--- Log opened Tue Nov 22 00:00:24 2022 00:00 -!- A_Dragon [A_D@libera/staff/dragon] has joined #hplusroadmap 00:30 -!- darsie [~darsie@84-113-55-200.cable.dynamic.surfer.at] has joined #hplusroadmap 00:44 -!- docl [~docl@user/docl] has quit [Read error: Software caused connection abort] 00:54 -!- juri_ [~juri@84.19.175.179] has quit [Read error: Software caused connection abort] 00:55 -!- juri_ [~juri@84-19-175-179.pool.ovpn.com] has joined #hplusroadmap 00:55 -!- docl [~docl@user/docl] has joined #hplusroadmap 01:58 -!- dustinm [~dustinm@static.38.6.217.95.clients.your-server.de] has quit [Quit: Leaving] 02:01 -!- dustinm [~dustinm@static.38.6.217.95.clients.your-server.de] has joined #hplusroadmap 02:35 -!- lsneff [~lsneff@2001:470:69fc:105::1eaf] has quit [Quit: Bridge terminating on SIGTERM] 02:39 -!- lsneff [~lsneff@2001:470:69fc:105::1eaf] has joined #hplusroadmap 03:35 -!- CryptoDavid [uid14990@id-14990.uxbridge.irccloud.com] has joined #hplusroadmap 03:42 -!- Malvolio is now known as EVLTNSMSTX 04:59 -!- TMM_ [hp@amanda.tmm.cx] has quit [Quit: https://quassel-irc.org - Chat comfortably. Anywhere.] 04:59 -!- TMM_ [hp@amanda.tmm.cx] has joined #hplusroadmap 05:07 < kanzure> .tw https://twitter.com/bluelz18/status/1594899763857887234 05:07 < saxo> Excited to share our recent breakthrough in designing protein crystallization. We developed a general approach for designing protein self-assembly into 3D macroscopic crystals (>100 µm) at atomic accuracy. Preprint here: https://www.biorxiv.org/content/10.1101/2022.11.18.517014v1. (1/2) https://pbs.twimg.com/media/FiI4mAzacAAsRCw.jpg (@bluelz18) 05:25 -!- yashgaroth [~ffffffff@2601:5c4:c780:6aa0:d477:b7b5:b246:e29a] has joined #hplusroadmap 06:10 -!- o-90 [~o-90@gateway/tor-sasl/o-90] has joined #hplusroadmap 06:12 -!- EVLTNSMSTX is now known as Malvolio 06:12 -!- o-90 [~o-90@gateway/tor-sasl/o-90] has quit [Client Quit] 06:48 -!- spaceangel [~spaceange@ip-94-113-214-149.bb.vodafone.cz] has joined #hplusroadmap 06:59 -!- L29Ah [~L29Ah@wikipedia/L29Ah] has quit [Read error: Connection reset by peer] 07:00 -!- L29Ah [~L29Ah@wikipedia/L29Ah] has joined #hplusroadmap 07:31 -!- L29Ah [~L29Ah@wikipedia/L29Ah] has quit [Read error: Connection reset by peer] 07:32 -!- L29Ah [~L29Ah@wikipedia/L29Ah] has joined #hplusroadmap 07:37 -!- spaceangel_ [~spaceange@ip-94-113-214-149.bb.vodafone.cz] has joined #hplusroadmap 07:40 -!- spaceangel [~spaceange@ip-94-113-214-149.bb.vodafone.cz] has quit [Ping timeout: 256 seconds] 08:02 -!- spaceangel_ 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spaceangel_ [~spaceange@ip-94-113-214-149.bb.vodafone.cz] has joined #hplusroadmap 09:00 < ^ditto> [freenode] @searh test 09:00 < ^ditto> [freenode] @search test 09:04 -!- spaceangel [~spaceange@ip-94-113-214-149.bb.vodafone.cz] has quit [Ping timeout: 252 seconds] 09:19 -!- spaceangel [~spaceange@ip-94-113-214-149.bb.vodafone.cz] has joined #hplusroadmap 09:21 -!- spaceangel_ [~spaceange@ip-94-113-214-149.bb.vodafone.cz] has quit [Ping timeout: 252 seconds] 09:51 -!- CryptoDavid [uid14990@id-14990.uxbridge.irccloud.com] has quit [Quit: Connection closed for inactivity] 11:09 -!- yashgaroth [~ffffffff@2601:5c4:c780:6aa0:d477:b7b5:b246:e29a] has quit [Read error: Connection reset by peer] 11:09 -!- yashgaroth [~ffffffff@2601:5c4:c780:6aa0:d477:b7b5:b246:e29a] has joined #hplusroadmap 11:29 -!- spaceangel_ [~spaceange@ip-94-113-214-149.bb.vodafone.cz] has joined #hplusroadmap 11:30 -!- spaceangel [~spaceange@ip-94-113-214-149.bb.vodafone.cz] has quit [Ping timeout: 268 seconds] 11:43 -!