--- Log opened Wed Dec 28 00:00:58 2022
01:35 -!- TMM_ [hp@amanda.tmm.cx] has quit [Quit: https://quassel-irc.org - Chat comfortably. Anywhere.]
01:35 -!- TMM_ [hp@amanda.tmm.cx] has joined #hplusroadmap
02:38 -!- L29Ah [~L29Ah@wikipedia/L29Ah] has joined #hplusroadmap
02:58 -!- darsie [~darsie@84-113-55-200.cable.dynamic.surfer.at] has quit [Ping timeout: 260 seconds]
07:05 < jrayhawk> https://www.palladiummag.com/2022/12/27/palladium-08-scientific-authority/ the palladium 08 collection is pretty good
07:08 < nsh> who was asking about the russian robo patriarch meme?
07:09 < nsh> was informed it was due to the 'local superheroes' satire memes a while back 
07:09 < nsh> and it's patriarch kirill of moscow
07:09 < nsh> who's got an interesting backstory 
07:09 < nsh> .wik Patriarch Kirill of Moscow
07:09 < saxo> "Kirill or Cyril (Russian: Кирилл, Church Slavonic: Ст҃ѣ́йшїй патрїа́рхъ кѷрі́ллъ, secular name Vladimir Mikhailovich Gundyayev, Russian: Владимир Михайлович Гундяев; born 20 November 1946) is a Russian Orthodox [...]" - https://en.wikipedia.org/wiki/Patriarch_Kirill_of_Moscow
07:09 < nsh> made his bucks with tobacco now is church honcho
07:10 < nsh> 'On 3 April 1969, Metropolitan Nicodemus (Rotov) of Leningrad and Novgorod tonsured him with the name of Kirill after saint Cyril the Philosopher and on 7 April ordained him as hierodeacon and on 1 June as hieromonk.[4] '
07:12 < nsh> https://webcache.googleusercontent.com/search?client=firefox-b-d&q=cache%3Ahttps%3A%2F%2Fnftu.net%2Fpatriarch-kirill-why-he-was-called-the-tobacco-metropolitan%2F
07:31 < kanzure> .diffusion a really cool looking lie detector machine, LEDs, blinkenlight, intimidating, intimidation, trending on ArtStation, as featured in Wire magazine
08:23 < kanzure> "Since Hemgenix hasn’t actually been on the market yet, let’s look at the last gene therapy approved, Zolgensma. It generates around $1.5 billion to $2 billion a year for Novartis while they pull in around $52 billion total revenue annually with a net income of over $8 billion. Look, don’t get me wrong, I believe that pharmaceutical companies should make profit off the drugs they ...
08:23 < kanzure> ...develop. But like, Zolgensma didn’t require geniuses to develop. It’s a pretty standard gene replacement for Spinal Muscular Atrophy (SMA) They put the SMN1 gene in a standard AAV viral capsid. Any reasonable genetic engineer could have designed it in an hour."
08:24 < kanzure> enhancement gene therapy would have a larger market
08:24 < kanzure> and therefore the price could be driven down lower
08:47 < lsneff> did someone hook up saxo to sd??
09:02 < kanzure> nah
10:03 -!- ANACHRON [~Malvolio@idlerpg/player/Malvolio] has quit [Read error: Connection reset by peer]
13:33 < nsh> could be done
13:33 < nsh> but then people would pretend it's good more and that's getting tiresome
13:46 < fenn> prompt design requires skill, i'm shocked, shocked i say
13:47 < fenn> this isn't the fully automated luxury gay meme utopia i was promised
13:49 < fenn> and do you really have a server lying around with a GPU with 10GB of VRAM
13:50 < fenn> oh it works with 4GB
14:03 -!- L29Ah [~L29Ah@wikipedia/L29Ah] has quit [Ping timeout: 265 seconds]
18:53 < kanzure> "Smaller brains in laying hens: New insights into the influence of pure breeding and housing conditions on brain size and brain composition" https://www.sciencedirect.com/science/article/pii/S0032579120302133
18:56 < kanzure> "The relationship of spectral sensitivity with growth and reproductive response in avian breeders (Gallus gallus)" https://www.nature.com/articles/srep19291
18:59 < kanzure> "Dynamic visualization of the developing nervous system of the bullfrog Rana catesbeiana" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2080828/
19:07 < kanzure> "Latent effect of larval rearing environment on post-metamorphic brain growth in an anuran amphibian" https://www.sciencedirect.com/science/article/abs/pii/S0944200622000125
19:07 < kanzure> that's a neat effect
19:10 < kanzure> frog vs dog brain https://qph.cf2.quoracdn.net/main-qimg-1bc484a839f5fb9babf26c2fd1ebb4b3-lq
19:17 < kanzure> "In a study published in 2020, it was found that chickens shared between 71% - 79% of their genome with red junglefowl, with the period of domestication dated to 8,000 years ago.[57]"
19:19 < muurkha> that's an astoundingly low number
19:19 < muurkha> 21% or ore of their genome is new in the last 8000 years?
19:19 < muurkha> *more
19:20 < kanzure> actually i don't know what it means to not share the other 20%- does even a single mutation mean it's not shared?
19:21 < muurkha> I thought the number for humans and chimpanzees was like 95%
19:21 < kanzure> [56] "The wild species genome ancestry of domestic chickens" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014787/
19:22 < kanzure> er, i mean 57
19:24 < muurkha> that's numberwang!
19:24 < kanzure> chicken ~60m brain neurons, frog ~16m neurons total so maybe 1-5m for the brain.
19:26 < kanzure> "project hyperchicken" might have more of a chance than "project kermit: kermit the frog engineered by research made intelligent today"
19:26 < kanzure> although the frogs have much larger clutch sizes available.....
19:32 < kanzure> frogs should be able to support large brain development in a way that birthing mammals can't; bird eggs are size constrained.
19:34 < kanzure> do several million years worth of selection pressure on frog brain in an enormous frog farm
19:47 < kanzure> https://www.atlasobscura.com/articles/frog-farming-1930s-failure-ponds-canning-legs-conservation
19:47 < kanzure> https://thefishsite.com/articles/amphibious-aquaculture-why-frog-farming-is-set-for-success
19:47 -!- deltab [~deltab@user/deltab] has quit [Ping timeout: 252 seconds]
19:54 < kanzure> brazilian bullfrog farming overview https://www.sciencedirect.com/science/article/abs/pii/S0044848621012862
19:56 -!- deltab [~deltab@user/deltab] has joined #hplusroadmap
20:04 -!- test_ [flooded@gateway/vpn/protonvpn/flood/x-43489060] has joined #hplusroadmap
20:07 -!- _flood [flooded@gateway/vpn/protonvpn/flood/x-43489060] has quit [Ping timeout: 248 seconds]
--- Log closed Thu Dec 29 00:00:59 2022