--- Log opened Mon Nov 21 00:00:23 2022
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10:30 < kanzure> hmph
10:38 < kanzure> .tw https://twitter.com/leashless/status/1594759500053241857
10:38 < saxo> I wrote a science fiction novel called “Mother of Hydrogen” about totalitarian governments policing the entire earth after an xrisk event—but not the Moon and Mars! // You can read the first draft here for free http://files.howtolivewiki.com/MOTHER_OF_HYDROGEN_NOVEL/index.html https://twitter.com/peterhartree/status/1594429794044694528 (@leashless)
10:41 < kanzure> can't vouch for the quality, haven't read it
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11:02 < muurkha> kanzure: I read it, it's pretty enjoyable
11:03 < streety> should I know what an xrisk event is?
11:07 < kanzure> streety: it's this thing you get when you multiply low probabilities by large effects
11:08 < kanzure> and then you run around telling everyone that because the effect is so theoretically large, it is therefore the most important thing to focus on, or something
11:08 < kanzure> or, in some cases, you construe the low probability as a high probability, and then demand everyone donates to your non-profit to stop The Problem which you don't actually solve
11:13 < streety> thanks, I assumed it was short for existential risk but from a quick search all I could add was that it might be a genre of science fiction.
11:15 < kanzure> .tw https://twitter.com/maxhodak_/status/1594756798627520513
11:15 < saxo> we're excited to take the covers off our first product program, an optogenetic retinal prosthesis! // https://science.xyz/news/announcing-the-science-eye/ (@maxhodak_)
11:19 < fenn> streety: it's just short for existential risk
11:25 < fenn> "science eye" is a bad name
11:25 < fenn> to state the obvious
11:26 < fenn> i guess they intend to do more prostheses
11:27 < fenn> still, "science" is your business name? is that legal?
11:27 < fenn> it's going to piss off a lot of scientists at least
11:28 < kanzure> .tw https://twitter.com/elonmusk/status/1594732430933782528
11:28 < saxo> @Rainmaker1973 I can’t think of a worse curse than living forever (@elonmusk, in reply to tw:1594730398709616640)
11:28 < kanzure> .tw https://twitter.com/kanzure/status/1594763652443566080
11:28 < saxo> @elonmusk @Rainmaker1973 it's ok, nobody has been pushing for involuntary immortality && involuntary invulnerability anyway (@kanzure, in reply to tw:1594732430933782528)
11:40 < fenn> i just want to dig through your connectome for the juicy details
11:41 < fenn> presumably hodak & co want to do an optogenetic brain interface, but figured an optic nerve interface would be simpler to develop and with less regulation and safety problems
11:46 < kanzure> .tw https://twitter.com/typedfemale/status/1594620275760730112
11:46 < saxo> my father would womanize, he would drink. he would make outrageous claims about funding water oxygenation for shrimp farms in vietnam (@typedfemale)
11:47 < kanzure> apparently shrimp suffering is high priority on their list, although i think outrageous claims about "inventing the question mark" would be better
11:52 < kanzure> gibson's codexdna has rebranded to telesis bio https://telesisbio.com/ (they have a desktop DNA synthesis machine)
11:53 < kanzure> https://www.forbes.com/sites/johncumbers/2022/11/21/can-a-desktop-dna-printer-stomp-out-the-next-pandemic/?sh=18002b17f50c
11:53 < kanzure> "One of the things that Telesis Bio is doing is replacing chemical synthesis with faster and more benign enzyme chemistry. They have developed a new DNA synthesis chemistry known as SOLA (short oligonucleotide ligation assembly), which will be integrated into the BioXP™ 9600 system in 2023."
11:59 < kanzure> "Sperm syringe: 3d sorting platform for assisted reproduction" https://onlinelibrary.wiley.com/doi/10.1002/admt.202101291
12:10 < fenn> forbes says "The global gene synthesis market is currently valued at $1.8 billion and estimated to expand at a 17.5% compound annual growth rate."
12:10 < fenn> which is an order of magnitude higher than rob carlson's estimate
12:17 < kanzure> well, john cumbers can't be considered forbes; i mean this is one of those blog sites.
12:23 < fenn> sheesh everything's a platform these days
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13:03 < kanzure> https://www.finsmes.com/2022/09/enplusone-biosciences-raises-12m-in-seed-financing.html
13:03 < kanzure> enzymatic RNA synthesis company https://www.enplusonebio.com/solutions/
13:04 < kanzure> "Founded by George Church, PhD, Daniel Wiegand, Jonathan Rittichier, PhD, and Dan Ahlstedt as a technology spinout from the Wyss Institute for Biologically Inspired Engineering at Harvard University, EnPlusOne is a biotechnology company harnessing the power of enzymes to synthesize RNA oligonucleotides. It leverages an ezRNA synthesis platform that can incorporate a diverse array of nucleotide ...
13:04 < kanzure> ...modifications to support direct RNA synthesis"
13:04 < kanzure> "The RNA synthesis platform aims to target synthesis lengths greater than 100-nt"
13:06 < kanzure> looks like terminal transferase again https://patents.google.com/patent/US20220145295A1/en
13:07 < kanzure> maybe they found total length is greater when doing RNA synthesis with terminal transferase, unlike DNA?
13:21 < yashgaroth> I think they're just targeting the RNA niche but hard to say. Is Fig. 11E their best depiction of the extension efficiency? because it's traaash
13:21 < kanzure> OH ANOTHER STARTUP, OKAY DOCTOR CHURCH HERE'S YOUR NINE MILLION DOLLARS
13:22 < kanzure> oh, $12m actually
13:23 < yashgaroth> ah they claim "sample loss" for why the signal degrades on that gel, easier to hide the unextended bands when there's nothing to see
14:01 < kanzure> "The race for enzymatic DNA synthesis heats up" https://www.nature.com/articles/d41586-019-00682-0
14:10 < kanzure> nuclera acquired E Ink's digital microfluidics division
14:10 < kanzure> https://www.taylorwessing.com/en/insights-and-events/news/media-centre/press-releases/2021/05/revolutionising-access-to-biology-with-transformational-acquisition-by-nuclera
14:28 < kanzure> animation of glphyic bio's protein sequencing technique https://www.youtube.com/watch?v=2gL2aGg7_34
14:28 < Muaddib> [2gL2aGg7_34] Glyphic Biotechnologies - Protein Sequencing Process (1:48)
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15:04 < kanzure> a post about kalshi's prediction market https://news.ycombinator.com/item?id=33696486
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17:57 < L29Ah> . https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381899/
17:57 < L29Ah> .t https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381899/
17:57 < saxo> Human age reversal: Fact or fiction? - PMC
17:57 < L29Ah> omg clickbait on my pubmed
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20:36 < lsneff> varda space is trying to recruit me, any of you have thoughts about them?
21:07 < maaku> People I respect in this space think highly of them. I have no first-hand knowledge to share.
21:08 < maaku> El Segundo is better than Seattle.  You experienced dreasy Seattle weather yet?
21:16 < lsneff> Love the weather here
21:16 < lsneff> Cloudy and overcast
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--- Log closed Tue Nov 22 00:00:24 2022