--- Log opened Sun Jan 22 00:00:21 2023
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09:41 < Jay_Dugger> Today marks 10 years, 6 months, and two weeks of 19-5 intermittent fasting for me.
09:42 < Jay_Dugger> Not counting the six weeks I did it immediately before starting tracking.
09:44 < Jay_Dugger> The first two days extremely difficult, the next two weeks only hard, and normalized after first six weeks.
09:44 < Jay_Dugger> No blood tests available for this period.
09:48 < L29Ah> Jay_Dugger: how about some metformin?
09:49 < Jay_Dugger> Are you offering?
09:49 < Jay_Dugger> At a guess, IF costs less and has fewer side effects.
09:50 < Jay_Dugger> I don't know which works better.
09:50 < Jay_Dugger> One could do both.
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11:11 < nsh> balanced diet, restraint and exercise will always be better for health than whatever fads are in vogue. if some kinda of structure like intermittent fasting helps with the restraint aspect then there's no harm in it. one can even try to 'optimise' regimens if that makes it more engaging to stick to them and even flatter themselves that they're hacking anything other than their own will 
11:12 < nsh> ceremony is often an end in itself
11:13 < fenn> how about not parading your ignorance around the channel
11:13 < fenn> at least show some restraint
11:21 < L29Ah> what if balanced diet, restraint and exercise are fads that are in vogue
11:24 < jrayhawk> re: metformin: attempting to indiscriminantly blunt oxidative stress and inflammation to compensate for a lifestyle of reckless disregard for oxidative safety and immunological safety has its downsides https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351883/ https://academic.oup.com/innovateage/article/2/suppl_1/544/5169519
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11:24 < jrayhawk> IF also has some unique advantages in inducing yamanaka factors and autophagy
11:28 < fenn> i wish there were a drug that made exercise not feel awful
11:29 < fenn> (and also said drug would not be horribly addictive and dangerous)
11:30 < fenn> most people seem to actually enjoy exercise, something i've always had a hard time believing
11:30 < L29Ah> i recommend caffeine
11:30 < fenn> that just lowers the threshold for activity
11:30 < L29Ah> 200mg and some heavy metal makes you eager to chop all this firewood and more
11:30 < fenn> it helps, sure
11:31 < L29Ah> amphetamine takes it a little further additionally, but arguably more dangerous
11:32 < fenn> i'll admit i haven't tried amphetamines as part of an exercise regimen
11:32 < jrayhawk> the side effects of caffeine are worse for the same level of stimulation
11:34 < jrayhawk> fenn: is it metabolic conditioning or strength conditioning that feels awful?
11:34 < hprmbridge> docl> lisdex generic should be available next month https://www.drugs.com/availability/generic-vyvanse.html
11:36 < fenn> generally anything that goes beyond mere "physical activity"
11:38 < fenn> metabolic i guess
11:39 < hprmbridge> docl> is it more noticeably awful during, after, or leading up to/getting motivated?
11:40 < L29Ah> jrayhawk: well caffeine doesn't really stimulate you, it's more about ignoring fatigue
11:40 < fenn> during and immediately after
11:42 < fenn> i also don't particularly like spicy food or being spanked or whatever
11:42 < fenn> or hugs
11:43 < hprmbridge> docl> any physical activity you can get lost in / forget the activity feeling? some flavor of dancing maybe
11:44 < fenn> i usually ride my bike but it's not fun to push my limits
11:52 < L29Ah> climbing rocks
11:54 < L29Ah> also sex can get your ass moving
12:04 < kanzure> maybe we should just estimate protein-protein effects for all possible combinations of protein pairs https://twitter.com/luost26/status/1617035277108936704
12:04 < hplusbot> kanzure: error: unauthorized
12:07 < kanzure> and this is a different protein-protein interaction manuscript using protein language models https://www.nature.com/articles/s42003-023-04462-5
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16:13 < Jay_Dugger> What's "hplusbot"?
16:17 < hprmbridge> kanzure> it replaces saxo for titles, twitter, and wikipedia
16:20 < L29Ah> but it sux
16:30 < Jay_Dugger> Thank you. I thought I'd asked that earlier this year. I had.
17:29 < jrayhawk> yeah, not sure why that API key is failing now
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20:37 < jrayhawk> https://www.anti-agingfirewalls.com/2023/01/22/two-faces-of-life-extension/ more vince giuliano
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--- Log closed Mon Jan 23 00:00:22 2023