--- Log opened Mon Jan 09 00:00:09 2023
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06:16 < kanzure> "Not even trying: the corruption of real science" http://corruption-of-science.blogspot.com/2013/07/not-even-trying-corruption-of-real.html
06:27 < kanzure> "A single TRPV1 amino acid controls species sensitivity to capsaicin" https://www.nature.com/articles/s41598-020-64584-2
06:28 < kanzure> "Phage therapy: From biological mechanisms to future directions" https://www.cell.com/cell/fulltext/S0092-8674(22)01461-1
06:29 < kanzure> "Sequence-to-sequence translation from mass spectra to peptides with a transformer model" https://www.biorxiv.org/content/10.1101/2023.01.03.522621v2
06:30 < kanzure> "Gene therapy mediated partial reprogramming extends lifespan and reverses age-related changes in aged mice" https://www.biorxiv.org/content/10.1101/2023.01.04.522507v1 https://twitter.com/ArtirKel/status/1612152817611051008
06:30 < kanzure> above is from rejuvenatebio.com
06:31 < kanzure> apparently you need to exclude liver + gut https://www.biorxiv.org/content/10.1101/2022.05.27.493700v1
06:31 < kanzure> "Beyond lifespan as a metric in aging research: why reprogramming is promising" https://nintil.com/lifespan-aging
06:32 < kanzure> "Aging is already solved in vitro. What comes next?" https://nintil.com/aging-solved-in-vitro
06:38 < kanzure> no recent posts on https://www.anti-agingfirewalls.com/
08:28 < kanzure> https://insider.si.edu/2011/12/brains-of-tiny-spiders-fill-their-body-cavities-and-legs-smithsonian-researchers-find/ https://www.sciencedirect.com/science/article/abs/pii/S1467803911000727
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13:52 < kanzure> "Unlocking de novo antibody design with generative artificial intelligence" https://www.biorxiv.org/content/10.1101/2023.01.08.523187v1
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17:27 < kanzure> .tw https://twitter.com/notresz/status/1612583090601480194
17:27 < saxo> @kanzure hey bryan, curious what RFdiffusion does. It wasn't clear to me from reading the paper, just seems like a denoising NN but I don't understand how that's applied. Does it just straighten up "half assed" designs? (@notresz, in reply to tw:1606364598529032192) psa from .tw cmd: fuck twitter
17:29 < kanzure> i'll tell him to read https://stephanheijl.com/rfdiffusion.html (under "Implementation")
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18:30 < fenn> i'm going to attempt to go to a neuroscience meetup in SF tomorrow, anyone in particular i should talk to (and about what) on this list? https://fennetic.net/brains_and_bites_guest_list_2023-01-09.txt
18:49 < kanzure> no. nectome should organize these.
18:50 < kanzure> even if it's just a journal club
18:51 < kanzure> or 3scan should have done it, first.
18:53 < kanzure> talked with someone today who was pitching a startup to make "smart pets" ~8 years ago.. something about making cats better understand human speech.
18:53 < kanzure> by integrating humanized FOXP3 gene
18:54 < kanzure> .wik foxp3
18:54 < saxo> "FOXP3 (forkhead box P3), also known as scurfin, is a protein involved in immune system responses. A member of the FOX protein family, FOXP3 appears to function as a master regulator of the regulatory pathway in the development and function of regulatory T cells." - https://en.wikipedia.org/wiki/Foxp3
18:54 < kanzure> oh looks like it's FOXP2 that is associated with speech, not FOXP3
18:55 < kanzure> i can only hope that they were naming their startup "Sphinx" or "Bastet"
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19:00 < kanzure> https://fluent.pet/collections/products/products/get-started
19:00 < fenn> .tw https://twitter.com/phillip_isola/status/1532189616106881027
19:00 < saxo> Language-conditional models can act a bit like decision transformers, in that you can prompt them with a desired level of "reward". // E.g., want prettier #dalle creations? "Just ask" by adding "[very]^n beautiful": // n=0: "A beautiful painting of a mountain next to a waterfall." https://pbs.twimg.com/media/FUNtOExXsAYw51i.jpg (@phillip_isola) psa from .tw cmd: fuck twitter
19:01 < fenn> worth to look at the thread to see the effect of adding very very very...
19:02 < fenn> kanzure what did you mean by "3scan should have done it, first"
19:04 < kanzure> i mean i can't blame nectome for not heading the bay area neuroscience community when 3scan didn't try
19:04 < kanzure> ((or maybe they did and i don't know about it))
19:04 < kanzure> https://www.youtube.com/watch?v=A_aTKZRKA8o
19:04 < Muaddib> [A_aTKZRKA8o] How many times do I have to tell you to come when called?!? | BilliSpeaks (4:28)
19:05 < fenn> this is being put on by e11 (todd huffman and jun axup) so why is that bad? they have the same broad goal as nectome
19:06 < fenn> uh.. e11 is adam marblestone's "focused research organization" or something
19:06 < fenn> i don't really understand how it's all put together or what they are actually doing
19:07 < fenn> "We are engaged in moonshot neuroscience to map the architecture of mammalian brain circuits."
19:08 < fenn> and andrew payne https://twitter.com/Andrew_C_Payne/status/1354960093763272709
19:08 < fenn> .tw
19:08 < saxo> So happy to have contributed to ExSEQ, out today in @ScienceMagazine! We use hydrogel chemistry (ExM) to swell intact tissues like a balloon 🎈🧠, enabling spatial transcriptomics 🧬🔬 more precise than a single wavelength of light! // https://science.sciencemag.org/content/371/6528/eaax2656 (@Andrew_C_Payne) psa from .tw cmd: fuck twitter
19:12 < kanzure> oh it's todd, that's good
19:12 < kanzure> hm, do we not have enough mammalian architecture? what is the argument for getting all the microcircuit stuff btw?
19:24 < fenn> reading between the lines, i think they want to implement a process digitize all of the information required to emulate a brain, and the "architecture" stuff is a minimum viable product for researchers
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--- Log closed Tue Jan 10 00:00:10 2023