--- Log opened Fri Dec 23 00:00:15 2022
--- Day changed Fri Dec 23 2022
00:00 < fenn> better to use white paint on the styrofoam
00:00 < muurkha> the black paint heats the air trapped under the pstretch film
00:00 < muurkha> which heats the pipes
00:00 < fenn> does it tho
00:00 < muurkha> yes, try it
00:01 < fenn> i expect it to melt the styrofoam and the stretch wrap
00:01 < muurkha> no, you'd need a more efficient solar collector for that
00:01 < muurkha> if you want to go to higher temperatures and get potable water for your shower out, you would benefit from using sturdier materials
00:02 < muurkha> like copper and glass
00:03 < muurkha> and so you end up paying US$100/m²
00:03 < muurkha> but if you're just trying to dehydrate calcium chloride to the dihydrate, 45.5° is enough for that
00:04 < muurkha> another low-cost design that has been used very effectively in rooftop preheat thermosiphons in Brazil is transparent coroplast panels backed with styrofoam
00:05 < muurkha> water flows through the channels in the coroplast between PVC pipes that run along the top and bottom of the panel
00:05 < fenn> not black coroplast?
00:05 < muurkha> no, black paint on the back of the coroplast
00:05 < fenn> does the water have dye added?
00:06 < muurkha> so that the heat is generated between the coroplast and styrofoam
00:06 < muurkha> no dye, this is for preheating water for showers to cut your electric bill
00:06 < muurkha> the panels aren't efficient enough to reach more than about 40° because of the lack of insulation between them and the outside air
00:07 < muurkha> by the same token they're inherently scald-safe without a flow-balancing valve, and allow you to build your hot water tank from concrete instead of stainless steel
00:08 < muurkha> that's also about US$10/m²
00:08 < fenn> i guess you just bleach it periodically
00:08 < muurkha> to keep bacteria from eating the coroplast?  apparently municipal water chlorination is enough
00:08 < fenn> to prevent listeriosis
00:09 < fenn> bacteria in the water get breathed in as aerosol and cause pneumonia
00:09 < fenn> er. legionella
00:09 < fenn> i always mix those up
00:10 < fenn> if the tap water is chlorinated it's probably fine
00:10 < muurkha> legionella is aerobic, can't grow in a water pipe
00:10 < muurkha> even a transparent one
00:10 < fenn> um, well, it happens
00:11 < muurkha> usually it happens in air conditioners and things
00:11 < fenn> this is why water heaters have minimum temperatures
00:11 < fenn> 60C kills legionella
00:11 < muurkha> https://en.wikipedia.org/wiki/Legionella_pneumophila#Ecology_and_reservoirs helpfully explains I'm wrong
00:13 < muurkha> anyway, black polyethylene pipe doesn't cost US$100 per square meter
00:13 < fenn> indeed
00:13 < muurkha> and actually PV is down to about US$40 per square meter
00:14 < fenn> it's cheaper to heat water with electricity when you take into account professional installation costs
00:17 < muurkha> I guess a square meter of PV is probably worth about half a square meter of efficient solar thermal collectors
00:22 < fenn> with a large install it sometimes makes sense to use a heat pump
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09:15 < kanzure> "Language models generalize beyond natural proteins" https://www.biorxiv.org/content/10.1101/2022.12.21.521521v1 https://twitter.com/BasileWicky/status/1606259095861923840
09:16 < kanzure> "A high-level programming language for generative protein design" https://www.biorxiv.org/content/10.1101/2022.12.21.521526v1 https://twitter.com/BrianHie/status/1606074806620737536
09:16 < kanzure> "End-to-end protein-ligand complex structure generation with diffusion-based generative models" https://www.biorxiv.org/content/10.1101/2022.12.20.521309v1 https://twitter.com/simonbatzner/status/1606046044717867008
09:17 < kanzure> "Generative language modeling for antibody design" https://www.biorxiv.org/content/10.1101/2021.12.13.472419v2 https://twitter.com/jeffruffolo/status/1606058881171406848
09:17 < kanzure> "Systematic multi-trait AAV capsid engineering for efficient gene delivery" https://www.biorxiv.org/content/10.1101/2022.12.22.521680v1
09:19 < kanzure> "Anatomy of the complete mouse eye vasculature in development and pathology explored by light-sheet fluorescence microscopy" https://www.biorxiv.org/content/10.1101/2022.12.20.521194v1 https://twitter.com/AlainChedotal/status/1605855847082598400
09:21 < kanzure> oh yeah, already had that one yesterday
09:47 < kanzure> okay i think i am caught up on the latest protein diffusion or protein language model things https://diyhpl.us/~bryan/papers2/bio/protein-engineering/?C=M;O=D
11:02 < kanzure> twitter thread with recent protein engineering stuff https://twitter.com/kanzure/status/1606364590740107265
11:05 < lsneff> insane progress
11:05 < lsneff> prompt engineering and DSLs for protein design? lfg
11:10 < lsneff> it honestly feels like we're maybe a year away from "design a protein which positions a binding site in 3D based on incoming light wavelengths -> monomer sequence"
11:11 < kanzure> lsneff: yashgaroth and i have an important advancement for that specific problem that we have not published yet.
