--- Log opened Sat Dec 31 00:00:01 2022
02:38 < maaku> lsneff: on here, or?
02:42 < maaku> kanzure: e/acc has a twitter groupchat. I was on it for a week or so. waste of time
02:45 < maaku> lsneff: you looked into that adhd diagnosis?
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05:11 < lsneff> maaku: whenever we next meet or smth
05:12 < lsneff> not yet, been very busy
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07:37 < kanzure> https://www.greaterwrong.com/posts/mHqQxwKuzZS69CXX5/whole-brain-emulation-no-progress-on-c-elgans-after-10-years
07:48 < lsneff> it’s not surprising how little progress there is, from the literature I’ve read for my thesis, we still really have no idea exactly how to model the complete behavior of neurons
07:50 < kanzure> .title https://nitter.nl/vexadecimal/status/1445792101225041922
07:50 < saxo> Michael Skuhersky (@vexadecimal): '1/  I'm on the ground trying to make a reasonably good worm emulation for my PhD thesis. Part of the issue is that you need passionate people with experience in microscopy, worm behavior/connectomics, and applied ML, who also have a lot of time to sink into trying sometime new.'|nitter
07:57 < kanzure> we should breed chihuahua border collies and select for tiny brains that don't throw out intelligence or memory, and then you'd see what structures are more important
07:58 < kanzure> (or other small dogs)
07:58 < kanzure> (alternately, tiny puppies that happen to be smart, although i know less about this)
08:00 < kanzure> .title https://github.com/jonathanking/sidechainnet
08:00 < saxo> GitHub - jonathanking/sidechainnet: An all-atom protein structure dataset for machine learning.
08:07 < lsneff> not even the structure of brains, but what interactions are occurring inside neurons and what matters
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08:41 < nsh> can't even into nondual logic. how expect to grok life... 
10:09 < maaku> lsneff: ok
10:10 < maaku> kanzure: do little dogs actually have brains with fewer neurons? this seems non-obvious to me
10:23 < muurkha> I think they do but I agree it's non-obvious
10:41 < L29Ah> my partner is busy exploring nondual logics and related philosophy
10:49 < muurkha> sounds difficult
11:06 < lsneff> .wik nondual logic
11:06 < saxo> Article not found: https://en.wikipedia.org/wiki/Nondual_logic gave 404 | Searched en for 'nondual logic' | https://en.wikipedia.org/wiki/No_result_found gave 404 | Searched en for 'No result found'
11:06 < lsneff> .g nondual logic
11:06 < saxo> https://www.scienceandnonduality.com/article/nondual-logic
11:07 < lsneff> Someone needs to give saxo access to gpt3 so it can summarize articles like that without me having to read them
11:09 < nsh> baker man once went to the judge and said the poor man who lived above the bakery was stealing by enjoying the fragrance of the breads and cakes as they were baked
11:09 < nsh> and demand recompense
11:10 < nsh> the judge weighed the matter and demanded of the poor man some coins. upon hearing hearing the clinking of the coins as they were placed onto a plate of offering the avaricious baker salivated in delight, expecting his just reward
11:10 < nsh> the judge said "you have received the satisfaction you deserve" and returned the coins to the poor man
11:10 < nsh> one might enjoy the sound of someone eating but not be nourished
11:11 < nsh> synopsis is useful for decisions of perusal; it's not a replacement for engaging with the discourse
11:12 < nsh> *demanded
11:18 < nsh> these slides by Lou Kauffman are a good place to start: https://sufipathoflove.files.wordpress.com/2019/02/1952-initiation-and-spiritual-realization.pdf
11:18 < nsh> sorry wrong link
11:18 < nsh> http://homepages.math.uic.edu/~kauffman/KauffSAND.pdf
11:18 < nsh> (which accompany this talk: https://www.youtube.com/watch?v=UqMl_Wb04nU )
11:18 < Muaddib> [UqMl_Wb04nU] Sign and Space (Prof. Louis H. Kauffman) (54:46)
11:22 < lsneff> Ah, this is related to nondualism?