- 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#hplusroadmap 14:09 -!- spaceangel [~spaceange@ip-94-113-214-149.bb.vodafone.cz] has quit [Remote host closed the connection] 14:21 -!- darsie [~darsie@84-113-55-200.cable.dynamic.surfer.at] has quit [Ping timeout: 248 seconds] 14:25 < kanzure> who is spaceangel 14:40 -!- darsie [~darsie@84-113-55-200.cable.dynamic.surfer.at] has joined #hplusroadmap 14:55 -!- luna__ [~luna@2a01:4c8:4a:6d2e:b821:ad80:869b:7ba1] has joined #hplusroadmap 14:58 -!- sknebel_ [~quassel@v22016013254630973.happysrv.de] has joined #hplusroadmap 14:59 -!- lkcl- [lkcl@freebnc.bnc4you.xyz] has joined #hplusroadmap 14:59 -!- berndj-blackout [~berndj@197.189.254.139] has joined #hplusroadmap 15:04 -!- Netsplit *.net <-> *.split quits: berndj, lkcl, superkuh, sknebel, luna_ 15:04 -!- berndj-blackout is now known as berndj 15:14 -!- superkuh [~superkuh@user/superkuh] has joined #hplusroadmap 15:27 -!- Croran [~Croran@c-73-118-187-65.hsd1.wa.comcast.net] has quit [Ping timeout: 256 seconds] 16:10 < fenn> they've never said anything 17:01 -!- srk [~sorki@user/srk] has quit [Ping timeout: 252 seconds] 17:29 < kanzure> "OpenFold: Retraining AlphaFold2 yields new insights into its learning mechanisms and capacity for generalization" https://www.biorxiv.org/content/10.1101/2022.11.20.517210v1 17:59 -!- yashgaroth [~ffffffff@2601:5c4:c780:6aa0:d477:b7b5:b246:e29a] has quit [Quit: Leaving] 18:02 < kanzure> .tw https://twitter.com/NedPagliarulo/status/1595168290216808468 18:02 < saxo> Gene therapy launches prices in the U.S. // Luxturna, for a form of blindness - $425,000 (per eye) / Zolgensma, for a spinal muscular atrophy - $2,100,000 / Zynteglo, for beta thalassemia - $2,800,000 / Skysona, for CALD - $3,000,000 / Hemgenix, for hemophilia B - $3,500,000 (@NedPagliarulo) 18:03 < muurkha> are these cures or palliatives? 18:16 < kanzure> change of name from codexdna to telesis may be because of the lawsuit from codexis against codexdna 18:55 -!- abetusk [~abetusk@cpe-24-59-252-206.twcny.res.rr.com] has joined #hplusroadmap 19:41 -!- darsie [~darsie@84-113-55-200.cable.dynamic.surfer.at] has quit [Ping timeout: 248 seconds] 22:47 < nmz787> kanzure: https://diyhpl.us/~bryan/papers2/bio/Molecular%20surgery%20of%20DNA%20based%20on%20electrostatic%20manipulation%20-%201998.pdf 22:48 < nmz787> the optical tweezers might be quite large compared to the DNA bases, but I wonder if the latex bead it was tweezing only had 1 enzyme... 22:48 < nmz787> and also, just because the "pencil handle" is large, it doesn't mean the tip isn't sharp (1 enzyme) and it doesn't mean you can't scribble very finely 22:49 < nmz787> wouldn't some 4k LCD screen work for optical tweezing, such that you could get nanometer control? 22:49 < nmz787> or galvanometers 22:49 < muurkha> sounds like a plausible thing to try 22:49 < nmz787> just throw more ADC bits at the galvo 22:52 < muurkha> depends on the noise 22:52 < nmz787> heck, for that matter, could you just electrophorese the DNA across a series of enzymes which were recessed in a well that could be electrically biased to retract or unhide the enzyme 22:52 < nmz787> DNA typewriter 22:52 < muurkha> are the latex beads spherical? that's two (or maybe three) degrees of freedom the tweezers have little leverage on 22:53 < nmz787> MEMS up some enzyme-coated cantilevers to really style out the idea 22:54 < nmz787> fuck DNA printers, I want a DNA typewriter... way more retro 23:54 -!- muurkha [~kragen@adjuvant.canonical.org] has quit [Ping timeout: 255 seconds] --- Log closed Wed Nov 23 00:00:25 2022