--- Log opened Thu Jan 26 00:00:25 2023
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05:07 < hprmbridge> kanzure>  https://cdn.discordapp.com/attachments/1064664282450628710/1068155302555418644/image0.jpg
05:10 < L29Ah> sci-hub.se is dead :<
05:13 < kanzure> you might be able to genomically encode a statistical connectome by having a stretch of DNA on a chromosome that encodes different expression profiles
05:13 < kanzure> each one would have a timer, say at least 12 hours but possibly more, before it self-histone-modifies itself to turn off
05:13 < kanzure> meanwhile, descendant cells would also have that same timer, and eventually they would all be differentiating into the next cell type specified
05:14 < kanzure> you wouldn't be able to specify the connection matrix because there's not enough room (and/or i don't know how to do that), but you could specify cell types and connection tendencies (cell growth rate, axon growth, dendrite branching factors, cell-cell homing and discrimination, cell type differentiation)
05:14 < kanzure> kind of a conceptual reverse of the "cell lineage tracing" stuff
05:17 < kanzure> long-range projections would be a lot easier if the connections were made earlier, and then they just naturally grow and extend the axons based on geometrical constraint or physical stress as the neuron bodies grow further apart to accommodate the growth of other cells in the brain
05:18 < kanzure> (you would also need to disable the natural neuronal stem cell differentiation plan, which currently escapes me.)
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07:30 < hprmbridge> nmz787> How about pseudopodia/dendrite homing based on quorum sensing? Probably not enough quorum signals in existence? Plus smelling them means they're diffusing around the growth media.
07:31 < hprmbridge> nmz787> The one starting cell would need to sit and wait until all neurons involved were present before any connections would be made
07:32 < hprmbridge> nmz787> Then simultaneously, maybe, they start expressing their odor, and their dendrites start smelling around for their target
07:34 < hprmbridge> kanzure> what's the goal?
07:34 < hprmbridge> nmz787> Or maybe there's some optimization like the genomic storage encoding is breadth-first search... Such that when the first/starting cell on during regrowth has it's connecting cells born, it can quickly connect
07:34 < hprmbridge> nmz787> Connectome connecting
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07:50 < kanzure> yeah it would be nice to be able to just print entire brains, but so far the only reliable way of doing this is just growing whole organisms with brains
08:46 < hprmbridge> nmz787> Until the printer jams
08:46 < hprmbridge> nmz787> PC LOAD LETTER
08:48 < hprmbridge> nmz787> Today in "growing whole organisms with brains"... Getting sick monthly from the organism attending school is quite undesirable
09:14 < hprmbridge> kanzure> any three-dimensional connection graph should be expressable in two dimensions right?
09:37 < hprmbridge> kanzure> what dylan morris is up to (protein language models startup): https://twitter.com/thisismadani/status/1618657841761624066
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10:20 < kanzure> doudna 10 year review article on CRISPR/Cas9 https://www.science.org/doi/10.1126/science.add8643
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13:35 < kanzure> is the squid giant axon really just a single axon of a single neuron (like a normal neuron with a single nuclei)? https://en.wikipedia.org/wiki/Squid_giant_axon
13:37 < kanzure> https://en.wikipedia.org/wiki/Squid_giant_synapse Lateral giant interneuron
13:40 < kanzure> you could just do a circuit board of this stuff https://www.youtube.com/watch?v=CXCGqwdtJ78&t=1m20s
13:41 < kanzure> "axoplasm" pffft
13:42 < kanzure> you could place this on a 2d sheet and then just staple it down, haha
13:56 < kanzure> "axons growing inside microfluidic channels" https://www.youtube.com/watch?v=Mo7ffc56XvY
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22:49 < hprmbridge> nmz787> huh, pretty neat
22:49 < hprmbridge> nmz787> that giant neuron makes me wonder about bio-pumping ions
22:50 < hprmbridge> nmz787> like, selective osmosis or something
--- Log closed Fri Jan 27 00:00:26 2023