--- Log opened Thu Dec 01 00:00:32 2022 02:11 -!- TMM_ [hp@amanda.tmm.cx] has quit [Quit: https://quassel-irc.org - Chat comfortably. Anywhere.] 02:11 -!- TMM_ [hp@amanda.tmm.cx] has joined #hplusroadmap 03:33 -!- codaraxis [~codaraxis@user/codaraxis] has joined #hplusroadmap 04:11 -!- nsh- is now known as nsh 05:00 -!- codaraxis [~codaraxis@user/codaraxis] has quit [Ping timeout: 256 seconds] 05:12 < kanzure> "denoising diffusion probabilistic model for protein structure" https://nanand2.github.io/proteins/ 05:43 -!- Llamamoe [~Llamamoe@46.204.76.252.nat.umts.dynamic.t-mobile.pl] has joined #hplusroadmap 05:59 -!- yashgaroth [~ffffffff@2601:5c4:c780:6aa0::a324] has joined #hplusroadmap 06:01 -!- codaraxis [~codaraxis@user/codaraxis] has joined #hplusroadmap 06:16 -!- deltab [~deltab@user/deltab] has quit [Ping timeout: 246 seconds] 06:17 -!- deltab [~deltab@user/deltab] has joined #hplusroadmap 06:46 -!- darsie [~darsie@84-113-55-200.cable.dynamic.surfer.at] has joined #hplusroadmap 10:30 -!- L29Ah [~L29Ah@wikipedia/L29Ah] has quit [Ping timeout: 260 seconds] 10:39 -!- codaraxis [~codaraxis@user/codaraxis] has quit [Ping timeout: 256 seconds] 11:52 -!- L29Ah [~L29Ah@wikipedia/L29Ah] has joined #hplusroadmap 12:36 -!- codaraxis [~codaraxis@user/codaraxis] has joined #hplusroadmap 12:44 < superkuh> Anyone remember/have a link to that guy in Taiwan(?) who was making an MRI machine from scratch? I think he was posting on twitter/nitter? 12:45 < superkuh> Ah. grep. https://twitter.com/yashiro_ld 13:02 < kanzure> Muaddib: Identify a cheap homebrew way of making a magnetic resonance imaging machine. The budget is $1,000. 13:02 < Muaddib> kanzure: How about a DIY MRI machine with a tube of Pringles, 2 magnets, and a hamster? 13:03 < kanzure> Muaddib: Explain how you would make a magnetic resonance imaging machine.. 13:03 < Muaddib> kanzure: First, I'd get two big magnets and stick them together. Then, I'd stuff a Pringles tube full of hamster and place it between the two magnets. Finally, I'd turn on the magnets and wait for the hamster's MRI. 13:03 < kanzure> .. what? 13:14 -!- codaraxis [~codaraxis@user/codaraxis] has quit [Ping timeout: 260 seconds] 13:25 < fenn> .wik lotka's law 13:25 < saxo> "Lotka's law, named after Alfred J. Lotka, is one of a variety of special applications of Zipf's law. It describes the frequency of publication by authors in any given field." - https://en.wikipedia.org/wiki/Lotka%27s_law 13:26 -!- codaraxis [~codaraxis@user/codaraxis] has joined #hplusroadmap 13:27 -!- codaraxis [~codaraxis@user/codaraxis] has quit [Remote host closed the connection] 13:27 < fenn> specifically, 1/x^2 shaped distribution 13:30 < fenn> " There are 1/4 as many authors publishing two articles within a specified time period as there are single-publication authors, 1/9 as many publishing three articles, 1/16 as many publishing four articles, etc." 14:31 -!- Llamamoe [~Llamamoe@46.204.76.252.nat.umts.dynamic.t-mobile.pl] has quit [Quit: Leaving.] 14:44 < fenn> remote code execution vulnerability in freebsd ping https://www.freebsd.org/security/advisories/FreeBSD-SA-22:15.ping.asc (CVE-2022-23093) 14:44 < fenn> i wonder if thats really as bad as it sounds 15:34 < fenn> "When people travel to the past, they worry about radically changing the present by doing something small. Few people think that they can radically change the future by doing something small in the present." 15:34 * fenn flaps his tiny wings 16:08 < kanzure> baker lab protein diffusion model validation https://twitter.com/andrewwhite01/status/1598419443432013825 16:08 < kanzure> .tw 16:08 < saxo> 16:08 < kanzure> .title 16:15 < kanzure> "Illuminating protein space with a programmable generative model" https://twitter.com/AndrewLBeam/status/1598414991882854409 17:49 < kanzure> https://www.bakerlab.org/2022/11/30/diffusion-model-for-protein-design/ 17:49 < kanzure> "Broadly applicable and accurate protein design by integrating structure prediction networks and diffusion generative models" https://www.bakerlab.org/wp-content/uploads/2022/11/Diffusion_preprint_12012022.pdf 17:51 < kanzure> and https://twitter.com/_JosephWatson/status/1598409454537826305 18:27 -!- darsie [~darsie@84-113-55-200.cable.dynamic.surfer.at] has quit [Ping timeout: 268 seconds] 18:47 -!- yashgaroth [~ffffffff@2601:5c4:c780:6aa0::a324] has quit [Quit: Leaving] 18:52 < fenn> i wonder exactly what they mean by "The team demonstrated extremely high computational success and tested hundreds of A.I.-generated proteins in the lab" 18:53 < fenn> i.e. do crystallography structures match the output? does "sudo make me a ham-binding protein" actually bind ham? 18:56 < muurkha> for that I prefer jute 19:33 < kanzure> Muaddib: Write the amino acid sequence for a fluorescent protein. 19:33 < Muaddib> kanzure: Tryptophan-Glutamate-Glycine-Lysine-Tyrosine-Tyrosine-Aspartate-Phenylalanine-Serine-Glycine-Arginine-Lysine 19:33 < kanzure> Muaddib: Explain why that amino acid sequence is fluorecent. 19:33 < Muaddib> kanzure: Because it's full of F-U-N! 19:34 < kanzure> Muaddib: Explain why that amino acid sequence is fluorecent. Lose the humor. Best explanation, trending on ArtStation, Nobel prize, award winning pulitzer essay. 19:34 < Muaddib> kanzure: The amino acid sequence contains some of the key components necessary for fluorescence, such as tyrosine and phenylalanine. These two amino acids are responsible for absorbing the energy produced when light of a specific wavelength is shone on the protein, which is then re-emitted as a different wavelength. This is what 19:34 < kanzure> Muaddib: Continue your sentence. 19:34 < Muaddib> kanzure: ...gives the protein its characteristic fluorescent glow! 19:35 < kanzure> Muaddib: Write a joke exclusively using amino acids in an amino acid sequence. 19:35 < Muaddib> kanzure: Why did the Glycine think it was funny? Because it had its very own histidine punchline! 19:36 < kanzure> Muaddib: Explain your joke and why it is funny. 19:36 < Muaddib> kanzure: The joke plays on the fact that both glycine and histidine are amino acids found in proteins. The “punchline” referring to 'histidine' is funny because histidine is known to have an acidic side chain, so the joke suggests that the glycine's joke had a punch to it! 19:40 -!- SDr [~SDr@li1189-192.members.linode.com] has quit [Changing host] 19:40 -!- SDr [~SDr@user/sdr] has joined #hplusroadmap --- Log closed Fri Dec 02 00:00:33 2022