11:25 < nsh> the first line in the slides is 'Laws of Form and the Logic of Non-Duality'
11:25 < nsh> but perhaps it was a typo
11:25 < nsh> and he meant to write an exposition of what happens between pearls and swine
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12:45 < nsh> (background: https://www.kurtvonmeier.com/who-is-g-spencer-brown-and-where-is-that-marvelous-music-coming-from )
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13:29 < kanzure> maaku: i don't know if anyone has checked!
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13:39 < nsh> .ety bounty
13:39 < saxo> "bounty (n.)late 13c., 'a gift, a reward, a favor bestowed freely;' c. 1300, 'goodness, virtue; beauty; ; excellence; knightly prowess, strength, valor, chivalry,' early 14c., 'a helpful act, an act of generosity, a good deed,' also 'liberality in giving, generosity, munificence,' from Anglo-French bountee, Old French ..." - https://www.etymonline.com/word/bounty
13:39 < nsh> --
13:39 < nsh> rom Anglo-French bountee, Old French bonte "goodness" (12c., Modern French bonté), from Latin bonitatem (nominative bonitas) "goodness," from bonus "good" (see bonus).
13:39 < nsh> The sense of "gift bestowed by a sovereign or the state" led to the extended senses of "premium or gratuity to a military recruit" (1702) and "reward for killing or taking a criminal or enemy" (1764) or dangerous animal (1847).
13:39 < nsh> Bounty-jumper "one who enlists in the military, collects the bounty, and flees without reporting for duty" is from the American Civil War (by 1864). Bounty-hunter is from 1893, American English, originally in reference to wild animals.
13:39 < nsh>     I do ... promise, that there shall be paid ... the following several and respective premiums and Bounties for the prisoners and Scalps of the Enemy Indians that shall be taken or killed .... ["Papers of the Governor of Pennsylvania," 1764]
13:40 < nsh> --
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15:12 < fenn> my new rice cooker uses fuzzy logic, and it even manages to cook rice!
15:13 < fenn> it also sings
15:15 < L29Ah> but can it tell you what steps you should optimally take to improve your rice even further at any given step of perfection?
15:16 < fenn> no it just mumbles useless platitudes
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18:54 < kanzure> .g PDE4 inhibitor rolipram memory
18:54 < saxo> https://scholar.google.com/scholar?q=PDE4+inhibitor+rolipram+memory
18:54 < kanzure> hmph
18:58 < kanzure> rolipram and PDE4 inhibitors last mentioned https://gnusha.org/logs/2017-01-29.log https://gnusha.org/logs/2015-08-16.log
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19:00 < kanzure> .wik phosphodiesterase-4 inhibitor
19:00 < saxo> "A phosphodiesterase-4 inhibitor, commonly referred to as a PDE4 inhibitor, is a drug used to block the degradative action of phosphodiesterase 4 (PDE4) on cyclic adenosine monophosphate (cAMP)." - https://en.wikipedia.org/wiki/Phosphodiesterase-4_inhibitor
19:01 < kanzure> .wik rolipram
19:01 < saxo> "Rolipram is a selective phosphodiesterase-4 inhibitor discovered and developed by Schering AG as a potential antidepressant drug in the early 1990s.  It served as a prototype molecule for several companies' drug discovery and development efforts.: 668ff |  Rolipram was [...]" - https://en.wikipedia.org/wiki/Rolipram
19:04 < kanzure> "Acute administration of roflumilast enhances immediate recall of verbal word memory in healthy young adults" https://www.sciencedirect.com/science/article/pii/S0028390817306160 ".. Treatment with 100 μg roflumilast increased the immediate recall performance with 2–3 words" [set of 30 from which usually ~21 recalled]
21:01 < muurkha> ROFLumilast?
--- Log closed Sun Jan 01 00:00:02 2023