56 < muurkha> Old Dan looked at water flowing through a thin pipe that was fed from a thick pipe, and noted that, since the volume flow rate was the same in both sections of pipe, the water in the thin pipe was moving faster, so it had more kinetic energy
13:57 < muurkha> the question he was considering was, where does that energy come from?  how does the energy get into the water?  what is pushing on it to speed it up?
13:57 < muurkha> so that's how he derived his principle, which Euler later formalized as ½v² + gz + p/ρ = k
13:59 < muurkha> viscous drag could maybe explain why water moving from a thin section of pipe into a thick section slows down, but is it evident why it can't explain how water speeds up going from a thick pipe into a thin one?
14:06 < docl> that seems like maybe the inverse of what I was thinking of, like if you have a stream of air going past an opening at high speed it makes a vacuum in the opening
14:07 < docl> molecules in the opening will mix with the high speed air and not get a chance to bounce back out because their inertia is aligned with the air
14:20 < docl> from wikipedia, thick/thin pipes transforming pressure/velocity seems to be venturi effect?
14:33 < kanzure> https://scientistnobee.wordpress.com/2020/03/22/electromagnetic-probe-for-dna-isolation/
14:39 < kanzure> "Catalog says its current prototype DNA computation and storage platform, or DNA writer, called Shannon, has demonstrated the potential of DNA computation and storage as a proof of concept, but it is a large machine that requires a significant amount of chemistry. The size of Shannon is like an average family kitchen, according to Catalog."
14:39 < kanzure> from https://techcrunch.com/2022/09/08/synthetic-dna-startup-catalog-partners-with-seagate-for-its-dna-based-data-storage-platform/
15:05 < kanzure> "Computational design of mechanically coupled axle-rotor protein assemblies" https://www.bakerlab.org/wp-content/uploads/2022/04/science.abm1183.pdf
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16:48 < muurkha> docl: yes, the Venturi effect is an application of Bernoulli's principle, as the "Background" section of the "Venturi effect" Wikipedia article explains
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19:41 < lsneff> Apparently, my manager interviewed someone from Phil metzgers lab a few years ago
19:41 < muurkha> Perry, I hope?
19:41 < muurkha> not Phil
19:42 < muurkha> oh, no, maybe you do mean Phil Metzger
19:46 < lsneff> Yeah, phil
19:54 < muurkha> sorry
19:54 < muurkha> I have nothing against Phil Metzger, I was confusing him with someone else
19:56 < lsneff> Well, they said that his code sucked lol
20:00 < muurkha> heh
21:46 < muurkha> https://danluu.com/futurist-predictions/ is pretty devastating
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--- Log closed Sat Sep 17 00:00:21 2022