11:12 < lsneff> that's exciting
11:12 < kanzure> yeah
11:14 < muurkha> great
11:26 < kanzure> .tw https://twitter.com/NeuroLuebbert/status/1555968042948915200
11:26 < saxo> gget alphafold: Predict the 3D structure of a protein from its amino acid sequence using @DeepMind’s AlphaFold v2.0 from a Python or command-line environment in 3 lines of code. Runs on any laptop and requires only ~4 GB of disk space. Simply ‘pip install gget’ and: https://video.twimg.com/ext_tw_video/1555960809167024128/pu/vid/640x360/x-wTp3apdl1PYQ_o.mp4?tag=12 (@NeuroLuebbert) psa from .tw cmd: fuck twitter
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12:00 < kanzure> "Point-E: A system for generating 3d point clouds from complex prompts" https://arxiv.org/abs/2212.08751 https://github.com/openai/point-e
12:03 < kanzure> "Multi-concept customization of text-to-image diffusion" https://arxiv.org/abs/2212.04488 https://github.com/adobe-research/custom-diffusion
12:06 < kanzure> "large language models for code" https://www.bigcode-project.org/ also includes "SantaCoder": https://huggingface.co/spaces/bigcode/santacoder-demo https://twitter.com/BigCodeProject/status/1605958778330849281
12:45 < L29Ah> .t https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-022-01400-1
12:45 < saxo> Vaginal microbiome-host interactions modeled in a human vagina-on-a-chip | Microbiome | Full Text
13:14 < fenn> gget alphaphold works by repeatedly querying a remote protein structure database over the internet
13:14 < kanzure> a text-to-video thing https://tuneavideo.github.io/ https://arxiv.org/abs/2212.11565 
13:18 < kanzure> "Scalable diffusion models with transformers" https://arxiv.org/abs/2212.09748 https://twitter.com/DrJimFan/status/1605893566575820800 and the follow-up https://twitter.com/DrJimFan/status/1606278209556779009
13:20 < kanzure> .tw https://twitter.com/MetaAI/status/1605991218953191424
13:20 < saxo> Announcing OPT-IML: a new language model from Meta AI with 175B parameters, fine-tuned on 2,000 language tasks — openly available soon under a noncommercial license for research use cases. // Research paper & more details on GitHub ⬇️ (@MetaAI) psa from .tw cmd: fuck twitter
13:21 < kanzure> alright the whole field is basically a firehose at the moment (can't tell if that's because of the holiday rush tho)
13:21 < fenn> everyone's trying to get it out the door so they can have a vacation
13:22 < fenn> adobe's "custom diffusion" was already a thing with "embeddings" - small sub-networks trained on the desired concept
13:24 < fenn> i guess it's faster to train?
13:50 < lsneff> .t https://arxiv.org/abs/2211.11754
13:50 < saxo> [2211.11754] An Algorithm for Routing Vectors in Sequences
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14:45 < kanzure> https://theopenroadproject.org/ https://ece.engin.umich.edu/stories/open-source-hardware-a-growing-movement-to-democratize-ic-design https://twitter.com/wladek60/status/1606193533945364480
14:45 < fenn> .tw
14:45 < saxo> You sought out a nest, and the songbird’s sweet chirping. But you found naught.
14:45 < fenn> .tw 1606193533945364480
14:45 < saxo> #Opensource hardware: a growing movement to democratize #IC design. // “If I’m a guy in my garage,” said Prof. Sylvester, UMich, “I can’t afford to pay millions of dollars for licensed software tools.” https://buff.ly/3FSETJS https://pbs.twimg.com/media/FkpYgbaWYAEsfYT.jpg (@wladek60) psa from .tw cmd: fuck twitter
14:46 < kanzure> .title https://ieeexplore.ieee.org/abstract/document/9256818
14:46 < saxo> The Missing Pieces of Open Design Enablement: A Recent History of Google Efforts : lnvited Paper | IEEE Conference Publication | IEEE Xplore
14:47 < kanzure> "opentapeout conference day 1" https://www.youtube.com/watch?v=wvPZREaP7E0
14:47 < Muaddib> [wvPZREaP7E0] OpenTapeOut conference Day 1 (124:42)
14:47 < kanzure> cc lkcl
14:49 < fenn> "Objective:  Enable no-human-in-loop, 24-hour design to remove the barrier to hardware innovation" well that's ambitious
14:50 < fenn> "Mantra: Embrace freedom from choice" ???
