--- Log opened Fri Feb 17 00:00:46 2023
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06:02 < muurkha> fenn: yeah, I've read that a couple of times, and I think it's plausible, but evidence is weak
06:04 < nsh> maybe your zoloft stopped working because anyone who still reads slatestarcodex is beyond antidepressants 
06:04 < nsh> kiddin' on
06:05 < nsh> or am i...
06:27 < L29Ah> <3
06:32 < hprmbridge> kanzure> "Symbolic discovery of optimization algorithms" https://arxiv.org/abs/2302.06675
06:34 < hprmbridge> kanzure> "practical timelock encryption from threshold BLS" https://twitter.com/AnomalRoil/status/1625805755780661248 https://eprint.iacr.org/2023/189
07:25 < kanzure> "Hypoimmunogenic neural cells for the treatment of neurological disorders and conditions" https://patents.google.com/patent/BR112022019060A2/en
07:26 < kanzure> ah, this one has the description https://patents.google.com/patent/CA3173096A1/en
07:27 < kanzure> "... genetically modifying human pluripotent stem cells to i) reduce expression of MHC class I human leukocyte antigens and/or MHC class II human leukocyte antigens in the human pluripotent stem cells and ii) overexpress an exogenous CD47 polypeptide in the human pluripotent stem cells, b) differentiating the human pluripotent stem cells into neural cells; and c) assaying the neural cells for ...
07:27 < kanzure> ...a hypoimmunogenicity phenotype"
07:28 < kanzure> why? if you can take a patient's stem cells and induce pluripotency, reinject into patient, then immunogenicity shouldn't be an issue right?
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08:09 < muurkha> I think the immune system does take action in cases of cancer and is also somehow involved in wound healing
08:35 < yashgaroth> it handles the many pre-cancerous growths everyone has, up to a point. Also keeps pathogens from entering wounds. Inflammation triggers the healing process, in part, but it's complicated
08:36 < yashgaroth> I assume that patent is to generate cells that aren't attacked in autoimmune disorders, where the immune system is already attacking their own cells
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10:14 < kanzure> https://www.reddit.com/r/bing/comments/113z1a6/the_bing_persistent_memory_thread/
10:22 < kanzure> "Information retrieval methods for DNA data storage" https://digital.lib.washington.edu/researchworks/handle/1773/49653  (someone's phd thesis published ~today)
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14:11 < fenn> automatic conversion of 3D mesh to CSG tree https://dl.acm.org/doi/10.1145/3272127.3275006
14:13 < fenn> i wonder how well it works on photogrammetry data
14:19 < fenn> what CAN'T be improved by framing it as a program synthesis problem?
14:28 < fenn> "Lion (EvoLved Sign Momentum)" is the most stretched backronym i've ever seen
14:30 < fenn> evoLved sIgn mOmeNtum
14:45 < TMA> INTERCAL - Compiler Language With No Pronounceable Acronym is even more stretched
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15:58 < muurkha> TMA: good point
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20:16 < hprmbridge> nmz787> Has anyone asked chat gpt or bing about chemical retrosynthesis?
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--- Log closed Sat Feb 18 00:00:47 2023