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14:54 < fenn> a conspiracy theorist would have fun with this site
14:54 < fenn> i'm _hoping_ means something like python's "there's only one way to do it"
15:07 < kanzure> "Illuminating protein space with a programmable generative model" https://www.biorxiv.org/content/10.1101/2022.12.01.518682v1.full
15:10 < kanzure> "Will we run out of data? An analysis of the limits of scaling datasets in machine learning" https://arxiv.org/pdf/2211.04325.pdf https://twitter.com/emollick/status/1605756428941246466
15:11 < kanzure> "Diffusion art or digital forgery? Investigating data replication in diffusion models" https://arxiv.org/abs/2212.03860 
15:15 < kanzure> how about a 500 page review of quantum chromodynamics? https://arxiv.org/abs/2212.11107 https://twitter.com/PKoppenburg/status/1605862271183380487
15:22 < kanzure> "A survey of deep learning for mathematical reasoning" https://arxiv.org/abs/2212.10535 https://twitter.com/lupantech/status/1605400505697841155
15:26 < kanzure> "radiance field diffusion" for 3d model generation from masks (an alternative to point-e above, without the text prompts) https://sirwyver.github.io/DiffRF/ https://arxiv.org/abs/2212.01206 https://twitter.com/sstj389/status/1604248235698425856
15:28 < kanzure> .tw https://twitter.com/rodrigowillrich/status/1605708028715704322
15:28 < saxo> ar5iv is such a live saver when you want to read an article and all you have is a mobile device. Here I am, in a bar, drinking an ale and re-reading "Do be do be do" by Connor McBride. https://ar5iv.labs.arxiv.org/ (@rodrigowillrich) psa from .tw cmd: fuck twitter
16:28 < fenn> is ar5iv OCR?
16:29 < fenn> or do all arxiv papers have raw TeX in the submitted manuscript?
16:37 < fenn> "diffusion art or digital forgery" just illustrates how hard it is to decide if something is "the same"
16:38 < fenn> "Prompt: A painting of the Great Wave off Kanagawa by Katsushika Hokusai"
16:38 < fenn> omg AI steals!
16:38 < fenn> ffs
16:47 < fenn> the most egregious examples are the "insert your design here" stock photo templates, which probably have zillions of copies in the data set
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17:00 < kanzure> well arxiv:2212.03860 on ar5iv seems to redirect to the arxiv abstract, so it doesn't seem to work for every one
17:01 < kanzure> oh, "Sources upto the end of November 2022"
17:06 < kanzure> and now for something completely different: "LiDAR analyses in the contiguous Mirador-Calakmul Karst Basin, Guatemala" https://doi.org/10.1017/s0956536122000244
17:12 < kanzure> "consensus of parts" alright roddenberry.... we get it.
17:23 < fenn> "Little is known about the Consensus of Parts, other than its supposed existence as a vast machine empire based on the precepts of logic."
17:23 < fenn> sounds more like orion's arm
17:25 < fenn> and for the record, roddenberry hated the borg idea, it came from the intellectual property lawyer who was bored of all the regular wimpy star trek villains
17:26 < kanzure> https://www.youtube.com/watch?v=4RTdc_C_PIk&t=2m20s
17:26 < Muaddib> [4RTdc_C_PIk] The Sum of Its Parts (42:58)
17:26 < kanzure> oh, he did? maybe this was also a shoehorn
17:31 < kanzure> (why is hercules barking commands?)
17:33 < fenn> the hidden evil villain pulling the strings behind star trek: https://memory-alpha.fandom.com/wiki/Leonard_Maizlish
17:33 < fenn> there's not even a photo of him haha
17:34 < fenn> apparently i'm not the first to have this idea https://static1.thegamerimages.com/wordpress/wp-content/uploads/2018/01/Leonard-Maizlish.png
17:36 < fenn> an "illegal" story editor, that's rich
17:49 < kanzure> .tw https://twitter.com/kane/status/1606166714718093313
17:49 < saxo> in awe of this official photo the commander of the JSDF 21st Air Group chose https://twitter.com/jmsdf_21aw/status/1605835537738215430 https://pbs.twimg.com/media/FkpAFo9VUAAAHzq.jpg (@kane) psa from .tw cmd: fuck twitter
18:30 < kanzure> licensing terms from technology transfer offices as exposed in SEC S-1 filings https://airtable.com/shrQQhnklJAN8ACfN/tblio1v6t6r5rLLC1
18:30 < kanzure> via https://twitter.com/sethbannon/status/1605654828994002944
18:55 < kanzure> "Unexpected awakenings in severe dementia from case reports to laboratory" https://pubmed.ncbi.nlm.nih.gov/33064369/
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19:05 < fenn> "terminal lucidity" is a great band name
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--- Log closed Sat Dec 24 00:00:54 2022